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Article

Cancer stem cell biomarkers for head and neck squamous cell carcinoma: A bioinformatic analysis

  • Authors:
    • Meng Xiao
    • Liu Liu
    • Shijian Zhang
    • Xi Yang
    • Yan'an Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial‑Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, P.R. China
  • Pages: 3843-3851
    |
    Published online on: October 8, 2018
       https://doi.org/10.3892/or.2018.6771
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Abstract

Several putative biomarkers have been reported to identify cancer stem cells (CSCs) in head and neck squamous cell carcinoma (HNSCC). Herein, we aimed to demonstrate the validity and the underlying relationship for these biomarkers in HNSCC. Bioinformatic analyses for the reported CSC biomarkers of HNSCC were performed based on the TCGA primary HNSCC cohort using the UCSC Xena browser. Targeted strategies for the validated biomarkers were searched and summarized. A total of 27 reported CSC biomarkers for HNSCC were identified and comprehensively evaluated. In regards to the expression pattern of CD44 in HNSCC, the expression patterns for the remaining 26 biomarkers presented 3 different tendencies. We managed to include all the 27 CSC biomarkers for HNSCC into 3 groups. Moreover, the biomarkers in each group indicated distinct clinicopathological features and a different overall survival status for HNSCC patients. The above information suggested the existence of CSC subpopulations in HNSCC. Accordingly, we demonstrated that precisely targeted strategies based on the CSC subgrouping clusters might effectively supplement conventional therapies, and benefit HNSCC patients. Further relevant studies are still necessary to improve treatment strategies for HNSCC based on the CSC area.
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Copy and paste a formatted citation
Spandidos Publications style
Xiao M, Liu L, Zhang S, Yang X and Wang Y: Cancer stem cell biomarkers for head and neck squamous cell carcinoma: A bioinformatic analysis. Oncol Rep 40: 3843-3851, 2018.
APA
Xiao, M., Liu, L., Zhang, S., Yang, X., & Wang, Y. (2018). Cancer stem cell biomarkers for head and neck squamous cell carcinoma: A bioinformatic analysis. Oncology Reports, 40, 3843-3851. https://doi.org/10.3892/or.2018.6771
MLA
Xiao, M., Liu, L., Zhang, S., Yang, X., Wang, Y."Cancer stem cell biomarkers for head and neck squamous cell carcinoma: A bioinformatic analysis". Oncology Reports 40.6 (2018): 3843-3851.
Chicago
Xiao, M., Liu, L., Zhang, S., Yang, X., Wang, Y."Cancer stem cell biomarkers for head and neck squamous cell carcinoma: A bioinformatic analysis". Oncology Reports 40, no. 6 (2018): 3843-3851. https://doi.org/10.3892/or.2018.6771
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao M, Liu L, Zhang S, Yang X and Wang Y: Cancer stem cell biomarkers for head and neck squamous cell carcinoma: A bioinformatic analysis. Oncol Rep 40: 3843-3851, 2018.
APA
Xiao, M., Liu, L., Zhang, S., Yang, X., & Wang, Y. (2018). Cancer stem cell biomarkers for head and neck squamous cell carcinoma: A bioinformatic analysis. Oncology Reports, 40, 3843-3851. https://doi.org/10.3892/or.2018.6771
MLA
Xiao, M., Liu, L., Zhang, S., Yang, X., Wang, Y."Cancer stem cell biomarkers for head and neck squamous cell carcinoma: A bioinformatic analysis". Oncology Reports 40.6 (2018): 3843-3851.
Chicago
Xiao, M., Liu, L., Zhang, S., Yang, X., Wang, Y."Cancer stem cell biomarkers for head and neck squamous cell carcinoma: A bioinformatic analysis". Oncology Reports 40, no. 6 (2018): 3843-3851. https://doi.org/10.3892/or.2018.6771
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