miR‑144‑3p regulates the resistance of lung cancer to cisplatin by targeting Nrf2

  • Authors:
    • Yan Yin
    • Hua Liu
    • Junhui Xu
    • Dongsheng Shi
    • Liang Zhai
    • Bin Liu
    • Lei Wang
    • Guangxin Liu
    • Jianwen Qin
  • View Affiliations

  • Published online on: October 8, 2018     https://doi.org/10.3892/or.2018.6772
  • Pages: 3479-3488
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Abstract

Chemotherapeutic drug resistance is correlated with treatment failure and poor prognosis among lung cancer patients. Numerous studies indicate the relevance of miRNAs in inducing certain drug resistance. In the course of the study, we unexpectedly found that miR‑144‑3p could regulate the cisplatin resistance of lung cancer cells via Nrf2. However, Nrf2 also could reverse activate the expression of miR‑144‑3p by binding to the ARE box in the miR‑144‑3p promoter. This may be a self‑protection mechanism of the body. In addition, we also found that in other cancer cell lines, such as HepG2, miR‑144‑3p also had the function of regulating cisplatin resistance. These findings may provide some theoretical reference for the clinical inhibition of cisplatin resistance.
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December-2018
Volume 40 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yin Y, Liu H, Xu J, Shi D, Zhai L, Liu B, Wang L, Liu G and Qin J: miR‑144‑3p regulates the resistance of lung cancer to cisplatin by targeting Nrf2 . Oncol Rep 40: 3479-3488, 2018
APA
Yin, Y., Liu, H., Xu, J., Shi, D., Zhai, L., Liu, B. ... Qin, J. (2018). miR‑144‑3p regulates the resistance of lung cancer to cisplatin by targeting Nrf2 . Oncology Reports, 40, 3479-3488. https://doi.org/10.3892/or.2018.6772
MLA
Yin, Y., Liu, H., Xu, J., Shi, D., Zhai, L., Liu, B., Wang, L., Liu, G., Qin, J."miR‑144‑3p regulates the resistance of lung cancer to cisplatin by targeting Nrf2 ". Oncology Reports 40.6 (2018): 3479-3488.
Chicago
Yin, Y., Liu, H., Xu, J., Shi, D., Zhai, L., Liu, B., Wang, L., Liu, G., Qin, J."miR‑144‑3p regulates the resistance of lung cancer to cisplatin by targeting Nrf2 ". Oncology Reports 40, no. 6 (2018): 3479-3488. https://doi.org/10.3892/or.2018.6772