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Dendritic cell factor 1 inhibits proliferation and migration and induces apoptosis of neuroblastoma cells by inhibiting the ERK signaling pathway

  • Authors:
    • Guanghong Luo
    • Ruili Feng
    • Yangyang Sun
    • Lili Zheng
    • Yajiang Wang
    • Yanlu Chen
    • Tieqiao Wen
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai 200444, P.R. China
    Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 103-112
    |
    Published online on: October 16, 2018
       https://doi.org/10.3892/or.2018.6796
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Abstract

Neuroblastoma (NB) is the most common extracranial solid tumor that affects mainly children and has extremely high mortality and recurrence rates. A previous study revealed that dendritic cell factor 1 (DCF1), also called transmembrane protein 59, could activate apoptosis in glioma cells. In the present study, we applied immunofluorescence, western blot analysis, flow cytometry and cell tumorigenicity to investigate the DCF1 mechanisms involved in NB apoptosis. DCF1 was overexpressed in Neuro-2a and SK-N-SH cells through instantaneous transfection. The data revealed that overexpression of DCF1 could inhibit cell proliferation, migration, invasion and promote cell apoptosis in vitro, and suppress NB growth in vivo. The ERK1/2 signaling pathway, which promotes cell survival, was the target of DCF1 in neuroblastoma cells. All the results indicated that DCF1 could be a potential therapeutic target for the understanding and treatment of NB.
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1 

Siegel RL, Miller KD and Jemal A: Cancer Statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Maris JM, Hogarty MD, Bagatell R and Cohn SL: Neuroblastoma. Lancet. 369:2106–2120. 2007. View Article : Google Scholar : PubMed/NCBI

3 

DuBois SG, Kalika Y, Lukens JN, Brodeur GM, Seeger RC, Atkinson JB, Haase GM, Black CT, Perez C, Shimada H, et al: Metastatic sites in stage IV and IVS neuroblastoma correlate with age, tumor biology, and survival. J Pediatr Hematol Oncol. 21:181–189. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Cotterill SJ, Parker L, More L and Craft AW: Neuroblastoma: Changing incidence and survival in young people aged 0–24 years. A report from the North of England Young Persons' Malignant Disease Registry. Med Pediatr Oncol. 36:231–234. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Cohn SL, Pearson AD, London WB, Monclair T, Ambros PF, Brodeur GM, Faldum A, Hero B, Iehara T, Machin D, et al: ; INRG Task Force: The International Neuroblastoma Risk Group (INRG) classification system: An INRG Task Force report. J Clin Oncol. 27:289–297. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Yang XH, Tang F, Shin J and Cunningham JM: A c-Myc-regulated stem cell-like signature in high-risk neuroblastoma: A systematic discovery (Target neuroblastoma ESC-like signature). Sci Rep. 7:412017. View Article : Google Scholar : PubMed/NCBI

8 

DeNardo BD, Holloway MP, Ji Q, Nguyen KT, Cheng Y, Valentine MB, Salomon A and Altura RA: Quantitative phosphoproteomic analysis identifies activation of the RET and IGF-1R/IR signaling pathways in neuroblastoma. PLoS One. 8:e825132013. View Article : Google Scholar : PubMed/NCBI

9 

Martinez MA, Ubeda A, Cid MA and Trillo MA: The proliferative response of NB69 human neuroblastoma cells to a 50 Hz magnetic field is mediated by ERK1/2 signaling. Cell Physiol Biochem. 29:675–686. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Vieira GC, Chockalingam S, Melegh Z, Greenhough A, Malik S, Szemes M, Park JH, Kaidi A, Zhou L, Catchpoole D, et al: LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma. Oncotarget. 6:40053–40067. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Vujic I, Posch C, Sanlorenzo M, Yen AJ, Tsumura A, Kwong A, Feichtenschlager V, Lai K, Arneson DV, Rappersberger K, et al: Mutant NRASQ61 shares signaling similarities across various cancer types-potential implications for future therapies. Oncotarget. 5:7936–7944. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Pugh TJ, Morozova O, Attiyeh EF, Asgharzadeh S, Wei JS, Auclair D, Carter SL, Cibulskis K, Hanna M, Kiezun A, et al: The genetic landscape of high-risk neuroblastoma. Nat Genet. 45:279–284. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Eleveld TF, Oldridge DA, Bernard V, Koster J, Colmet Daage L, Diskin SJ, Schild L, Bentahar NB, Bellini A, Chicard M, et al: Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations. Nat Genet. 47:864–871. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Schramm A, Köster J, Assenov Y, Althoff K, Peifer M, Mahlow E, Odersky A, Beisser D, Ernst C, Henssen AG, et al: Mutational dynamics between primary and relapse neuroblastomas. Nat Genet. 47:872–877. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Roberts PJ and Der CJ: Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene. 26:3291–3310. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Montagut C and Settleman J: Targeting the RAF-MEK-ERK pathway in cancer therapy. Cancer Lett. 283:125–134. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Yu Z, Ye S, Hu G, Lv M, Tu Z, Zhou K and Li Q: The RAF-MEK-ERK pathway: Targeting ERK to overcome obstacles to effective cancer therapy. Future Med Chem. 7:269–289. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Wang L, Wang J, Wu Y, Wu J, Pang S, Pan R and Wen T: A novel function of dcf1 during the differentiation of neural stem cells in vitro. Cell Mol Neurobiol. 28:887–894. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Li X, Feng R, Huang C, Wang H, Wang J, Zhang Z, Yan H and Wen T: MicroRNA-351 regulates TMEM 59 (DCF1) expression and mediates neural stem cell morphogenesis. RNA Biol. 9:292–301. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Xie Y, Li Q, Yang Q, Yang M, Zhang Z, Zhu L, Yan H, Feng R, Zhang S, Huang C, et al: Overexpression of DCF1 inhibits glioma through destruction of mitochondria and activation of apoptosis pathway. Sci Rep. 4:37022014. View Article : Google Scholar : PubMed/NCBI

21 

Liu Q, Feng R, Chen Y, Luo G, Yan H, Chen L, Lin R, Ding Y and Wen T: Dcf1 triggers dendritic spine formation and facilitates memory acquisition. Mol Neurobiol. 55:763–775. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Liu Q, Chen Y, Li Q, Wu L and Wen T: Dcf1 regulates neuropeptide expression and maintains energy balance. Neurosci Lett. 650:1–7. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Xie Y, Li Q, Yang Q, Yang M, Zhang Z, Zhu L, Yan H, Feng R, Zhang S, Huang C, et al: Overexpression of DCF1 inhibits glioma through destruction of mitochondria and activation of apoptosis pathway. Sci Rep. 4:pp. 37022014, https://doi.org/10.1038/srep03702 View Article : Google Scholar : PubMed/NCBI

24 

Kim MS, Yu JM, Kim HJ, Kim HB, Kim ST, Jang SK, Choi YW, Lee DI and Joo SS: Ginsenoside Re and Rd enhance the expression of cholinergic markers and neuronal differentiation in Neuro-2a cells. Biol Pharm Bull. 37:826–833. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Weibel S, Hofmann E, Basse-Luesebrink TC, Donat U, Seubert C, Adelfinger M, Gnamlin P, Kober C, Frentzen A, Gentschev I, et al: Treatment of malignant effusion by oncolytic virotherapy in an experimental subcutaneous xenograft model of lung cancer. J Transl Med. 11:1062013.https://doi.org/10.1186/1479-5876-11-106 View Article : Google Scholar : PubMed/NCBI

26 

Pagano M, Pepperkok R, Verde F, Ansorge W and Draetta G: Cyclin A is required at two points in the human cell cycle. EMBO J. 11:961–971. 1992. View Article : Google Scholar : PubMed/NCBI

27 

Chipuk JE, Fisher JC, Dillon CP, Kriwacki RW, Kuwana T and Green DR: Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. Proc Natl Acad Sci USA. 105:20327–20332. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Ambrosini G, Adida C and Altieri DC: A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med. 3:917–921. 1997. View Article : Google Scholar : PubMed/NCBI

29 

Shin S, Sung BJ, Cho YS, Kim HJ, Ha NC, Hwang JI, Chung CW, Jung YK and Oh BH: An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and-7. Biochemistry. 40:1117–1123. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Lavoie JN, L'Allemain G, Brunet A, Müller R and Pouysségur J: Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem. 271:20608–20616. 1996. View Article : Google Scholar : PubMed/NCBI

31 

Caunt CJ, Sale MJ, Smith PD and Cook SJ: ME K1 and MEK2 inhibitors and cancer therapy: The long and winding road. Nat Rev Cancer. 15:577–592. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Liu Y, Zhang X, Yang B, Zhuang H, Guo H, Wei W, Li Y, Chen R, Li Y and Zhang N: Demethylation-induced overexpression of Shc3 drives c-Raf-independent activation of MEK/ERK in HCC. Cancer Res. 78:2219–2232. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Yang C, Zheng W and Du W: CXCR3A contributes to the invasion and metastasis of gastric cancer cells. Oncol Rep. 36:1686–1692. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Hou H, Ge C, Sun H, Li H, Li J and Tian H: Tunicamycin inhibits cell proliferation and migration in hepatocellular carcinoma through suppression of CD44s and the ERK1/2 pathway. Cancer Sci. 109:1088–1100. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Zhao H, Liu B and Li J: LIM and SH3 protein 1 knockdown suppresses proliferation and metastasis of colorectal carcinoma cells via inhibition of the mitogen-activated protein kinase signaling pathway. Oncol Lett. 15:6839–6844. 2018.PubMed/NCBI

36 

Ferreira-Silva GA, Lages CC, Sartorelli P, Hasegawa FR, Soares MG and Ionta M: Casearin D inhibits ERK phosphorylation and induces downregulation of cyclin D1 in HepG2 cells. Toxicol In Vitro. 38:27–32. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Xu X, Wang Q, He Y, Ding L, Zhong F, Ou Y, Shen Y, Liu H and He S: ADP-ribosylation factor 1 (ARF1) takes part in cell proliferation and cell adhesion-mediated drug resistance (CAM-DR). Ann Hematol. 96:847–858. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Yan Y, Wang L, He J, Liu P, Lv X and Zhang Y, Xu X, Zhang L and Zhang Y: Synergy with interferon-lambda 3 and sorafenib suppresses hepatocellular carcinoma proliferation. Biomed Pharmacother. 88:395–402. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Uehling DE and Harris PA: Recent progress on MAP kinase pathway inhibitors. Bioorg Med Chem Lett. 25:4047–4056. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Wu PK and Park JI: MEK1/2 Inhibitors: Molecular activity and resistance mechanisms. Semin Oncol. 42:849–862. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Serini S and Calviello G: Modulation of Ras/ERK and phosphoinositide signaling by long-chain n-3 PUFA in breast cancer and their potential complementary role in combination with targeted drugs. Nutrients. 9:1852017.doi:10.3390/nu9030185. View Article : Google Scholar :

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Copy and paste a formatted citation
Spandidos Publications style
Luo G, Feng R, Sun Y, Zheng L, Wang Y, Chen Y and Wen T: Dendritic cell factor 1 inhibits proliferation and migration and induces apoptosis of neuroblastoma cells by inhibiting the ERK signaling pathway. Oncol Rep 41: 103-112, 2019.
APA
Luo, G., Feng, R., Sun, Y., Zheng, L., Wang, Y., Chen, Y., & Wen, T. (2019). Dendritic cell factor 1 inhibits proliferation and migration and induces apoptosis of neuroblastoma cells by inhibiting the ERK signaling pathway. Oncology Reports, 41, 103-112. https://doi.org/10.3892/or.2018.6796
MLA
Luo, G., Feng, R., Sun, Y., Zheng, L., Wang, Y., Chen, Y., Wen, T."Dendritic cell factor 1 inhibits proliferation and migration and induces apoptosis of neuroblastoma cells by inhibiting the ERK signaling pathway". Oncology Reports 41.1 (2019): 103-112.
Chicago
Luo, G., Feng, R., Sun, Y., Zheng, L., Wang, Y., Chen, Y., Wen, T."Dendritic cell factor 1 inhibits proliferation and migration and induces apoptosis of neuroblastoma cells by inhibiting the ERK signaling pathway". Oncology Reports 41, no. 1 (2019): 103-112. https://doi.org/10.3892/or.2018.6796
Copy and paste a formatted citation
x
Spandidos Publications style
Luo G, Feng R, Sun Y, Zheng L, Wang Y, Chen Y and Wen T: Dendritic cell factor 1 inhibits proliferation and migration and induces apoptosis of neuroblastoma cells by inhibiting the ERK signaling pathway. Oncol Rep 41: 103-112, 2019.
APA
Luo, G., Feng, R., Sun, Y., Zheng, L., Wang, Y., Chen, Y., & Wen, T. (2019). Dendritic cell factor 1 inhibits proliferation and migration and induces apoptosis of neuroblastoma cells by inhibiting the ERK signaling pathway. Oncology Reports, 41, 103-112. https://doi.org/10.3892/or.2018.6796
MLA
Luo, G., Feng, R., Sun, Y., Zheng, L., Wang, Y., Chen, Y., Wen, T."Dendritic cell factor 1 inhibits proliferation and migration and induces apoptosis of neuroblastoma cells by inhibiting the ERK signaling pathway". Oncology Reports 41.1 (2019): 103-112.
Chicago
Luo, G., Feng, R., Sun, Y., Zheng, L., Wang, Y., Chen, Y., Wen, T."Dendritic cell factor 1 inhibits proliferation and migration and induces apoptosis of neuroblastoma cells by inhibiting the ERK signaling pathway". Oncology Reports 41, no. 1 (2019): 103-112. https://doi.org/10.3892/or.2018.6796
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