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Article

Mechanisms underlying the increased chemosensitivity of bortezomib-resistant multiple myeloma by silencing nuclear transcription factor Snail1

  • Authors:
    • Zhenqi Huang
    • Xinglin Liang
    • Wei Wu
    • Xiaowen Chen
    • Qingshu Zeng
    • Mingzhen Yang
    • Jian Ge
    • Ruixiang Xia
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui 230032, P.R. China
  • Pages: 415-426
    |
    Published online on: October 16, 2018
       https://doi.org/10.3892/or.2018.6797
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Abstract

The Snail family transcriptional repressor 1 gene (Snail1) was screened in multiple myeloma cells (MMCs) from bortezomib-resistant MM patients and was found to be significantly associated with the development of drug-resistance mechanisms. In the present study, we first confirmed that the protein expression of Snail1 in bortezomib-resistant MMCs was significantly higher than that in MMCs without bortezomib resistance. The mechanistic studies confirmed that the enhancement of Snail1 expression in bortezomib-resistant MMCs directly upregulated transcription of the intracellular MDR1 gene to immediately develop multiple drug resistance mechanisms and inhibited P53 protein expression through the Snail1/hsa-miRNA-22-3p/P53 pathway to inhibit tumor cell apoptosis. By upregulating MDR1 and downregulating P53, Snail1 induced the drug resistance of MMCs to bortezomib, while Snail1 gene silencing effectively improved the drug sensitivity of MMCs to bortezomib chemotherapy. The present study further elucidated the drug resistance mechanisms of MMCs and provides evidence for increased clinical efficacy of bortezomib in MM patients.
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Copy and paste a formatted citation
Spandidos Publications style
Huang Z, Liang X, Wu W, Chen X, Zeng Q, Yang M, Ge J and Xia R: Mechanisms underlying the increased chemosensitivity of bortezomib-resistant multiple myeloma by silencing nuclear transcription factor Snail1. Oncol Rep 41: 415-426, 2019.
APA
Huang, Z., Liang, X., Wu, W., Chen, X., Zeng, Q., Yang, M. ... Xia, R. (2019). Mechanisms underlying the increased chemosensitivity of bortezomib-resistant multiple myeloma by silencing nuclear transcription factor Snail1. Oncology Reports, 41, 415-426. https://doi.org/10.3892/or.2018.6797
MLA
Huang, Z., Liang, X., Wu, W., Chen, X., Zeng, Q., Yang, M., Ge, J., Xia, R."Mechanisms underlying the increased chemosensitivity of bortezomib-resistant multiple myeloma by silencing nuclear transcription factor Snail1". Oncology Reports 41.1 (2019): 415-426.
Chicago
Huang, Z., Liang, X., Wu, W., Chen, X., Zeng, Q., Yang, M., Ge, J., Xia, R."Mechanisms underlying the increased chemosensitivity of bortezomib-resistant multiple myeloma by silencing nuclear transcription factor Snail1". Oncology Reports 41, no. 1 (2019): 415-426. https://doi.org/10.3892/or.2018.6797
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Z, Liang X, Wu W, Chen X, Zeng Q, Yang M, Ge J and Xia R: Mechanisms underlying the increased chemosensitivity of bortezomib-resistant multiple myeloma by silencing nuclear transcription factor Snail1. Oncol Rep 41: 415-426, 2019.
APA
Huang, Z., Liang, X., Wu, W., Chen, X., Zeng, Q., Yang, M. ... Xia, R. (2019). Mechanisms underlying the increased chemosensitivity of bortezomib-resistant multiple myeloma by silencing nuclear transcription factor Snail1. Oncology Reports, 41, 415-426. https://doi.org/10.3892/or.2018.6797
MLA
Huang, Z., Liang, X., Wu, W., Chen, X., Zeng, Q., Yang, M., Ge, J., Xia, R."Mechanisms underlying the increased chemosensitivity of bortezomib-resistant multiple myeloma by silencing nuclear transcription factor Snail1". Oncology Reports 41.1 (2019): 415-426.
Chicago
Huang, Z., Liang, X., Wu, W., Chen, X., Zeng, Q., Yang, M., Ge, J., Xia, R."Mechanisms underlying the increased chemosensitivity of bortezomib-resistant multiple myeloma by silencing nuclear transcription factor Snail1". Oncology Reports 41, no. 1 (2019): 415-426. https://doi.org/10.3892/or.2018.6797
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