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Article

Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression

  • Authors:
    • Lei Zhu
    • Xiao‑Xia Li
    • Liang Shi
    • Jing Wu
    • Jia‑Yi Qian
    • Tian‑Song Xia
    • Wen‑Bin Zhou
    • Xi Sun
    • Xu‑Jie Zhou
    • Ji‑Fu Wei
    • Qiang Ding
  • View Affiliations / Copyright

    Affiliations: Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Critical Care Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Research Division of Clinical Pharmacology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 455-464
    |
    Published online on: November 1, 2018
       https://doi.org/10.3892/or.2018.6842
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Abstract

A total of 70% of breast cancers express the estrogen receptor (ER)α; therefore, targeting the ER may be an effective endocrine therapy with which to inhibit breast cancer growth. Tamoxifen is the most common‑used clinically used drug for the treatment of advanced or metastatic ER‑positive (ER+) breast cancer. However, a substantial proportion of patients become resistant to endocrine therapies. To overcome this limitation, in this stud, we sought to maximize the benefits associated with tamoxifen therapy via drug combination strategies. We demonstrated that rapamycin, an FDA‑approved mammalian target of rapamycin (mTOR) inhibitor, enhanced the effects of endocrine therapy with tamoxifen, and the concentration of tamoxifen required for ER+ breast cancer cell growth inhibition was substantially reduced. Moreover, treatment with rapamycin plus tamoxifen significantly inhibited tumor growth in vivo. In addition, this synergistic effect may be mediated by the induction of p73. We revealed a novel mechanism in which p73 increases ERα expression by directly binding to the promoter region of the ERα gene. Taken together, the findings of this study indicate that combination therapy with rapamycin and tamoxifen underlying p73‑mediated ERα expression may provide new insight into the drug combination for the treatment of ER+ breast cancer.
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View References

1 

Cancer Genome Atlas Network: Comprehensive molecular portraits of human breast tumors. Nature. 490:61–70. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 98:10869–10874. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Creighton CJ: The molecular profile of luminal B breast cancer. Biologics. 6:289–297. 2012.PubMed/NCBI

4 

Katzenellenbogen BS and Katzenellenbogen JA: Estrogen receptor transcription and transactivation: Estrogen receptor alpha and estrogen receptor beta: Regulation by selective estrogen receptor modulators and importance in breast cancer. Breast Cancer Res. 2:335–344. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Burns KA and Korach KS: Estrogen receptors and human disease: An update. Arch Toxicol. 86:1491–1504. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Higa GM and Fell RG: Sex hormone receptor repertoire in breast cancer. Int J Breast Cancer. 2013:2840362013. View Article : Google Scholar : PubMed/NCBI

7 

Yager JD and Davidson NE: Estrogen carcinogenesis in breast cancer. N Engl J Med. 354:270–282. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Shanle EK and Xu W: Selectively targeting estrogen receptors for cancer treatment. Adv Drug Deliver Rev. 62:1265–1276. 2010. View Article : Google Scholar

9 

Britton DJ, Hutcheson IR, Knowlden JM, Barrow D, Giles M, McClelland RA, Gee JMW and Nicholson RI: Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth. Breast Cancer Res Treat. 96:131–146. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Jeselsohn R, Buchwalter G, De Angelis C, Brown M and Schiff R: ESR1 mutations-a mechanism for acquired endocrine resistance in breast cancer. Nat Rev Clin Oncol. 12:573–583. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Morandi A, Martin L, Gao Q, Pancholi S, Mackay A, Robertson D, Zvelebil M, Dowsett M, Plaza-Menacho I and Isacke CM: GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors. Cancer Res. 73:3783–3795. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Wang P, Bahreini A, Gyanchandani R, Lucas PC, Hartmaier RJ, Watters RJ, Jonnalagadda AR, Trejo Bittar HE, Berg A, Hamilton RL, et al: Sensitive detection of mono- and polyclonal ESR1 mutations in primary tumors, metastatic lesions and cell free DNA of breast cancer patients. Clin Cancer Res. 22:1130–1137. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Ali S and Coombes RC: Endocrine-responsive breast cancer and strategies for combating resistance. Nat Rev Cancer. 2:101–112. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Stathopoulos GP and Trafalis D: High-dose tamoxifen in breast cancer bone metastasis. J BUON. 18:532–534. 2013.PubMed/NCBI

15 

Hendrick A and Subramanian VP: Tamoxifen and thromboembolism. JAMA. 243:514–515. 1980. View Article : Google Scholar : PubMed/NCBI

16 

Musgrove EA and Sutherland L: Biological determinants of endocrine resistance in breast cancer. Nat Rev Cancer. 9:631–643. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Lorizio W, Wu AH, Beattie MS, Rugo H, Tchu S, Kerlikowske K and Ziv E: Clinical and biomarker predictors of side effects from tamoxifen. Breast Cancer Res Treat. 132:1107–1118. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Castrellon AB: Novel strategies to improve the endocrine therapy of breast cancer. Oncol Rev. 11:3232017. View Article : Google Scholar : PubMed/NCBI

19 

Ma J, Guo Y, Chen S, Zhong C, Xue Y, Zhang Y, Lai X, Wei Y, Yu S, Zhang J, et al: Metformin enhances tamoxifen-mediated tumor growth inhibition in ER-positive breast carcinoma. BMC Cancer. 14:1722014. View Article : Google Scholar : PubMed/NCBI

20 

Kumar BN, Rajput S, Dey KK, Parekh A, Das S, Mazumdar A and Mandal M: Celecoxib alleviates tamoxifen-instigated angiogenic effects by ROS-dependent VEGF/VEGFR2 autocrine signaling. BMC Cancer. 13:2732013. View Article : Google Scholar : PubMed/NCBI

21 

Hare SH and Harvey AJ: mTOR function and therapeutic targeting in breast cancer. Am J Cancer Res. 7:383–404. 2017.PubMed/NCBI

22 

Wong SW, Tiong KH, Kong WY, Yue YC, Chua CH, Lim JY, Lee CY, Quah SI, Fow C, Chung C, et al: Rapamycin synergizes cisplatin sensitivity in basal-like breast cancer cells through up-regulation of p73. Breast Cancer Res Treat. 128:301–313. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Martin L, Pancholi S, Farmer I, Guest S, Ribas R, Weigel MT, Thornhill AM, Ghazoui Z, A'Hern R, Evans DB, et al: Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo. Breast Cancer Res. 14:R1322012. View Article : Google Scholar : PubMed/NCBI

24 

Chou T and Talalay P: Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul. 22:27–55. 1984. View Article : Google Scholar : PubMed/NCBI

25 

Schindlbeck C, Jeschke U, Schulze S, Karsten U, Janni W, Rack B, Krajewski S, Sommer H and Friese K: Prognostic impact of Thomsen-Friedenreich tumor antigen and disseminated tumor cells in the bone marrow of breast cancer patients. Breast Cancer Res Treat. 101:17–25. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Lou P, Li C, Shi L, Xia TS, Zhou W, Wu J, Zhou X, Li X, Wang Y, Wei JF, et al: RNPC1 enhances progesterone receptor functions by regulating its mRNA stability in breast cancer. Oncotarget. 8:16387–16400. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Shi L, Xia T, Wei X, Zhou W, Xue J, Cheng L, Lou P, Li C, Wang Y, Wei JF, et al: Estrogen receptor (ER) was regulated by RNPC1 stabilizing mRNA in ER positive breast cancer. Oncotarget. 6:12264–12278. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Li XX, Shi L, Zhou XJ, Wu J, Xia TS, Zhou WB, Sun X, Zhu L, Wei JF and Ding Q: The role of c-Myc-RBM38 loop in the growth suppression in breast cancer. J Exp Clin Cancer Res. 36:492017. View Article : Google Scholar : PubMed/NCBI

30 

Tamoxifen for early breast cancer: An overview of the randomised trials. Early breast cancer trialists' collaborative group. Lancet. 351:1451–1467. 1998. View Article : Google Scholar : PubMed/NCBI

31 

Osborne CK: Tamoxifen in the treatment of breast cancer. N Engl J Med. 339:1609–1618. 1998. View Article : Google Scholar : PubMed/NCBI

32 

Davies C, Pan H, Godwin J, Gray R, Arriagada R, Raina V, Abraham M, Medeiros Alencar VH, Badran A, Bonfill X, et al: Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet. 381:805–816. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Raje N, Kumar S, Hideshima T, Ishitsuka K, Chauhan D, Mitsiades C, Podar K, Le Gouill S, Richardson P, Munshi NC, et al: Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma. Blood. 104:4188–4193. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Markman B, Dienstmann R and Tabernero J: Targeting the PI3K/Akt/mTOR pathway-beyond rapalogs. Oncotarget. 1:530–543. 2010.PubMed/NCBI

35 

Ellis MJ, Tao Y, Young O, White S, Proia AD, Murray J, Renshaw L, Faratian D, Thomas J, Dowsett M, et al: Estrogen-independent proliferation is present in estrogen-receptor HER2-positive primary breast cancer after neoadjuvant letrozole. J Clin Oncol. 24:3019–3025. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Law JH, Habibi G, Hu K, Masoudi H, Wang MY, Stratford AL, Park E, Gee JM, Finlay P, Jones HE, et al: Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival. Cancer Res. 68:10238–10246. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Creighton CJ, Fu X, Hennessy BT, Casa AJ, Zhang Y, Gonzalez-Angulo AM, Lluch A, Gray JW, Brown PH, Hilsenbeck SG, et al: Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer. Breast Cancer Res. 12:R402010. View Article : Google Scholar : PubMed/NCBI

38 

Saal LH, Johansson P, Holm K, Gruvberger-Saal SK, She QB, Maurer M, Koujak S, Ferrando AA, Malmström P, Memeo L, et al: Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. Proc Natl Acad Sci USA. 104:7564–7569. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Gonzalez-Angulo AM, Ferrer-Lozano J, Stemke-Hale K, Sahin A, Liu S, Barrera JA, Burgues O, Lluch AM, Chen H, Hortobagyi GN, et al: PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer. Mol Cancer Ther. 10:1093–1101. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Pérez-Tenorio G, Alkhori L, Olsson B, Waltersson MA, Nordenskjöld B, Rutqvist LE, Skoog L and Stål O: PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer. Clin Cancer Res. 13:3577–3584. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Ciruelos Gil EM: Targeting the PI3K/AKT/mTOR pathway in estrogen receptor-positive breast cancer. Cancer Treat Rev. 40:862–871. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Shirley SH, Rundhaug JE, Tian J, Cullinan-Ammann N, Lambertz I, Conti CJ and Fuchs-Young R: Transcriptional regulation of estrogen receptor-alpha by p53 in human breast cancer cells. Cancer Res. 69:3405–3414. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Rosenbluth JM, Mays DJ, Jiang A, Shyr Y and Pietenpol JA: Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis. Proc Natl Acad Sci USA. 108:2076–2081. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Bachelot T, Bourgier C, Cropet C, Ray-Coquard I, Ferrero J, Freyer G, Abadie-Lacourtoisie S, Eymard J, Debled M, Spaëth D, et al: Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: A GINECO study. J Clin Oncol. 30:2718–2724. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhu L, Li XX, Shi L, Wu J, Qian JY, Xia TS, Zhou WB, Sun X, Zhou XJ, Wei JF, Wei JF, et al: Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression. Oncol Rep 41: 455-464, 2019.
APA
Zhu, L., Li, X., Shi, L., Wu, J., Qian, J., Xia, T. ... Ding, Q. (2019). Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression. Oncology Reports, 41, 455-464. https://doi.org/10.3892/or.2018.6842
MLA
Zhu, L., Li, X., Shi, L., Wu, J., Qian, J., Xia, T., Zhou, W., Sun, X., Zhou, X., Wei, J., Ding, Q."Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression". Oncology Reports 41.1 (2019): 455-464.
Chicago
Zhu, L., Li, X., Shi, L., Wu, J., Qian, J., Xia, T., Zhou, W., Sun, X., Zhou, X., Wei, J., Ding, Q."Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression". Oncology Reports 41, no. 1 (2019): 455-464. https://doi.org/10.3892/or.2018.6842
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu L, Li XX, Shi L, Wu J, Qian JY, Xia TS, Zhou WB, Sun X, Zhou XJ, Wei JF, Wei JF, et al: Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression. Oncol Rep 41: 455-464, 2019.
APA
Zhu, L., Li, X., Shi, L., Wu, J., Qian, J., Xia, T. ... Ding, Q. (2019). Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression. Oncology Reports, 41, 455-464. https://doi.org/10.3892/or.2018.6842
MLA
Zhu, L., Li, X., Shi, L., Wu, J., Qian, J., Xia, T., Zhou, W., Sun, X., Zhou, X., Wei, J., Ding, Q."Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression". Oncology Reports 41.1 (2019): 455-464.
Chicago
Zhu, L., Li, X., Shi, L., Wu, J., Qian, J., Xia, T., Zhou, W., Sun, X., Zhou, X., Wei, J., Ding, Q."Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression". Oncology Reports 41, no. 1 (2019): 455-464. https://doi.org/10.3892/or.2018.6842
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