Open Access

CDK5 suppresses the metastasis of gastric cancer cells by interacting with and regulating PP2A

  • Authors:
    • Jun Lu
    • Jian‑Xian Lin
    • Peng‑Yang Zhang
    • Yu‑Qin Sun
    • Ping Li
    • Jian‑Wei Xie
    • Jia‑Bin Wang
    • Qi‑Yue Chen
    • Long‑Long Cao
    • Yao Lin
    • Chang‑Ming Huang
    • Chao‑Hui Zheng
  • View Affiliations

  • Published online on: November 9, 2018     https://doi.org/10.3892/or.2018.6860
  • Pages: 779-788
  • Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Several previous studies have demonstrated that cyclin‑dependent kinase (CDK)‑5 expression serves an important role in promoting the development of malignant tumours. We have previously reported that CDK5 suppresses gastric tumourigenesis. The aim of the present study was to investigate the mechanistic basis of CDK5. The results of immunoprecipitation and western blot analysis demonstrated that CDK5 could interact with serine/threonine‑protein phosphatase 2A (PP2A). The use of an inhibitor of PP2A in CDK5‑overexpressing gastric cancer (GC) cell lines antagonized CDK5‑mediated suppression in GC cells. Further analysis revealed that PP2A expression was downregulated in GC and patients with low levels of PP2A had worse survival outcomes than those with high levels of PP2A (P=0.035). Therefore, the present study provided a novel mechanism for CDK5‑mediated tumour suppression, suggesting that CDK5 may be an attractive target for future therapeutic strategies for treating GC. In addition, low levels of PP2A may indicate a tendency for poor prognosis in patients with GC.
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February-2019
Volume 41 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Lu J, Lin JX, Zhang PY, Sun YQ, Li P, Xie JW, Wang JB, Chen QY, Cao LL, Lin Y, Lin Y, et al: CDK5 suppresses the metastasis of gastric cancer cells by interacting with and regulating PP2A. Oncol Rep 41: 779-788, 2019
APA
Lu, J., Lin, J., Zhang, P., Sun, Y., Li, P., Xie, J. ... Zheng, C. (2019). CDK5 suppresses the metastasis of gastric cancer cells by interacting with and regulating PP2A. Oncology Reports, 41, 779-788. https://doi.org/10.3892/or.2018.6860
MLA
Lu, J., Lin, J., Zhang, P., Sun, Y., Li, P., Xie, J., Wang, J., Chen, Q., Cao, L., Lin, Y., Huang, C., Zheng, C."CDK5 suppresses the metastasis of gastric cancer cells by interacting with and regulating PP2A". Oncology Reports 41.2 (2019): 779-788.
Chicago
Lu, J., Lin, J., Zhang, P., Sun, Y., Li, P., Xie, J., Wang, J., Chen, Q., Cao, L., Lin, Y., Huang, C., Zheng, C."CDK5 suppresses the metastasis of gastric cancer cells by interacting with and regulating PP2A". Oncology Reports 41, no. 2 (2019): 779-788. https://doi.org/10.3892/or.2018.6860