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Article

Exosomes derived from PM2.5‑treated lung cancer cells promote the growth of lung cancer via the Wnt3a/β‑catenin pathway

  • Authors:
    • Hui Xu
    • Xingai Jiao
    • Yilei Wu
    • Shuo Li
    • Lili Cao
    • Liang Dong
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China, Department of General Surgery, Ruian People's Hospital, Wenzhou, Zhejiang 325200, P.R. China
  • Pages: 1180-1188
    |
    Published online on: November 9, 2018
       https://doi.org/10.3892/or.2018.6862
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Abstract

Fine particulate matter (PM2.5) is associated with an increased lung cancer risk. However, the effect of PM2.5 exposure on lung cancer cells is still largely unknown. The present study revealed that A549 lung cancer cells secreted exosomes containing high levels of Wnt3a after treatment with PM2.5. These exosomes activated β‑catenin signalling in A549 cells. These exosomes exhibited no effects on migration and invasion, but promoted proliferation of A549 cells via the Wnt3a/β‑catenin pathway in vitro. These exosomes promoted A549 tumour progression in a Wnt3a‑dependent fashion in vivo. These results demonstrated that PM2.5 has a direct effect on promoting lung tumour development. Inhibition of exosome production by tumour cells or blockade of the Wnt3a/β‑catenin pathway represents a promising strategy to impede PM2.5‑mediated lung tumour progression.
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Copy and paste a formatted citation
Spandidos Publications style
Xu H, Jiao X, Wu Y, Li S, Cao L and Dong L: Exosomes derived from PM2.5‑treated lung cancer cells promote the growth of lung cancer via the Wnt3a/β‑catenin pathway. Oncol Rep 41: 1180-1188, 2019.
APA
Xu, H., Jiao, X., Wu, Y., Li, S., Cao, L., & Dong, L. (2019). Exosomes derived from PM2.5‑treated lung cancer cells promote the growth of lung cancer via the Wnt3a/β‑catenin pathway. Oncology Reports, 41, 1180-1188. https://doi.org/10.3892/or.2018.6862
MLA
Xu, H., Jiao, X., Wu, Y., Li, S., Cao, L., Dong, L."Exosomes derived from PM2.5‑treated lung cancer cells promote the growth of lung cancer via the Wnt3a/β‑catenin pathway". Oncology Reports 41.2 (2019): 1180-1188.
Chicago
Xu, H., Jiao, X., Wu, Y., Li, S., Cao, L., Dong, L."Exosomes derived from PM2.5‑treated lung cancer cells promote the growth of lung cancer via the Wnt3a/β‑catenin pathway". Oncology Reports 41, no. 2 (2019): 1180-1188. https://doi.org/10.3892/or.2018.6862
Copy and paste a formatted citation
x
Spandidos Publications style
Xu H, Jiao X, Wu Y, Li S, Cao L and Dong L: Exosomes derived from PM2.5‑treated lung cancer cells promote the growth of lung cancer via the Wnt3a/β‑catenin pathway. Oncol Rep 41: 1180-1188, 2019.
APA
Xu, H., Jiao, X., Wu, Y., Li, S., Cao, L., & Dong, L. (2019). Exosomes derived from PM2.5‑treated lung cancer cells promote the growth of lung cancer via the Wnt3a/β‑catenin pathway. Oncology Reports, 41, 1180-1188. https://doi.org/10.3892/or.2018.6862
MLA
Xu, H., Jiao, X., Wu, Y., Li, S., Cao, L., Dong, L."Exosomes derived from PM2.5‑treated lung cancer cells promote the growth of lung cancer via the Wnt3a/β‑catenin pathway". Oncology Reports 41.2 (2019): 1180-1188.
Chicago
Xu, H., Jiao, X., Wu, Y., Li, S., Cao, L., Dong, L."Exosomes derived from PM2.5‑treated lung cancer cells promote the growth of lung cancer via the Wnt3a/β‑catenin pathway". Oncology Reports 41, no. 2 (2019): 1180-1188. https://doi.org/10.3892/or.2018.6862
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