|
1
|
Wu Q and Ni X: ROS-mediated DNA
methylation pattern alterations in carcinogenesis. Curr Drug
Targets. 16:13–19. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Cooke MS, Evans MD, Dizdaroglu M and Lunec
J: Oxidative DNA damage: Mechanisms, mutation, and disease. FASEB
J. 17:1195–1214. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Oliveira PJ, Goncalves L, Monteiro P,
Providencia LA and Moreno AJ: Are the antioxidant properties of
carvedilol important for the protection of cardiac mitochondria?
Curr Vasc Pharmacol. 3:147–158. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Erguven M, Yazihan N, Aktas E, Sabanci A,
Li CJ, Oktem G and Bilir A: Carvedilol in glioma treatment alone
and with imatinib in vitro. Int J Oncol. 36:857–866. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Dezong G, Zhongbing M, Qinye F and Zhigang
Y: Carvedilol suppresses migration and invasion of malignant breast
cells by inactivating Src involving cAMP/PKA and PKCδ signaling
pathway. J Cancer Res Ther. 10:998–1003. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Lin CS, Lin WS, Lin CL and Kao CH:
Carvedilol use is associated with reduced cancer risk: A nationwide
population-based cohort study. Int J Cardiol. 184:9–13. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Chang A, Yeung S, Thakkar A, Huang KM, Liu
MM, Kanassatega RS, Parsa C, Orlando R, Jackson EK, Andresen BT, et
al: Prevention of skin carcinogenesis by the β-blocker carvedilol.
Cancer Prev Res (Phila). 8:27–36. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Kastrati I, Edirisinghe PD, Hemachandra
LP, Chandrasena ER, Choi J, Wang YT, Bolton JL and Thatcher GR:
Raloxifene and desmethylarzoxifene block estrogen-induced malignant
transformation of human breast epithelial cells. PLoS One.
6:e278762011. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Nkrumah-Elie YM, Reuben JS, Hudson A, Taka
E, Badisa R, Ardley T, Israel B, Sadrud-Din SY, Oriaku E and
Darling-Reed SF: Diallyl trisulfide as an inhibitor of
benzo(a)pyrene-induced precancerous carcinogenesis in MCF-10A
cells. Food Chem Toxicol. 50:2524–2530. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Song X, Siriwardhana N, Rathore K, Lin D
and Wang HC: Grape seed proanthocyanidin suppression of breast cell
carcinogenesis induced by chronic exposure to combined
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and
benzo[a]pyrene. Mol Carcinog. 49:450–463. 2010.PubMed/NCBI
|
|
11
|
Yue TL, McKenna PJ, Lysko PG, Gu JL, Lysko
KA, Ruffolo RR Jr and Feuerstein GZ: SB211475, a metabolite of
carvedilol, a novel antihypertensive agent, is a potent
antioxidant. Eur J Pharmacol. 251:237–243. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Mohapatra P, Preet R, Das D, Satapathy SR,
Siddharth S, Choudhuri T, Wyatt MD and Kundu CN: The contribution
of heavy metals in cigarette smoke condensate to malignant
transformation of breast epithelial cells and in vivo initiation of
neoplasia through induction of a PI3K-AKT-NFκB cascade. Toxicol
Appl Pharmacol. 274:168–179. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Son YO, Pratheeshkumar P, Wang L, Wang X,
Fan J, Kim DH, Lee JY, Zhang Z, Lee JC and Shi X: Reactive oxygen
species mediate Cr(VI)-induced carcinogenesis through
PI3K/AKT-dependent activation of GSK-3β/β-catenin signaling.
Toxicol Appl Pharmacol. 271:239–248. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Astle MV, Hannan KM, Ng PY, Lee RS, George
AJ, Hsu AK, Haupt Y, Hannan RD and Pearson RB: AKT induces
senescence in human cells via mTORC1 and p53 in the absence of DNA
damage: Implications for targeting mTOR during malignancy.
Oncogene. 31:1949–1962. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
He J, Zhu G, Gao L, Chen P, Long Y, Liao
S, Yi H, Yi W, Pei Z, Wu M, et al: Fra-1 is upregulated in gastric
cancer tissues and affects the PI3K/Akt and p53 signaling pathway
in gastric cancer. Int J Oncol. 47:1725–1734. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Wojtovich AP and Foster TH: Optogenetic
control of ROS production. Redox Biol. 2:368–376. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Gupta SC, Hevia D, Patchva S, Park B, Koh
W and Aggarwal BB: Upsides and downsides of reactive oxygen species
for cancer: The roles of reactive oxygen species in tumorigenesis,
prevention, and therapy. Antioxid Redox Signal. 16:1295–1322. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Zhang C, Cao S, Toole BP and Xu Y: Cancer
may be a pathway to cell survival under persistent hypoxia and
elevated ROS A model for solid-cancer initiation and early
development. Int J Cancer. 136:2001–2011. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Cichon MA and Radisky DC: ROS-induced
epithelial-mesenchymal transition in mammary epithelial cells is
mediated by NF-κB-dependent activation of Snail. Oncotarget.
5:2827–2838. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Nourazarian AR, Kangari P and Salmaninejad
A: Roles of oxidative stress in the development and progression of
breast cancer. Asian Pac J Cancer Prev. 15:4745–4751. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Pluchino LA, Liu AK and Wang HC: Reactive
oxygen species-mediated breast cell carcinogenesis enhanced by
multiple carcinogens and intervened by dietary ergosterol and
mimosine. Free Radic Biol Med. 80:12–26. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Yue TL, Cheng HY, Lysko PG, McKenna PJ,
Feuerstein R, Gu JL, Lysko KA, Davis LL and Feuerstein G:
Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is
an antioxidant and free radical scavenger. J Pharmacol Exp Ther.
263:92–98. 1992.PubMed/NCBI
|
|
23
|
Sigounas G, Hairr JW, Cooke CD, Owen JR,
Asch AS, Weidner DA and Wiley JE: Role of benzo[a]pha]pyrene
in generation of clustered DNA damage in human breast tissue. Free
Radic Biol Med. 49:77–87. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Siriwardhana N and Wang HC: Precancerous
carcinogenesis of human breast epithelial cells by chronic exposure
to benzo[a]pyrene. Mol Carcinog. 47:338–348. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Petrulea MS, Plantinga TS, Smit JW,
Georgescu CE and NeteaMaier RT: PI3K/Akt/mTOR: A promising
therapeutic target for non-medullary thyroid carcinoma. Cancer
Treat Rev. 41:707–713. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Su CH, Wang CY, Lan KH, Li CP, Chao Y, Lin
HC, Lee SD and Lee WP: Akt phosphorylation at Thr308 and Ser473 is
required for CHIP-mediated ubiquitination of the kinase. Cell
Signal. 23:1824–1830. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Vincent EE, Elder DJ, Thomas EC, Phillips
L, Morgan C, Pawade J, Sohail M, May MT, Hetzel MR and Tavaré JM:
Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt
protein kinase activity in human non-small cell lung cancer. Br J
Cancer. 104:1755–1761. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Mayo LD and Donner DB: A
phosphatidylinositol 3-kinase/Akt pathway promotes translocation of
Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci USA.
98:11598–11603. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Umannová L, Machala M, Topinka J,
Schmuczerová J, Krčmář P, Neča J, Šujanová K, Kozubík A and
Vondráček J: Benzo[a]pyrene and tumor necrosis factor-α
coordinately increase genotoxic damage and the production of
proinflammatory mediators in alveolar epithelial type II cells.
Toxicol Lett. 206:121–129. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Cromie MM, Liu Z and Gao W:
Epigallocatechin-3-gallate augments the therapeutic effects of
benzo[a]pyrene-mediated lung carcinogenesis. Biofactors.
43:529–539. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Pääjärvi G, Jernström B, Seidel A and
Stenius U: Anti-diol epoxide of benzo[a]pyrene induces
transient Mdm2 and p53 Ser15 phosphorylation, while anti-diol
epoxide of dibenzo[a,l]pyrene induces a nontransient p53 Ser15
phosphorylation. Mol Carcinog. 47:301–309. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Lambert PF, Kashanchi F, Radonovich MF,
Shiekhattar R and Brady JN: Phosphorylation of p53 serine 15
increases interaction with CBP. J Biol Chem. 273:33048–33053. 1998.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Zhou BP, Liao Y, Xia W, Zou Y, Spohn B and
Hung MC: HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2
phosphorylation. Nat Cell Biol. 3:973–982. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Freedman AN, Yu B, Gail MH, Costantino JP,
Graubard BI, Vogel VG, Anderson GL and McCaskill-Stevens W:
Benefit/risk assessment for breast cancer chemoprevention with
raloxifene or tamoxifen for women age 50 years or older. J Clin
Oncol. 29:2327–2333. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Hemachandra LP, Patel H, Chandrasena RE,
Choi J, Piyankarage SC, Wang S, Wang Y, Thayer EN, Scism RA,
Michalsen BT, et al: SERMs attenuate estrogen-induced malignant
transformation of human mammary epithelial cells by up-regulating
detoxification of oxidative metabolites. Cancer Prev Res (Phila).
7:505–515. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Balaha M, Kandeel S and Barakat W:
Carvedilol suppresses circulating and hepatic IL-6 responsible for
hepatocarcinogenesis of chronically damaged liver in rats. Toxicol
Appl Pharmacol. 311:1–11. 2016. View Article : Google Scholar : PubMed/NCBI
|
