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MicroRNA‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7

  • Authors:
    • Junfeng Zhang
    • Shiyu Mao
    • Longsheng Wang
    • Wentao Zhang
    • Ziwei Zhang
    • Yadong Guo
    • Yuan Wu
    • Faxian Yi
    • Xudong Yao
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China, Department of Urology, The Affiliated Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia 010050, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 819-828
    |
    Published online on: November 21, 2018
       https://doi.org/10.3892/or.2018.6879
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Abstract

Aberrant expression of miR‑154 is usually found in cancer studies; however, the role of miR‑154 has seldom been reported in bladder cancer (BCa). In this study, we observed that miR‑154 expression was significantly downregulated in BCa tissues and cell lines, and was associated with several clinicopathological characteristics, including advanced T stage, lymphatic invasion, and distant metastasis. Low expression level of miR‑154 was associated with poor survival outcomes in BCa patients. Overexpression of miR‑154 led to significant decrease in the proliferation, migration, and invasion of BCa cells, while knockdown of miR‑154 yielded the opposite effect. ATG7 was identified as a direct target of miR‑154. ATG7 expression was negatively correlated with miR‑154 expression in BCa tissues. Silencing of ATG7 achieved a similar effect to miR‑154 overexpression; overexpression of ATG7 reversed the inhibitory effect of miR‑154 on BCa cell proliferation, migration and invasion. A xenograft study revealed that miR‑154 inhibited BCa cell growth in vivo, and suppressed ATG7 expression. Altogether, this study demonstrated that miR‑154 may function as a tumor suppressor in BCa and indicated that miR‑154 may be a potential therapeutic target for BCa patients.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Mao S, Wang L, Zhang W, Zhang Z, Guo Y, Wu Y, Yi F and Yao X: MicroRNA‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7. Oncol Rep 41: 819-828, 2019.
APA
Zhang, J., Mao, S., Wang, L., Zhang, W., Zhang, Z., Guo, Y. ... Yao, X. (2019). MicroRNA‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7. Oncology Reports, 41, 819-828. https://doi.org/10.3892/or.2018.6879
MLA
Zhang, J., Mao, S., Wang, L., Zhang, W., Zhang, Z., Guo, Y., Wu, Y., Yi, F., Yao, X."MicroRNA‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7". Oncology Reports 41.2 (2019): 819-828.
Chicago
Zhang, J., Mao, S., Wang, L., Zhang, W., Zhang, Z., Guo, Y., Wu, Y., Yi, F., Yao, X."MicroRNA‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7". Oncology Reports 41, no. 2 (2019): 819-828. https://doi.org/10.3892/or.2018.6879
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Mao S, Wang L, Zhang W, Zhang Z, Guo Y, Wu Y, Yi F and Yao X: MicroRNA‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7. Oncol Rep 41: 819-828, 2019.
APA
Zhang, J., Mao, S., Wang, L., Zhang, W., Zhang, Z., Guo, Y. ... Yao, X. (2019). MicroRNA‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7. Oncology Reports, 41, 819-828. https://doi.org/10.3892/or.2018.6879
MLA
Zhang, J., Mao, S., Wang, L., Zhang, W., Zhang, Z., Guo, Y., Wu, Y., Yi, F., Yao, X."MicroRNA‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7". Oncology Reports 41.2 (2019): 819-828.
Chicago
Zhang, J., Mao, S., Wang, L., Zhang, W., Zhang, Z., Guo, Y., Wu, Y., Yi, F., Yao, X."MicroRNA‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7". Oncology Reports 41, no. 2 (2019): 819-828. https://doi.org/10.3892/or.2018.6879
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