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Review

Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review)

  • Authors:
    • Mingzhe Li
    • Xin Bu
    • Bolei Cai
    • Ping Liang
    • Kai Li
    • Xuan Qu
    • Liangliang Shen
  • View Affiliations / Copyright

    Affiliations: The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, The State Key Laboratory of Cancer Biology, Department of Pharmacogenomics, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Clinical Laboratory, General Hospital of Xinjiang Military Command, Xinjiang 830000, P.R. China, School of Basic Medical Sciences, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, P.R. China
  • Pages: 727-741
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    Published online on: November 23, 2018
       https://doi.org/10.3892/or.2018.6882
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Abstract

Epithelial‑mesenchymal transition (EMT) is required for the distant metastasis of tumors. The degree of tumor malignancy increases as EMT progresses. Notably, the biology of tumor cells differs from that of normal cells, with regards to characteristics and energy metabolism mechanisms; abnormal glucose metabolism, excessive accumulation of fatty acids and other metabolic disorders occur in metastatic tumors. Previous studies have confirmed that the regulation of tumor cell metabolism can affect tumor metastasis and some findings have resulted in novel clinical applications. The present review aimed to provide a basis for treatments targeting the tumor EMT process and metabolic reprogramming.
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Copy and paste a formatted citation
Spandidos Publications style
Li M, Bu X, Cai B, Liang P, Li K, Qu X and Shen L: Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review). Oncol Rep 41: 727-741, 2019.
APA
Li, M., Bu, X., Cai, B., Liang, P., Li, K., Qu, X., & Shen, L. (2019). Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review). Oncology Reports, 41, 727-741. https://doi.org/10.3892/or.2018.6882
MLA
Li, M., Bu, X., Cai, B., Liang, P., Li, K., Qu, X., Shen, L."Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review)". Oncology Reports 41.2 (2019): 727-741.
Chicago
Li, M., Bu, X., Cai, B., Liang, P., Li, K., Qu, X., Shen, L."Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review)". Oncology Reports 41, no. 2 (2019): 727-741. https://doi.org/10.3892/or.2018.6882
Copy and paste a formatted citation
x
Spandidos Publications style
Li M, Bu X, Cai B, Liang P, Li K, Qu X and Shen L: Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review). Oncol Rep 41: 727-741, 2019.
APA
Li, M., Bu, X., Cai, B., Liang, P., Li, K., Qu, X., & Shen, L. (2019). Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review). Oncology Reports, 41, 727-741. https://doi.org/10.3892/or.2018.6882
MLA
Li, M., Bu, X., Cai, B., Liang, P., Li, K., Qu, X., Shen, L."Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review)". Oncology Reports 41.2 (2019): 727-741.
Chicago
Li, M., Bu, X., Cai, B., Liang, P., Li, K., Qu, X., Shen, L."Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review)". Oncology Reports 41, no. 2 (2019): 727-741. https://doi.org/10.3892/or.2018.6882
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