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Article

Chemokine profiling in serum from patients with ovarian cancer reveals candidate biomarkers for recurrence and immune infiltration

  • Authors:
    • Agata Mlynska
    • Greta Salciuniene
    • Karolina Zilionyte
    • Sima Garberyte
    • Marius Strioga
    • Birute Intaite
    • Ausrine Barakauskiene
    • Gianrocco Lazzari
    • Neringa Dobrovolskiene
    • Jan Aleksander Krasko
    • Vita Pasukoniene
  • View Affiliations / Copyright

    Affiliations: Laboratory of Immunology, National Cancer Institute, Vilnius LT‑08660, Lithuania, Life Sciences Center, Vilnius University, Vilnius LT‑10257, Lithuania, Swiss Federal Institute of Technology Global Health Institute, Lausanne CH‑1015, Switzerland
  • Pages: 1238-1252
    |
    Published online on: November 27, 2018
       https://doi.org/10.3892/or.2018.6886
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Abstract

The management of advanced ovarian cancer is challenging due to the high frequency of recurrence, often associated with the development of resistance to platinum‑based chemotherapy. Molecular analyses revealed the complexity of ovarian cancer with particular emphasis on the immune system, which may contribute to disease progression and response to treatment. Cytokines and chemokines mediate the cross‑talk between cancer and immune cells, and therefore, present as potential biomarkers, reflecting the tumor microenvironment. A panel of circulating C‑C motif chemokine ligand (CCL) and C‑X‑C motif chemokine ligand (CXCL) chemokines were examined in the serum of 40 high‑grade patients with ovarian cancer prior to primary surgery. The level of immune infiltration in tumors was also analyzed. The preoperative levels of chemokines differ between patients. Elevated levels of circulating CXCL4 + CCL20 + CXCL1 combination can discriminate patients with shorter recurrence‑free survival and overall survival. The presence of tumor‑infiltrating T lymphocytes was detected in half of the patients. The mRNA expression analysis suggests the presence of antitumoral and immunosuppressive elements in the tumor microenvironment. The combination of circulating CXCL9 + CXCL10 can distinguish immune‑infiltrated tumors that will lead to shorter recurrence‑free survival. The results suggest that preoperative profiling of circulating chemokines in patients with ovarian cancer may provide valuable information regarding tumor recurrence and immune infiltration. The findings demonstrate that combinations have better prognostic utility than single chemokines, and may serve as patient stratification tools.
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Copy and paste a formatted citation
Spandidos Publications style
Mlynska A, Salciuniene G, Zilionyte K, Garberyte S, Strioga M, Intaite B, Barakauskiene A, Lazzari G, Dobrovolskiene N, Krasko JA, Krasko JA, et al: Chemokine profiling in serum from patients with ovarian cancer reveals candidate biomarkers for recurrence and immune infiltration. Oncol Rep 41: 1238-1252, 2019.
APA
Mlynska, A., Salciuniene, G., Zilionyte, K., Garberyte, S., Strioga, M., Intaite, B. ... Pasukoniene, V. (2019). Chemokine profiling in serum from patients with ovarian cancer reveals candidate biomarkers for recurrence and immune infiltration. Oncology Reports, 41, 1238-1252. https://doi.org/10.3892/or.2018.6886
MLA
Mlynska, A., Salciuniene, G., Zilionyte, K., Garberyte, S., Strioga, M., Intaite, B., Barakauskiene, A., Lazzari, G., Dobrovolskiene, N., Krasko, J. A., Pasukoniene, V."Chemokine profiling in serum from patients with ovarian cancer reveals candidate biomarkers for recurrence and immune infiltration". Oncology Reports 41.2 (2019): 1238-1252.
Chicago
Mlynska, A., Salciuniene, G., Zilionyte, K., Garberyte, S., Strioga, M., Intaite, B., Barakauskiene, A., Lazzari, G., Dobrovolskiene, N., Krasko, J. A., Pasukoniene, V."Chemokine profiling in serum from patients with ovarian cancer reveals candidate biomarkers for recurrence and immune infiltration". Oncology Reports 41, no. 2 (2019): 1238-1252. https://doi.org/10.3892/or.2018.6886
Copy and paste a formatted citation
x
Spandidos Publications style
Mlynska A, Salciuniene G, Zilionyte K, Garberyte S, Strioga M, Intaite B, Barakauskiene A, Lazzari G, Dobrovolskiene N, Krasko JA, Krasko JA, et al: Chemokine profiling in serum from patients with ovarian cancer reveals candidate biomarkers for recurrence and immune infiltration. Oncol Rep 41: 1238-1252, 2019.
APA
Mlynska, A., Salciuniene, G., Zilionyte, K., Garberyte, S., Strioga, M., Intaite, B. ... Pasukoniene, V. (2019). Chemokine profiling in serum from patients with ovarian cancer reveals candidate biomarkers for recurrence and immune infiltration. Oncology Reports, 41, 1238-1252. https://doi.org/10.3892/or.2018.6886
MLA
Mlynska, A., Salciuniene, G., Zilionyte, K., Garberyte, S., Strioga, M., Intaite, B., Barakauskiene, A., Lazzari, G., Dobrovolskiene, N., Krasko, J. A., Pasukoniene, V."Chemokine profiling in serum from patients with ovarian cancer reveals candidate biomarkers for recurrence and immune infiltration". Oncology Reports 41.2 (2019): 1238-1252.
Chicago
Mlynska, A., Salciuniene, G., Zilionyte, K., Garberyte, S., Strioga, M., Intaite, B., Barakauskiene, A., Lazzari, G., Dobrovolskiene, N., Krasko, J. A., Pasukoniene, V."Chemokine profiling in serum from patients with ovarian cancer reveals candidate biomarkers for recurrence and immune infiltration". Oncology Reports 41, no. 2 (2019): 1238-1252. https://doi.org/10.3892/or.2018.6886
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