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Article

YWHAZ promotes ovarian cancer metastasis by modulating glycolysis

  • Authors:
    • Jie Shi
    • Jun Ye
    • He Fei
    • Shu‑Hen Jiang
    • Zhi‑Yong Wu
    • Ya‑Ping Chen
    • Li‑Wen Zhang
    • Xiao‑Mei Yang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240, P.R. China, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, P.R. China, Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, P.R. China
  • Pages: 1101-1112
    |
    Published online on: December 7, 2018
       https://doi.org/10.3892/or.2018.6920
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Abstract

Ovarian cancer is one of the three most deadly gynecological cancers, with the highest mortality rate. As the main cause of death, metastasis is considered to be a crucial factor that reduces the survival time of ovarian carcinoma patients. YWHAZ (also known as 14‑3‑3ζ) influences diverse vital cellular processes such as metabolism, signal transduction, apoptosis and cell cycle regulation. In the present study, we determined that YWHAZ is upregulated in ovarian cancers in contrast to normal tissues by immunohistochemical staining. High YWHAZ expression was found to be associated with TNM stage and metastasis‑free prognosis of ovarian cancer patients. Silencing of YWHAZ inhibited the proliferation and facilitated serum starvation‑induced apoptosis of ovarian cancer cells. Cell migration was also suppressed by YWHAZ silencing. Furthermore, using an in vivo metastatic model, we found that YWHAZ silence also inhibited ovarian cancer metastasis in vivo. Notably, glycolysis was clearly inhibited in YWHAZ‑silenced ovarian cancer cells as determined by lactate production assay and Seahorse XF analysis. YWHAZ also regulated the PI3K/Akt1/vimentin signaling pathway in ovarian cancer cells as detected by western blot analysis. Taken together, our results demonstrated that YWHAZ plays an important role in the progression of ovarian cancer and can be used as a potential target for the diagnosis and treatment of epithelial ovarian cancer.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Baldwin LA, Huang B, Miller RW, Tucker T, Goodrich ST, Podzielinski I, DeSimone CP, Ueland FR, van Nagell JR and Seamon LG: Ten-year relative survival for epithelial ovarian cancer. Obstet Gynecol. 120:612–618. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Damia G and Sessa C: Successes and limitations of targeted cancer therapy in ovarian cancer. Prog Tumor Res. 41:89–97. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB and Goga A: 13C-pyruvate imaging reveals alterations in glycolysis that precede c-MYC induced tumor formation and regression. Cell Metab. 14:131–142. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Jiang SH, Li J, Dong FY, Yang JY, Liu DJ, Yang XM, Wang YH, Yang MW, Fu XL, Zhang XX, et al: Increased serotonin signaling contributes to the Warburg effect in pancreatic tumor cells under metabolic stress and promotes growth of pancreatic tumors in mice. Gastroenterology. 153:277–291.e19. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Chang CC, Zhang C, Zhang Q, Sahin O, Wang H, Xu J, Xiao Y, Zhang J, Rehman SK, Li P, et al: Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression. Oncotarget. 7:35270–35283. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Slupsky CM, Steed H, Wells TH, Dabbs K, Schepansky A, Capstick V, Faught W and Sawyer MB: Urine metabolite analysis offers potential early diagnosis of ovarian and breast cancers. Clin Cancer Res. 16:5835–5841. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Anderson AS, Roberts PC, Frisard MI, McMillan RP, Brown TJ, Lawless MH, Hulver MW and Schmelz EM: Metabolic changes during ovarian cancer progression as targets for sphingosine treatment. Exp Cell Res. 19:1431–1442. 2013. View Article : Google Scholar

10 

Sun L, Yin Y, Clark LH, Sun W, Sullivan SA, Tran AQ, Han J, Zhang L, Guo H, Madugu E, et al: Dual inhibition of glycolysis and glutaminolysis as a therapeutic strategy in the treatment of ovarian cancer. Oncotarget. 8:63551–63561. 2017.PubMed/NCBI

11 

Watanabe N, Komatsu S, Ichikawa D, Miyamae M, Ohashi T, Okajima W, Kosuga T, Konishi H, Shiozaki A, Fujiwara H, et al: Overexpression of YWHAZ as an independent prognostic factor in adenocarcinoma of the esophago-gastric junction. Am J Cancer Res. 6:2729–2736. 2016.PubMed/NCBI

12 

Neal CL, Yao J, Yang W, Zhou X, Nguyen NT, Lu J, Danes CG, Guo H, Lan KH, Ensor J, et al: 14-3-3zeta overexpression defines high risk for breast cancer recurrence and promotes cancer cell survival. Cancer Res. 69:3425–3432. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Lin M, Morrison CD, Jones S, Mohamed N, Bacher J and Plass C: Copy number gain and oncogenic activity of YWHAZ/14-3-3zeta in head and neck squamous cell carcinoma. Int J Cancer. 125:603–611. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Tang Y, Liu S, Li N, Guo W, Shi J, Yu H, Zhang L, Wang K, Liu S and Cheng S: 14-3-3ζ promotes hepatocellular carcinoma venous metastasis by modulating hypoxia-inducible factor-1α. Oncotarget. 7:15854–15867. 2016.PubMed/NCBI

15 

Lu J, Guo H, Treekitkarnmongkol W, Li P, Zhang J, Shi B, Ling C, Zhou X, Chen T, Chiao PJ, et al: 14-3-3zeta cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. Cancer Cell. 16:195–207. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Bergamaschi A, Frasor J, Borgen K, Stanculescu A, Johnson P, Rowland K, Wiley EL and Katzenellenbogen BS: 14-3-3ζ as a predictor of early time to recurrence and distant metastasis in hormone receptor-positive and -negative breast cancers. Breast Cancer Res Treat. 137:689–696. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Pozuelo Rubio M, Peggie M, Wong BH, Morrice N and MacKintosh C: 14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase. EMBO J. 2:3514–3523. 2003. View Article : Google Scholar

18 

Lim GE, Piske M and Johnson JD: 14-3-3 proteins are essential signaling hubs for beta cell survival. Diabetologia. 56:825–837. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Kim CY, Jeong SY, Chong GO, Son SH, Jung JH, Kim DH, Lee SW, Ahn BC and Lee J: Quantitative metabolic parameters measured on F-18 FDG PET/CT predict survival after relapse in patients with relapsed epithelial ovarian cancer. Gynecol Oncol. 136:498–504. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Yang XM, Cao XY, He P, Li J, Feng MX, Zhang YL, Zhang XL, Wang YH, Yang Q, Zhu L, et al: Overexpression of Rac GTPase activating protein 1 contributes to proliferation of cancer cells by reducing hippo signaling to promote cytokinesis. Gastroenterology. 155:1233–1249.e22. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Powell DW, Rane MJ, Chen Q, Singh S and McLeish KR: Identification of 14-3-3zeta as a protein kinase B/Akt substrate. J Biol Chem. 277:21639–21642. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Yeung TL, Leung CS, Yip KP, Au Yeung CL, Wong ST and Mok SC: Cellular and molecular processes in ovarian cancer metastasis. A review in the theme: Cell and molecular processes in cancer metastasis. Am J Physiol Cell Physiol. 309:C444–C456. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Vaughan S, Coward JI, Bast RC Jr, Berchuck A, Berek JS, Brenton JD, Coukos G, Crum CC, Drapkin R, Etemadmoghadam D, et al: Rethinking ovarian cancer: Recommendations for improving outcomes. Nat Rev Cancer. 11:719–725. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Murata T, Takayama K, Urano T, Fujimura T, Ashikari D, Obinata D, Horie-Inoue K, Takahashi S, Ouchi Y, Homma Y and Inoue S: 14-3-3ζ, a novel androgen-responsive gene, is upregulated in prostate cancer and promotes prostate cancer cell proliferation and survival. Clin Cancer Res. 18:5617–5627. 2012. View Article : Google Scholar : PubMed/NCBI

26 

He Y, Wu X, Liu X, Yan G and Xu C: LC-MS/MS analysis of ovarian cancer metastasis-related proteins using a nude mouse model: 14-3-3 zeta as a candidate biomarker. J Proteome Res. 9:6180–6190. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Su R, Gong JN, Chen MT, Song L, Shen C, Zhang XH, Yin XL, Ning HM, Liu B, Wang F, et al: c-Myc suppresses miR-451_ǀYWTAZ/AKT axis via recruiting HDAC3 in acute myeloid leukemia. Oncotarget. 7:77430–77443. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Weerasekara VK, Panek DJ, Broadbent DG, Mortenson JB, Mathis AD, Logan GN, Prince JT, Thomson DM, Thompson JW and Andersen JL: Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9. Mol Cell Biol. 34:4379–4388. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Goc A, Abdalla M, Al-Azayzih A and Somanath PR: Rac1 activation driven by 14-3-3ζ dimerization promotes prostate cancer cell-matrix interactions, motility and transendothelial migration. PLoS One. 7:e405942012. View Article : Google Scholar : PubMed/NCBI

30 

Choi JE, Hur W, Jung CK, Piao LS, Lyoo K, Hong SW, Kim SW, Yoon HY and Yoon SK: Silencing of 14-3-3ζ over-expression in hepatocellular carcinoma inhibits tumor growth and enhances chemosensitivity to cis-diammined dichloridoplatium. Cancer Lett. 303:99–107. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Anderson AS, Roberts PC, Frisard MI, Hulver MW and Schmelz EM: Ovarian tumor-initiating cells display a flexible metabolism. Exp Cell Res. 328:44–57. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Lim GE, Piske M, Lulo JE, Ramshaw HS, Lopez AF and Johnson JD: Ywhaz/14-3-3ζ deletion improves glucose tolerance through a GLP-1-dependent mechanism. Endocrinology. 157:2649–2659. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Taylor C, Mannion D, Miranda F, Karaminejadranjbar M, Herrero-Gonzalez S, Hellner K, Zheng Y, Bartholomeusz G, Bast RC Jr and Ahmed AA: Loss of PFKFB4 induces cell death in mitotically arrested ovarian cancer cells. Oncotarget. 8:17960–17980. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Danes CG, Wyszomierski SL, Lu J, Neal CL, Yang W and Yu D: 14-3-3 zeta down-regulates p53 in mammary epithelial cells and confers luminal filling. Cancer Res. 68:1760–1767. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shi J, Ye J, Fei H, Jiang SH, Wu ZY, Chen YP, Zhang LW and Yang XM: YWHAZ promotes ovarian cancer metastasis by modulating glycolysis. Oncol Rep 41: 1101-1112, 2019.
APA
Shi, J., Ye, J., Fei, H., Jiang, S., Wu, Z., Chen, Y. ... Yang, X. (2019). YWHAZ promotes ovarian cancer metastasis by modulating glycolysis. Oncology Reports, 41, 1101-1112. https://doi.org/10.3892/or.2018.6920
MLA
Shi, J., Ye, J., Fei, H., Jiang, S., Wu, Z., Chen, Y., Zhang, L., Yang, X."YWHAZ promotes ovarian cancer metastasis by modulating glycolysis". Oncology Reports 41.2 (2019): 1101-1112.
Chicago
Shi, J., Ye, J., Fei, H., Jiang, S., Wu, Z., Chen, Y., Zhang, L., Yang, X."YWHAZ promotes ovarian cancer metastasis by modulating glycolysis". Oncology Reports 41, no. 2 (2019): 1101-1112. https://doi.org/10.3892/or.2018.6920
Copy and paste a formatted citation
x
Spandidos Publications style
Shi J, Ye J, Fei H, Jiang SH, Wu ZY, Chen YP, Zhang LW and Yang XM: YWHAZ promotes ovarian cancer metastasis by modulating glycolysis. Oncol Rep 41: 1101-1112, 2019.
APA
Shi, J., Ye, J., Fei, H., Jiang, S., Wu, Z., Chen, Y. ... Yang, X. (2019). YWHAZ promotes ovarian cancer metastasis by modulating glycolysis. Oncology Reports, 41, 1101-1112. https://doi.org/10.3892/or.2018.6920
MLA
Shi, J., Ye, J., Fei, H., Jiang, S., Wu, Z., Chen, Y., Zhang, L., Yang, X."YWHAZ promotes ovarian cancer metastasis by modulating glycolysis". Oncology Reports 41.2 (2019): 1101-1112.
Chicago
Shi, J., Ye, J., Fei, H., Jiang, S., Wu, Z., Chen, Y., Zhang, L., Yang, X."YWHAZ promotes ovarian cancer metastasis by modulating glycolysis". Oncology Reports 41, no. 2 (2019): 1101-1112. https://doi.org/10.3892/or.2018.6920
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