|
1
|
Valko M, Leibfritz D, Moncol J, Cronin MT,
Mazur M and Telser J: Free radicals and antioxidants in normal
physiological functions and human disease. Int J Biochem Cell Biol.
39:44–84. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Luo M, He H, Kelley MR and Georgiadis MM:
Redox regulation of DNA repair: Implications for human health and
cancer therapeutic development. Antioxid Redox Signal.
12:1247–1269. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Rai P: Human Mut T Homolog 1 (MTH1): A
roadblock for the tumor-suppressive effects of oncogenic
RAS-induced ROS. Small GTPases. 3:120–125. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Puigvert JC, Sanjiv K and Helleday T:
Targeting DNA repair, DNA metabolism and replication stress as
anti-cancer strategies. FEBS J. 283:232–245. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Nakabeppu Y: Cellular levels of
8-oxoguanine in either DNA or the nucleotide pool play pivotal
roles in carcinogenesis and survival of cancer cells. Int J Mol
Sci. 15:12543–12557. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Gao T, Gu S, Liu F, Li L, Wang Z, Yang J
and Li G: Investigation of MTH1 activity via mismatch-based DNA
chain elongation. Anal Chim Acta. 905:66–71. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Nakabeppu Y, Ohta E and Abolhassani N:
MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe. Free
Radic Biol Med. 107:151–158. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Fujikawa K, Kamiya H, Yakushiji H,
Nakabeppu Y and Kasai H: Human MTH1 protein hydrolyzes the oxidized
ribonucleotide, 2-hydroxy-ATP. Nucleic Acids Res. 29:449–454. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Bialkowski K, Szpila A and Kasprzak KS:
Up-regulation of 8-oxo-dGTPase activity of MTH1 protein in the
brain, testes and kidneys of mice exposed to 137Cs γ
radiation. Radiat Res. 172:187–197. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Waz S, Nakamura T, Hirata K, Koga-Ogawa Y,
Chirifu M, Arimori T, Tamada T, Ikemizu S, Nakabeppu Y and Yamagata
Y: Structural and kinetic studies of the human nudix hydrolase MTH1
reveal the mechanism for its broad substrate specificity. J Biol
Chem. 292:2785–2794. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Maki H and Sekiguchi M: MutT protein
specifically hydrolyses a potent mutagenic substrate for DNA
synthesis. Nature. 355:273–275. 1992. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Tsuzuki T, Egashira A and Kura S: Analysis
of MTH1 gene function in mice with targeted mutagenesis.
Mutat Res. 477:71–78. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Gad H, Koolmeister T, Jemth AS, Eshtad S,
Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T,
Einarsdottir BO, et al: MTH1 inhibition eradicates cancer by
preventing sanitation of the dNTP pool. Nature. 508:215–221. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Wang JY, Liu GZ, Wilmott JS, La T, Feng
YC, Yari H, Yan XG, Thorne RF, Scolyer RA, Zhang XD and Jin L:
Skp2-mediated stabilization of MTH1 promotes survival of melanoma
cells upon oxidative stress. Cancer Res. 77:6226–6239. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Kennedy CH, Cueto R, Belinsky SA, Lechner
JF and Pryor WA: Overexpression of hMTH1 mRNA: A molecular
marker of oxidative stress in lung cancer cells. FEBS Lett.
429:17–20. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Borrego S, Vazquez A, Dasí F, Cerdá C,
Iradi A, Tormos C, Sánchez JM, Bagán L, Boix J, Zaragoza C, et al:
Oxidative stress and DNA damage in human gastric carcinoma:
8-Oxo-7′8-dihydro-2′-deoxyguanosine (8-oxo-dG) as a possible tumor
marker. Int J Mol Sci. 14:3467–3486. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Huber KV, Salah E, Radic B, Gridling M,
Elkins JM, Stukalov A, Jemth AS, Göktürk C, Sanjiv K, Strömberg K,
et al: Stereospecific targeting of MTH1 by (S)-crizotinib as an
anticancer strategy. Nature. 508:222–227. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Svensson LM, Jemth AS, Desroses M, Loseva
O, Helleday T, Högbom M and Stenmark P: Crystal structure of human
MTH1 and the 8-oxo-dGMP product complex. FEBS Lett. 585:2617–2621.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Koga Y, Inazato M, Nakamura T, Hashikawa
C, Chirifu M, Michi A, Yamashita T, Toma S, Kuniyasu A, Ikemizu S,
et al: Crystallization and preliminary X-ray analysis of human MTH1
with a homogeneous N-terminus. Acta Crystallogr Sect F Struct Biol
Cryst Commun. 69:45–48. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Carter M, Jemth AS, Hagenkort A, Page BD,
Gustafsson R, Griese JJ, Gad H, Valerie NC, Desroses M, Boström J,
et al: Crystal structure, biochemical and cellular activities
demonstrate separate functions of MTH1 and MTH2. Nat Commun.
6:78712015. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Ellermann M, Eheim A, Rahm F, Viklund J,
Guenther J, Andersson M, Ericsson U, Forsblom R, Ginman T,
Lindström J, et al: Novel class of potent and cellularly active
inhibitors devalidates MTH1 as broad-Spectrum cancer target. ACS
Chem Biol. 12:1986–1992. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Köhler G and Milstein C: Continuous
cultures of fused cells secreting antibody of predefined
specificity. Nature. 256:495–497. 1975. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Fan X, He C, Jing W, Zhou X, Chen R, Cao
L, Zhu M, Jia R, Wang H and Guo Y: Intracellular osteopontin
inhibits toll-like receptor signaling and impedes liver
carcinogenesis. Cancer Res. 75:86–97. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Cornelissen B, Hu M, McLarty K, Costantini
D and Reilly RM: Cellular penetration and nuclear importation
properties of 111In-labeled and 123I-labeled
HIV-1 tat peptide immunoconjugates in BT-474 human breast cancer
cells. Nucl Med Biol. 34:37–46. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Lee Y, Ishii T, Kim HJ, Nishiyama N,
Hayakawa Y, Itaka K and Kataoka K: Efficient delivery of bioactive
antibodies into the cytoplasm of living cells by
charge-conversional polyion complex micelles. Angew Chem Int Ed
Engl. 49:2552–2555. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Yamada Y, Perez SM, Tabata M, Abe J,
Yasuzaki Y and Harashima H: Efficient and high-speed transduction
of an antibody into living cells using a multifunctional
nanocarrier system to control intracellular trafficking. J Pharm
Sci. 104:2845–2854. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Shin SM, Choi DK, Jung K, Bae J, Kim JS,
Park SW, Song KH and Kim YS: Antibody targeting intracellular
oncogenic Ras mutants exerts anti-tumour effects after systemic
administration. Nat Commun. 8:150902017. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Baykov AA, Evtushenko OA and Avaeva SM: A
malachite green procedure for orthophosphate determination and its
use in alkaline phosphatase-based enzyme immunoassay. Anal Biochem.
171:266–270. 1988. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Malik A, Alsenaidy AM, Elrobh M, Khan W,
Alanazi MS and Bazzi MD: Optimization of expression and
purification of HSPA6 protein from Camelus dromedarius in
E. coli. Saudi J Biol Sci. 23:410–419. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Coskun E, Jaruga P, Jemth AS, Loseva O,
Scanlan LD, Tona A, Lowenthal MS, Helleday T and Dizdaroglu M:
Addiction to MTH1 protein results in intense expression in human
breast cancer tissue as measured by liquid
chromatography-isotope-dilution tandem mass spectrometry. DNA
Repair. 33:101–110. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Ji D, Beharry AA, Ford JM and Kool ET: A
Chimeric ATP-Linked nucleotide enables luminescence signaling of
damage surveillance by MTH1, a cancer target. J Am Chem Soc.
138:9005–9008. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Nakabeppu Y: Regulation of intracellular
localization of human MTH1, OGG1, and MYH proteins for repair of
oxidative DNA damage. Prog Nucleic Acid Res Mol Biol. 68:75–94.
2001. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Fujikawa K, Kamiya H, Yakushiji H, Fujii
Y, Nakabeppu Y and Kasai H: The oxidized forms of dATP are
substrates for the human MutT homologue, the hMTH1 protein. J Biol
Chem. 274:18201–18205. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Yakushiji H, Maraboeuf F, Takahashi M,
Deng ZS, Kawabata S, Nakabeppu Y and Sekiguchi M: Biochemical and
physicochemical characterization of normal and variant forms of
human MTH1 protein with antimutagenic activity. Mutat Res.
384:181–194. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Ling S, Xiao S, Xie C, Wang R, Zeng L,
Wang K, Zhang D, Li X and Wang S: Preparation of monoclonal
antibody for brevetoxin 1 and development of Ic-ELISA and colloidal
gold strip to detect brevetoxin 1. Toxins. 10:E752018. View Article : Google Scholar : PubMed/NCBI
|
