Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
March-2019 Volume 41 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2019 Volume 41 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy

  • Authors:
    • Xiangkun Wang
    • Xiwen Liao
    • Chengkun Yang
    • Ketuan Huang
    • Tingdong Yu
    • Long Yu
    • Chuangye Han
    • Guangzhi Zhu
    • Xianmin Zeng
    • Zhengqian Liu
    • Xin Zhou
    • Wei Qin
    • Hao Su
    • Xinping Ye
    • Tao Peng
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1586-1602
    |
    Published online on: January 3, 2019
       https://doi.org/10.3892/or.2019.6953
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hepatocellular carcinoma (HCC) is a lethal malignancy with high morbidity and mortality rates worldwide. The identification of prognosis‑associated biomarkers is crucial to improve HCC patient survival. The present study aimed to explore potential predictive biomarkers for HCC. Differentially expressed genes (DEGs) were analyzed in the GSE36376 dataset using GEO2R. Hub genes were identified and further investigated for prognostic value in HCC patients. A risk score model and nomogram were constructed to predict HCC prognosis using the prognosis‑associated genes and clinical factors. Pearson's correlation was employed to show interactions among hub genes. Gene enrichment analysis was performed to identify detailed biological processes and pathways. A total of 71 DEGs were obtained and seven (ADH4, CYP2C8, CYP2C9, CYP8B1, SLC22A1, TAT and HSD17B13, all adjusted P≤0.05) of the 10 hub genes were identified as prognosis‑related genes for survival analysis in HCC patients, including alcohol dehydrogenase 4 (class II), pi polypeptide (ADH4), cytochrome p450 family 2 subfamily C member 8 (CYP2C8), cytochrome P450 family 2 subfamily C member 9 (CYP2C9), cytochrome P450 family 8 subfamily B member 1 (CYP8B1), solute carrier family 22 member 1 (SLC22A1), tyrosine aminotransferase (TAT) and hydroxysteroid 17‑β dehydrogenase 13 (HSD17B13). The risk score model could predict HCC prognosis and the nomogram visualized gene expression and clinical factors of probability for HCC prognosis. The majority of genes showed significant Pearson's correlations with others (41 Pearson correlations P≤0.01, four Pearson correlations P>0.05). GO analysis revealed that terms such as ‘chemical carcinogenesis’ and ‘drug metabolism‑cytochrome P450’ were enriched and may prove helpful to elucidate the mechanisms of hepatocarcinogenesis. Hub genes ADH4, CYP2C8, CYP2C9, CYP8B1, SLC22A1, TAT and HSD17B13 may be useful as predictive biomarkers for HCC prognosis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

Figure 11

Figure 12

View References

1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Kolonel LN and Wilkens LR: Migrant studies. Cancer Epidemiology and Prevention. Schottenfeld D and Fraumeni JF Jr: 3rd. Oxford University Press, Inc.; New York, NY: pp. 189–201. 2006, View Article : Google Scholar

3 

Kgatle MM, Setshedi M and Hairwadzi HN: Hepatoepigenetic alterations in viral and nonviral-induced hepatocellular carcinoma. Biomed Res Int 2016. 39564852016.

4 

Marotta F, Vangieri B, Cecere A and Gattoni A: The pathogenesis of hepatocellular carcinoma is multifactorial event. Novel immunological treatment in prospect. Clin Ter. 155:187–199. 2004.PubMed/NCBI

5 

Coleman WB: Mechanisms of human hepatocarcinogenesis. Curr Mol Med. 3:573–388. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Dominguez-Malagón H and Gaytan-Graham S: Hepatocellular carcinoma: An update. Ultrastruct Pathol. 25:497–516. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Chen G, Wang D, Zhao X, Cao J, Zhao Y, Wang F, Bai J, Luo D and Li L: miR-155-5p modulates malignant behaviors of hepatocellular carcinoma by directly targeting CTHRC1 and indirectly regulating GSK-3β-involved Wnt/β-catenin signaling. Cancer Cell Int. 17:1182017. View Article : Google Scholar : PubMed/NCBI

8 

Balogh J, Victor D III, Asham EH, Burroughs SG, Boktour M, Saharia A, Li X, Ghobrial RM and Monsour HP Jr: Hepatocellular carcinoma: A review. J Hepatocell Carcinoma. 3:41–53. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Tien AJ, Chien CY, Chen YH, Lin LC and Chien CT: fruiting bodies of antrodia cinnamomea and its active triterpenoid, antcin K, ameliorates N-nitrosodiethylamine-induced hepatic inflammation, fibrosis and carcinogenesis in rats. Am J Chin Med. 45:173–198. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Quintavalle C, Hindupur SK, Quagliata L, Pallante P, Nigro C, Condorelli G, Andersen JB, Tagscherer KE, Roth W, Beguinot F, et al: Phosphoprotein enriched in diabetes (PED/PEA15) promotes migration in hepatocellular carcinoma and confers resistance to sorafenib. Cell Death Dis. 8:e31382017. View Article : Google Scholar : PubMed/NCBI

11 

Xu G and Dang C: CMTM5 is downregulated and suppresses tumour growth in hepatocellular carcinoma through regulating PI3K-AKT signalling. Cancer Cell Int. 17:1132017. View Article : Google Scholar : PubMed/NCBI

12 

Cao MQ, You AB, Zhu XD, Zhang W, Zhang YY, Zhang SZ, Zhang KW, Cai H, Shi WK, Li XL, et al: miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a. J Hematol Oncol. 11:122018. View Article : Google Scholar : PubMed/NCBI

13 

Maass T, Sfakianakis I, Staib F, Krupp M, Galle PR and Teufel A: Microarray-based gene expression analysis of hepatocellular carcinoma. Curr Genomics. 11:261–268. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Fu Q, Yang F, Zhao J, Yang X, Xiang T, Huai G, Zhang J, Wei L, Deng S and Yang H: Bioinformatical identification of key pathways and genes in human hepatocellular carcinoma after CSN5 depletion. Cell Signal. 49:79–86. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Huang da W, Sherman BT and Lempicki RA: Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37:1–13. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Davis S and Meltzer PS: GEOquery: A bridge between the gene expression omnibus (GEO) and BioConductor. Bioinformatics. 23:1846–1847. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Lim HY, Sohn I, Deng S, Lee J, Jung SH, Mao M, Xu J, Wang K, Shi S, Joh JW, et al: Prediction of disease-free survival in hepatocellular carcinoma by gene expression profiling. Ann Surg Oncol. 20:3747–3753. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45(W1): W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, et al: Proteomics. Tissue-based map of the human proteome. Science. 347:12604192015. View Article : Google Scholar : PubMed/NCBI

21 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

22 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44572009. View Article : Google Scholar : PubMed/NCBI

24 

Maere S, Heymans K and Kuiper M: BiNGO: A Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks. Bioinformatics. 21:3448–3449. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Montojo J, Zuberi K, Rodriguez H, Kazi F, Wright G, Donaldson SL, Morris Q and Bader GD: GeneMANIA Cytoscape plugin: Fast gene function predictions on the desktop. Bioinformatics. 26:2927–2928. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Szklarczyk D, Morris JH, Cook H, Kuhn M, Wyder S, Simonovic M, Santos A, Doncheva NT, Roth A, Bork P, et al: The STRING database in 2017: Quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res. 45:D362–D368. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Lu X, Sun W, Tang Y, Zhu L, Li Y, Ou C, Yang C, Su J, Luo C, Hu Y and Cao J: Identification of key genes in hepatocellular carcinoma and validation of the candidate gene, cdc25a, using gene set enrichment analysis, meta-analysis and cross-species comparison. Mol Med Rep. 13:1172–1178. 2016. View Article : Google Scholar : PubMed/NCBI

28 

MacDonald JW and Ghosh D: COPA-cancer outlier profile analysis. Bioinformatics. 22:2950–2951. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Luo X, Zuo L, Kranzler HR, Wang S, Anton RF and Gelernter J: Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test. Behav Brain Funct. 4:422008. View Article : Google Scholar : PubMed/NCBI

30 

Edenberg HJ, Xuei X, Chen HJ, Tian H, Wetherill LF, Dick DM, Almasy L, Bierut L, Bucholz KK, Goate A, et al: Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. Hum Mol Genet. 15:1539–1549. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Edenberg HJ, Jerome RE and Li M: Polymorphism of the human alcohol dehydrogenase 4 (ADH4) promoter affects gene expression. Pharmacogenetics. 9:25–30. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Guindalini C, Scivoletto S, Ferreira RGM, Breen G, Zilberman M, Peluso MA and Zatz M: Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients. Am J Psychiatry. 162:1005–1007. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Luo X, Kranzler HR, Zuo L, Wang S and Gelernter J: Personality traits of agreeableness and extraversion are associated with ADH4 variation. Biol Psychiatry. 61:599–608. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Goode EL, White KL, Vierkant RA, Phelan CM, Cunningham JM, Schildkraut JM, Berchuck A, Larson MC, Fridley BL, Olson JE, et al: Xenobiotic-metabolizing gene polymorphisms and ovarian cancer risk. Mol Carcinog. 50:397–402. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Oze I, Matsuo K, Suzuki T, Kawase T, Watanabe M, Hiraki A, Ito H, Hosono S, Ozawa T, Hatooka S, et al: Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population. Cancer Epidemiol Biomarkers Prev. 18:3097–3102. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Wei RR, Zhang MY, Rao HL, Pu HY, Zhang HZ and Wang HY: Identification of ADH4 as a novel and potential prognostic marker in hepatocellular carcinoma. Med Oncol. 29:2737–2743. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Wang X, Yu T, Liao X, Yang C, Han C, Zhu G, Huang K, Yu L, Qin W, Su H, et al: The prognostic value of CYP2C subfamily genes in hepatocellular carcinoma. Cancer Med. 7:966–980. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Gelboin HV and Krausz K: Monoclonal antibodies and multifunctional cytochrome P450: Drug metabolism as paradigm. J Clin Pharmacol. 46:353–372. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Goldstein JA and de Morais SM: Biochemistry and molecular biology of the human CYP2C subfamily. Pharmacogenetics. 4:285–299. 1994. View Article : Google Scholar : PubMed/NCBI

40 

Hamman MA, Thompson GA and Hall SD: Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C. Biochem Pharmacol. 54:33–41. 1997. View Article : Google Scholar : PubMed/NCBI

41 

Jaakkola T, Laitila J, Neuvonen PJ and Backman JT: Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: Potential for interactions with CYP2C8 inhibitors. Basic Clin Pharmacol Toxicol. 99:44–51. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Unger T: Inhibiting angiotensin receptors in the brain: Possible therapeutic implications. Curr Med Res Opin. 19:449–451. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Kiang TK, Ping CH, Anari MR, Tong V, Abbott FS and Chang TK: Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype. Toxicol Sci. 94:261–271. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Tzveova R, Naydenova G, Yaneva T, Dimitrov G, Vandeva S, Matrozova Y, Pendicheva-Duhlenska D, Popov I, Beltheva O, Naydenov C, et al: Gender-specific effect of CYP2C8*3 on the risk of essential hypertension in bulgarian patients. Biochem Genet. 53:319–333. 2005. View Article : Google Scholar

45 

Bosó V, Herrero MJ, Santaballa A, Palomar L, Megias JE, de la Cueva H, Rojas L, Marqués MR, Poveda JL, Montalar J and Aliño SF: SNPs and taxane toxicity in breast cancer patients. Pharmacogenomics. 15:1845–1858. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Liu W, Wang B, Ding HU, Wang DW and Zeng H: A potential therapeutic effect of CYP2C8 overexpression on anti-TNF-α activity. Int J Mol Med. 34:725–732. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Wei X, Zhang D, Dou X, Niu N, Huang W, Bai J and Zhang G: Elevated 14,15-epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer. BMC Cancer. 14:8412014. View Article : Google Scholar : PubMed/NCBI

48 

Yu D, Green B, Marrone A, Guo Y, Kadlubar S, Lin D, Fuscoe J, Pogribny I and Ning B: Suppression of CYP2C9 by microRNA hsa-miR-128-3p in human liver cells and association with hepatocellular carcinoma. Sci Rep. 5:85342015. View Article : Google Scholar : PubMed/NCBI

49 

Wang J, Greene S, Eriksson LC, Reihnér E, Reihner E, Einarsson C, Eggertsen G and Gåfvels M: Human sterol 12a-hydroxylase (CYP8B1) is mainly expressed in hepatocytes in a homogenous pattern. Histochem Cell Biol. 123:441–446. 2005. View Article : Google Scholar : PubMed/NCBI

50 

Björkhem I and Eggertsen G: Genes involved in initial steps of bile acid synthesis. Curr Opin Lipidol. 12:97–103. 2001. View Article : Google Scholar : PubMed/NCBI

51 

Xu Y, Li F, Zalzala M, Xu J, Gonzalez FJ, Adorini L, Lee YK, Yin L and Zhang Y: Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice. Hepatology. 64:1072–1085. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Qin J, Han TQ, Yuan WT, Zhang J, Fei J, Jiang ZY, Niu ZM, Zhang KY, Hua Q, Cai XX, et al: Single nucleotide polymorphism rs3732860 in the 3’-untranslated region of CYP8B1 gene is associated with gallstone disease in Han Chinese. J Gastroenterol Hepatol. 28:717–722. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Qin J, Jiang ZY, Niu ZM, Zhang KY, Hua Q, Jiang ZH, Wang Y, Huang W, Han TQ and Zhang SD: Association of single nucleotide polymorphism in human CYP8B1 gene with gallstone disease. Zhonghua Yi Xue Za Zhi. 91:2092–2095. 2011.(In Chinese). PubMed/NCBI

54 

White DL, Saunders VA, Dang P, Engler J, Venables A, Zrim S, Zannettino A, Lynch K, Manley PW and Hughes T: Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: Higher doses of imatinib may overcome the negative impact of low OCT-1 activity. Blood. 110:4064–4072. 2007. View Article : Google Scholar : PubMed/NCBI

55 

de Lima LT, Vivona D, Bueno CT, Hirata RD, Hirata MH, Luchessi AD, de Castro FA, de Lourdes F, Chauffaille M, Zanichelli MA, et al: Reduced ABCG2 and increased SLC22A1 mRNA expression are associated with imatinib response in chronic myeloid leukemia. Med Oncol. 31:8512014. View Article : Google Scholar : PubMed/NCBI

56 

Singh O, Chan JY, Lin K, Heng CC and Chowbay B: SLC22A1- ABCB1 haplotype profiles predict imatinib pharmacokinetics in Asian patients with chronic myeloid leukemia. PLoS One. 7:e517712012. View Article : Google Scholar : PubMed/NCBI

57 

Rulcova A, Krausova L, Smutny T, Vrzal R, Dvorak Z, Jover R and Pavek P: Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes. Pharmacol Rep. 65:1322–1335. 2013. View Article : Google Scholar : PubMed/NCBI

58 

Herraez E, Lozano E, Macias RI, Vaquero J, Bujanda L, Banales JM, Marin JJ and Briz O: Expression of SLC22A1 variants may affect the response of hepatocellular carcinoma and cholangiocarcinoma to sorafenib. Hepatology. 58:1065–1073. 2013. View Article : Google Scholar : PubMed/NCBI

59 

Lautem A, Heise M, Gräsel A, Hoppe-Lotichius M, Weiler N, Foltys D, Knapstein J, Schattenberg JM, Schad A, Zimmermann A, et al: Downregulation of organic cation transporter 1 (SLC22A1) is associated with tumor progression and reduced patient survival in human cholangiocellular carcinoma. Int J Oncol. 42:1297–1304. 2013. View Article : Google Scholar : PubMed/NCBI

60 

Mehere P, Han Q, Lemkul JA, Vavricka CJ, Robinson H, Bevan DR and Li J: Tyrosine aminotransferase: Biochemical and structural properties and molecular dynamics simulations. Protein Cell. 1:1023–1032. 2010. View Article : Google Scholar : PubMed/NCBI

61 

Maydan G, Andresen BS, Madsen PP, Zeigler M, Raas- Rothschild A, Zlotogorski A, Gutman A and Korman SH: TAT gene mutation analysis in three Palestinian kindreds with oculocutaneous tyrosinaemia type II; characterization of a silent exonic transversion that causes complete missplicing by exon 11 skipping. J Inherit Metab Dis. 29:620–626. 2006. View Article : Google Scholar : PubMed/NCBI

62 

Bouyacoub Y, Zribi H, Azzouz H, Nasrallah F, Abdelaziz RB, Kacem M, Rekaya B, Messaoud O, Romdhane L, Charfeddine C, et al: Novel and recurrent mutations in the TAT gene in Tunisian families affected with Richner-Hanhart syndrome. Gene. 529:45–49. 2003. View Article : Google Scholar

63 

Fu L, Dong SS, Xie YW, Tai LS, Chen L, Kong KL, Man K, Xie D, Li Y, Cheng Y, et al: Down-regulation of tyrosine aminotransferase at a frequently deleted region 16q22 contributes to the pathogenesis of hepatocellular carcinoma. Hepatology. 51:1624–1634. 2010. View Article : Google Scholar : PubMed/NCBI

64 

Su W, Wang Y, Jia X, Wu W, Li L, Tian X, Li S, Wang C, Xu H, Cao J, et al: Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease. Proc Natl Acad Sci USA. 111:11437–11442. 2014. View Article : Google Scholar : PubMed/NCBI

65 

Fujimoto Y, Itabe H, Sakai J, Makita M, Noda J, Mori M, Higashi Y, Kojima S and Takano T: Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Biochim Biophys Acta 1644. 47–59. 2004.

66 

Chen J, Zhuo JY, Yang F, Liu ZK, Zhou L, Xie HY, Xu X and Zheng SS: 17-beta-hydroxysteroid dehydrogenase 13 inhibits the progression and recurrence of hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 17:220–226. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang X, Liao X, Yang C, Huang K, Yu T, Yu L, Han C, Zhu G, Zeng X, Liu Z, Liu Z, et al: Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy. Oncol Rep 41: 1586-1602, 2019.
APA
Wang, X., Liao, X., Yang, C., Huang, K., Yu, T., Yu, L. ... Peng, T. (2019). Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy. Oncology Reports, 41, 1586-1602. https://doi.org/10.3892/or.2019.6953
MLA
Wang, X., Liao, X., Yang, C., Huang, K., Yu, T., Yu, L., Han, C., Zhu, G., Zeng, X., Liu, Z., Zhou, X., Qin, W., Su, H., Ye, X., Peng, T."Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy". Oncology Reports 41.3 (2019): 1586-1602.
Chicago
Wang, X., Liao, X., Yang, C., Huang, K., Yu, T., Yu, L., Han, C., Zhu, G., Zeng, X., Liu, Z., Zhou, X., Qin, W., Su, H., Ye, X., Peng, T."Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy". Oncology Reports 41, no. 3 (2019): 1586-1602. https://doi.org/10.3892/or.2019.6953
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Liao X, Yang C, Huang K, Yu T, Yu L, Han C, Zhu G, Zeng X, Liu Z, Liu Z, et al: Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy. Oncol Rep 41: 1586-1602, 2019.
APA
Wang, X., Liao, X., Yang, C., Huang, K., Yu, T., Yu, L. ... Peng, T. (2019). Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy. Oncology Reports, 41, 1586-1602. https://doi.org/10.3892/or.2019.6953
MLA
Wang, X., Liao, X., Yang, C., Huang, K., Yu, T., Yu, L., Han, C., Zhu, G., Zeng, X., Liu, Z., Zhou, X., Qin, W., Su, H., Ye, X., Peng, T."Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy". Oncology Reports 41.3 (2019): 1586-1602.
Chicago
Wang, X., Liao, X., Yang, C., Huang, K., Yu, T., Yu, L., Han, C., Zhu, G., Zeng, X., Liu, Z., Zhou, X., Qin, W., Su, H., Ye, X., Peng, T."Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy". Oncology Reports 41, no. 3 (2019): 1586-1602. https://doi.org/10.3892/or.2019.6953
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team