Ubiquitination‑deubiquitination in the Hippo signaling pathway (Review)

  • Authors:
    • Yanting Liu
    • Jun Deng
  • View Affiliations

  • Published online on: January 8, 2019     https://doi.org/10.3892/or.2019.6956
  • Pages: 1455-1475
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Abstract

The Hippo signaling pathway is considered to be a tissue growth regulator and tumor suppressor pathway that controls cell proliferation, differentiation, survival, regeneration and tissue homeostasis. Defects in Hippo kinases and hyperactivation of transcriptional co‑activator with PDZ‑binding motif and Yes‑associated protein (YAP) may contribute to the development of different types of cancer. The Hippo pathway is regulated in a variety of way, of which ubiquitination is of considerable importance. Ubiquitination is a crucial post‑translational protein modification in cancer cells and is an applicable target for pharmacological intervention. Ubiquitin modifications are involved in regulating various physiological processes and are counteracted by deubiquitination. Imbalanced ubiquitination‑deubiquitination is closely associated with tumor initiation and progression. Therefore, the examination of the specific association between the Hippo pathway and ubiquitination is of interest. The present study reviews the modulatory mechanism of ubiquitination‑deubiquitination in the Hippo signaling pathway, the recent progress in identifying therapeutic targets and strategies, and the future directions in the field that may contribute to better tumor diagnosis and treatment.
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March-2019
Volume 41 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Liu Y and Liu Y: Ubiquitination‑deubiquitination in the Hippo signaling pathway (Review). Oncol Rep 41: 1455-1475, 2019
APA
Liu, Y., & Liu, Y. (2019). Ubiquitination‑deubiquitination in the Hippo signaling pathway (Review). Oncology Reports, 41, 1455-1475. https://doi.org/10.3892/or.2019.6956
MLA
Liu, Y., Deng, J."Ubiquitination‑deubiquitination in the Hippo signaling pathway (Review)". Oncology Reports 41.3 (2019): 1455-1475.
Chicago
Liu, Y., Deng, J."Ubiquitination‑deubiquitination in the Hippo signaling pathway (Review)". Oncology Reports 41, no. 3 (2019): 1455-1475. https://doi.org/10.3892/or.2019.6956