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miR‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4

  • Authors:
    • Yueying Zheng
    • Caifei Pan
    • Manli Chen
    • Aijie Pei
    • Liwei Xie
    • Shengmei Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1707-1717
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    Published online on: January 9, 2019
       https://doi.org/10.3892/or.2019.6961
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Abstract

Ischemic stroke is the main cause of brain injury and results in a high rate of morbidity, disability and mortality. In the present study, we aimed to determine whether miR‑29a played a protective role in oxygen glucose deprivation (OGD) injury via regulation of the water channel protein aquaporin 4 (AQP4). Real‑time PCR and western blotting were used to assess miR‑29a levels and AQP4 protein levels, respectively. Apoptosis was detected by flow cytometry, and lactate dehydrogenase (LDH) was determined by enzyme‑linked immunosorbent assay (ELISA). Overexpression of miR‑29a was significantly downregulated in OGD‑induced primary astrocytes, and transfection with a miR‑29a mimic decreased LDH release and apoptosis, and improved cell health in OGD‑induced astrocytes. AQP4 was the target of miR‑29a, which suppressed AQP4 expression, and knockdown of AQP4 mitigated OGD‑induced astrocyte injury. Furthermore, miR‑29a regulated AQP4 expression in OGD‑induced astrocytes. AQP4 exacerbated astrocyte injury following ischemic stroke, and knockdown of AQP4 protected OGD/RX‑induced primary cultured astrocytes against injury. The effect of miR‑29a inhibitor on primary astrocytes was lost following AQP4 knockdown. These findings indicated that miR‑29a prevented astrocyte injury in vitro by inhibiting AQP4. Thus, miR‑29a may protect primary cultured astrocytes after OGD‑induced injury by targeting AQP4, and may be a potential therapeutic target for ischemic injury of astrocytes.
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1 

Liu P, Zhao H, Wang R, Wang P, Tao Z, Gao L, Yan F, Liu X, Yu S, Ji X, et al: MicroRNA-424 protects against focal cerebral ischemia and reperfusion injury in mice by suppressing oxidative stress. Stroke. 46:513–519. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Yin KJ, Deng Z, Huang H, Hamblin M, Xie C, Zhang J and Chen YE: miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia. Neurobiol Dis. 38:17–26. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Tan JR, Tan KS, Koo YX, Yong FL, Wang CW, Armugam A and Jeyaseelan K: Blood microRNAs in low or no risk ischemic stroke patients. Int J Mol Sci. 14:2072–2084. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Saito Y and Saito H: MicroRNAs in cancers and neurodegenerative disorders. Front Genet. 3:1942012. View Article : Google Scholar : PubMed/NCBI

6 

Rink C and Khanna S: MicroRNA in ischemic stroke etiology and pathology. Physiol Genomics. 43:521–528. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Jickling GC, Ander BP, Zhan X, Noblett D, Stamova B and Liu D: microRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets. PLoS One. 9:e992832014. View Article : Google Scholar : PubMed/NCBI

8 

Bhalala OG, Srikanth M and Kessler JA: The emerging roles of microRNAs in CNS injuries. Nat Rev Neurol. 9:328–339. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Sun Y, Gui H, Li Q, Luo ZM, Zheng MJ, Duan JL and Liu X: MicroRNA-124 protects neurons against apoptosis in cerebral ischemic stroke. CNS Neurosci Ther. 19:813–819. 2013.PubMed/NCBI

10 

Guo X, Liu Q, Wang G, Zhu S, Gao L, Hong W, Chen Y, Wu M, Liu H, Jiang C, et al: microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming. Cell Res. 23:142–156. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Pfaff N, Fiedler J, Holzmann A, Schambach A, Moritz T, Cantz T and Thum T: miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2. EMBO Rep. 12:1153–1159. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Yang CS, Li Z and Rana TM: microRNAs modulate iPS cell generation. RNA. 17:1451–1460. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Smirnova L, Gräfe A, Seiler A, Schumacher S, Nitsch R and Wulczyn FG: Regulation of miRNA expression during neural cell specification. Eur J Neurosci. 21:1469–1477. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Mott JL, Kurita S, Cazanave SC, Bronk SF, Werneburg NW and Fernandez-Zapico ME: Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB. J Cell Biochem. 110:1155–1164. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Tan KS, Armugam A, Sepramaniam S, Lim KY, Setyowati KD, Wang CW and Jeyaseelan K: Expression profile of MicroRNAs in young stroke patients. PLoS One. 4:e76892009. View Article : Google Scholar : PubMed/NCBI

16 

Liu DZ, Tian Y, Ander BP, Xu H, Stamova BS, Zhan X, Turner RJ, Jickling G and Sharp FR: Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab. 30:92–101. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Hutchison ER, Okun E and Mattson MP: The therapeutic potential of microRNAs in nervous system damage, degeneration, and repair. Neuromolecular Med. 11:153–161. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Zhao H, Wang J, Gao L, Wang R, Liu X, Gao Z, Tao Z, Xu C, Song J, Ji X, et al: MiRNA-424 protects against permanent focal cerebral ischemia injury in mice involving suppressing microglia activation. Stroke. 44:1706–1713. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Stary CM, Xu L, Sun X, Ouyang YB, White RE, Leong J, Li J, Xiong X and Giffard RG: MicroRNA-200c contributes to injury from transient focal cerebral ischemia by targeting Reelin. Stroke. 46:551–556. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Zhou J and Zhang J: Identification of miRNA-21 and miRNA-24 in plasma as potential early stage markers of acute cerebral infarction. Mol Med Rep. 10:971–976. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Yi H, Huang Y, Yang F, Liu W, He S and Hu X: MicroRNA-182 aggravates cerebral ischemia injury by targeting inhibitory member of the ASPP family (iASPP). Arch Biochem Biophys. 620:52–58. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Doeppner TR, Doehring M, Bretschneider E, Zechariah A, Kaltwasser B, Müller B, Koch JC, Bähr M, Hermann DM and Michel U: MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation. Acta Neuropathol. 126:251–265. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Nielsen S, Nagelhus EA, Amiry-Moghaddam M, Bourque C, Agre P and Ottersen OP: Specialized membrane domains for water transport in glial cells: High-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J Neurosci. 17:171–180. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Nagelhus EA, Mathiisen TM and Ottersen OP: Aquaporin-4 in the central nervous system: Cellular and subcellular distribution and coexpression with KIR4.1. Neuroscience. 129:905–913. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Costa C, Tortosa R, Domènech A, Vidal E, Pumarola M and Bassols A: Mapping of aggrecan, hyaluronic acid, heparan sulphate proteoglycans and aquaporin 4 in the central nervous system of the mouse. J Chem Neuroanat. 33:111–123. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P and Verkman AS: Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med. 6:159–163. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Zhang C, Chen J and Lu H: Expression of aquaporin-4 and pathological characteristics of brain injury in a rat model of traumatic brain injury. Mol Med Rep. 12:7351–7357. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Wang Y, Huang J, Ma Y, Tang G, Liu Y, Chen X, Zhang Z, Zeng L, Wang Y, Ouyang YB and Yang GY: MicroRNA-29b is a therapeutic target in cerebral ischemia associated with aquaporin 4. J Cereb Blood Flow Metab. 35:1977–1984. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Oh TW, Park KH, Jung HW and Park YK: Neuroprotective effect of the hairy root extract of Angelica gigas NAKAI on transient focal cerebral ischemia in rats through the regulation of angiogenesis. BMC Complement Altern Med. 15:1012015. View Article : Google Scholar : PubMed/NCBI

30 

Li Q, He Q, Baral S, Mao L, Li Y, Jin H, Chen S, An T, Xia Y and Hu B: MicroRNA-493 regulates angiogenesis in a rat model of ischemic stroke by targeting MIF. FEBS J. 283:1720–1733. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Iwata-Ichikawa E, Kondo Y, Miyazaki I, Asanuma M and Ogawa N: Glial cells protect neurons against oxidative stress via transcriptional up-regulation of the glutathione synthesis. J Neurochem. 72:2334–2344. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Lin SP, Ye S, Long Y, Fan Y, Mao HF, Chen MT and Ma QJ: Circular RNA expression alterations are involved in OGD/R-induced neuron injury. Biochem Biophys Res Commun. 471:52–56. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Zheng L, Cheng W, Wang X, Yang Z, Zhou X and Pan C: Overexpression of MicroRNA-145 ameliorates astrocyte injury by targeting aquaporin 4 in cerebral ischemic stroke. Biomed Res Int 2017. 95309512017.

34 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Huang J, Li Y, Tang Y, Tang G, Yang GY and Wang Y: CXCR4 antagonist AMD3100 protects blood-brain barrier integrity and reduces inflammatory response after focal ischemia in mice. Stroke. 44:190–197. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Wang P, Zhang N, Liang J and Li J, Han S and Li J: Micro-RNA-30a regulates ischemia-induced cell death by targeting heat shock protein HSPA5 in primary cultured cortical neurons and mouse brain after stroke. J Neurosci Res. 93:1756–1768. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Martinez B and Peplow PV: Blood microRNAs as potential diagnostic and prognostic markers in cerebral ischemic injury. Neural Regen Res. 11:1375–1378. 2016.PubMed/NCBI

38 

Kriegel AJ, Liu Y, Fang Y, Ding X and Liang M: The miR-29 family: Genomics, cell biology, and relevance to renal and cardiovascular injury. Physiol Genomics. 44:237–244. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Jeyaseelan K, Lim KY and Armugam A: MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion. Stroke. 39:959–966. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Liu P, Sun J, Zhao J, Liu X, Gu X, Li J, Xiao T and Xu LX: Microvascular imaging using synchrotron radiation. J Synchrotron Radiat. 17:517–521. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Ouyang YB, Xu L, Lu Y, Sun X, Yue S, Xiong XX and Giffard RG: Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia. Glia. 61:1784–1794. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Stary CM, Sun X, Ouyang Y, Li L and Giffard RG: miR-29a differentially regulates cell survival in astrocytes from cornu ammonis 1 and dentate gyrus by targeting VDAC1. Mitochondrion. 30:248–254. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Yao S, Tang B, Li G, Fan R and Cao F: miR-455 inhibits neuronal cell death by targeting TRAF3 in cerebral ischemic stroke. Neuropsychiatr Dis Treat. 12:3083–3092. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Tang XJ, Yang MH, Cao G, Lu JT, Luo J, Dai LJ, Huang KM and Zhang LI: Protective effect of microRNA-138 against cerebral ischemia/reperfusion injury in rats. Exp Ther Med. 11:1045–1050. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Xu J, Qiu GP, Huang J, Zhang B, Sun SQ, Gan SW, Lu WT, Wang KJ, Huang SQ and Zhu SJ: Internalization of aquaporin-4 after collagenase-induced intracerebral hemorrhage. Anat Rec. 298:554–561. 2015. View Article : Google Scholar

46 

Tang G, Liu Y, Zhang Z, Lu Y, Wang Y, Huang J, Li Y, Chen X, Gu X, Wang Y, et al: Mesenchymal stem cells maintain blood-brain barrier integrity by inhibiting aquaporin-4 upregulation after cerebral ischemia. Stem Cells. 32:3150–3162. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Nito C, Kamada H, Endo H, Narasimhan P, Lee YS and Chan PH: Involvement of mitogen-activated protein kinase pathways in expression of the water channel protein aquaporin-4 after ischemia in rat cortical astrocytes. J Neurotrauma. 29:2404–2412. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Fukuda AM and Badaut J: Aquaporin 4: A player in cerebral edema and neuroinflammation. J Neuroinflammation. 9:2792012. View Article : Google Scholar : PubMed/NCBI

49 

Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang F, Rangroo Thrane V, Enger R, et al: Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc Natl Acad Sci USA. 108:846–851. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Zeng HK, Wang QS, Deng YY, Fang M, Chen CB, Fu YH, Jiang WQ and Jiang X: Hypertonic saline ameliorates cerebral edema through downregulation of aquaporin-4 expression in the astrocytes. Neuroscience. 166:878–885. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Tang G and Yang GY: Aquaporin-4: A potential therapeutic target for cerebral edema. Int J Mol Sci. 17:E14132016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zheng Y, Pan C, Chen M, Pei A, Xie L and Zhu S: miR‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4. Oncol Rep 41: 1707-1717, 2019.
APA
Zheng, Y., Pan, C., Chen, M., Pei, A., Xie, L., & Zhu, S. (2019). miR‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4. Oncology Reports, 41, 1707-1717. https://doi.org/10.3892/or.2019.6961
MLA
Zheng, Y., Pan, C., Chen, M., Pei, A., Xie, L., Zhu, S."miR‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4". Oncology Reports 41.3 (2019): 1707-1717.
Chicago
Zheng, Y., Pan, C., Chen, M., Pei, A., Xie, L., Zhu, S."miR‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4". Oncology Reports 41, no. 3 (2019): 1707-1717. https://doi.org/10.3892/or.2019.6961
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng Y, Pan C, Chen M, Pei A, Xie L and Zhu S: miR‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4. Oncol Rep 41: 1707-1717, 2019.
APA
Zheng, Y., Pan, C., Chen, M., Pei, A., Xie, L., & Zhu, S. (2019). miR‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4. Oncology Reports, 41, 1707-1717. https://doi.org/10.3892/or.2019.6961
MLA
Zheng, Y., Pan, C., Chen, M., Pei, A., Xie, L., Zhu, S."miR‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4". Oncology Reports 41.3 (2019): 1707-1717.
Chicago
Zheng, Y., Pan, C., Chen, M., Pei, A., Xie, L., Zhu, S."miR‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4". Oncology Reports 41, no. 3 (2019): 1707-1717. https://doi.org/10.3892/or.2019.6961
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