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Review

Predicting resistance to endocrine therapy in breast cancer: It's time for epigenetic biomarkers (Review)

  • Authors:
    • Mário Fontes‑Sousa
    • Maria Amorim
    • Sofia Salta
    • Susana Palma De Sousa
    • Rui Henrique
    • Carmen Jerónimo
  • View Affiliations / Copyright

    Affiliations: Cancer Biology and Epigenetics Group, IPO Porto Research Center (CI‑IPOP), Portuguese Oncology Institute of Porto (IPOPorto) 4200‑072 Porto, Portugal, Department of Medical Oncology, Portuguese Oncology Institute of Porto (IPOPorto) 4200‑072 Porto, Portugal
  • Pages: 1431-1438
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    Published online on: January 11, 2019
       https://doi.org/10.3892/or.2019.6967
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Abstract

Notwithstanding the marked progress in breast cancer (BC) management, it still constitutes the most common malignancy in women and a major cause of morbidity and mortality, thus remaining a major health issue worldwide. Most BC cases are hormone receptor (HR) positive (luminal A or B molecular subtypes) and endocrine treatment (ET) is an important therapeutic modality at all disease stages. Nevertheless, despite substantial improvements in BC patient outcome, effectiveness of ET is limited, as up to 40% of patients eventually relapse or progress and endocrine resistant BC has a less favorable prognosis and constitutes a therapeutic challenge. The biological mechanisms underlying endocrine resistance are, however, still poorly understood. In this review, we focused on data regarding the main epigenetic mechanisms associated with the development of endocrine treated‑resistant BC described so far, including alterations in DNA methylation, non‑coding RNAs, chromatin remodeling, post‑translational histone modifications and histone variants. Notably, specific epigenetic alterations have been characterized in this subset of breast tumors and may be of clinical value for individualized patient management in the future.
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Copy and paste a formatted citation
Spandidos Publications style
Fontes‑Sousa M, Amorim M, Salta S, Palma De Sousa S, Henrique R and Jerónimo C: Predicting resistance to endocrine therapy in breast cancer: It's time for epigenetic biomarkers (Review). Oncol Rep 41: 1431-1438, 2019.
APA
Fontes‑Sousa, M., Amorim, M., Salta, S., Palma De Sousa, S., Henrique, R., & Jerónimo, C. (2019). Predicting resistance to endocrine therapy in breast cancer: It's time for epigenetic biomarkers (Review). Oncology Reports, 41, 1431-1438. https://doi.org/10.3892/or.2019.6967
MLA
Fontes‑Sousa, M., Amorim, M., Salta, S., Palma De Sousa, S., Henrique, R., Jerónimo, C."Predicting resistance to endocrine therapy in breast cancer: It's time for epigenetic biomarkers (Review)". Oncology Reports 41.3 (2019): 1431-1438.
Chicago
Fontes‑Sousa, M., Amorim, M., Salta, S., Palma De Sousa, S., Henrique, R., Jerónimo, C."Predicting resistance to endocrine therapy in breast cancer: It's time for epigenetic biomarkers (Review)". Oncology Reports 41, no. 3 (2019): 1431-1438. https://doi.org/10.3892/or.2019.6967
Copy and paste a formatted citation
x
Spandidos Publications style
Fontes‑Sousa M, Amorim M, Salta S, Palma De Sousa S, Henrique R and Jerónimo C: Predicting resistance to endocrine therapy in breast cancer: It's time for epigenetic biomarkers (Review). Oncol Rep 41: 1431-1438, 2019.
APA
Fontes‑Sousa, M., Amorim, M., Salta, S., Palma De Sousa, S., Henrique, R., & Jerónimo, C. (2019). Predicting resistance to endocrine therapy in breast cancer: It's time for epigenetic biomarkers (Review). Oncology Reports, 41, 1431-1438. https://doi.org/10.3892/or.2019.6967
MLA
Fontes‑Sousa, M., Amorim, M., Salta, S., Palma De Sousa, S., Henrique, R., Jerónimo, C."Predicting resistance to endocrine therapy in breast cancer: It's time for epigenetic biomarkers (Review)". Oncology Reports 41.3 (2019): 1431-1438.
Chicago
Fontes‑Sousa, M., Amorim, M., Salta, S., Palma De Sousa, S., Henrique, R., Jerónimo, C."Predicting resistance to endocrine therapy in breast cancer: It's time for epigenetic biomarkers (Review)". Oncology Reports 41, no. 3 (2019): 1431-1438. https://doi.org/10.3892/or.2019.6967
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