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Article

17β‑hydroxysteroid dehydrogenase 4 induces liver cancer proliferation‑associated genes via STAT3 activation

  • Authors:
    • Xin Lu
    • Lingyu Kong
    • Xi Wang
    • Weiran Liu
    • Panpan Ma
    • Lingling Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Tangshan Maternal and Children Hospital, Tangshan, Hebei 063000, P.R. China, College of Integrative Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China, Department of Endocrinology, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China, Department of Chinese Medicine, Tangshan Maternal and Children Hospital, Tangshan, Hebei 063000, P.R. China, Department of Blood Transfusion, Hebei Provincial People's Hospital, Shijiazhuang, Hebei 050017, P.R. China, Department of Biochemistry and Molecular Biology, The Key Laboratory of Neurobiology and Vascular Biology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China
  • Pages: 2009-2019
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    Published online on: January 23, 2019
       https://doi.org/10.3892/or.2019.6981
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Abstract

Accumulating evidence has implicated that the activation of signal transducer and activator of transcription 3 (STAT3) contributes to the progression of liver cancer by affecting the expression of proliferation‑associated genes. A previous study reported that elevated levels of 17β‑hydroxysteroid dehydrogenase 4 (HSD17B4) are observed in patients with liver cancer. The current study investigated how upregulated HSD17B4 expression promoted the expression of proliferation‑associated genes in rats with liver cancer. HSD17B4 expression in rats with liver cancer was significantly increased compared with the control group as determined by reverse transcription‑quantitative polymerase chain reaction and western blot assays. Immunohistochemical results revealed that STAT3 activation was positively correlated with increased HSD17B4 expression in tumor tissues from patients with liver cancer. Western blot results further suggested that HSD17B4 overexpression increased STAT3 activation via the protein kinase B and the mitogen‑activated protein kinase/extracellular‑signal‑regulated kinase signaling pathways in HepG2 cells. The present study suggested that overexpression may promote HepG2 proliferation by enhancing expression of various downstream targets of STAT3. Targeted inhibition of HSD17B4 may describe a novel approach in the prevention and treatment of liver cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Lu X, Kong L, Wang X, Liu W, Ma P and Jiang L: 17β‑hydroxysteroid dehydrogenase 4 induces liver cancer proliferation‑associated genes via STAT3 activation. Oncol Rep 41: 2009-2019, 2019.
APA
Lu, X., Kong, L., Wang, X., Liu, W., Ma, P., & Jiang, L. (2019). 17β‑hydroxysteroid dehydrogenase 4 induces liver cancer proliferation‑associated genes via STAT3 activation. Oncology Reports, 41, 2009-2019. https://doi.org/10.3892/or.2019.6981
MLA
Lu, X., Kong, L., Wang, X., Liu, W., Ma, P., Jiang, L."17β‑hydroxysteroid dehydrogenase 4 induces liver cancer proliferation‑associated genes via STAT3 activation". Oncology Reports 41.3 (2019): 2009-2019.
Chicago
Lu, X., Kong, L., Wang, X., Liu, W., Ma, P., Jiang, L."17β‑hydroxysteroid dehydrogenase 4 induces liver cancer proliferation‑associated genes via STAT3 activation". Oncology Reports 41, no. 3 (2019): 2009-2019. https://doi.org/10.3892/or.2019.6981
Copy and paste a formatted citation
x
Spandidos Publications style
Lu X, Kong L, Wang X, Liu W, Ma P and Jiang L: 17β‑hydroxysteroid dehydrogenase 4 induces liver cancer proliferation‑associated genes via STAT3 activation. Oncol Rep 41: 2009-2019, 2019.
APA
Lu, X., Kong, L., Wang, X., Liu, W., Ma, P., & Jiang, L. (2019). 17β‑hydroxysteroid dehydrogenase 4 induces liver cancer proliferation‑associated genes via STAT3 activation. Oncology Reports, 41, 2009-2019. https://doi.org/10.3892/or.2019.6981
MLA
Lu, X., Kong, L., Wang, X., Liu, W., Ma, P., Jiang, L."17β‑hydroxysteroid dehydrogenase 4 induces liver cancer proliferation‑associated genes via STAT3 activation". Oncology Reports 41.3 (2019): 2009-2019.
Chicago
Lu, X., Kong, L., Wang, X., Liu, W., Ma, P., Jiang, L."17β‑hydroxysteroid dehydrogenase 4 induces liver cancer proliferation‑associated genes via STAT3 activation". Oncology Reports 41, no. 3 (2019): 2009-2019. https://doi.org/10.3892/or.2019.6981
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