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Article

Autophagy and apoptotic machinery caused by Polygonum cuspidatum extract in cisplatin‑resistant human oral cancer CAR cells

  • Authors:
    • Yin‑Lai Wang
    • Chi‑Ting Horng
    • Min‑Tsang Hsieh
    • Hung‑Che Chen
    • Yu‑Syuan Huang
    • Jai‑Sing Yang
    • Guo‑Kai Wang
    • Jo‑Hua Chiang
    • Hul‑Han Chen
    • Chi‑Cheng Lu
    • Fu‑An Chen
  • View Affiliations / Copyright

    Affiliations: Department of Dentistry, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan, R.O.C., Department of Ophthalmology, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan, R.O.C., School of Pharmacy, China Medical University, Taichung 40402, Taiwan, R.O.C., Department of Pharmacy and Master Program, Tajen University, Pingtung 90741, Taiwan, R.O.C., Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan, R.O.C., School of Pharmacy, Anhui University of Chinese Medicine, Anhui Key Lab of Modern Chinese Materia Medica, Hefei, Anhui 230012, P.R. China, Department of Nursing, Chung Jen Catholic Junior College, Chiayi 62241, Taiwan, R.O.C., Division of Practice Advancement and Clinical Education, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 275297, USA, Department of Sport Performance, National Taiwan University of Sport, Taichung 40404, Taiwan, R.O.C.
  • Pages: 2549-2557
    |
    Published online on: January 28, 2019
       https://doi.org/10.3892/or.2019.6985
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Abstract

Polygonum cuspidatum (Hu Zhang) is a traditional Chinese medicine (TCM) and has been revealed to exert anticancer, anti‑angiogenesis, anti‑human immunodeficiency virus (HIV), anti‑hepatitis B virus, anti‑microbial, anti‑inflammatory, and neuro‑protective bio‑activities. However, the effect of P. cuspidatum extract (PCE) on drug‑resistant human oral cancer cells regarding cell death is not fully understood yet. The present study was undertaken to explore the induction of autophagic and apoptotic cell death and to investigate their underlying molecular mechanisms in PCE‑treated cisplatin‑resistant human oral cancer CAR cells. Our results revealed that PCE was determined via HPLC analytic method, and it was revealed that resveratrol may be a major compound in PCE. The data also demonstrated that PCE reduced CAR cell viability in a concentration‑ and time‑dependent response via an MTT assay. PCE had an extremely low toxicity in human normal gingival fibroblasts (HGF). Autophagic and apoptotic cell death was found after PCE treatment by morphological determination. PCE was revealed to induce autophagy as determined using acridine orange (AO), LC3‑GFP, monodansylcadaverine (MDC) and LysoTracker Red staining in CAR cells. In addition, PCE was revealed to induce apoptosis in CAR cells via 4',6‑diamidino‑2‑phenylindole (DAPI)/terminal deoxynucleotidyl transferase dUTP nick‑end labeling (TUNEL) double staining. PCE significantly stimulated caspase‑9 and ‑3 activities as revealed using caspase activity assays. PCE markedly increased the protein levels of Atg5, Atg7, Atg12, Beclin‑1, LC3, Bax and cleaved caspase‑3, while it decreased the protein expression of Bcl‑2 in CAR cells as determined by western blotting. In conclusion, our findings are the first to suggest that PCE may be potentially efficacious for the treatment of cisplatin‑resistant human oral cancer.
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View References

1 

Wei Y, Yang P, Cao S and Zhao L: The combination of curcumin and 5-fluorouracil in cancer therapy. Arch Pharm Res. 41:1–13. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW and et al: Molecular mechanisms of cell death: Recommendations of the nomenclature committee on cell death 2018. Cell Death Differ. 25:486–541. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Chang CH, Lee CY, Lu CC, Tsai FJ, Hsu YM, Tsao JW, Juan YN, Chiu HY, Yang JS and Wang CC: Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling. Int J Oncol. 50:873–882. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Marinkovic M, Šprung M, Buljubašić M and Novak I: Autophagy modulation in cancer: Current knowledge on action and therapy. Oxid Med Cell Longev. 2018:80238212018. View Article : Google Scholar : PubMed/NCBI

5 

Yang JS, Lu CC, Kuo SC, Hsu YM, Tsai SC, Chen SY, Chen YT, Lin YJ, Huang YC, Chen CJ and et al: Autophagy and its link to type II diabetes mellitus. Biomedicine. 7:82017. View Article : Google Scholar : PubMed/NCBI

6 

Zhang SJ, Yang W, Wang C, He WS, Deng HY, Yan YG, Zhang J, Xiang YX and Wang WJ: Autophagy: A double-edged sword in intervertebral disk degeneration. Clin Chim Acta. 457:27–35. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Li YJ, Lei YH, Yao N, Wang CR, Hu N, Ye WC, Zhang DM and Chen ZS: Autophagy and multidrug resistance in cancer. Chin J Cancer. 36:522017. View Article : Google Scholar : PubMed/NCBI

8 

Han Y, Fan S, Qin T, Yang J, Sun Y, Lu Y, Mao J and Li L: Role of autophagy in breast cancer and breast cancer stem cells (Review). Int J Oncol. 52:1057–1070. 2018.PubMed/NCBI

9 

Chowdhury RM, Singh G, Joshi A, Singh DK, Bhatia S and Goswami S: Autophagy and oral cancers: A short review. J Stomatol Oral Maxillofac Surg. 119:37–39. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Campbell KJ and Tait SWG: Targeting BCL-2 regulated apoptosis in cancer. Open Biol. 8(pii): 1800022018. View Article : Google Scholar : PubMed/NCBI

11 

Adams JM and Cory S: The BCL-2 arbiters of apoptosis and their growing role as cancer targets. Cell Death Differ. 25:27–36. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Zhang H, Li C, Kwok ST, Zhang QW and Chan SW: A Review of the pharmacological effects of the dried root of Polygonum cuspidatum (Hu Zhang) and its constituents. Evid Based Complement Alternat Med. 2013:2083492013. View Article : Google Scholar : PubMed/NCBI

13 

Peng W, Qin R, Li X and Zhou H: Botany, phytochemistry, pharmacology, and potential application of Polygonum cuspidatum Sieb. et Zucc.: A review. J Ethnopharmacol. 148:729–745. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Nonomura S, Kanagawa H and Makimoto A: Chemical constituents of polygonaceous plants. I. Studies on the components of Ko-J O-Kon. (Polygonum cuspidatum Sieb. Et Zucc.). Yakugaku Zasshi. 83:988–990. 1963.(In Japanese). View Article : Google Scholar : PubMed/NCBI

15 

Wang S, Zheng Z, Weng Y, Yu Y, Zhang D, Fan W, Dai R and Hu Z: Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts. Life Sci. 74:2467–2478. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Lin CJ, Lin HJ, Chen TH, Hsu YA, Liu CS, Hwang GY and Wan L: Polygonum cuspidatum and its active components inhibit replication of the influenza virus through toll-like receptor 9-induced interferon beta expression. PLoS One. 10:e01176022015. View Article : Google Scholar : PubMed/NCBI

17 

Jiewei T, Lei W, Xiufeng L, Heming Z, Xiaoguang L, Haiyan F and Yongqiang T: Microbial transformation of resveratrol by endophyte Streptomyces sp. A12 isolated from Polygonum cuspidatum. Nat Prod Res. 32:2343–2346. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Sun W, Qu D, Ma Y, Chen Y, Liu C and Zhou J: Enhanced stability and antibacterial efficacy of a traditional Chinese medicine-mediated silver nanoparticle delivery system. Int J Nanomedicine. 9:5491–5502. 2014.PubMed/NCBI

19 

Sohn E, Kim J, Kim CS, Lee YM and Kim JS: Extract of Polygonum cuspidatum attenuates diabetic retinopathy by inhibiting the high-mobility group box-1 (HMGB1) signaling pathway in streptozotocin-induced diabetic rats. Nutrients. 8:1402016. View Article : Google Scholar : PubMed/NCBI

20 

Fan P, Zhang T and Hostettmann K: Anti-inflammatory activity of the invasive neophyte Polygonum cuspidatum Sieb. and Zucc. (Polygonaceae) and the chemical comparison of the invasive and native varieties with regard to resveratrol. J Tradit Complement Med. 3:182–187. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Han JH, Koh W, Lee HJ, Lee HJ, Lee EO, Lee SJ, Khil JH, Kim JT, Jeong SJ and Kim SH: Analgesic and anti-inflammatory effects of ethyl acetate fraction of Polygonum cuspidatum in experimental animals. Immunopharmacol Immunotoxicol. 34:191–195. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Shen B, Truong J, Helliwell R, Govindaraghavan S and Sucher NJ: An in vitro study of neuroprotective properties of traditional Chinese herbal medicines thought to promote healthy ageing and longevity. BMC Complement Altern Med. 13:3732013. View Article : Google Scholar : PubMed/NCBI

23 

Shin JA, Shim JH, Jeon JG, Choi KH, Choi ES, Cho NP and Cho SD: Apoptotic effect of Polygonum Cuspidatum in oral cancer cells through the regulation of specificity protein 1. Oral Dis. 17:162–170. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Chang CJ, Ashendel CL, Geahlen RL, McLaughlin JL and Waters DJ: Oncogene signal transduction inhibitors from medicinal plants. In Vivo. 10:185–190. 1996.PubMed/NCBI

25 

Owen HC, Appiah S, Hasan N, Ghali L, Elayat G and Bell C: Phytochemical modulation of apoptosis and autophagy: Strategies to overcome chemoresistance in leukemic stem cells in the bone marrow microenvironment. Int Rev Neurobiol. 135:249–278. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Jiao Y, Wu Y and Du D: Polydatin inhibits cell proliferation, invasion and migration, and induces cell apoptosis in hepatocellular carcinoma. Braz J Med Biol Res. 51:e68672018. View Article : Google Scholar : PubMed/NCBI

27 

Lee KH, Song JL, Park ES, Ju J, Kim HY and Park KY: Anti-obesity effects of starter fermented kimchi on 3T3-L1 adipocytes. Prev Nutr Food Sci. 20:298–302. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Liu J, Zhang Q, Chen K, Liu J, Kuang S, Chen W and Yu Q: Small-molecule STAT3 signaling pathway modulators from Polygonum cuspidatum. Planta Med. 78:1568–1570. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Chang JS, Liu HW, Wang KC, Chen MC, Chiang LC, Hua YC and Lin CC: Ethanol extract of Polygonum cuspidatum inhibits hepatitis B virus in a stable HBV-producing cell line. Antiviral Res. 66:29–34. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Sun P, Qi Y, Mu Z and Wang K: Quantitative determination of resveratrol in Polygonum cuspidatum and its anti-proliferative effect on melanoma A375 cells. Biomed Res. 26:750–754. 2015.

31 

Lu CC, Yang SH, Hsia SM, Wu CH and Yen GC: Inhibitory effects of Phyllanthus emblica L. on hepatic steatosis and liver fibrosis in vitro. J Funct Foods. 20:20–30. 2016. View Article : Google Scholar

32 

Chang HP, Lu CC, Chiang JH, Tsai FJ, Juan YN, Tsao JW, Chiu HY and Yang JS: Pterostilbene modulates the suppression of multidrug resistance protein 1 and triggers autophagic and apoptotic mechanisms in cisplatin-resistant human oral cancer CAR cells via AKT signaling. Int J Oncol. Mar 2–2018.(Epub ahead of print). doi: 10.3892/ijo.2018.4298. View Article : Google Scholar

33 

Chiu YJ, Yang JS, Hsu HS, Tsai CH and Ma H: Adipose-derived stem cell conditioned medium attenuates cisplatin-triggered apoptosis in tongue squamous cell carcinoma. Oncol Rep. 39:651–658. 2018.PubMed/NCBI

34 

Lee MR, Lin C, Lu CC, Kuo SC, Tsao JW, Juan YN, Chiu HY, Lee FY, Yang JS and Tsai FJ: YC-1 induces G0/G1 phase arrest and mitochondria-dependent apoptosis in cisplatin-resistant human oral cancer CAR cells. Biomedicine. 7:122017. View Article : Google Scholar : PubMed/NCBI

35 

Yuan CH, Horng CT, Lee CF, Chiang NN, Tsai FJ, Lu CC, Chiang JH, Hsu YM, Yang JS and Chen FA: Epigallocatechin gallate sensitizes cisplatin-resistant oral cancer CAR cell apoptosis and autophagy through stimulating AKT/STAT3 pathway and suppressing multidrug resistance 1 signaling. Environ Toxicol. 32:845–855. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Hsieh MT, Chen HP, Lu CC, Chiang JH, Wu TS, Kuo DH, Huang LJ, Kuo SC and Yang JS: The novel pterostilbene derivative ANK-199 induces autophagic cell death through regulating PI3 kinase class III/beclin 1/Atg-related proteins in cisplatin-resistant CAR human oral cancer cells. Int J Oncol. 45:782–794. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Chang PY, Peng SF, Lee CY, Lu CC, Tsai SC, Shieh TM, Wu TS, Tu MG, Chen MY and Yang JS: Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells. Int J Oncol. 43:1141–1150. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Gosepath EM, Eckstein N, Hamacher A, Servan K, von Jonquieres G, Lage H, Györffy B, Royer HD and Kassack MU: Acquired cisplatin resistance in the head-neck cancer cell line Cal27 is associated with decreased DKK1 expression and can partially be reversed by overexpression of DKK1. Int J Cancer. 123:2013–2019. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Chen CF, Yang JS, Chen WK, Lu CC, Chiang JH, Chiu HY, Tsai SC, Juan YN, Huang HJ and Way TD: Ursolic acid elicits intrinsic apoptotic machinery by downregulating the phosphorylation of AKT/BAD signaling in human cisplatin-resistant oral cancer CAR cells. Oncol Rep. 40:1752–1760. 2018.PubMed/NCBI

40 

Lu CC, Yang JS, Chiang JH, Hour MJ, Lin KL, Lee TH and Chung JG: Cell death caused by quinazolinone HMJ-38 challenge in oral carcinoma CAL 27 cells: Dissections of endoplasmic reticulum stress, mitochondrial dysfunction and tumor xenografts. Biochim Biophys Acta. 1840:2310–2320. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Lu CC, Huang BR, Liao PJ and Yen GC: Ursolic acid triggers nonprogrammed death (necrosis) in human glioblastoma multiforme DBTRG-05MG cells through MPT pore opening and ATP decline. Mol Nutr Food Res. 58:2146–2156. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Chiang JH, Yang JS, Lu CC, Hour MJ, Chang SJ, Lee TH and Chung JG: Newly synthesized quinazolinone HMJ-38 suppresses angiogenetic responses and triggers human umbilical vein endothelial cell apoptosis through p53-modulated Fas/death receptor signaling. Toxicol Appl Pharmacol. 269:150–162. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Chang CH, Wu JB, Yang JS, Lai YJ, Su CH, Lu CC and Hsu YM: The suppressive effects of geniposide and genipin on helicobacter pylori infections in vitro and in vivo. J Food Sci. 82:3021–3028. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Ho TJ, Jiang SJ, Lin GH, Li TS, Yiin LM, Yang JS, Hsieh MC, Wu CC, Lin JG and Chen HP: The in vitro and in vivo wound healing properties of the Chinese herbal medicine ‘Jinchuang Ointment’. Evid Based Complement Alternat Med. 2016:16540562016. View Article : Google Scholar : PubMed/NCBI

45 

Wang C, Yang S, Lu H, You H, Ni M, Shan W, Lin T, Gao X, Chen H, Zhou Q, et al: A natural product from Polygonum cuspidatum sieb. Et Zucc. Promotes Tat-dependent HIV latency reversal through triggering P-TEFb's release from 7SK snRNP. PLoS One. 10:e01427392015. View Article : Google Scholar : PubMed/NCBI

46 

Lange KW and Li S: Resveratrol, pterostilbene, and dementia. Biofactors. 44:83–90. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Rauf A, Imran M, Butt MS, Nadeem M, Peters DG and Mubarak MS: Resveratrol as an anti-cancer agent: A review. Crit Rev Food Sci Nutr. 58:1428–1447. 2018. View Article : Google Scholar : PubMed/NCBI

48 

Nunes S, Danesi F, Del Rio D and Silva P: Resveratrol and inflammatory bowel disease: The evidence so far. Nutr Res Rev. 31:85–97. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Jardim FR, de Rossi FT, Nascimento MX, da Silva Barros RG, Borges PA, Prescilio IC and de Oliveira MR: Resveratrol and brain mitochondria: A review. Mol Neurobiol. 55:2085–2101. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Perez-Vizcaino F and Fraga CG: Research trends in flavonoids and health. Arch Biochem Biophys. 646:107–112. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Lin W and Xu G: Autophagy: A role in the apoptosis, survival, inflammation, and development of the retina. Ophthalmic Res. 1–8. 2018.(Epub ahead of print).

52 

Peña-Blanco A and García-Sáez AJ: Bax, Bak and beyond-mitochondrial performance in apoptosis. FEBS J. 285:416–431. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Garcia-Zepeda SP, Garcia-Villa E, Díaz-Chávez J, Hernández- Pando R and Gariglio P: Resveratrol induces cell death in cervical cancer cells through apoptosis and autophagy. Eur J Cancer Prev. 22:577–584. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Hsu KF, Wu CL, Huang SC, Wu CM, Hsiao JR, Yo YT, Chen YH, Shiau AL and Chou CY: Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells. Autophagy. 5:451–460. 2009. View Article : Google Scholar : PubMed/NCBI

55 

Hong EH, Heo EY, Song JH, Kwon BE, Lee JY, Park Y, Kim J, Chang SY, Chin YW, Jeon SM, et al: Trans-scirpusin A showed antitumor effects via autophagy activation and apoptosis induction of colorectal cancer cells. Oncotarget. 8:41401–41411. 2017. View Article : Google Scholar : PubMed/NCBI

56 

Talero E, Ávila-Roman J and Motilva V: Chemoprevention with phytonutrients and microalgae products in chronic inflammation and colon cancer. Curr Pharm Des. 18:3939–3965. 2012. View Article : Google Scholar : PubMed/NCBI

57 

Trincheri NF, Follo C, Nicotra G, Peracchio C, Castino R and Isidoro C: Resveratrol-induced apoptosis depends on the lipid kinase activity of Vps34 and on the formation of autophagolysosomes. Carcinogenesis. 29:381–389. 2008. View Article : Google Scholar : PubMed/NCBI

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Wang YL, Horng CT, Hsieh MT, Chen HC, Huang YS, Yang JS, Wang GK, Chiang JH, Chen HH, Lu CC, Lu CC, et al: Autophagy and apoptotic machinery caused by Polygonum cuspidatum extract in cisplatin‑resistant human oral cancer CAR cells. Oncol Rep 41: 2549-2557, 2019.
APA
Wang, Y., Horng, C., Hsieh, M., Chen, H., Huang, Y., Yang, J. ... Chen, F. (2019). Autophagy and apoptotic machinery caused by Polygonum cuspidatum extract in cisplatin‑resistant human oral cancer CAR cells. Oncology Reports, 41, 2549-2557. https://doi.org/10.3892/or.2019.6985
MLA
Wang, Y., Horng, C., Hsieh, M., Chen, H., Huang, Y., Yang, J., Wang, G., Chiang, J., Chen, H., Lu, C., Chen, F."Autophagy and apoptotic machinery caused by Polygonum cuspidatum extract in cisplatin‑resistant human oral cancer CAR cells". Oncology Reports 41.4 (2019): 2549-2557.
Chicago
Wang, Y., Horng, C., Hsieh, M., Chen, H., Huang, Y., Yang, J., Wang, G., Chiang, J., Chen, H., Lu, C., Chen, F."Autophagy and apoptotic machinery caused by Polygonum cuspidatum extract in cisplatin‑resistant human oral cancer CAR cells". Oncology Reports 41, no. 4 (2019): 2549-2557. https://doi.org/10.3892/or.2019.6985
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Spandidos Publications style
Wang YL, Horng CT, Hsieh MT, Chen HC, Huang YS, Yang JS, Wang GK, Chiang JH, Chen HH, Lu CC, Lu CC, et al: Autophagy and apoptotic machinery caused by Polygonum cuspidatum extract in cisplatin‑resistant human oral cancer CAR cells. Oncol Rep 41: 2549-2557, 2019.
APA
Wang, Y., Horng, C., Hsieh, M., Chen, H., Huang, Y., Yang, J. ... Chen, F. (2019). Autophagy and apoptotic machinery caused by Polygonum cuspidatum extract in cisplatin‑resistant human oral cancer CAR cells. Oncology Reports, 41, 2549-2557. https://doi.org/10.3892/or.2019.6985
MLA
Wang, Y., Horng, C., Hsieh, M., Chen, H., Huang, Y., Yang, J., Wang, G., Chiang, J., Chen, H., Lu, C., Chen, F."Autophagy and apoptotic machinery caused by Polygonum cuspidatum extract in cisplatin‑resistant human oral cancer CAR cells". Oncology Reports 41.4 (2019): 2549-2557.
Chicago
Wang, Y., Horng, C., Hsieh, M., Chen, H., Huang, Y., Yang, J., Wang, G., Chiang, J., Chen, H., Lu, C., Chen, F."Autophagy and apoptotic machinery caused by Polygonum cuspidatum extract in cisplatin‑resistant human oral cancer CAR cells". Oncology Reports 41, no. 4 (2019): 2549-2557. https://doi.org/10.3892/or.2019.6985
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