Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
April-2019 Volume 41 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2019 Volume 41 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association of CCL2, CCR2 and CCL5 genetic polymorphisms with the development and progression of benign prostatic hyperplasia

  • Authors:
    • Yangyang Pang
    • Haoran Li
    • Yuwen Gong
    • Suoshi Jing
    • Cheng Peng
    • Wei Liu
    • Youli Zhao
    • Hanzhang Wang
    • Dharam Kaushik
    • Ronald Rodriguez
    • Zhiping Wang
  • View Affiliations / Copyright

    Affiliations: Institute of Urology, Lanzhou University Second Hospital, Key Laboratory of Urological Diseases in Gansu Province, Gansu Nephro-Urological Clinical Center, Lanzhou, Gansu 730030, P.R. China, Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China, Department of Urology, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA
  • Pages: 2491-2501
    |
    Published online on: February 6, 2019
       https://doi.org/10.3892/or.2019.7002
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Benign prostatic hyperplasia (BPH) is a common chronic disease in older males. The pathogenesis of BPH remains elusive but may be associated with chronic inflammation. Chemokines and chemokine receptors have been implicated as critical mediators in the immune response and inflammatory processes. In the present study, the aim was to evaluate the association of three polymorphisms in chemokine genes, namely C‑C motif chemokine ligand (CCL)2 rs1024611, CC chemokine receptor 2 (CCR2) rs1799864 and CCL5 rs2107538, with BPH risk. These polymorphisms were genotyped in 109 patients with BPH and 160 control subjects, using the polymerase chain reaction and multiple ligase detection reaction method. The CCL5 rs2107538 polymorphism was identified to be associated with a significantly lower risk of BPH [A/G vs. G/G: odds ratio (OR)=0.37, 95% confidence interval (CI)=0.17‑0.78; A/A + A/G vs. G/G: OR=0.39, 95% CI=0.19‑0.79; A vs. G: OR=0.58, 95% CI=0.35‑0.96). However, this polymorphism was also associated with the development of larger prostate volumes in patients with BPH (A/G vs. G/G: OR=3.02, 95% CI=1.28‑7.11; AA + AG vs. GG: OR=2.83, 95% CI=1.28‑6.26; A vs. G: OR=1.94, 95% CI=1.08‑3.49). The CCR2 rs1799864 polymorphism was associated with lower International Prostate Symptom Score values (A/A + A/G vs. G/G: OR=0.39, 95% CI=0.17‑0.91; A vs. G: OR=0.43, 95% CI=0.20‑0.90) and low Qmax (A/G vs. G/G: OR=0.38, 95% CI=0.16‑0.92; AA + AG vs. GG: OR=0.39, 95% CI=0.17‑0.91) in the patients. No association was observed between the CCL2 rs1024611 polymorphism and BPH. These results suggest that the CCR2 and CCL5 genes may contribute to the occurrence and progression of BPH.
View Figures

Figure 1

Figure 2

View References

1 

Thorpe A and Neal D: Benign prostatic hyperplasia. Lancet. 361:1359–1367. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Roehrborn CG: Male lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH). Med Clin North Am. 95:87–100. 2011. View Article : Google Scholar : PubMed/NCBI

3 

He Q, Wang Z, Liu G, Daneshgari F, MacLennan GT and Gupta S: Metabolic syndrome, inflammation and lower urinary tract symptoms: Possible translational links. Prostate Cancer Prostatic Dis. 19:7–13. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Fibbi B, Penna G, Morelli A, Adorini L and Maggi M: Chronic inflammation in the pathogenesis of benign prostatic hyperplasia. Int J Androl. 33:475–488. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Bostanci Y, Kazzazi A, Momtahen S, Laze J and Djavan B: Correlation between benign prostatic hyperplasia and inflammation. Curr Opin Urol. 23:5–10. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Kramer G, Mitteregger D and Marberger M: Is benign prostatic hyperplasia (BPH) an immune inflammatory disease? Eur Urol. 51:1202–1216. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Sambyal V, Guleria K, Kapahi R, Manjari M, Sudan M, Uppal MS and Singh NR: Association of the-2518 A/G polymorphism of MCP-1 with breast cancer in Punjab, North-West India. Asian Pac J Cancer Prev. 16:7243–7248. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Gao J, Liu X, Wei L, Niu D, Wei J, Wang L, Ge H, Wang M, Yu Q, Jin T, et al: Genetic variants of MCP-1 and CCR2 genes and IgA nephropathy risk. Oncotarget. 7:77950–77957. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Kouhpayeh HR, Taheri M, Baziboroon M, Naderi M, Bahari G and Hashemi M: CCL5 rs2107538 polymorphism increased the risk of tuberculosis in a sample of Iranian population. Prague Med Rep. 117:90–97. 2016. View Article : Google Scholar : PubMed/NCBI

10 

De Nunzio C, Presicce F and Tubaro A: Inflammatory mediators in the development and progression of benign prostatic hyperplasia. Nat Rev Urol. 13:613–626. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Sáenz-López P, Carretero R, Cózar JM, Romero JM, Canton J, Vilchez JR, Tallada M, Garrido F and Ruiz-Cabello F: Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer. BMC Cancer. 8:3822008. View Article : Google Scholar : PubMed/NCBI

12 

Sun T, Mary LG, Oh WK, Freedman ML, Pomerantz M, Pienta KJ and Kantoff PW: Inherited variants in the chemokine CCL2 gene and prostate cancer aggressiveness in a Caucasian cohort. Clin Cancer Res. 17:1546–1552. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Kucukgergin C, Isman FK, Cakmakoglu B, Sanli O and Seckin S: Association of polymorphisms in MCP-1, CCR2, and CCR5 genes with the risk and clinicopathological characteristics of prostate cancer. DNA Cell Biol. 31:1418–1424. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Mandal RK, Agrawal T and Mittal RD: Genetic variants of chemokine CCL2 and chemokine receptor CCR2 genes and risk of prostate cancer. Tumour Biol. 36:375–381. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Kaplan SA, Olsson CA and Te AE: The American Urological Association symptom score in the evaluation of men with lower urinary tract symptoms: At 2 years of followup, does it work? J Urol. 155:1971–1974. 1996. View Article : Google Scholar : PubMed/NCBI

16 

Homma Y, Yoshida M, Seki N, Yokoyama O, Kakizaki H, Gotoh M, Yamanishi T, Yamaguchi O, Takeda M and Nishizawa O: Symptom assessment tool for overactive bladder syndrome-overactive bladder symptom score. Urology. 68:318–323. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Kaplan SA, McConnell JD, Roehrborn CG, Meehan AG, Lee MW, Noble WR, Kusek JW and Nyberg LM Jr; Medical Therapy of Prostatic Symptoms (MTOPS) Research Group, : Combination therapy with doxazosin and finasteride for benign prostatic hyperplasia in patients with lower urinary tract symptoms and a baseline total prostate volume of 25 ml or greater. J Urol. 175:217–221. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Siami P, Roehrborn CG, Barkin J, Damiao R, Wyczolkowski M, Duggan A, Major-Walker K and Morrill BB; CombAT study group, : Combination therapy with dutasteride and tamsulosin in men with moderate-to-severe benign prostatic hyperplasia and prostate enlargement: The CombAT (Combination of Avodart and Tamsulosin) trial rationale and study design. Contemp Clin Trials. 28:770–779. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Boyle AP, Hong EL, Hariharan M, Cheng Y, Schaub MA, Kasowski M, Karczewski KJ, Park J, Hitz BC, Weng S, et al: Annotation of functional variation in personal genomes using RegulomeDB. Genome Res. 22:1790–1797. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Grzegorzewska AE, Pajzderski D, Sowinska A and Jagodzinski PP: Monocyte chemoattractant protein-1 gene (MCP-1-2518 A/G) polymorphism and serological markers of hepatitis B virus infection in hemodialysis patients. Med Sci Monit. 20:1101–1116. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Zhang J, Song Q, Zhu K, Lu J, Xiong X and Hao F: The association of genetic variants in chemokine genes with the risk of psoriasis vulgaris in Chinese population: A case-control study. Medicine. 96:e82832017. View Article : Google Scholar : PubMed/NCBI

22 

Nakayama EE, Tanaka Y, Nagai Y, Iwamoto A and Shioda T: A CCR2-V64I polymorphism affects stability of CCR2A isoform. AIDS. 18:729–738. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Zhao N, Liu X, Wang Y, Liu X, Li J, Yu L, Ma L, Wang S, Zhang H, Liu L, et al: Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population. J Neuroinflammation. 9:1622012. View Article : Google Scholar : PubMed/NCBI

24 

Nyquist PA, Winkler CA, McKenzie LM, Yanek LR, Becker LC and Becker DM: Single nucleotide polymorphisms in monocyte chemoattractant protein-1 and its receptor act synergistically to increase the risk of carotid atherosclerosis. Cerebrovasc Dis. 28:124–130. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Singh V, Srivastava P, Srivastava N, Kapoor R and Mittal RD: Association of inflammatory chemokine gene CCL2I/D with bladder cancer risk in North Indian population. Mol Biol Rep. 39:9827–9834. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Fujita K, Ewing CM, Getzenberg RH, Parsons JK, Isaacs WB and Pavlovich CP: Monocyte chemotactic protein-1 (MCP-1/CCL2) is associated with prostatic growth dysregulation and benign prostatic hyperplasia. Prostate. 70:473–481. 2010.PubMed/NCBI

27 

Santos EU, Lima GD, Oliveira Mde L, Heráclio Sde A, Silva HD, Crovella S, Maia Mde M and Souza PR: CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: A case-control study. Mem Inst Oswaldo Cruz. 111:174–180. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Nickel RG, Casolaro V, Wahn U, Beyer K, Barnes KC, Plunkett BS, Freidhoff LR, Sengler C, Plitt JR, Schleimer RP, et al: Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES. J Immunol. 164:1612–1616. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Areeshi MY, Mandal RK, Panda AK and Haque S: A meta-analysis of the association between the CC chemokine ligand 5 (CCL5)-403 G>A gene polymorphism and tuberculosis susceptibility. PLoS One. 8:e721392013. View Article : Google Scholar : PubMed/NCBI

30 

Kidd LR, Jones DZ, Rogers EN, Kidd NC, Beache S, Rudd JE, Ragin C, Jackson M, McFarlane-Anderson N, Tulloch-Reid M, et al: Chemokine Ligand 5 (CCL5), chemokine receptor (CCR5) genetic variants, prostate cancer risk among men of African Descent: A case-control study. Hered Cancer Clin Pract. 10:162012. View Article : Google Scholar : PubMed/NCBI

31 

Zhou Y, Lim KC, Onodera K, Takahashi S, Ohta J, Minegishi N, Tsai FY, Orkin SH, Yamamoto M and Engel JD: Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development. EMBO J. 17:6689–6700. 1998. View Article : Google Scholar : PubMed/NCBI

32 

Robinson JL, Tzou KS, Parker AS, Heckman MG, Wu KJ, Hilton TW, Pisansky TM, Schild SE, Peterson JL, Vallow LA, et al: GATA2 expression and biochemical recurrence following salvage radiation therapy for relapsing prostate cancer. Br J Radiol. 90:201701742017. View Article : Google Scholar : PubMed/NCBI

33 

Rodriguez-Bravo V, Carceles-Cordon M, Hoshida Y, Cordon-Cardo C, Galsky MD and Domingo-Domenech J: The role of GATA2 in lethal prostate cancer aggressiveness. Nat Rev Urol. 14:38–48. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Vidal SJ, Rodriguez-Bravo V, Quinn SA, Rodriguez-Barrueco R, Lujambio A, Williams E, Sun X, de la Iglesia-Vicente J, Lee A, Readhead B, et al: A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer. Cancer Cell. 27:223–239. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Zhernakova A, Alizadeh BZ, Eerligh P, Hanifi-Moghaddam P, Schloot NC, Diosdado B, Wijmenga C, Roep BO and Koeleman BP: Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes. Genes Immun. 7:544–549. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Bracci PM, Skibola CF, Conde L, Halperin E, Lightfoot T, Smith A, Paynter RA, Skibola DR, Agana L, Roman E, et al: Chemokine polymorphisms and lymphoma: A pooled analysis. Leuk Lymphoma. 51:497–506. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Pang Y, Li H, Gong Y, Jing S, Peng C, Liu W, Zhao Y, Wang H, Kaushik D, Rodriguez R, Rodriguez R, et al: Association of CCL2, CCR2 and CCL5 genetic polymorphisms with the development and progression of benign prostatic hyperplasia. Oncol Rep 41: 2491-2501, 2019.
APA
Pang, Y., Li, H., Gong, Y., Jing, S., Peng, C., Liu, W. ... Wang, Z. (2019). Association of CCL2, CCR2 and CCL5 genetic polymorphisms with the development and progression of benign prostatic hyperplasia. Oncology Reports, 41, 2491-2501. https://doi.org/10.3892/or.2019.7002
MLA
Pang, Y., Li, H., Gong, Y., Jing, S., Peng, C., Liu, W., Zhao, Y., Wang, H., Kaushik, D., Rodriguez, R., Wang, Z."Association of CCL2, CCR2 and CCL5 genetic polymorphisms with the development and progression of benign prostatic hyperplasia". Oncology Reports 41.4 (2019): 2491-2501.
Chicago
Pang, Y., Li, H., Gong, Y., Jing, S., Peng, C., Liu, W., Zhao, Y., Wang, H., Kaushik, D., Rodriguez, R., Wang, Z."Association of CCL2, CCR2 and CCL5 genetic polymorphisms with the development and progression of benign prostatic hyperplasia". Oncology Reports 41, no. 4 (2019): 2491-2501. https://doi.org/10.3892/or.2019.7002
Copy and paste a formatted citation
x
Spandidos Publications style
Pang Y, Li H, Gong Y, Jing S, Peng C, Liu W, Zhao Y, Wang H, Kaushik D, Rodriguez R, Rodriguez R, et al: Association of CCL2, CCR2 and CCL5 genetic polymorphisms with the development and progression of benign prostatic hyperplasia. Oncol Rep 41: 2491-2501, 2019.
APA
Pang, Y., Li, H., Gong, Y., Jing, S., Peng, C., Liu, W. ... Wang, Z. (2019). Association of CCL2, CCR2 and CCL5 genetic polymorphisms with the development and progression of benign prostatic hyperplasia. Oncology Reports, 41, 2491-2501. https://doi.org/10.3892/or.2019.7002
MLA
Pang, Y., Li, H., Gong, Y., Jing, S., Peng, C., Liu, W., Zhao, Y., Wang, H., Kaushik, D., Rodriguez, R., Wang, Z."Association of CCL2, CCR2 and CCL5 genetic polymorphisms with the development and progression of benign prostatic hyperplasia". Oncology Reports 41.4 (2019): 2491-2501.
Chicago
Pang, Y., Li, H., Gong, Y., Jing, S., Peng, C., Liu, W., Zhao, Y., Wang, H., Kaushik, D., Rodriguez, R., Wang, Z."Association of CCL2, CCR2 and CCL5 genetic polymorphisms with the development and progression of benign prostatic hyperplasia". Oncology Reports 41, no. 4 (2019): 2491-2501. https://doi.org/10.3892/or.2019.7002
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team