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Overexpression of Opa interacting protein 5 increases the progression of liver cancer via BMPR2/JUN/CHEK1/RAC1 dysregulation

  • Authors:
    • Yuwen Li
    • Fei Xiao
    • Wenting Li
    • Pingping Hu
    • Ruirui Xu
    • Jun Li
    • Guimei Li
    • Chuanlong Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Infectious Diseases, The Fifth Affiliated Hospital of Sun Yat‑sen University, Zhuhai, Guangdong 519000, P.R. China , Third Liver Unit, Department of Infectious Disease, The First Affiliated Hospital of Science and Technology of China, Hefei, Anhui 230001, P.R. China, Department of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Pages: 2075-2088
    |
    Published online on: February 11, 2019
       https://doi.org/10.3892/or.2019.7006
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Abstract

Opa interacting protein 5 (OIP5) overexpression is associated with human carcinoma. However, its biological function, underlying mechanism and clinical significance in liver cancer remain unknown. In the present study, the effects of OIP5 expression on liver cancer, and the mechanisms regulating these effects, were investigated. OIP5 expression was measured in human hepatocellular carcinoma (HCC) tissues and liver cancer cell lines. The effect of OIP5 knockdown on tumorigenesis was also detected in nude mice, and differentially‑expressed genes (DEGs) were identified and their biological functions were identified. The results indicated that OIP5 expression was significantly upregulated in HCC tissues and four liver cancer cell lines (P<0.01). Increased OIP5 protein expression significantly predicted reduced survival rate of patients with HCC (P<0.01). OIP5 knockdown resulted in the suppression of proliferation and colony forming abilities, cell cycle arrest at the G0/G1 or G2/M phases, and promotion of cell apoptosis. A total of 628 DEGs, including 87 upregulated and 541 downregulated genes, were identified following OIP5 knockdown. Functional enrichment analysis indicated that DEGs were involved in ‘RNA Post‑Transcriptional Modification, Cancer and Organismal Injury and Abnormalities’. Finally, OIP5 knockdown in Huh7 cells dysregulated bone morphogenetic protein receptor type 2/JUN/checkpoint kinase 1/Rac family small GTPase 1 expression. In conclusion, the overall results demonstrated the involvement of OIP5 in the progression of liver cancer and its mechanism of action.
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View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Heimbach JK, Kulik LM, Finn RS, Sirlin CB, Abecassis MM, Roberts LR, Zhu AX, Murad MH and Marrero JA: AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology. 67:358–380. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Roayaie S, Obeidat K, Sposito C, Mariani L, Bhoori S, Pellegrinelli A, Labow D, LIovet JM, Schwartz M and Mazzaferro V: Resection of hepatocellular cancer ≤2 cm: Results from two Western centers. Hepatology. 57:1426–1435. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Chun JM, Kwon HJ, Sohn J, Kim SG, Park JY, Bae HI, Yun YK and Hwang YJ: Prognostic factors after early recurrence in patients who underwent curative resection for hepatocellular carcinoma. J Surg Oncol. 103:148–151. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Zhang Y, Li K, Ying Y, Chen B, Hao K, Chen B, Zheng Y, Lyu J, Tong X, Chen X, et al: C21 steroid-enriched fraction refined from Marsdenia tenacissima inhibits hepatocellular carcinoma through the coordination of Hippo-Yap and PTEN-PI3K/AKT signaling pathways. Oncotarget. 8:110576–110591. 2017.PubMed/NCBI

7 

Wang Y, Attar BM, Fuentes HE, Jaiswal P and Tafur AJ: Evaluation of the prognostic value of platelet to lymphocyte ratio in patients with hepatocellular carcinoma. J Gastrointest Oncol. 8:1065–1071. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Afsharpad M, Nowroozi MR, Mobasheri MB, Ayati M, Nekoohesh L, Saffari M, Zendehdel K and Modarressi MH: Cancer-testis antigens as new candidate diagnostic biomarkers for transitional cell carcinoma of bladder. Pathol Oncol Res. 25:191–199. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C and Yanagida M: Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. Dev Cell. 12:17–30. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Naetar N, Hutter S, Dorner D, Dechat T, Korbei B, Gotzmann J, Beug H and Foisner R: LAP2alpha-binding protein LINT-25 is a novel chromatin-associated protein involved in cell cycle exit. J Cell Sci. 120:737–747. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Gong M, Xu Y, Dong W, Guo G, Ni W, Wang Y, Wang Y and An R: Expression of Opa interacting protein 5 (OIP5) is associated with tumor stage and prognosis of clear cell renal cell carcinoma. Acta Histochem. 115:810–815. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Chun HK, Chung KS, Kim HC, Kang JE, Kang MA, Kim JT, Choi EH, Jung KE, Kim MH, Song EY, et al: OIP5 is a highly expressed potential therapeutic target for colorectal and gastric cancers. BMB Rep. 43:349–354. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Nakamura Y, Tanaka F, Nagahara H, Ieta K, Haraguchi N, Mimori K, Sasaki A, Inoue H, Yanaga K and Mori M: Opa interacting protein 5 (OIP5) is a novel cancer-testis specific gene in gastric cancer. Ann Surg Oncol. 14:885–892. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Yazarloo F, Shirkoohi R, Mobasheri M, Emami A and Modarressi M: Expression analysis of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L in acute myeloid leukemia: A gender-dependent expression pattern. Med Oncol. 30:3682013. View Article : Google Scholar : PubMed/NCBI

15 

Koinuma J, Akiyama H, Fujita M, Hosokawa M, Tsuchiya E, Kondo S, Nakamura Y and Daigo Y: Characterization of an Opa interacting protein 5 involved in lung and esophageal carcinogenesis. Cancer Sci. 103:577–586. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Li H, Zhang J, Lee MJ, Yu GR, Han X and Kim DG: OIP5, a target of miR-15b-5p, regulates hepatocellular carcinoma growth and metastasis through the AKT/mTORC1 and β-catenin signaling pathways. Oncotarget. 8:18129–18144. 2017.PubMed/NCBI

17 

Deng L, Tang J, Yang H, Cheng C, Lu S, Jiang R and Sun B: MTA1 modulated by miR-30e contributes to epithelial-to-mesenchymal transition in hepatocellular carcinoma through an ErbB2-dependent pathway. Oncogene. 36:3976–3985. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Edmondson HA and Steiner PE: Primary carcinoma of the liver: A study of 100 cases among 48,900 necropsies. Cancer. 7:462–503. 1954. View Article : Google Scholar : PubMed/NCBI

19 

Edge SB and Compton CC: The American Joint Committee on cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Szász AM, Lánczky A, Nagy A, Förster S, Hark K, Green JE, Boussioutas A, Busuttil R, Szabó A and Gyorffy B: Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients. Oncotarget. 7:49322–49333. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Lois C, Hong EJ, Pease S, Brown EJ and Baltimore D: Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science. 295:868–872. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e452001. View Article : Google Scholar : PubMed/NCBI

23 

Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:680–685. 1970. View Article : Google Scholar : PubMed/NCBI

24 

Liu N, Bi F, Pan Y, Sun L, Xue Y, Shi Y, Yao X, Zheng Y and Fan D: Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity. Clin Cancer Res. 10:6239–6247. 2004. View Article : Google Scholar : PubMed/NCBI

25 

National research council (US) Committee for the update of the guide for the care, use of laboratory animals, . Guide for the care and use of laboratory animals. 8th edition. National Academies Press. (Washington, DC). 2011.

26 

Kim IS, Lee M, Park JH, Jeon R, Baek SH and Kim KI: βTrCP-mediated ubiquitylation regulates protein stability of Mis18β in a cell cycle-dependent manner. Biochem Biophys Res Commun. 443:62–67. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Williams JM, Chen GC, Zhu L and Rest RF: Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: Intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. Mol Microbiol. 27:171–186. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Gjerstorff MF, Andersen MH and Ditzel HJ: Oncogenic cancer/testis antigens: Prime candidates for immunotherapy. Oncotarget. 6:15772–15787. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Fu J, Luo B, Guo WW, Zhang QM, Shi L, Hu QP, Chen F, Xiao SW and Xie XX: Down-regulation of cancer/testis antigen OY-TES-1 attenuates malignant behaviors of hepatocellular carcinoma cells in vitro. Int J Clin Exp Pathol. 8:7786–7797. 2015.PubMed/NCBI

30 

Fratta E, Coral S, Covre A, Parisi G, Colizzi F, Danielli R, Nicolay HJ, Sigalotti L and Maio M: The biology of cancer testis antigens: Putative function, regulation and therapeutic potential. Mol Oncol. 5:164–182. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Hu GW, Wu L, Kuang W, Chen Y, Zhu XG, Guo H and Lang HL: Knockdown of linc-OIP5 inhibits proliferation and migration of glioma cells through down-regulation of YAP-NOTCH signaling pathway. Gene. 610:24–31. 2017. View Article : Google Scholar : PubMed/NCBI

32 

He X, Hou J, Ping J, Wen D and He J: Opa interacting protein 5 acts as an oncogene in bladder cancer. J Cancer Res Clin Oncol. 143:2221–2233. 2017. View Article : Google Scholar : PubMed/NCBI

33 

He X, Ding X, Wen D, Hou J, Ping J and He J: Exploration of the pathways and interaction network involved in bladder cancer cell line with knockdown of Opa interacting protein 5. Pathol Res Pract. 213:1059–1066. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Li HC, Chen YF, Feng W, Cai H, Mei Y, Jiang YM, Chen T, Xu K and Feng DX: Loss of the Opa interacting protein 5 inhibits breast cancer proliferation through miR-139-5p/NOTCH1 pathway. Gene. 603:1–8. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Mobasheri MB, Shirkoohi R and Modarressi MH: Cancer/Testis OIP5 and TAF7L genes are up-regulated in breast cancer. Asian Pac J Cancer Prev. 16:4623–4628. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Inoue K, Maeda N, Mori T, Sekimoto R, Tsushima Y, Matsuda K, Yamaoka M, Suganami T, Nishizawa H, Ogawa Y, et al: Possible involvement of Opa-interacting protein 5 in adipose proliferation and obesity. PLoS One. 9:e876612014. View Article : Google Scholar : PubMed/NCBI

37 

Kim TW, Lee SJ, Park YJ, Park SY, Oh BM, Park YS, Kim BY, Lee YH, Cho HJ, Yoon SR, et al: Opa-interacting protein 5 modulates docetaxel-induced cell death via regulation of mitophagy in gastric cancer. Tumour Biol. 39:10104283177339852017. View Article : Google Scholar : PubMed/NCBI

38 

Schnelzer A, Prechtel D, Knaus U, Dehne K, Gerhard M, Graeff H, Harbeck N, Schmitt M and Lengyel E: Rac1 in human breast cancer: Overexpression, mutation analysis, and characterization of a new isoform, Rac1b. Oncogene. 19:3013–3020. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Hordijk PL: Regulation of NADPH oxidases: The role of Rac proteins. Circ Res. 98:453–462. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Melzer C, von der Ohe J, Hass R and Ungefroren H: TGF-β-dependent growth arrest and cell migration in benign and malignant breast epithelial cells are antagonistically controlled by Rac1 and Rac1b. Int J Mol Sci. 18(pii): E15742017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Xiao F, Li W, Hu P, Xu R, Li J, Li G and Zhu C: Overexpression of Opa interacting protein 5 increases the progression of liver cancer via BMPR2/JUN/CHEK1/RAC1 dysregulation. Oncol Rep 41: 2075-2088, 2019.
APA
Li, Y., Xiao, F., Li, W., Hu, P., Xu, R., Li, J. ... Zhu, C. (2019). Overexpression of Opa interacting protein 5 increases the progression of liver cancer via BMPR2/JUN/CHEK1/RAC1 dysregulation. Oncology Reports, 41, 2075-2088. https://doi.org/10.3892/or.2019.7006
MLA
Li, Y., Xiao, F., Li, W., Hu, P., Xu, R., Li, J., Li, G., Zhu, C."Overexpression of Opa interacting protein 5 increases the progression of liver cancer via BMPR2/JUN/CHEK1/RAC1 dysregulation". Oncology Reports 41.4 (2019): 2075-2088.
Chicago
Li, Y., Xiao, F., Li, W., Hu, P., Xu, R., Li, J., Li, G., Zhu, C."Overexpression of Opa interacting protein 5 increases the progression of liver cancer via BMPR2/JUN/CHEK1/RAC1 dysregulation". Oncology Reports 41, no. 4 (2019): 2075-2088. https://doi.org/10.3892/or.2019.7006
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Xiao F, Li W, Hu P, Xu R, Li J, Li G and Zhu C: Overexpression of Opa interacting protein 5 increases the progression of liver cancer via BMPR2/JUN/CHEK1/RAC1 dysregulation. Oncol Rep 41: 2075-2088, 2019.
APA
Li, Y., Xiao, F., Li, W., Hu, P., Xu, R., Li, J. ... Zhu, C. (2019). Overexpression of Opa interacting protein 5 increases the progression of liver cancer via BMPR2/JUN/CHEK1/RAC1 dysregulation. Oncology Reports, 41, 2075-2088. https://doi.org/10.3892/or.2019.7006
MLA
Li, Y., Xiao, F., Li, W., Hu, P., Xu, R., Li, J., Li, G., Zhu, C."Overexpression of Opa interacting protein 5 increases the progression of liver cancer via BMPR2/JUN/CHEK1/RAC1 dysregulation". Oncology Reports 41.4 (2019): 2075-2088.
Chicago
Li, Y., Xiao, F., Li, W., Hu, P., Xu, R., Li, J., Li, G., Zhu, C."Overexpression of Opa interacting protein 5 increases the progression of liver cancer via BMPR2/JUN/CHEK1/RAC1 dysregulation". Oncology Reports 41, no. 4 (2019): 2075-2088. https://doi.org/10.3892/or.2019.7006
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