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Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer

  • Authors:
    • Yuexiong Yi
    • Yanyan Liu
    • Wanrong Wu
    • Kejia Wu
    • Wei Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China
    Copyright: © Yi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2209-2225
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    Published online on: February 21, 2019
       https://doi.org/10.3892/or.2019.7028
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Abstract

The present study was performed with the aim of understanding the mechanisms of pathogenesis and providing novel biomarkers for cervical cancer by constructing a regulatory circular (circ)RNA‑micro (mi)RNA‑mRNA network. Using an adjusted P-value of <0.05 and an absolute log value of fold-change >1, 16 and 156 miRNAs from GSE30656 and The Cancer Genome Atlas (TCGA), 5,321 mRNAs from GSE63514, 4,076 mRNAs from cervical squamous cell carcinoma and endocervical adenocarcinoma (from TCGA) and 75 circRNAs from GSE102686 were obtained. Using RNAhybrid, Venn and UpSetR plot, 12 circRNA‑miRNA pairs and 266 miRNA‑mRNA pairs were obtained. Once these pairs were combined, a circRNA‑miRNA‑mRNA network with 11 circRNA nodes, 4 miRNA nodes, 153 mRNA nodes and 203 edges was constructed. By constructing the protein‑protein interaction network using Molecular Complex Detection scores >5 and >5 nodes, 7 hubgenes (RRM2, CEP55, CHEK1, KIF23, RACGAP1, ATAD2 and KIF11) were identified. By mapping the 7 hubgenes into the preliminary circRNA‑miRNA‑mRNA network, a circRNA‑miRNA‑hubgenes network consisting of 5 circRNAs (hsa_circRNA_000596, hsa_circRNA_104315, hsa_circRNA_400068, hsa_circRNA_101958 and hsa_circRNA_103519), 2 mRNAs (hsa‑miR‑15b and hsa‑miR‑106b) and 7 mRNAs (RRM2, CEP55, CHEK1, KIF23, RACGAP1, ATAD2 and KIF11) was constructed. There were 22 circRNA‑miRNA‑mRNA regulatory axes identified in the subnetwork. By analyzing the overall survival for the 7 hubgenes using the Gene Expression Profiling Interactive Analysis tool, higher expression of RRM2 was demonstrated to be associated with a significantly poorer overall survival. PharmGkb analysis identified single nucleotide polymorphisms (SNPs) of rs5030743 and rs1130609 of RRM2, which can be treated with cladribine and cytarabine. RRM2 was also indicated to be involved in the gemcitabine pathway. The 5 circRNAs (hsa_circRNA_000596, hsa_circRNA_104315, hsa_circRNA_400068, hsa_circRNA_101958 and hsa_circRNA_103519) may function as competing endogenous RNAs and serve critical roles in cervical cancer. In addition, cytarabine may produce similar effects to gemcitabine and may be an optional chemotherapeutic drug for treating cervical cancer by targeting rs5030743 and rs1130609 or other similar SNPs. However, the specific mechanism of action should be confirmed by further study.
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View References

1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Marth C, Landoni F, Mahner S, McCormack M, Gonzalez-Martin A and Colombo N; ESMO Guidelines Committee, : Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 28 (Suppl 4):iv72–iv83. 2017. View Article : Google Scholar : PubMed/NCBI

3 

GuYu Z, YiMin Z, ChongDong L, GuangMing C, Ran C and ZhenYu Z: Current status and future of targeted therapy for patients with local advanced cervical cancer. Chinese J Pract Gynecol Obstet. 34:1216–1220. 2018.

4 

Fleming ND, Frumovitz M, Schmeler KM, dos Reis R, Munsell MF, Eifel PJ, Soliman PT, Nick AM, Westin SN and Ramirez PT: Significance of lymph node ratio in defining risk category in node-positive early stage cervical cancer. Gynecol Oncol. 136:48–53. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Kapranov P, Cawley SE, Drenkow J, Bekiranov S, Strausberg RL, Fodor SP and Gingeras TR: Large-scale transcriptional activity in chromosomes 21 and 22. Science. 296:916–919. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Esteller M: Non-coding RNAs in human disease. Nat Rev Genet. 12:861–874. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Kogo R, How C, Chaudary N, Bruce J, Shi W, Hill RP, Zahedi P, Yip KW and Liu FF: The microRNA-218~Survivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer. Oncotarget. 6:1090–1100. 2014.

8 

Hou T, Ou J, Zhao X, Huang X, Huang Y and Zhang Y: MicroRNA-196a promotes cervical cancer proliferation through the regulation of FOXO1 and p27Kip1. Br J Cancer. 110:1260–1268. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Wang Q, Qin J, Chen A, Zhou J, Liu J, Cheng J, Qiu J and Zhang J: Downregulation of microRNA-145 is associated with aggressive progression and poor prognosis in human cervical cancer. Tumor Biol. 36:3703–3708. 2015. View Article : Google Scholar

10 

Fang H, Shuang D, Yi Z, Sheng H and Liu Y: Up-regulated microRNA-155 expression is associated with poor prognosis in cervical cancer patients. Biomed Pharmacother. 83:64–69. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Bumrungthai S, Ekalaksananan T, Evans MF, Chopjitt P, Tangsiriwatthana T, Patarapadungkit N, Kleebkaow P, Luanratanakorn S, Kongyingyoes B, Worawichawong S, et al: Up-regulation of miR-21 is associated with cervicitis and human papillomavirus infection in cervical tissues. PLoS One. 10:e01271092015. View Article : Google Scholar : PubMed/NCBI

12 

Salmena L, Poliseno L, Tay Y, Kats L and Pandolfi PP: A ceRNA hypothesis: The Rosetta Stone of a hidden RNA language? Cell. 146:353–8. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Sanger HL, Klotz G, Riesner D, Gross HJ and Kleinschmidt AK: Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci USA. 73:3852–3856. 1976. View Article : Google Scholar : PubMed/NCBI

14 

Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, et al: Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 495:333–338. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function as efficient microRNA sponges. Nature. 495:384–388. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Tian M, Chen R, Li T and Xiao B: Reduced expression of circRNA hsa_circ_0003159 in gastric cancer and its clinical significance. J Clin Lab Anal. 32:2018. View Article : Google Scholar

17 

Liu Q, Zhang X, Hu X, Yuan L, Cheng J, Jiang Y and Ao Y: Emerging roles of circRNA related to the mechanical stress in human cartilage degradation of osteoarthritis. Mol Ther Nucleic Acids. 7:223–230. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Huang XY, Huang ZL, Xu YH, Zheng Q, Chen Z, Song W, Zhou J, Tang ZY and Huang XY: Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/MIR-141-3p pathway in hepatitis B-related hepatocellular carcinoma. Sci Rep. 7:54282017. View Article : Google Scholar : PubMed/NCBI

19 

Hsiao KY, Lin YC, Gupta SK, Chang N, Yen L, Sun HS and Tsai SJ: Noncoding effects of circular RNA CCDC66 promote colon cancer growth and metastasis. Cancer Res. 77:2339–2350. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Wang Y, Huang L, Li D, Shao J, Xiong S, Wang C and Lu S: Hsa_circ_0101996 combined with hsa_circ_0101119 in peripheral whole blood can serve as the potential biomarkers for human cervical squamous cell carcinoma. Int J Clin Exp Pathol. 10:11924–11931. 2017.

21 

Gao YL, Zhang MY, Xu B, Han LJ, Lan SF, Chen J, Dong YJ and Cao LL: Circular RNA expression profiles reveal that hsa_circ_0018289 is up-regulated in cervical cancer and promotes the tumorigenesis. Oncotarget. 8:86625–86633. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Ma HB, Yao YN, Yu JJ, Chen XX and Li HF: Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506. Am J Transl Res. 10:592–604. 2018.PubMed/NCBI

23 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al: NCBI GEO: Archive for functional genomics data sets-update. Nucleic Acids Res. 41:D991–D995. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

25 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

26 

Dweep H and Gretz N: MiRWalk2.0: A comprehensive atlas of microRNA-target interactions. Nat Methods. 12:6972015. View Article : Google Scholar : PubMed/NCBI

27 

Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. Elife. 4:2015. View Article : Google Scholar

28 

Pasquinelli AE: MicroRNAs and their targets: Recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet. 13:271–282. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Conway JR, Lex A and Gehlenborg N: UpSetR: An R package for the visualization of intersecting sets and their properties. Bioinformatics. 33:2938–2940. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Kozomara A and Griffiths-Jones S: MiRBase: Annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res 42 (Database Issue). D68–D73. 2014. View Article : Google Scholar

31 

Krüger J and Rehmsmeier M: RNAhybrid: MicroRNA target prediction easy, fast and flexible. Nucleic Acids Res. 34:W451–W454. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Jiang H, Ma R, Zou S, Wang Y, Li Z and Li W: Reconstruction and analysis of the lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in rheumatoid arthritis. Mol Biosyst. 13:1182–1192. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Jiao X, Sherman BT, Huang da W, Stephens R, Baseler MW, Lane HC and Lempicki RA: DAVID-WS: A stateful web service to facilitate gene/protein list analysis. Bioinformatics. 28:1805–1806. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Walter W, Sánchez-Cabo F and Ricote M: GOplot: An R package for visually combining expression data with functional analysis. Bioinformatics. 31:2912–2914. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43:D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI

38 

Xia S, Feng J, Chen K, Ma Y, Gong J, Cai F, Jin Y, Gao Y, Xia L, Chang H, et al: CSCD: A database for cancer-specific circular RNAs. Nucleic Acids Res. 46:D925–D929. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Kerpedjiev P, Hammer S and Hofacker IL: Forna (force-directed RNA): Simple and effective online RNA secondary structure diagrams. Bioinformatics. 31:3377–3379. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45:W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Schoen MW, Woelich SK, Braun JT, Reddy DV, Fesler MJ, Petruska PJ, Freter CE and Lionberger JM: Acute myeloid leukemia induction with cladribine: Outcomes by age and leukemia risk. Leuk Res. 68:72–78. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Johnston JB: Mechanism of action of pentostatin and cladribine in hairy cell leukemia. Leuk Lymphoma. 52 (Suppl 2):S43–S45. 2011. View Article : Google Scholar

43 

Mulligan SP, Karlsson K, Strömberg M, Jønsson V, Gill D, Hammerström J, Hertzberg M, McLennan R, Uggla B, Norman J, et al: Cladribine prolongs progression-free survival and time to second treatment compared to fludarabine and high-dose chlorambucil in chronic lymphocytic leukemia. Leuk Lymphoma. 55:2769–2777. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Mego M, Sycova-Mila Z, Obertova J, Rajec J, Liskova S, Palacka P, Porsok S and Mardiak J: Intrathecal administration of trastuzumab with cytarabine and methotrexate in breast cancer patients with leptomeningeal carcinomatosis. Breast. 20:478–480. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Rusch VW, Figlin R, Godwin D and Piantadosi S: Intrapleural cisplatin and cytarabine in the management of malignant pleural effusions: A Lung Cancer Study Group trial. J Clin Oncol. 9:313–319. 1991. View Article : Google Scholar : PubMed/NCBI

46 

Baker JAR, Wickremsinhe ER, Li CH, Oluyedun OA, Dantzig AH, Hall SD, Qian YW, Ring BJ, Wrighton SA and Guo Y: Pharmacogenomics of gemcitabine metabolism: Functional analysis of genetic variants in cytidine deaminase and deoxycytidine kinase. Drug Metab Dispos. 41:541–545. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Lamba JK: Genetic factors influencing cytarabine therapy. Pharmacogenomics. 10:1657–1674. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, Snijders PJ, Peto J, Meijer CJ and Muñoz N: Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 189:12–19. 1999. View Article : Google Scholar : PubMed/NCBI

49 

Rong D, Sun H, Li Z, Liu S, Dong C, Fu K, Tang W and Cao H: An emerging function of circRNA-miRNAs-mRNA axis in human diseases. Oncotarget. 8:73271–73281. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Du WW, Zhang C, Yang W, Yong T, Awan FM and Yang BB: Identifying and characterizing circRNA-protein interaction. Theranostics. 7:4183–4191. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Ebbesen KK, Hansen TB and Kjems J: Insights into circular RNA biology. RNA Biol. 14:1035–1045. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Pamudurti NR, Bartok O, Jens M, Ashwal-Fluss R, Stottmeister C, Ruhe L, Hanan M, Wyler E, Perez-Hernandez D, Ramberger E, et al: Translation of CircRNAs. Mol Cell. 66:9–21.e7. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Holdt LM, Kohlmaier A and Teupser D: Molecular roles and function of circular RNAs in eukaryotic cells. Cell Mol Life Sci. 75:1071–1098. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF and Sharpless NE: Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 19:141–57. 2013. View Article : Google Scholar : PubMed/NCBI

55 

Xie B, Zhao Z, Liu Q, Wang X, Ma Z and Li H: CircRNA has_circ_0078710 acts as the sponge of microRNA-31 involved in hepatocellular carcinoma progression. Gene. 683:253–261. 2019. View Article : Google Scholar : PubMed/NCBI

56 

Xiong D, Dang Y, Lin P, Wen DY, He RQ, Luo DZ, Feng ZB and Chen G: A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma. J Transl Med. 16:2202018. View Article : Google Scholar : PubMed/NCBI

57 

Salzman J, Chen RE, Olsen MN, Wang PL and Brown PO: Cell-type specific features of circular RNA expression. PLoS Genet. 9:e10037772013. View Article : Google Scholar : PubMed/NCBI

58 

Zhang Y, Zhang XO, Chen T, Xiang JF, Yin QF, Xing YH, Zhu S, Yang L and Chen LL: Circular intronic long noncoding RNAs. Mol Cell. 51:792–806. 2013. View Article : Google Scholar : PubMed/NCBI

59 

Li Z, Huang C, Bao C, Chen L, Lin M, Wang X, Zhong G, Yu B, Hu W, Dai L, et al: Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 22:256–264. 2015. View Article : Google Scholar : PubMed/NCBI

60 

You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, et al: Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. Nat Neurosci. 18:603–610. 2015. View Article : Google Scholar : PubMed/NCBI

61 

Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, et al: Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis. Mol Cell. 66:22–37.e9. 2017. View Article : Google Scholar : PubMed/NCBI

62 

Yang Y, Fan X, Mao M, Song X, Wu P, Zhang Y, Jin Y, Yang Y, Chen LL, Wang Y, et al: Extensive translation of circular RNAs driven by N6-methyladenosine. Cell Res. 27:626–641. 2017. View Article : Google Scholar : PubMed/NCBI

63 

Li F, Zhang L, Li W, Deng J, Zheng J, An M, Lu J and Zhou Y: Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway. Oncotarget. 6:6001–6013. 2015.PubMed/NCBI

64 

Xie H, Ren X, Xin S, Lan X, Lu G, Lin Y, Yang S, Zeng Z, Liao W, Ding YQ and Liang L: Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer. Oncotarget. 7:26680–26691. 2016.PubMed/NCBI

65 

Li P, Chen S, Chen H, Mo X, Li T, Shao Y, Xiao B and Guo J: Using circular RNA as a novel type of biomarker in the screening of gastric cancer. Clin Chim Acta. 444:132–136. 2015. View Article : Google Scholar : PubMed/NCBI

66 

Mitra A, Pfeifer K and Park KS: Circular RNAs and competing endogenous RNA (ceRNA) networks. Transl Cancer Res. 7 (Suppl 5):S624–S628. 2018. View Article : Google Scholar : PubMed/NCBI

67 

Holdt LM, Kohlmaier A and Teupser D: Molecular functions and specific roles of circRNAs in the cardiovascular system. Non-coding RNA Res. 3:75–98. 2018. View Article : Google Scholar

68 

Liu Q, Zhang X, Hu X, Dai L, Fu X, Zhang J and Ao Y: Circular RNA related to the chondrocyte ECM regulates MMP13 expression by functioning as a miR-136 ‘Sponge’ in human cartilage degradation. Sci Rep. 6:225722016. View Article : Google Scholar : PubMed/NCBI

69 

Wang X, Tang S, Le SY, Lu R, Rader JS, Meyers C and Zheng ZM: Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS One. 3:e25572008. View Article : Google Scholar : PubMed/NCBI

70 

Li Y, Wang F, Xu J, Ye F, Shen Y, Zhou J, Lu W, Wan X, Ma D and Xie X: Progressive miRNA expression profiles in cervical carcinogenesis and identification of HPV-related target genes for miR-29. J Pathol. 224:484–495. 2011. View Article : Google Scholar : PubMed/NCBI

71 

Yi Y, Liu Y, Wu W, Wu K and Zhang W: The role of miR-106p-5p in cervical cancer: From expression to molecular mechanism. Cell death Discov. 4:362018.PubMed/NCBI

72 

Park S, Eom K, Kim J, Bang H, Wang HY, Ahn S, Kim G, Jang H, Kim S, Lee D, et al: MiR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer. BMC Cancer. 17:6582017. View Article : Google Scholar : PubMed/NCBI

73 

Xu L, Xu Q, Li X and Zhang X: MicroRNA-21 regulates the proliferation and apoptosis of cervical cancer cells via tumor necrosis factor-α. Mol Med Rep. 16:4659–4663. 2017. View Article : Google Scholar : PubMed/NCBI

74 

Zhu X, Er K, Mao C, Yan Q, Xu H, Zhang Y, Zhu J, Cui F, Zhao W and Shi H: miR-203 suppresses tumor growth and angiogenesis by targeting VEGFA in cervical cancer. Cell Physiol Biochem. 32:64–73. 2013. View Article : Google Scholar : PubMed/NCBI

75 

Melar-New M and Laimins LA: Human papillomaviruses modulate expression of MicroRNA 203 upon epithelial differentiation to control levels of p63 proteins. J Virol. 84:5212–5221. 2010. View Article : Google Scholar : PubMed/NCBI

76 

Mao L, Zhang Y, Mo W, Yu Y and Lu H: BANF1 is downregulated by IRF1-regulated microRNA-203 in cervical cancer. PLoS One. 10:e01170352015. View Article : Google Scholar : PubMed/NCBI

77 

Reshmi G and Pillai MR: Beyond HPV: Oncomirs as new players in cervical cancer. FEBS Lett. 582:4113–4116. 2008. View Article : Google Scholar : PubMed/NCBI

78 

Zhao S, Yao D, Chen J and Ding N: Circulating miRNA-20a and miRNA-203 for screening lymph node metastasis in early stage cervical cancer. Genet Test Mol Biomarkers. 17:631–636. 2013. View Article : Google Scholar : PubMed/NCBI

79 

Wang N, Li Y and Zhou J: Downregulation of ribonucleotide reductase subunits M2 induces apoptosis and G1 arrest of cervical cancer cells. Oncol Lett. 15:3719–3725. 2018.PubMed/NCBI

80 

Mazumder Indra D, Mitra S, Singh RK, Dutta S, Roy A, Mondal RK, Basu PS, Roychoudhury S and Panda CK: Inactivation of CHEK1 and EI24 is associated with the development of invasive cervical carcinoma: Clinical and prognostic implications. Int J cancer. 129:1859–1871. 2011. View Article : Google Scholar : PubMed/NCBI

81 

Zheng L, Li T, Zhang Y, Guo Y, Yao J, Dou L and Guo K: Oncogene ATAD2 promotes cell proliferation, invasion and migration in cervical cancer. Oncol Rep. 33:2337–2344. 2015. View Article : Google Scholar : PubMed/NCBI

82 

Cheng J, Lu X, Wang J, Zhang H, Duan P and Li C: Interactome analysis of gene expression profiles of cervical cancer reveals dysregulated mitotic gene clusters. Am J Transl Res. 9:3048–3059. 2017.PubMed/NCBI

83 

Mutch DG and Bloss JD: Gemcitabine in cervical cancer. Gynecol Oncol. 90:S8–S15. 2003. View Article : Google Scholar : PubMed/NCBI

84 

Roy S, Devleena, Maji T, Chaudhuri P, Lahiri D and Biswas J: Addition of gemcitabine to standard therapy in locally advanced cervical cancer: A randomized comparative study. Indian J Med Paediatr Oncol. 32:133–138. 2011. View Article : Google Scholar : PubMed/NCBI

85 

Kalaghchi B, Abdi R, Amouzegar-Hashemi F, Esmati E and Alikhasi A: Concurrent chemoradiation with weekly paclitaxel and cisplatin for locally advanced cervical cancer. Asian Pac J Cancer Prev. 17:287–291. 2016. View Article : Google Scholar : PubMed/NCBI

86 

Seidman AD: Gemcitabine as single-agent therapy in the management of advanced breast cancer. Oncology 15 (2 Suppl 3). S11–S14. 2001.

87 

Wang E, Gulbis A, Hart JW and Nieto Y: The emerging role of gemcitabine in conditioning regimens for hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 20:1382–1389. 2014. View Article : Google Scholar : PubMed/NCBI

88 

Hu XC, Zhang J, Xu BH, Cai L, Ragaz J, Wang ZH, Wang BY, Teng YE, Tong ZS, Pan YY, et al: Cisplatin plus gemcitabine versus paclitaxel plus gemcitabine as first-line therapy for metastatic triple-negative breast cancer (CBCSG006): A randomised, open-label, multicentre, phase 3 trial. Lancet Oncol. 16:436–446. 2015. View Article : Google Scholar : PubMed/NCBI

89 

Telli ML, Jensen KC, Vinayak S, Kurian AW, Lipson JA, Flaherty PJ, Timms K, Abkevich V, Schackmann EA, Wapnir IL, et al: Phase II study of gemcitabine, carboplatin, and iniparib as neoadjuvant therapy for triple-negative and BRCA1/2 mutation-associated breast cancer with assessment of a tumor-based measure of genomic instability: PrECOG 0105. J Clin Oncol. 33:1895–1901. 2015. View Article : Google Scholar : PubMed/NCBI

90 

Park YH, Im SA, Kim SB, Sohn JH, Lee KS, Chae YS, Lee KH, Kim JH, Im YH, Kim JY, et al: Phase II, multicentre, randomised trial of eribulin plus gemcitabine versus paclitaxel plus gemcitabine as first-line chemotherapy in patients with HER2-negative metastatic breast cancer. Eur J Cancer. 86:385–393. 2017. View Article : Google Scholar : PubMed/NCBI

91 

Niwińska A, Rudnicka H and Murawska M: Breast cancer leptomeningeal metastasis: The results of combined treatment and the comparison of methotrexate and liposomal cytarabine as intra-cerebrospinal fluid chemotherapy. Clin Breast Cancer. 15:66–72. 2015. View Article : Google Scholar : PubMed/NCBI

92 

Laakmann E, Witzel I and Müller V: Efficacy of Liposomal Cytarabine in the treatment of leptomeningeal metastasis of breast cancer. Breast Care. 12:165–167. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yi Y, Liu Y, Wu W, Wu K and Zhang W: Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer. Oncol Rep 41: 2209-2225, 2019.
APA
Yi, Y., Liu, Y., Wu, W., Wu, K., & Zhang, W. (2019). Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer. Oncology Reports, 41, 2209-2225. https://doi.org/10.3892/or.2019.7028
MLA
Yi, Y., Liu, Y., Wu, W., Wu, K., Zhang, W."Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer". Oncology Reports 41.4 (2019): 2209-2225.
Chicago
Yi, Y., Liu, Y., Wu, W., Wu, K., Zhang, W."Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer". Oncology Reports 41, no. 4 (2019): 2209-2225. https://doi.org/10.3892/or.2019.7028
Copy and paste a formatted citation
x
Spandidos Publications style
Yi Y, Liu Y, Wu W, Wu K and Zhang W: Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer. Oncol Rep 41: 2209-2225, 2019.
APA
Yi, Y., Liu, Y., Wu, W., Wu, K., & Zhang, W. (2019). Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer. Oncology Reports, 41, 2209-2225. https://doi.org/10.3892/or.2019.7028
MLA
Yi, Y., Liu, Y., Wu, W., Wu, K., Zhang, W."Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer". Oncology Reports 41.4 (2019): 2209-2225.
Chicago
Yi, Y., Liu, Y., Wu, W., Wu, K., Zhang, W."Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer". Oncology Reports 41, no. 4 (2019): 2209-2225. https://doi.org/10.3892/or.2019.7028
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