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Article

miR‑146a regulates the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis through NF‑κB signaling by targeting TRAF6

  • Authors:
    • Tian Li
    • Mengxiong Li
    • Chengfang Xu
    • Xiaoyu Xu
    • Jie Ding
    • Li Cheng
    • Rongying Ou
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The Seventh Affiliated Hospital of Sun Yat‑sen University, Shenzhen, Guangdong, P.R. China, Department of Obstetrics, The Third Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong, P.R. China, Department of Gynecology, The Third Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong, P.R. China, Department of Gynecology and Obstetrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China
  • Pages: 2897-2908
    |
    Published online on: March 7, 2019
       https://doi.org/10.3892/or.2019.7046
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Abstract

The aim of the present study was to investigate whether miRNA‑146a regulated the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis. miR‑146a expression was increased in human cervical cancer. Both overall survival (OS) and disease‑free survival (DFS) of low miR‑146a expression were higher than those of high miR‑146a expression. Additionally, IL‑17a expression was lower in patients with high miR‑146a expression compared to that of patients with lower miR‑146a expression. In a co‑culture of cervical cancer and CD4+ T cells, downregulation of miR‑146a inhibited cell growth and induced apoptosis of cervical cancer cells, while overexpression of miR‑146a promoted cell growth and reduced apoptosis of cervical cancer cells. Downregulation of miR‑146a induced TRAF6 and NF‑κB protein expression, increased IL‑6, IL‑17A and IL‑21 levels, and enhanced p‑STAT3 protein expression. The inhibition of TRAF6 attenuated the effects of anti‑miR‑146a on the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis. Collectively, miR‑146a regulated the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis through NF‑κB signaling by targeting TRAF6. miR‑146a may function as an oncogene in cervical cancer via Th17 cell differentiation by targeting TRAF6.
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Copy and paste a formatted citation
Spandidos Publications style
Li T, Li M, Xu C, Xu X, Ding J, Cheng L and Ou R: miR‑146a regulates the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis through NF‑κB signaling by targeting TRAF6. Oncol Rep 41: 2897-2908, 2019.
APA
Li, T., Li, M., Xu, C., Xu, X., Ding, J., Cheng, L., & Ou, R. (2019). miR‑146a regulates the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis through NF‑κB signaling by targeting TRAF6. Oncology Reports, 41, 2897-2908. https://doi.org/10.3892/or.2019.7046
MLA
Li, T., Li, M., Xu, C., Xu, X., Ding, J., Cheng, L., Ou, R."miR‑146a regulates the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis through NF‑κB signaling by targeting TRAF6". Oncology Reports 41.5 (2019): 2897-2908.
Chicago
Li, T., Li, M., Xu, C., Xu, X., Ding, J., Cheng, L., Ou, R."miR‑146a regulates the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis through NF‑κB signaling by targeting TRAF6". Oncology Reports 41, no. 5 (2019): 2897-2908. https://doi.org/10.3892/or.2019.7046
Copy and paste a formatted citation
x
Spandidos Publications style
Li T, Li M, Xu C, Xu X, Ding J, Cheng L and Ou R: miR‑146a regulates the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis through NF‑κB signaling by targeting TRAF6. Oncol Rep 41: 2897-2908, 2019.
APA
Li, T., Li, M., Xu, C., Xu, X., Ding, J., Cheng, L., & Ou, R. (2019). miR‑146a regulates the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis through NF‑κB signaling by targeting TRAF6. Oncology Reports, 41, 2897-2908. https://doi.org/10.3892/or.2019.7046
MLA
Li, T., Li, M., Xu, C., Xu, X., Ding, J., Cheng, L., Ou, R."miR‑146a regulates the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis through NF‑κB signaling by targeting TRAF6". Oncology Reports 41.5 (2019): 2897-2908.
Chicago
Li, T., Li, M., Xu, C., Xu, X., Ding, J., Cheng, L., Ou, R."miR‑146a regulates the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis through NF‑κB signaling by targeting TRAF6". Oncology Reports 41, no. 5 (2019): 2897-2908. https://doi.org/10.3892/or.2019.7046
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