Open Access

MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway

  • Authors:
    • Qing Xie
    • Shuai Wang
    • Yue Zhao
    • Zhenchao Zhang
    • Chuan Qin
    • Xianjun Yang
  • View Affiliations

  • Published online on: March 7, 2019     https://doi.org/10.3892/or.2019.7050
  • Pages: 2647-2656
  • Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the potential anticancer effects of microRNA-216a on the growth of human breast cancer and the possible underlying mechanisms. The results demonstrated that serum microRNA-216a was significantly decreased in patients with breast cancer compared with healthy controls. MicroRNA-216a overexpression led to a decrease in cell proliferation and migration, as well as increases in apoptosis, caspase-3/8 activities, Bax expression and p53 protein expression in MCF-7 cells. It was also revealed that microRNA-216a suppressed Wnt and β-catenin expression in MCF-7 cells. The anticancer effects of microRNA-216a were reversed by anti-microRNA-216a by promoting the Wnt/β-catenin signaling pathway. Inactivation of the Wnt pathway increased the anticancer effects of microRNA-216a in MCF-7 cells. Collectively, the results of the present study indicated that microRNA-216a suppressed the growth of human breast cancer cells by targeting the Wnt/β‑catenin signaling pathway.
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May-2019
Volume 41 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Xie Q, Wang S, Zhao Y, Zhang Z, Qin C and Yang X: MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway. Oncol Rep 41: 2647-2656, 2019
APA
Xie, Q., Wang, S., Zhao, Y., Zhang, Z., Qin, C., & Yang, X. (2019). MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway. Oncology Reports, 41, 2647-2656. https://doi.org/10.3892/or.2019.7050
MLA
Xie, Q., Wang, S., Zhao, Y., Zhang, Z., Qin, C., Yang, X."MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway". Oncology Reports 41.5 (2019): 2647-2656.
Chicago
Xie, Q., Wang, S., Zhao, Y., Zhang, Z., Qin, C., Yang, X."MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway". Oncology Reports 41, no. 5 (2019): 2647-2656. https://doi.org/10.3892/or.2019.7050