Open Access

LATS2 inhibits cell proliferation and metastasis through the Hippo signaling pathway in glioma

  • Authors:
    • Chengyong Guo
    • Chaohui Liang
    • Jipeng Yang
    • Hongchao Hu
    • Bo Fan
    • Xin Liu
  • View Affiliations

  • Published online on: March 14, 2019     https://doi.org/10.3892/or.2019.7065
  • Pages: 2753-2761
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

As a core kinase in the Hippo pathway, large tumor suppressor kinase 2 (LATS2) regulates cell proliferation, migration and invasion through numerous signaling pathways. However, its functions on cell proliferation, migration and invasion in glioma have yet to be elucidated. The present study revealed that LATS2 was downregulated in glioma tissues and cells, as determined by reverse transcription‑quantitative polymerase chain reaction and immunohistochemistry. In addition, Cell Counting Kit‑8, scratch wound healing and Transwell assays revealed that overexpression of LATS2 in U‑372 MG cells inhibited cell proliferation, migration and invasion. Furthermore, western blot analysis indicated that the expression levels of phosphorylated (p)‑yes‑associated protein and p‑tafazzin were increased in cells with LATS2 overexpression. These results indicated that LATS2 is a potential tumor suppressor, and downregulation of LATS2 in glioma may contribute to cancer progression.
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May-2019
Volume 41 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Guo C, Liang C, Yang J, Hu H, Fan B and Liu X: LATS2 inhibits cell proliferation and metastasis through the Hippo signaling pathway in glioma. Oncol Rep 41: 2753-2761, 2019
APA
Guo, C., Liang, C., Yang, J., Hu, H., Fan, B., & Liu, X. (2019). LATS2 inhibits cell proliferation and metastasis through the Hippo signaling pathway in glioma. Oncology Reports, 41, 2753-2761. https://doi.org/10.3892/or.2019.7065
MLA
Guo, C., Liang, C., Yang, J., Hu, H., Fan, B., Liu, X."LATS2 inhibits cell proliferation and metastasis through the Hippo signaling pathway in glioma". Oncology Reports 41.5 (2019): 2753-2761.
Chicago
Guo, C., Liang, C., Yang, J., Hu, H., Fan, B., Liu, X."LATS2 inhibits cell proliferation and metastasis through the Hippo signaling pathway in glioma". Oncology Reports 41, no. 5 (2019): 2753-2761. https://doi.org/10.3892/or.2019.7065