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Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer

  • Authors:
    • Zhengwu Cheng
    • Xinyu Shao
    • Menglin Xu
    • Junfeng Wang
    • Xiaoyi Kuai
    • Liping Zhang
    • Jian Wu
    • Chunli Zhou
    • Jiading Mao
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China, Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 215006, P.R. China, Department of Oncology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2717-2728
    |
    Published online on: March 15, 2019
       https://doi.org/10.3892/or.2019.7071
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Abstract

Colorectal carcinoma (CRC) is one of the most common malignancies worldwide and the second leading cause of cancer‑related deaths in the US. Recently, Rab1A has been reported to be an activator of mTORC1 and p‑S6K1, which is downstream of mTORC1. However, the association between Rab1A and p‑S6K1 in CRC remains elusive. In the present study, we first demonstrated that Rab1A was overexpressed in CRC tissues and Rab1A overexpression was positively related to lymph node invasion, degree of differentiation, venous invasion and tumor‑node‑metastasis (TNM) stage. In both TNM stage I‑II and III‑IV patients, Rab1A‑positive patients had a shorter survival time than Rab1A‑negative patients. Furthermore, in univariate and multivariate analyses, only Rab1A expression was verified as an independent prognostic factor for survival in CRC patients. The level of p‑S6K1 was markedly high in CRC tissues and Rab1A expression level had a positive association with p‑S6K1 level. In addition, high levels of both Rab1A and p‑S6K1 were associated with a poorer prognosis compared with low expression of either Rab1A or p‑S6K1 level. Moreover, high levels of both Rab1A and p‑S6K1 were associated with a poorer prognosis than patients with high levels of either Rab1A or p‑S6K1 alone. Finally, knockdown of Rab1A expression inhibited migration and proliferation of SW480 and HCT116 cell lines by targeting regulation of p‑S6K1. Thus, our findings indicate that Rab1A plays an important role in CRC and may provide a therapeutic target for CRC, particularly for mTORC1‑targeted therapy‑resistant cancers.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Ng SC and Wong SH: Colorectal cancer screening in Asia. Br Med Bull. 105:29–42. 2013. View Article : Google Scholar : PubMed/NCBI

3 

DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, Alteri R, Robbins AS and Jemal A: Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 64:252–271. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Hutagalung AH and Novick PJ: Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev. 91:119–149. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Charng WL, Yamamoto S, Jaiswal M, Bayat V, Xiong B, Zhang K, Sandoval H, David G, Gibbs S, Lu HC, et al: Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11. PLoS Biol. 12:e10017772014. View Article : Google Scholar : PubMed/NCBI

6 

Wang C, Yoo Y, Fan H, Kim E, Guan KL and Guan JL: Regulation of Integrin β 1 recycling to lipid rafts by Rab1a to promote cell migration. J Biol Chem. 285:29398–29405. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Tanaka M, Mun S, Harada A, Ohkawa Y, Inagaki A, Sano S, Takahashi K, Izumi Y, Osada-Oka M, Wanibuchi H, et al: Hsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions. PLoS One. 9:e967852014. View Article : Google Scholar : PubMed/NCBI

8 

Coune PG, Bensadoun JC, Aebischer P and Schneider BL: Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease. J Parkinsons Dis. 1:373–387. 2011.PubMed/NCBI

9 

Wu G, Yussman MG, Barrett TJ, Hahn HS, Osinska H, Hilliard GM, Wang X, Toyokawa T, Yatani A, Lynch RA, et al: Increased myocardial Rab GTPase expression: A consequence and cause of cardiomyopathy. Circ Res. 89:1130–1137. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Xu H, Qian M, Zhao B, Wu C, Maskey N, Song H, Li D, Song J, Hua K and Fang L: Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells. Oncol Rep. 37:1619–1626. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Xu BH, Li XX, Yang Y, Zhang MY, Rao HL, Wang HY and Zheng XF: Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A. Oncotarget. 6:20813–20828. 2015.PubMed/NCBI

12 

Thomas JD, Zhang YJ, Wei YH, Cho JH, Morris LE, Wang HY and Zheng XF: Rab1A is an mTORC1 activator and a colorectal oncogene. Cancer Cell. 26:754–769. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Wullschleger S, Loewith R and Hall MN: TOR signaling in growth and metabolism. Cell. 124:471–484. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Wang X, Chu Y, Wang W and Yuan W: mTORC signaling in hematopoiesis. Int J Hematol. 103:510–518. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Laplante M and Sabatini DM: mTOR signaling in growth control and disease. Cell. 149:274–293. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Shaw RJ and Cantley LC: Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 441:424–430. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Han G, Gong H, Wang Y, Guo S and Liu K: AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell. Cancer Biol Ther. 16:77–87. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Don AS and Zheng XF: Recent clinical trials of mTOR-targeted cancer therapies. Rev Recent Clin Trials. 6:24–35. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Li L, Kim E, Yuan H, Inoki K, Goraksha-Hicks P, Schiesher RL, Neufeld TP and Guan KL: Regulation of mTORC1 by the Rab and Arf GTPases. J Biol Chem. 285:19705–19709. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Yang K, Jiang L, Hu Y, Yu J, Chen H, Yao Y and Zhu X: Short hairpin RNA- mediated gene knockdown of FOXM1 inhibits the proliferation and metastasis of human colon cancer cells through reversal of epithelial-to-mesenchymal transformation. J Exp Clin Cancer Res. 34:402015. View Article : Google Scholar : PubMed/NCBI

21 

Shao X, Kuai X, Pang Z, Zhang L, Wu L, Xu L and Zhou C: Correlation of Gli1 and HER2 expression in gastric cancer: Identification of novel target. Sci Rep. 8:3972018. View Article : Google Scholar : PubMed/NCBI

22 

Zhou WW, Chu YP and An GY: Significant difference of neutrophil-lymphocyte ratio between colorectal cancer, adenomatous polyp and healthy people. Eur Rev Med Pharmacol Sci. 21:5386–5391. 2017.PubMed/NCBI

23 

Zhang Z, Dong X, Yang X, Wan D, Sun L, Gu M, Li M, Zhu Z, Wang J, Shang Z, et al: Expression and clinical significance of absent in melanoma 2 in colorectal cancer. Biomed Pharmacother. 94:843–849. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Polivka J Jr and Janku F: Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway. Pharmacol Ther. 142:164–175. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Phyu SM, Tseng CC, Fleming IN and Smith TA: Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: Routes to glycogen synthase kinase 3. Sci Rep. 6:365442016. View Article : Google Scholar : PubMed/NCBI

26 

Satoh A, Wang Y, Malsam J, Beard MB and Warren G: Golgin-84 is a rab1 binding partner involved in Golgi structure. Traffic. 4:153–161. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Shimada K, Uzawa K, Kato M, Endo Y, Shiiba M, Bukawa H, Yokoe H, Seki N and Tanzawa H: Aberrant expression of RAB1A in human tongue cancer. Br J Cancer. 92:1915–1921. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Nikoshkov A, Broliden K, Attarha S, Sviatoha V, Hellström AC, Mints M and Andersson S: Expression pattern of the PRDX2, RAB1A, RAB1B, RAB5A and RAB25 genes in normal and cancer cervical tissues. Int J Oncol. 46:107–112. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Sun T, Wang X, He HH, Sweeney CJ, Liu SX, Brown M, Balk S, Lee GS and Kantoff PW: MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A. Oncogene. 33:2790–2800. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Abd Elmageed ZY, Yang Y, Thomas R, Ranjan M, Mondal D, Moroz K, Fang Z, Rezk BM, Moparty K, Sikka SC, et al: Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes. Stem Cells. 32:983–997. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Wang X, Liu F, Qin X, Huang T, Huang B, Zhang Y and Jiang B: Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage. Aging (Albany NY). 8:2790–2798. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Xu B, Huang C, Yang X, Li X, Li L and Ding Y: Significance and prognostic role of human epidermal growth factor receptor 2 and RAB1A expression in gastric cancer. Oncol Lett. 15:5185–5192. 2018.PubMed/NCBI

33 

Wang ZK, Cheng ZW, Chen SJ, Zhu XG, Gu YP, Yang XD, Sun L, Liu WT, Zhang YJ, Yuan JF, et al: Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer. Eur Rev Med Pharmacol Sci. 22:4509–4517. 2018.PubMed/NCBI

34 

Kim YM, Jung CH, Seo M, Kim EK, Park JM, Bae SS and Kim DH: mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation. Mol Cell. 57:207–218. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Xu J, Fotouhi M and McPherson PS: Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy. EMBO Rep. 16:709–718. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Vaira V, Lee CW, Goel HL, Bosari S, Languino LR and Altieri DC: Regulation of survivin expression by IGF-1/mTOR signaling. Oncogene. 26:2678–2684. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cheng Z, Shao X, Xu M, Wang J, Kuai X, Zhang L, Wu J, Zhou C and Mao J: Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer. Oncol Rep 41: 2717-2728, 2019.
APA
Cheng, Z., Shao, X., Xu, M., Wang, J., Kuai, X., Zhang, L. ... Mao, J. (2019). Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer. Oncology Reports, 41, 2717-2728. https://doi.org/10.3892/or.2019.7071
MLA
Cheng, Z., Shao, X., Xu, M., Wang, J., Kuai, X., Zhang, L., Wu, J., Zhou, C., Mao, J."Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer". Oncology Reports 41.5 (2019): 2717-2728.
Chicago
Cheng, Z., Shao, X., Xu, M., Wang, J., Kuai, X., Zhang, L., Wu, J., Zhou, C., Mao, J."Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer". Oncology Reports 41, no. 5 (2019): 2717-2728. https://doi.org/10.3892/or.2019.7071
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng Z, Shao X, Xu M, Wang J, Kuai X, Zhang L, Wu J, Zhou C and Mao J: Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer. Oncol Rep 41: 2717-2728, 2019.
APA
Cheng, Z., Shao, X., Xu, M., Wang, J., Kuai, X., Zhang, L. ... Mao, J. (2019). Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer. Oncology Reports, 41, 2717-2728. https://doi.org/10.3892/or.2019.7071
MLA
Cheng, Z., Shao, X., Xu, M., Wang, J., Kuai, X., Zhang, L., Wu, J., Zhou, C., Mao, J."Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer". Oncology Reports 41.5 (2019): 2717-2728.
Chicago
Cheng, Z., Shao, X., Xu, M., Wang, J., Kuai, X., Zhang, L., Wu, J., Zhou, C., Mao, J."Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer". Oncology Reports 41, no. 5 (2019): 2717-2728. https://doi.org/10.3892/or.2019.7071
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