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Cystatin F as a key family 2 cystatin subunit and prognostic biomarker for early‑stage pancreatic ductal adenocarcinoma

  • Authors:
    • Chengkun Yang
    • Tingdong Yu
    • Zhengqian Liu
    • Xinping Ye
    • Xiwen Liao
    • Xiangkun Wang
    • Chuangye Han
    • Guangzhi Zhu
    • Wei Qin
    • Tao Peng
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 79-90
    |
    Published online on: April 24, 2019
       https://doi.org/10.3892/or.2019.7135
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, and early diagnosis and assessment may enhance the quality of life and survival of patients. The prognostic value of key family 2 cystatins subunit in PDAC patients remains unknown. The potential molecular roles of family 2 cystatins and related pathways were investigated using bioinformatics analysis. The relationship of family 2 cystatin expression levels and clinical outcomes of 112 patients with early‑stage PDAC were evaluated via univariate and combined survival analysis. A prognostic nomogram model was also constructed and gene set enrichment analysis was performed to investigate potential pathways in PDAC. The pathways, interaction networks, and Gene Ontology term analysis of the cystatin gene family were analyzed in the present study. Cystatin F (CST7) was identified as the key subunit of family 2 cystatins in survival analysis. PDAC patients who harbored a higher expression level of CST7 had a lower risk in overall survival (adjusted HROS=0.44, 95% CI=0.25‑0.77, P=0.004) and a longer survival time in various subgroups. The prognostic nomogram indicated that the CST7 expression model effectively predicted the outcomes of patients with early‑stage PDAC (predictive ability >0.75). In the gene set enrichment analysis, it was revealed that CST7 expression may be involved in immune regulation and be associated with cell adhesion. CST7 could be a useful biomarker for the prognostic prediction of early‑stage PDAC after pancreaticoduodenectomy.
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Copy and paste a formatted citation
Spandidos Publications style
Yang C, Yu T, Liu Z, Ye X, Liao X, Wang X, Han C, Zhu G, Qin W, Peng T, Peng T, et al: Cystatin F as a key family 2 cystatin subunit and prognostic biomarker for early‑stage pancreatic ductal adenocarcinoma. Oncol Rep 42: 79-90, 2019.
APA
Yang, C., Yu, T., Liu, Z., Ye, X., Liao, X., Wang, X. ... Peng, T. (2019). Cystatin F as a key family 2 cystatin subunit and prognostic biomarker for early‑stage pancreatic ductal adenocarcinoma. Oncology Reports, 42, 79-90. https://doi.org/10.3892/or.2019.7135
MLA
Yang, C., Yu, T., Liu, Z., Ye, X., Liao, X., Wang, X., Han, C., Zhu, G., Qin, W., Peng, T."Cystatin F as a key family 2 cystatin subunit and prognostic biomarker for early‑stage pancreatic ductal adenocarcinoma". Oncology Reports 42.1 (2019): 79-90.
Chicago
Yang, C., Yu, T., Liu, Z., Ye, X., Liao, X., Wang, X., Han, C., Zhu, G., Qin, W., Peng, T."Cystatin F as a key family 2 cystatin subunit and prognostic biomarker for early‑stage pancreatic ductal adenocarcinoma". Oncology Reports 42, no. 1 (2019): 79-90. https://doi.org/10.3892/or.2019.7135
Copy and paste a formatted citation
x
Spandidos Publications style
Yang C, Yu T, Liu Z, Ye X, Liao X, Wang X, Han C, Zhu G, Qin W, Peng T, Peng T, et al: Cystatin F as a key family 2 cystatin subunit and prognostic biomarker for early‑stage pancreatic ductal adenocarcinoma. Oncol Rep 42: 79-90, 2019.
APA
Yang, C., Yu, T., Liu, Z., Ye, X., Liao, X., Wang, X. ... Peng, T. (2019). Cystatin F as a key family 2 cystatin subunit and prognostic biomarker for early‑stage pancreatic ductal adenocarcinoma. Oncology Reports, 42, 79-90. https://doi.org/10.3892/or.2019.7135
MLA
Yang, C., Yu, T., Liu, Z., Ye, X., Liao, X., Wang, X., Han, C., Zhu, G., Qin, W., Peng, T."Cystatin F as a key family 2 cystatin subunit and prognostic biomarker for early‑stage pancreatic ductal adenocarcinoma". Oncology Reports 42.1 (2019): 79-90.
Chicago
Yang, C., Yu, T., Liu, Z., Ye, X., Liao, X., Wang, X., Han, C., Zhu, G., Qin, W., Peng, T."Cystatin F as a key family 2 cystatin subunit and prognostic biomarker for early‑stage pancreatic ductal adenocarcinoma". Oncology Reports 42, no. 1 (2019): 79-90. https://doi.org/10.3892/or.2019.7135
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