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Article

miR‑29 promoter and enhancer methylation identified by pyrosequencing in Burkitt lymhoma cells: Interplay between MYC and miR‑29 regulation

  • Authors:
    • Luciano Mazzoccoli
    • Marcela Cristina Robaina
    • Carlos E. Bacchi
    • Sheila Coelho Soares Lima
    • Claudete Esteves Klumb
  • View Affiliations / Copyright

    Affiliations: Laboratory of Cellular and Molecular Hemato‑Oncology, Program of Molecular Hemato‑Oncology, Brazilian National Cancer Institute (INCA), Rio de Janeiro 20230‑130, Brazil, Bacchi Laboratory, Pathology Reference Laboratory, Botucatu, São Paulo 18602‑010, Brazil, Molecular Carcinogenesis Program, Brazilian National Cancer Institute (INCA), Rio de Janeiro 20231‑050, Brazil
  • Pages: 775-784
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    Published online on: June 3, 2019
       https://doi.org/10.3892/or.2019.7183
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Abstract

Deregulation of microRNA expression plays a significant role in several cancer types including Burkitt lymphoma (BL). MicroRNA genes may be regulated through epigenetic mechanisms, such as specific histone modifications and/or DNA methylation of CpG islands in promoter regions, or by regions that are located next to microRNA genes. Given the regulatory role of MYC in miR‑29 expression, methylation as an additional mechanism for miR‑29 silencing was investigated. Methylation of miR‑29a/b/c in BL tumour samples and BL cell lines (BL41 and Raji) was assessed by pyrosequencing assay. BL cells were treated with 5‑aza‑2'‑deoxicitidine (decitabine) and evaluated for miR‑29a/b/c expression and methylation status. MYC, DNMT1 and DNMT3B protein expression were accessed by western blotting. For Epstein‑Barr virus (EBV) microRNA (miR)‑BART6 inhibition, the cells were transiently transfected with anti‑BART6‑5p. BL tumour samples and BL cell lines presented miR‑29a/b1 and miR‑29b2/c genes methylated in CpG sites located in both the promoter and enhancer regions. The treatment of BL cells with decitabine reduced methylation, induced miR‑29s expression and downregulated MYC protein levels in a dose‑dependent manner. Notably, inhibition of EBV miR‑BART6‑5p combined with decitabine enhanced miR‑29 expression in an EBV‑BL cell line. In conclusion, the miR‑29a/b1 and miR‑29b2/c genes have methylated CpG sequences at promoter and enhancer regions that may contribute to the regulation of miR‑29 expression in BL tumours. The present findings indicated interplay between MYC and miR‑29 regulation, highlighting the potential role of EBV‑miRNAs in miR‑29 regulation for BL pathogenesis.
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View References

1 

Esteller M: Epigenetic changes in cancer. F1000 Biol Rep. 3:92011. View Article : Google Scholar : PubMed/NCBI

2 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Ying SY, Chang CP and Lin SL: Intron-mediated RNA interference, intronic microRNAs, and applications. Methods Mol Biol. 629:205–237. 2010.PubMed/NCBI

4 

Moutinho C and Esteller M: MicroRNAs and epigenetics. Adv Cancer Res. 135:189–220. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Suzuki HI, Young RA and Sharp PA: Super-enhancer-mediated RNA processing revealed by integrative MicroRNA network analysis. Cell. 168:1000–1014.e15. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, et al: A mammalian microRNA expression atlas based on small RNA library sequencing. Cell. 129:1401–1414. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Hochberg J, Waxman IM, Kelly KM, Morris E and Cairo MS: Adolescent non-Hodgkin lymphoma and Hodgkin lymphoma: State of the science. Br J Haematol. 144:24–40. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Brady G, Macarthur GJ and Farrell PJ: Epstein-Barr virus and Burkitt lymphoma. Postgrad Med J. 84:372–377. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Dalla-Favera R, Bregni M, Erikson J, Patterson D, Gallo RC and Croce CM: Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci USA. 79:7824–7827. 1982. View Article : Google Scholar : PubMed/NCBI

10 

Taub R, Kirsch I, Morton C, Lenoir G, Swan D, Tronick S, Aaronson S and Leder P: Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci USA. 79:7837–7841. 1982. View Article : Google Scholar : PubMed/NCBI

11 

Willis TG and Dyer MJ: The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies. Blood. 96:808–822. 2000.PubMed/NCBI

12 

Schmitz R, Young RM, Ceribelli M, Jhavar S, Xiao W, Zhang M, Wright G, Shaffer AL, Hodson DJ, Buras E, et al: Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. 490:116–120. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Sander S, Calado DP, Srinivasan L, Köchert K, Zhang B, Rosolowski M, Rodig SJ, Holzmann K, Stilgenbauer S, Siebert R, et al: Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis. Cancer Cell. 22:167–179. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Oduor CI, Kaymaz Y, Chelimo K, Otieno JA, Ong'echa JM, Moormann AM and Bailey JA: Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma. BMC Cancer. 17:7612017. View Article : Google Scholar : PubMed/NCBI

15 

Lenze D, Leoncini L, Hummel M, Volinia S, Liu CG, Amato T, De Falco G, Githanga J, Horn H, Nyagol J, et al: The different epidemiologic subtypes of Burkitt lymphoma share a homogenous micro RNA profile distinct from diffuse large B-cell lymphoma. Leukemia. 25:1869–1876. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Hezaveh K, Kloetgen A, Bernhart SH, Mahapatra KD, Lenze D, Richter J, Haake A, Bergmann AK, Brors B, Burkhardt B, et al: Alterations of microRNA and microRNA-regulated messenger RNA expression in germinal center B-cell lymphomas determined by integrative sequencing analysis. Haematologica. 101:1380–1389. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Zhu K, Liu L, Zhang J, Wang Y, Liang H, Fan G, Jiang Z, Zhang CY, Chen X and Zhou G: miR-29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6. Protein Cell. 7:434–444. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Kwon JJ, Factora TD, Dey S and Kota J: A systematic review of miR-29 in cancer. Mol Ther Oncolytics. 12:173–194. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, et al: MicroRNA 29b functions in acute myeloid leukemia. Blood. 114:5331–5341. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Zhang X, Zhao X, Fiskus W, Lin J, Lwin T, Rao R, Zhang Y, Chan JC, Fu K, Marquez VE, et al: Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomas. Cancer Cell. 22:506–523. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Mazzoccoli L, Robaina MC, Apa AG, Bonamino M, Pinto LW, Queiroga E, Bacchi CE and Klumb CE: miR-29 silencing modulates the expression of target genes related to proliferation, apoptosis and methylation in Burkitt lymphoma cells. J Cancer Res Clin Oncol. 144:483–497. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H and Jaffe ES: The 2008 WHO classification of lymphoid neoplasms and beyond: Evolving concepts and practical applications. Blood. 117:5019–5032. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Robaina MC, Mazzoccoli L, Arruda VO, Reis FR, Apa AG, de Rezende LM and Klumb CE: Deregulation of DNMT1, DNMT3B and miR-29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis. Exp Mol Pathol. 98:200–207. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Guan H, Xie L, Klapproth K, Weitzer CD, Wirth T and Ushmorov A: Decitabine represses translocated MYC oncogene in Burkitt lymphoma. J Pathol. 229:775–783. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Shinozaki-Ushiku A, Kunita A, Isogai M, Hibiya T, Ushiku T, Takada K and Fukayama M: Profiling of virus-encoded MicroRNAs in Epstein-Barr Virus-associated gastric carcinoma and their roles in gastric carcinogenesis. J Virol. 89:5581–5591. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Iizasa H, Wulff BE, Alla NR, Maragkakis M, Megraw M, Hatzigeorgiou A, Iwakiri D, Takada K, Wiedmer A, Showe L, et al: Editing of Epstein-Barr virus-encoded BART6 microRNAs controls their dicer targeting and consequently affects viral latency. J Biol Chem. 285:33358–33370. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Malumbres M: miRNAs and cancer: An epigenetics view. Mol Aspects Med. 34:863–874. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Fabbri M, Ivan M, Cimmino A, Negrini M and Calin GA: Regulatory mechanisms of microRNAs involvement in cancer. Expert Opin Biol Ther. 7:1009–1019. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, Dessureault S, Moscinski LC, Rezania D, Dalton WS, et al: microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. Blood. 115:2630–2639. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Kinoshita T, Nohata N, Hanazawa T, Kikkawa N, Yamamoto N, Yoshino H, Itesako T, Enokida H, Nakagawa M, Okamoto Y and Seki N: Tumour-suppressive microRNA-29s inhibit cancer cell migration and invasion by targeting laminin-integrin signalling in head and neck squamous cell carcinoma. Br J Cancer. 109:2636–2645. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Nishikawa R, Chiyomaru T, Enokida H, Inoguchi S, Ishihara T, Matsushita R, Goto Y, Fukumoto I, Nakagawa M and Seki N: Tumour-suppressive microRNA-29s directly regulate LOXL2 expression and inhibit cancer cell migration and invasion in renal cell carcinoma. FEBS Lett. 589:2136–2145. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A and Mendell JT: Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet. 40:43–50. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Sears RC: The life cycle of C-myc: From synthesis to degradation. Cell Cycle. 3:1133–1137. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Majello B and Perini G: Myc proteins in cell biology and pathology. Biochim Biophys Acta. 1849:467–468. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Zeller KI, Zhao X, Lee CW, Chiu KP, Yao F, Yustein JT, Ooi HS, Orlov YL, Shahab A, Yong HC, et al: Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci USA. 103:17834–17839. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Meyer N and Penn LZ: Reflecting on 25 years with MYC. Nat Rev Cancer. 8:976–990. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Kim JW, Mori S and Nevins JR: Myc-induced microRNAs integrate Myc-mediated cell proliferation and cell fate. Cancer Res. 70:4820–4828. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Tao J, Zhao X and Tao J: c-MYC-miRNA circuitry: A central regulator of aggressive B-cell malignancies. Cell Cycle. 13:191–198. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Baer C, Claus R and Plass C: Genome-wide epigenetic regulation of miRNAs in cancer. Cancer Res. 73:473–477. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Strmsek Z and Kunej T: MicroRNA silencing by DNA methylation in human cancer: A literature analysis. Noncoding RNA. 1:44–52. 2015.PubMed/NCBI

42 

Lopez-Serra P and Esteller M: DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer. Oncogene. 31:1609–1622. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Lujambio A and Esteller M: CpG island hypermethylation of tumor suppressor microRNAs in human cancer. Cell Cycle. 6:1455–1459. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Saito Y and Jones PA: Epigenetic activation of tumor suppressor microRNAs in human cancer cells. Cell Cycle. 5:2220–2222. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Tost J and Gut IG: DNA methylation analysis by pyrosequencing. Nat Protoc. 2:2265–2275. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Colella S, Shen L, Baggerly KA, Issa JP and Krahe R: Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites. Biotechniques. 35:146–150. 2003. View Article : Google Scholar : PubMed/NCBI

47 

Perino M and Veenstra GJ: Chromatin control of developmental dynamics and plasticity. Dev Cell. 38:610–620. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Whyte WA, Orlando DA, Hnisz D, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI and Young RA: Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell. 153:307–319. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Elghoroury EA, ElDine HG, Kamel SA, Abdelrahman AH, Mohammed A, Kamel MM and Ibrahim MH: Evaluation of miRNA-21 and miRNA let-7 as prognostic markers in patients with breast cancer. Clin Breast Cancer. 18:e721–e726. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Karpinski P, Pesz K and Sasiadek MM: Pan-cancer analysis reveals presence of pronounced DNA methylation drift in CpG island methylator phenotype clusters. Epigenomics. 9:1341–1352. 2017. View Article : Google Scholar : PubMed/NCBI

51 

El Baroudi M, Corà D, Bosia C, Osella M and Caselle M: A curated database of miRNA mediated feed-forward loops involving MYC as master regulator. PLoS One. 6:e147422011. View Article : Google Scholar : PubMed/NCBI

52 

Sabò A, Kress TR, Pelizzola M, De Pretis S, Gorski MM, Tesi A, Morelli MJ, Bora P, Doni M, Verrecchia A, et al: Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis. Nature. 511:488–492. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Poole CJ, Zheng W, Lodh A, Yevtodiyenko A, Liefwalker D, Li H, Felsher DW and van Riggelen J: DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma. Oncotarget. 8:76898–76920. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Godshalk SE, Bhaduri-McIntosh S and Slack FJ: Epstein-Barr virus-mediated dysregulation of human microRNA expression. Cell Cycle. 7:3595–3600. 2008. View Article : Google Scholar : PubMed/NCBI

55 

Paschos K, Smith P, Anderton E, Middeldorp JM, White RE and Allday MJ: Epstein-barr virus latency in B cells leads to epigenetic repression and CpG methylation of the tumour suppressor gene Bim. PLoS Pathog. 5:e10004922009. View Article : Google Scholar : PubMed/NCBI

56 

Price AM and Luftig MA: To be or not IIb: A multi-step process for Epstein-Barr virus latency establishment and consequences for B cell tumorigenesis. PLoS Pathog. 11:e10046562015. View Article : Google Scholar : PubMed/NCBI

57 

Klinke O, Feederle R and Delecluse HJ: Genetics of Epstein-Barr virus microRNAs. Semin Cancer Biol. 26:52–59. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Vereide DT, Seto E, Chiu YF, Hayes M, Tagawa T, Grundhoff A, Hammerschmidt W and Sugden B: Epstein-Barr virus maintains lymphomas via its miRNAs. Oncogene. 33:1258–1264. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mazzoccoli L, Robaina MC, Bacchi CE, Soares Lima SC and Klumb CE: miR‑29 promoter and enhancer methylation identified by pyrosequencing in Burkitt lymhoma cells: Interplay between MYC and miR‑29 regulation. Oncol Rep 42: 775-784, 2019.
APA
Mazzoccoli, L., Robaina, M.C., Bacchi, C.E., Soares Lima, S.C., & Klumb, C.E. (2019). miR‑29 promoter and enhancer methylation identified by pyrosequencing in Burkitt lymhoma cells: Interplay between MYC and miR‑29 regulation. Oncology Reports, 42, 775-784. https://doi.org/10.3892/or.2019.7183
MLA
Mazzoccoli, L., Robaina, M. C., Bacchi, C. E., Soares Lima, S. C., Klumb, C. E."miR‑29 promoter and enhancer methylation identified by pyrosequencing in Burkitt lymhoma cells: Interplay between MYC and miR‑29 regulation". Oncology Reports 42.2 (2019): 775-784.
Chicago
Mazzoccoli, L., Robaina, M. C., Bacchi, C. E., Soares Lima, S. C., Klumb, C. E."miR‑29 promoter and enhancer methylation identified by pyrosequencing in Burkitt lymhoma cells: Interplay between MYC and miR‑29 regulation". Oncology Reports 42, no. 2 (2019): 775-784. https://doi.org/10.3892/or.2019.7183
Copy and paste a formatted citation
x
Spandidos Publications style
Mazzoccoli L, Robaina MC, Bacchi CE, Soares Lima SC and Klumb CE: miR‑29 promoter and enhancer methylation identified by pyrosequencing in Burkitt lymhoma cells: Interplay between MYC and miR‑29 regulation. Oncol Rep 42: 775-784, 2019.
APA
Mazzoccoli, L., Robaina, M.C., Bacchi, C.E., Soares Lima, S.C., & Klumb, C.E. (2019). miR‑29 promoter and enhancer methylation identified by pyrosequencing in Burkitt lymhoma cells: Interplay between MYC and miR‑29 regulation. Oncology Reports, 42, 775-784. https://doi.org/10.3892/or.2019.7183
MLA
Mazzoccoli, L., Robaina, M. C., Bacchi, C. E., Soares Lima, S. C., Klumb, C. E."miR‑29 promoter and enhancer methylation identified by pyrosequencing in Burkitt lymhoma cells: Interplay between MYC and miR‑29 regulation". Oncology Reports 42.2 (2019): 775-784.
Chicago
Mazzoccoli, L., Robaina, M. C., Bacchi, C. E., Soares Lima, S. C., Klumb, C. E."miR‑29 promoter and enhancer methylation identified by pyrosequencing in Burkitt lymhoma cells: Interplay between MYC and miR‑29 regulation". Oncology Reports 42, no. 2 (2019): 775-784. https://doi.org/10.3892/or.2019.7183
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