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Identification and characterization of a murine model of BCR‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis

  • Authors:
    • Xiaozhuo Yu
    • Hua Zhang
    • Meng Yuan
    • Ping Zhang
    • Yang Wang
    • Mingzhe Zheng
    • Zhuangwei Lv
    • Woodvine Otieno Odhiambo
    • Canyu Li
    • Chengcheng Liu
    • Yunfeng Ma
    • Yanhong Ji
  • View Affiliations / Copyright

    Affiliations: Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, Shaanxi 710061, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 521-532
    |
    Published online on: June 3, 2019
       https://doi.org/10.3892/or.2019.7184
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Abstract

Breakpoint cluster region (BCR)‑Abelson murine leukemia (ABL)1+ acute B‑lymphoblastic leukemia (B‑ALL) is a disease associated with a dismal prognosis and a high incidence of central nervous system (CNS) metastasis. However, BCR‑ABL1+ B‑ALL with CNS infiltration has not been previously characterized, at least to the best of our knowledge. In the present study, a murine model of BCR‑ABL1+ B‑ALL with CNS metastasis was established using retroviral transduction. The vast majority of BCR‑ABL1+ leukemic cells were found to be immature B cells with a variable proportion of pro‑B and pre‑B populations. The present results indicated that the BCR‑ABL1+ B‑leukemic cells expressed high levels integrin subunit alpha 6 (Itga6) and L‑selectin adhesion molecules, and have an intrinsic ability to disseminate and accumulate in CNS tissues, predominantly in meninges. On the whole, these results provide an approach for addressing the mechanisms of BCR‑ABL1+ B‑ALL with CNS metastasis and may guide the development of novel therapeutic strategies.
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Copy and paste a formatted citation
Spandidos Publications style
Yu X, Zhang H, Yuan M, Zhang P, Wang Y, Zheng M, Lv Z, Odhiambo WO, Li C, Liu C, Liu C, et al: Identification and characterization of a murine model of BCR‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis. Oncol Rep 42: 521-532, 2019.
APA
Yu, X., Zhang, H., Yuan, M., Zhang, P., Wang, Y., Zheng, M. ... Ji, Y. (2019). Identification and characterization of a murine model of BCR‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis. Oncology Reports, 42, 521-532. https://doi.org/10.3892/or.2019.7184
MLA
Yu, X., Zhang, H., Yuan, M., Zhang, P., Wang, Y., Zheng, M., Lv, Z., Odhiambo, W. O., Li, C., Liu, C., Ma, Y., Ji, Y."Identification and characterization of a murine model of BCR‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis". Oncology Reports 42.2 (2019): 521-532.
Chicago
Yu, X., Zhang, H., Yuan, M., Zhang, P., Wang, Y., Zheng, M., Lv, Z., Odhiambo, W. O., Li, C., Liu, C., Ma, Y., Ji, Y."Identification and characterization of a murine model of BCR‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis". Oncology Reports 42, no. 2 (2019): 521-532. https://doi.org/10.3892/or.2019.7184
Copy and paste a formatted citation
x
Spandidos Publications style
Yu X, Zhang H, Yuan M, Zhang P, Wang Y, Zheng M, Lv Z, Odhiambo WO, Li C, Liu C, Liu C, et al: Identification and characterization of a murine model of BCR‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis. Oncol Rep 42: 521-532, 2019.
APA
Yu, X., Zhang, H., Yuan, M., Zhang, P., Wang, Y., Zheng, M. ... Ji, Y. (2019). Identification and characterization of a murine model of BCR‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis. Oncology Reports, 42, 521-532. https://doi.org/10.3892/or.2019.7184
MLA
Yu, X., Zhang, H., Yuan, M., Zhang, P., Wang, Y., Zheng, M., Lv, Z., Odhiambo, W. O., Li, C., Liu, C., Ma, Y., Ji, Y."Identification and characterization of a murine model of BCR‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis". Oncology Reports 42.2 (2019): 521-532.
Chicago
Yu, X., Zhang, H., Yuan, M., Zhang, P., Wang, Y., Zheng, M., Lv, Z., Odhiambo, W. O., Li, C., Liu, C., Ma, Y., Ji, Y."Identification and characterization of a murine model of BCR‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis". Oncology Reports 42, no. 2 (2019): 521-532. https://doi.org/10.3892/or.2019.7184
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