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Article Open Access

Comprehensive evaluation of FKBP10 expression and its prognostic potential in gastric cancer

  • Authors:
    • Liang Liang
    • Kun Zhao
    • Jin‑Hui Zhu
    • Gang Chen
    • Xin‑Gan Qin
    • Jun‑Qiang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China
    Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 615-628
    |
    Published online on: June 11, 2019
       https://doi.org/10.3892/or.2019.7195
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Abstract

FK506 binding protein 10 (FKBP10) has been reported to be dysregulated in numerous types of cancer; however, few reports have investigated FKBP10 in gastric cancer (GC). The aim of the present study was to investigate FKBP10 expression in GC and to analyze its association with the prognosis of patients with GC. FKBP10 mRNA expression was evaluated using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. The standardized mean differences of the meta‑analysis were comprehensively evaluated for FKBP10 expression from a series of GEO datasets. Kaplan‑Meier survival and Cox regression analyses were applied to predict the prognostic value of FKBP10 in patients with GC. Additionally, the protein expression levels of FKBP10 were validated by immunohistochemistry (IHC) in 40 GC and adjacent tissues. FKBP10 co‑expression network and bioinformatics analyses were then used to explore the potential functional mechanisms of FKBP10. The results revealed that the mRNA expression levels of FKBP10 were significantly increased in GC within the TCGA and GEO databases. Survival analysis revealed that high FKBP10 expression results in poorer overall survival and disease‑free survival (P<0.05). Multivariate cox regression analysis indicate FKBP10 as a dependent prognostic factor. The results of IHC indicated that the protein expression levels of FKBP10 were higher in GC tissues than in adjacent non‑GC tissues (P<0.001). Co‑expression networks and functional enrichment analysis suggested that FKBP10 may be involved in the development of GC via cell adhesion molecules and extracellular matrix‑receptor interaction pathways. Therefore, the findings of the present study indicated that FKBP10 is upregulated in GC tissues, and suggests its potential prognostic value. Therefore FKBP10 may be a potential therapeutic target for the treatment of GC.
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Copy and paste a formatted citation
Spandidos Publications style
Liang L, Zhao K, Zhu JH, Chen G, Qin XG and Chen JQ: Comprehensive evaluation of FKBP10 expression and its prognostic potential in gastric cancer. Oncol Rep 42: 615-628, 2019.
APA
Liang, L., Zhao, K., Zhu, J., Chen, G., Qin, X., & Chen, J. (2019). Comprehensive evaluation of FKBP10 expression and its prognostic potential in gastric cancer. Oncology Reports, 42, 615-628. https://doi.org/10.3892/or.2019.7195
MLA
Liang, L., Zhao, K., Zhu, J., Chen, G., Qin, X., Chen, J."Comprehensive evaluation of FKBP10 expression and its prognostic potential in gastric cancer". Oncology Reports 42.2 (2019): 615-628.
Chicago
Liang, L., Zhao, K., Zhu, J., Chen, G., Qin, X., Chen, J."Comprehensive evaluation of FKBP10 expression and its prognostic potential in gastric cancer". Oncology Reports 42, no. 2 (2019): 615-628. https://doi.org/10.3892/or.2019.7195
Copy and paste a formatted citation
x
Spandidos Publications style
Liang L, Zhao K, Zhu JH, Chen G, Qin XG and Chen JQ: Comprehensive evaluation of FKBP10 expression and its prognostic potential in gastric cancer. Oncol Rep 42: 615-628, 2019.
APA
Liang, L., Zhao, K., Zhu, J., Chen, G., Qin, X., & Chen, J. (2019). Comprehensive evaluation of FKBP10 expression and its prognostic potential in gastric cancer. Oncology Reports, 42, 615-628. https://doi.org/10.3892/or.2019.7195
MLA
Liang, L., Zhao, K., Zhu, J., Chen, G., Qin, X., Chen, J."Comprehensive evaluation of FKBP10 expression and its prognostic potential in gastric cancer". Oncology Reports 42.2 (2019): 615-628.
Chicago
Liang, L., Zhao, K., Zhu, J., Chen, G., Qin, X., Chen, J."Comprehensive evaluation of FKBP10 expression and its prognostic potential in gastric cancer". Oncology Reports 42, no. 2 (2019): 615-628. https://doi.org/10.3892/or.2019.7195
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