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Diagnostic and prognostic value of WNT family gene expression in hepatitis B virus‑related hepatocellular carcinoma

  • Authors:
    • Quanfa Han
    • Xiangkun Wang
    • Xiwen Liao
    • Chuangye Han
    • Tingdong Yu
    • Chengkun Yang
    • Guanghui Li
    • Bowen Han
    • Ketuan Huang
    • Guangzhi Zhu
    • Zhengqian Liu
    • Xin Zhou
    • Hao Su
    • Liming Shang
    • Yizhen Gong
    • Xiaowei Song
    • Tao Peng
    • Xinping Ye
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China, Department of Colorectal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China, Department of Gastrointestinal Gland Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 895-910
    |
    Published online on: July 5, 2019
       https://doi.org/10.3892/or.2019.7224
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Abstract

The aim of the present study was to investigate the diagnostic and prognostic value of Wingless‑type MMTV integration site (WNT) gene family expression in patients with hepatitis B virus (HBV)‑related hepatocellular carcinoma (HCC). The clinical data of the patients and gene expression levels were downloaded from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. Receiver operating characteristic curve analysis was used to investigate the diagnostic value of WNT genes. Cox proportional hazard regression analysis and Kaplan‑Meier survival analysis were performed to evaluate the association of WNT gene expression level with overall survival (OS) and recurrence‑free survival (RFS). A nomogram was constructed for the prediction of prognosis. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated. Diagnostic receiver operating characteristic curve analysis suggested that WNT2 had a high diagnostic value, with an area under the curve (AUC) of >0.800 (P<0.0001, AUC=0.810, 95% CI: 0.767‑0.852). Survival analysis indicated that the expression level of WNT1 was significantly associated with OS and RFS (adjusted P=0.033, adjusted HR=0.607, 95% CI: 0.384‑0.960; and adjusted P=0.007, adjusted HR=0.592, 95% CI: 0.404‑0.868, respectively). In the TCGA validation cohort, we also observed that WNT2 was significantly differentially expressed between HCC tissues and adjacent non‑tumor tissues, and WNT1 was associated with both the OS and RFS of HCC. Therefore, through the GSE14520 HBV‑related HCC cohort we concluded that WNT2 may serve as a diagnostic biomarker and WNT1 may serve as a prognostic biomarker. These results may also be extended to TCGA HCC verification cohort.
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View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Bosetti C, Turati F and La Vecchia C: Hepatocellular carcinoma epidemiology. Best Pract Res Clin Gastroenterol. 28:753–770. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Fan JH, Wang JB, Jiang Y, Xiang W, Liang H, Wei WQ, Qiao YL and Boffetta P: Attributable causes of liver cancer mortality and incidence in China. Asian Pac J Cancer Prev. 14:7251–7256. 2013. View Article : Google Scholar : PubMed/NCBI

4 

de Martel C, Maucort-Boulch D, Plummer M and Franceschi S: World-wide relative contribution of hepatitis B and C viruses in hepatocellular carcinoma. Hepatology. 62:1190–1200. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Balogh J, Victor D III, Asham EH, Burroughs SG, Boktour M, Saharia A, Li X, Ghobrial RM and Monsour HP Jr: Hepatocellular carcinoma: A review. J Hepatocell Carcinoma. 3:41–53. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Anastas JN and Moon RT: WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer. 13:11–26. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Cheng R, Sun B, Liu Z, Zhao X, Qi L, Li Y and Gu Q: Wnt5a suppresses colon cancer by inhibiting cell proliferation and epithelial-mesenchymal transition. J Cell Physiol. 229:1908–1917. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Shiah SG, Hsiao JR, Chang WM, Chen YW, Jin YT, Wong TY, Huang JS, Tsai ST, Hsu YM, Chou ST, et al: Downregulated miR329 and miR410 promote the proliferation and invasion of oral squamous cell carcinoma by targeting Wnt-7b. Cancer Res. 74:7560–7572. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Chen X, Jia C, Jia C, Jin X and Gu X: MicroRNA-374a inhibits aggressive tumor biological behavior in bladder carcinoma by suppressing Wnt/β-catenin signaling. Cell Physiol Biochem. 48:815–826. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Yamamoto H, Oue N, Sato A, Hasegawa Y, Yamamoto H, Matsubara A, Yasui W and Kikuchi A: Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase. Oncogene. 29:2036–2046. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Zhang W, Sun Z, Su L, Wang F, Jiang Y, Yu D, Zhang F, Sun Z and Liang W: miRNA-185 serves as a prognostic factor and suppresses migration and invasion through Wnt1 in colon cancer. Eur J Pharmacol. 825:75–84. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Bo H, Zhang S, Gao L, Chen Y, Zhang J, Chang X and Zhu M: Upregulation of Wnt5a promotes epithelial-to-mesenchymal transition and metastasis of pancreatic cancer cells. BMC Cancer. 13:4962013. View Article : Google Scholar : PubMed/NCBI

13 

Wang H, Fan L, Xia X, Rao Y, Ma Q, Yang J, Lu Y, Wang C and Huang X: Silencing Wnt2B by siRNA interference inhibits metastasis and enhances chemotherapy sensitivity in ovarian cancer. Int J Gynecol Cancer. 22:755–761. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Webster MR, Xu M, Kinzler KA, Kaur A, Appleton J, O'Connell MP, Marchbank K, Valiga A, Dang VM, Perego M, et al: Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells. Pigment Cell Melanoma Res. 28:184–195. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Chen PH, Liu AJ, Ho KH, Chiu YT, Anne Lin ZH, Lee YT, Shih CM and Chen KC: microRNA-199a/b-5p enhance imatinib efficacy via repressing WNT2 signaling-mediated protective autophagy in imatinib-resistant chronic myeloid leukemia cells. Chem Biol Interact. 291:144–151. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Fu L, Zhang C, Zhang LY, Dong SS, Lu LH, Chen J, Dai Y, Li Y, Kong KL, Kwong DL and Guan XY: Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway. Gut. 60:1635–1643. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Roessler S, Jia HL, Budhu A, Forgues M, Ye QH, Lee JS, Thorgeirsson SS, Sun Z, Tang ZY, Qin LX and Wang XW: A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients. Cancer Res. 70:10202–10212. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Roessler S, Long EL, Budhu A, Chen Y, Zhao X, Ji J, Walker R, Jia HL, Ye QH, Qin LX, et al: Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival. Gastroenterology. 142:957–966.e12. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Liao X, Liu X, Yang C, Wang X, Yu T, Han C, Huang K, Zhu G, Su H, Qin W, et al: Distinct diagnostic and prognostic values of minichromosome maintenance gene expression in patients with hepatocellular carcinoma. J Cancer. 9:2357–2373. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Anders S and Huber W: Differential expression analysis for sequence count data. Genome Biol. 11:R1062010. View Article : Google Scholar : PubMed/NCBI

21 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Maere S, Heymans K and Kuiper M: BiNGO: A Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks. Bioinformatics. 21:3448–3449. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Mostafavi S, Ray D, Warde-Farley D, Grouios C and Morris Q: GeneMANIA: A real-time multiple association network integration algorithm for predicting gene function. Genome Biol. 9 (Suppl 1):S42008. View Article : Google Scholar : PubMed/NCBI

24 

von Mering C, Huynen M, Jaeggi D, Schmidt S, Bork P and Snel B: STRING: A database of predicted functional associations between proteins. Nucleic Acids Res. 31:258–261. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Szklarczyk D, Morris JH, Cook H, Kuhn M, Wyder S, Simonovic M, Santos A, Doncheva NT, Roth A, Bork P, et al: The STRING database in 2017: Quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res. 45:D362–D368. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Shaul YD, Yuan B, Thiru P, Nutter-Upham A, McCallum S, Lanzkron C, Bell GW and Sabatini DM: MERAV: A tool for comparing gene expression across human tissues and cell types. Nucleic Acids Res. 44:D560–566. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Alonso L and Fuchs E: Stem cells in the skin: Waste not, Wnt not. Genes Dev. 17:1189–1200. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Monga SP: Role of Wnt/β-catenin signaling in liver metabolism and cancer. Int J Biochem Cell Biol. 43:1021–1029. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Beers MF and Morrisey EE: The three R's of lung health and disease: Repair, remodeling, and regeneration. J Clin Invest. 121:2065–2073. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Nemeth MJ, Mak KK, Yang Y and Bodine DM: Beta-Catenin expression in the bone marrow microenvironment is required for long-term maintenance of primitive hematopoietic cells. Stem Cells. 27:1109–1119. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Malhotra S and Kincade PW: Wnt-related molecules and signaling pathway equilibrium in hematopoiesis. Cell Stem Cell. 4:27–36. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Inestrosa NC and Arenas E: Emerging roles of Wnts in the adult nervous system. Nat Rev Neurosci. 11:77–86. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Polakis P: Drugging Wnt signalling in cancer. EMBO J. 31:2737–2746. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Herr P, Hausmann G and Basler K: WNT secretion and signalling in human disease. Trends Mol Med. 18:483–493. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Kikuchi A and Yamamoto H: Tumor formation due to abnormalities in the beta-catenin-independent pathway of Wnt signaling. Cancer Sci. 99:202–208. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Day TF, Guo X, Garrett-Beal L and Yang Y: Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell. 8:739–750. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Glass DA II, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA and Karsenty G: Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. 8:751–764. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Königshoff M, Balsara N, Pfaff EM, Kramer M, Chrobak I, Seeger W and Eickelberg O: Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. PLoS One. 3:e21422008. View Article : Google Scholar : PubMed/NCBI

39 

Henderson WR Jr, Chi EY, Ye X, Nguyen C, Tien YT, Zhou B, Borok Z, Knight DA and Kahn M: Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci USA. 107:14309–14314. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Akhmetshina A, Palumbo K, Dees C, Bergmann C, Venalis P, Zerr P, Horn A, Kireva T, Beyer C, Zwerina J, et al: Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis. Nat Commun. 3:7352012. View Article : Google Scholar : PubMed/NCBI

41 

Sen M, Lauterbach K, El-Gabalawy H, Firestein GS, Corr M and Carson DA: Expression and function of wingless and frizzled homologs in rheumatoid arthritis. Proc Natl Acad Sci USA. 97:2791–2796. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Nakamura Y, Nawata M and Wakitani S: Expression profiles and functional analyses of Wnt-related genes in human joint disorders. Am J Pathol. 167:97–105. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Keerthivasan S, Aghajani K, Dose M, Molinero L, Khan MW, Venkateswaran V, Weber C, Emmanuel AO, Sun T, Bentrem DJ, et al: β-catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells. Sci Transl Med. 6:225ra2282014. View Article : Google Scholar

44 

Kalkman HO: A review of the evidence for the canonical Wnt pathway in autism spectrum disorders. Mol Autism. 3:102012. View Article : Google Scholar : PubMed/NCBI

45 

De Ferrari GV, Papassotiropoulos A, Biechele T, Wavrant De-Vrieze F, Avila ME, Major MB, Myers A, Sáez K, Henríquez JP, Zhao A, et al: Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proc Natl Acad Sci USA. 104:9434–9439. 2007. View Article : Google Scholar : PubMed/NCBI

46 

García-Jiménez C: Wnt and incretin connections. Vitam Horm. 84:355–387. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Welters HJ and Kulkarni RN: Wnt signaling: Relevance to beta-cell biology and diabetes. Trends Endocrinol Metab. 19:349–355. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, et al: Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet. 38:320–323. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Kurayoshi M, Oue N, Yamamoto H, Kishida M, Inoue A, Asahara T, Yasui W and Kikuchi A: Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Res. 66:10439–10448. 2006. View Article : Google Scholar : PubMed/NCBI

50 

Schwartz AL, Malgor R, Dickerson E, Weeraratna AT, Slominski A, Wortsman J, Harii N, Kohn AD, Moon RT, Schwartz FL, et al: Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration. Clin Cancer Res. 15:4114–4122. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Li X, Placencio V, Iturregui JM, Uwamariya C, Sharif-Afshar AR, Koyama T, Hayward SW and Bhowmick NA: Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis. Oncogene. 27:7118–7130. 2008. View Article : Google Scholar : PubMed/NCBI

52 

Yoshioka S, King ML, Ran S, Okuda H, MacLean JA II, McAsey ME, Sugino N, Brard L, Watabe K and Hayashi K: WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/beta-catenin pathway. Mol Cancer Res. 10:469–482. 2012. View Article : Google Scholar : PubMed/NCBI

53 

Bitler BG, Nicodemus JP, Li H, Cai Q, Wu H, Hua X, Li T, Birrer MJ, Godwin AK, Cairns P and Zhang R: Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence. Cancer Res. 71:6184–6194. 2011. View Article : Google Scholar : PubMed/NCBI

54 

Ochoa-Hernández AB, Ramos-Solano M, Meza-Canales ID, García-Castro B, Rosales-Reynoso MA, Rosales-Aviña JA, Barrera-Chairez E, Ortíz-Lazareno PC, Hernández-Flores G, Bravo-Cuellar A, et al: Peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation. BMC Cancer. 12:602012. View Article : Google Scholar : PubMed/NCBI

55 

Sin MLY, Mach KE, Sinha R, Wu F, Trivedi DR, Altobelli E, Jensen KC, Sahoo D, Lu Y and Liao JC: Deep sequencing of urinary RNAs for bladder cancer molecular diagnostics. Clin Cancer Res. 23:3700–3710. 2017. View Article : Google Scholar : PubMed/NCBI

56 

Jiang K, Li S, Li L, Wang X, Gu Y and Jin Z: WNT6 is an effective marker for osteosarcoma diagnosis and prognosis. Medicine (Baltimore). 97:e130112018. View Article : Google Scholar : PubMed/NCBI

57 

Xu X, Sun PL, Li JZ, Jheon S, Lee CT and Chung JH: Aberrant Wnt1/β-catenin expression is an independent poor prognostic marker of non-small cell lung cancer after surgery. J Thorac Oncol. 6:716–724. 2011. View Article : Google Scholar : PubMed/NCBI

58 

Shi Q, Liu H, Han P, Li C, Wang Y, Wu W, Zhu D, Amos CI, Fang S, Lee JE, et al: Genetic variants in WNT2B and BTRC predict melanoma survival. J Invest Dermatol. 137:1749–1756. 2017. View Article : Google Scholar : PubMed/NCBI

59 

Geng M, Cao YC, Chen YJ, Jiang H, Bi LQ and Liu XH: Loss of Wnt5a and Ror2 protein in hepatocellular carcinoma associated with poor prognosis. World J Gastroenterol. 18:1328–1338. 2012. View Article : Google Scholar : PubMed/NCBI

60 

Wu ZC, Xiong L, Wang LX, Miao XY, Liu ZR, Li DQ, Zou Q, Liu KJ, Zhao H and Yang ZL: Comparative study of ROR2 and WNT5a expression in squamous/adenosquamous carcinoma and adenocarcinoma of the gallbladder. World J Gastroenterol. 23:2601–2612. 2017. View Article : Google Scholar : PubMed/NCBI

61 

Lee SE, Lim SD, Kang SY, Suh SB and Suh YL: Prognostic significance of Ror2 and Wnt5a expression in medulloblastoma. Brain Pathol. 23:445–453. 2013. View Article : Google Scholar : PubMed/NCBI

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Han Q, Wang X, Liao X, Han C, Yu T, Yang C, Li G, Han B, Huang K, Zhu G, Zhu G, et al: Diagnostic and prognostic value of WNT family gene expression in hepatitis B virus‑related hepatocellular carcinoma. Oncol Rep 42: 895-910, 2019.
APA
Han, Q., Wang, X., Liao, X., Han, C., Yu, T., Yang, C. ... Ye, X. (2019). Diagnostic and prognostic value of WNT family gene expression in hepatitis B virus‑related hepatocellular carcinoma. Oncology Reports, 42, 895-910. https://doi.org/10.3892/or.2019.7224
MLA
Han, Q., Wang, X., Liao, X., Han, C., Yu, T., Yang, C., Li, G., Han, B., Huang, K., Zhu, G., Liu, Z., Zhou, X., Su, H., Shang, L., Gong, Y., Song, X., Peng, T., Ye, X."Diagnostic and prognostic value of WNT family gene expression in hepatitis B virus‑related hepatocellular carcinoma". Oncology Reports 42.3 (2019): 895-910.
Chicago
Han, Q., Wang, X., Liao, X., Han, C., Yu, T., Yang, C., Li, G., Han, B., Huang, K., Zhu, G., Liu, Z., Zhou, X., Su, H., Shang, L., Gong, Y., Song, X., Peng, T., Ye, X."Diagnostic and prognostic value of WNT family gene expression in hepatitis B virus‑related hepatocellular carcinoma". Oncology Reports 42, no. 3 (2019): 895-910. https://doi.org/10.3892/or.2019.7224
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Spandidos Publications style
Han Q, Wang X, Liao X, Han C, Yu T, Yang C, Li G, Han B, Huang K, Zhu G, Zhu G, et al: Diagnostic and prognostic value of WNT family gene expression in hepatitis B virus‑related hepatocellular carcinoma. Oncol Rep 42: 895-910, 2019.
APA
Han, Q., Wang, X., Liao, X., Han, C., Yu, T., Yang, C. ... Ye, X. (2019). Diagnostic and prognostic value of WNT family gene expression in hepatitis B virus‑related hepatocellular carcinoma. Oncology Reports, 42, 895-910. https://doi.org/10.3892/or.2019.7224
MLA
Han, Q., Wang, X., Liao, X., Han, C., Yu, T., Yang, C., Li, G., Han, B., Huang, K., Zhu, G., Liu, Z., Zhou, X., Su, H., Shang, L., Gong, Y., Song, X., Peng, T., Ye, X."Diagnostic and prognostic value of WNT family gene expression in hepatitis B virus‑related hepatocellular carcinoma". Oncology Reports 42.3 (2019): 895-910.
Chicago
Han, Q., Wang, X., Liao, X., Han, C., Yu, T., Yang, C., Li, G., Han, B., Huang, K., Zhu, G., Liu, Z., Zhou, X., Su, H., Shang, L., Gong, Y., Song, X., Peng, T., Ye, X."Diagnostic and prognostic value of WNT family gene expression in hepatitis B virus‑related hepatocellular carcinoma". Oncology Reports 42, no. 3 (2019): 895-910. https://doi.org/10.3892/or.2019.7224
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