Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
September-2019 Volume 42 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2019 Volume 42 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Molecular mechanism of Forkhead box M1 inhibition by thiostrepton in breast cancer cells

  • Authors:
    • Mesayamas Kongsema
    • Sudtirak Wongkhieo
    • Mattaka Khongkow
    • Eric W.-F. Lam
    • Phansiri Boonnoy
    • Wanwipa Vongsangnak
    • Jirasak Wong‑Ekkabut
  • View Affiliations / Copyright

    Affiliations: Department of Zoology, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand, National Nanotechnology Centre (NANOTEC), National Science and Technology Development Agency, Pathum Thani 12120, Thailand, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK, Computational Biomodelling Laboratory for Agricultural Science and Technology (CBLAST), Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
    Copyright: © Kongsema et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 953-962
    |
    Published online on: July 8, 2019
       https://doi.org/10.3892/or.2019.7225
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Breast cancer is the most common type of malignancies in women worldwide, and genotoxic chemotherapeutic drugs are effective by causing DNA damage in cancer cells. However, >90% of patients with metastatic cancer are resistant to chemotherapy. The Forkhead box M1 (FOXM1) transcription factor plays a pivotal role in the resistance of breast cancer cells to chemotherapy by promoting DNA damage repair following genotoxic drug treatment. The aim of the present study was to investigate the inhibition of the FOXM1 protein by thiostrepton, a natural antibiotic produced by the Streptomyces species. Experimental studies were designed to examine the effectiveness of thiostrepton in downregulating FOXM1 mRNA expression and activity, leading to senescence and apoptosis of breast cancer cells. The cytotoxicity of thiostrepton in breast cancer was determined using cell viability assay. Additionally, thiostrepton treatment decreased the mRNA expression of cyclin B1 (CCNB1), a downstream target of FOXM1. The present results indicated that thiostrepton inhibited FOXM1 mRNA expression and its effect on CCNB1. Molecular dynamic simulations were performed to study the interactions between FOXM1‑DNA and thiostrepton after molecular docking. The results revealed that the possible mechanism underlying the inhibitory effect of thiostrepton on FOXM1 function was by forming a tight complex with the DNA and FOXM1 via its binding domain. Collectively, these results indicated that thiostrepton is a specific and direct inhibitor of the FOXM1 protein in breast cancer. The findings of the present study may lead to the development of novel therapeutic strategies for breast cancer and help overcome resistance to conventional chemotherapeutic drugs.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Krebs MG, Hou JM, Ward TH, Blackhall FH and Dive C: Circulating tumour cells: Their utility in cancer management and predicting outcomes. Ther Adv Med Oncol. 2:351–365. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Thorn CF, Oshiro C, Marsh S, Hernandez-Boussard T, McLeod H, Klein TE and Altman RB: Doxorubicin pathways: Pharmacodynamics and adverse effects. Pharmacogenet Genomics. 21:440–446. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Myatt SS, Kongsema M, Man CW, Kelly DJ, Gomes AR, Khongkow P, Karunarathna U, Zona S, Langer JK, Dunsby CW, et al: SUMOylation inhibits FOXM1 activity and delays mitotic transition. Oncogene. 33:4316–4329. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Khongkow P, Karunarathna U, Khongkow M, Gong C, Gomes AR, Yagüe E, Monteiro LJ, Kongsema M, Zona S, Man EP, Tsang JW, et al: FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance. Oncogene. 33:4144–4155. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Monteiro LJ, Khongkow P, Kongsema M, Morris JR, Man C, Weekes D, Koo CY, Gomes AR, Pinto PH, Varghese V, et al: The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment. Oncogene. 32:4634–4645. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Koo CY, Muir KW and Lam EW: FOXM1: From cancer initiation to progression and treatment. Biochim Biophys Acta. 1819:28–37. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Millour J, de Olano N, Horimoto Y, Monteiro LJ, Langer JK, Aligue R, Hajji N and Lam EW: ATM and p53 regulate FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance. Mol Cancer Ther. 10:1046–1058. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Karunarathna U, Kongsema M, Zona S, Gong C, Cabrera E, Gomes AR, Man EP, Khongkow P, Tsang JW, Khoo US, et al: OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance. Oncogene. 35:1433–1444. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Laoukili J, Stahl M and Medema RH: FoxM1: At the crossroads of ageing and cancer. Biochim Biophys Acta. 1775:92–102. 2007.PubMed/NCBI

10 

Nicolaou KC, Zak M, Rahimipour S, Estrada AA, Lee SH, O'Brate A, Giannakakou P and Ghadiri MR: Discovery of a biologically active thiostrepton fragment. J Am Chem Soc. 127:15042–15044. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Kwok JM, Myatt SS, Marson CM, Coombes RC, Constantinidou D and Lam EW: Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression. Mol Cancer Ther. 7:2022–2032. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Ahmed M, Hussain A, Begum R, Thangavel S, Ajarim DS, Beg S, Uddin S and Al-Kuraya KS: Abstract 55: Over-expression of FoxM1 in breast cancer can be therapeutically targeted using thiostrepton. Cancer Res. 75:55. 2015.

13 

Collado M and Serrano M: Senescence in tumours: Evidence from mice and humans. Nat Rev Cancer. 10:51–57. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Rodier F and Campisi J: Four faces of cellular senescence. J Cell Biol. 192:547–556. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Gartel AL: Thiostrepton, proteasome inhibitors and FOXM1. Cell Cycle. 10:4341–4342. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Hegde NS, Sanders DA, Rodriguez R and Balasubramanian S: The transcription factor FOXM1 is a cellular target of the natural product thiostrepton. Nat Chem. 3:725–731. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Gartel AL: Suppression of the oncogenic transcription factor FOXM1 by proteasome inhibitors. Scientifica (Cairo). 2014:5965282014.PubMed/NCBI

18 

Gartel AL: Targeting FOXM1 auto-regulation in cancer. Cancer Biol Ther. 16:185–186. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Bhat UG, Halasi M and Gartel AL: Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells. PLoS One. 4:e55922009. View Article : Google Scholar : PubMed/NCBI

20 

Gartel AL: A new target for proteasome inhibitors: FoxM1. Expert Opin Investig Drugs. 19:235–242. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Chen Y, Ruben EA, Rajadas J and Teng NN: In silico investigation of FOXM1 binding and novel inhibitors in epithelial ovarian cancer. Bioorg Med Chem. 23:4576–4582. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Gartel AL: Thiazole antibiotics siomycin a and thiostrepton inhibit the transcriptional activity of FOXM1. Front Oncol. 3:1502013. View Article : Google Scholar : PubMed/NCBI

23 

Nakamura S, Hirano I, Okinaka K, Takemura T, Yokota D, Ono T, Shigeno K, Shibata K, Fujisawa S and Ohnishi K: The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia. Carcinogenesis. 31:2012–2021. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Villa-Diaz LG, Garcia-Perez JL and Krebsbach PH: Enhanced transfection efficiency of human embryonic stem cells by the incorporation of DNA liposomes in extracellular matrix. Stem Cells Dev. 19:1949–1957. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Littler DR, Alvarez-Fernández M, Stein A, Hibbert RG, Heidebrecht T, Aloy P, Medema RH and Perrakis A: Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence. Nucleic Acids Res. 38:4527–4538. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Jonker HR, Baumann S, Wolf A, Schoof S, Hiller F, Schulte KW, Kirschner KN, Schwalbe H and Arndt HD: NMR structures of thiostrepton derivatives for characterization of the ribosomal binding site. Angew Chem Int Ed Engl. 50:3308–3312. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Malde AK, Zuo L, Breeze M, Stroet M, Poger D, Nair PC, Oostenbrink C and Mark AE: An automated force field topology builder (ATB) and repository: Version 1.0. J Chem Theory Comput. 7:4026–4037. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Canzar S, El-Kebir M, Pool R, Elbassioni K, Mark AE, Geerke DP, Stougie L and Klau GW: Charge Group Partitioning in Biomolecular Simulation. J Comput Biol. 20:188–198. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Koziara KB, Stroet M, Malde AK and Mark AE: Testing and validation of the Automated Topology Builder (ATB) version 2.0: Prediction of hydration free enthalpies. J Comput Aid Mol Des. 28:221–233. 2014. View Article : Google Scholar

30 

Trott O and Olson AJ: Software news and update AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 31:455–461. 2010.PubMed/NCBI

31 

Abraham MJ, Murtola T, Schulz R, Páll S, Smith JC, Hess B and Lindahl E: GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers. SoftwareX 1–2. 19–25. 2015. View Article : Google Scholar

32 

Oostenbrink C, Villa A, Mark AE and Van Gunsteren WF: A biomolecular force field based on the free enthalpy of hydration and solvation: The GROMOS force-field parameter sets 53A5 and 53A6. J Comput Chem. 25:1656–1676. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Berendsen HJC, Postma JPM, Gunsteren WF and Hermans J: Interaction models for water in relation to protein hydration. Intermolecular forces. Pullman B: 14. Springer; Berlin: pp. 331–334. 1981, View Article : Google Scholar

34 

Bussi G, Donadio D and Parrinello M: Canonical sampling through velocity rescaling. J Chem Phys. 126:2007. View Article : Google Scholar : PubMed/NCBI

35 

Bussi G, Zykova-Timan T and Parrinello M: Isothermal-isobaric molecular dynamics using stochastic velocity rescaling. J Chem Phys. 130:0741012009. View Article : Google Scholar : PubMed/NCBI

36 

Parrinello M and Rahman A: Polymorphic transitions in single crystals: A new molecular dynamics method. J Appl Phys. 52:1981. View Article : Google Scholar

37 

Darden T, York D and Pedersen L: Particle mesh Ewald: An N I log(N) method for Ewald sums in large systems. J Chem Phys. 98:100891993. View Article : Google Scholar

38 

Essmann U, Perera L and Berkowitz ML: A smooth particle mesh Ewald method. J Chem Phys. 103:85771995. View Article : Google Scholar

39 

Wong-Ekkabut J and Karttunen M: Assessment of common simulation protocols for simulations of nanopores, membrane proteins, and channels. J Chem Theory Comput. 8:2905–2911. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Hess B: P-LINCS: A parallel linear constraint solver for molecular simulation. J Chem Theory Comput. 4:116–122. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Humphrey W, Dalke A and Schulten K: VMD: Visual molecular dynamics. J Mol Graph. 14:33–38, 27-38. 1996. View Article : Google Scholar : PubMed/NCBI

42 

Halasi M and Gartel AL: A novel mode of FoxM1 regulation: Positive auto-regulatory loop. Cell Cycle. 8:1966–1967. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Leung TW, Lin SS, Tsang AC, Tong CS, Ching JC, Leung WY, Gimlich R, Wong GG and Yao KM: Over-expression of FoxM1 stimulates cyclin B1 expression. FEBS Lett. 507:59–66. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Liao GB, Li XZ, Zeng S, Liu C, Yang SM, Yang L, Hu CJ and Bai JY: Regulation of the master regulator FOXM1 in cancer. Cell Commun Signal. 16:572018. View Article : Google Scholar : PubMed/NCBI

45 

Kong X, Li L, Li Z, Le X, Huang C, Jia Z, Cui J, Huang S, Wang L and Xie K: Dysregulated expression of FOXM1 isoforms drives progression of pancreatic cancer. Cancer Res. 73:3987–3996. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Cheng XH, Black M, Ustiyan V, Le T, Fulford L, Sridharan A, Medvedovic M, Kalinichenko VV, Whitsett JA and Kalin TV: SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene. PLoS Genet. 10:e10046562014. View Article : Google Scholar : PubMed/NCBI

47 

Korver W, Roose J and Clevers H: The winged-helix transcription factor Trident is expressed in cycling cells. Nucleic Acids Res. 25:1715–1719. 1997. View Article : Google Scholar : PubMed/NCBI

48 

Sanders DA, Gormally MV, Marsico G, Beraldi D, Tannahill D and Balasubramanian S: FOXM1 binds directly to non-consensus sequences in the human genome. Genome Biol. 16:1302015. View Article : Google Scholar : PubMed/NCBI

49 

Tabatabaei-Dakhili SA, Aguayo-Ortiz R, Domínguez L and Velázquez-Martínez CA: Untying the knot of transcription factor druggability: Molecular modeling study of FOXM1 inhibitors. J Mol Graph Model. 80:197–210. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Van Der Spoel D, Lindahl E, Hess B, Groenhof G, Mark AE and Berendsen HJ: GROMACS: Fast, flexible, and free. J Comput Chem. 26:1701–1718. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Tassi RA, Todeschini P, Siegel ER, Calza S, Cappella P, Ardighieri L, Cadei M, Bugatti M, Romani C, Bandiera E, et al: FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients. J Exp Clin Cancer Res. 36:632017. View Article : Google Scholar : PubMed/NCBI

52 

Ye H, Kelly TF, Samadani U, Lim L, Rubio S, Overdier DG, Roebuck KA and Costa RH: Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues. Mol Cell Biol. 17:1626–1641. 1997. View Article : Google Scholar : PubMed/NCBI

53 

Yao KM, Sha M, Lu Z and Wong GG: Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain. J Biol Chem. 272:19827–19836. 1997. View Article : Google Scholar : PubMed/NCBI

54 

Gormally M, Marsico G, Rai G, Lowe C, Thomas C, Maloney D, Michael S, Matak-Vincovic D, Jadhav A, Simeonov A and Balasubramanian S: Abstract 3088: Transcription factor as target: Novel small molecule inhibits FOXM1 DNA binding and oncogenic gene products. Cancer Res. 76:3088. 2016.PubMed/NCBI

55 

Gormally MV, Dexheimer TS, Marsico G, Sanders DA, Lowe C, Matak-Vinković D, Michael S, Jadhav A, Rai G, Maloney DJ, et al: Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nat Commun. 5:51652014. View Article : Google Scholar : PubMed/NCBI

56 

Marsico G and Gormally MV: Small molecule inhibition of FOXM1: How to bring a novel compound into genomic context. Genom Data. 3:19–23. 2015. View Article : Google Scholar : PubMed/NCBI

57 

Marklund EG, Mahmutovic A, Berg OG, Hammar P, van der Spoel D, Fange D and Elf J: Transcription-factor binding and sliding on DNA studied using micro- and macroscopic models. Proc Natl Acad Sci USA. 110:19796–19801. 2013. View Article : Google Scholar : PubMed/NCBI

58 

Zhang X, Cheng L, Minn K, Madan R, Godwin AK, Shridhar V and Chien J: Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells. Oncotarget. 5:11365–11380. 2014.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kongsema M, Wongkhieo S, Khongkow M, Lam EW, Boonnoy P, Vongsangnak W and Wong‑Ekkabut J: Molecular mechanism of Forkhead box M1 inhibition by thiostrepton in breast cancer cells. Oncol Rep 42: 953-962, 2019.
APA
Kongsema, M., Wongkhieo, S., Khongkow, M., Lam, E.W., Boonnoy, P., Vongsangnak, W., & Wong‑Ekkabut, J. (2019). Molecular mechanism of Forkhead box M1 inhibition by thiostrepton in breast cancer cells. Oncology Reports, 42, 953-962. https://doi.org/10.3892/or.2019.7225
MLA
Kongsema, M., Wongkhieo, S., Khongkow, M., Lam, E. W., Boonnoy, P., Vongsangnak, W., Wong‑Ekkabut, J."Molecular mechanism of Forkhead box M1 inhibition by thiostrepton in breast cancer cells". Oncology Reports 42.3 (2019): 953-962.
Chicago
Kongsema, M., Wongkhieo, S., Khongkow, M., Lam, E. W., Boonnoy, P., Vongsangnak, W., Wong‑Ekkabut, J."Molecular mechanism of Forkhead box M1 inhibition by thiostrepton in breast cancer cells". Oncology Reports 42, no. 3 (2019): 953-962. https://doi.org/10.3892/or.2019.7225
Copy and paste a formatted citation
x
Spandidos Publications style
Kongsema M, Wongkhieo S, Khongkow M, Lam EW, Boonnoy P, Vongsangnak W and Wong‑Ekkabut J: Molecular mechanism of Forkhead box M1 inhibition by thiostrepton in breast cancer cells. Oncol Rep 42: 953-962, 2019.
APA
Kongsema, M., Wongkhieo, S., Khongkow, M., Lam, E.W., Boonnoy, P., Vongsangnak, W., & Wong‑Ekkabut, J. (2019). Molecular mechanism of Forkhead box M1 inhibition by thiostrepton in breast cancer cells. Oncology Reports, 42, 953-962. https://doi.org/10.3892/or.2019.7225
MLA
Kongsema, M., Wongkhieo, S., Khongkow, M., Lam, E. W., Boonnoy, P., Vongsangnak, W., Wong‑Ekkabut, J."Molecular mechanism of Forkhead box M1 inhibition by thiostrepton in breast cancer cells". Oncology Reports 42.3 (2019): 953-962.
Chicago
Kongsema, M., Wongkhieo, S., Khongkow, M., Lam, E. W., Boonnoy, P., Vongsangnak, W., Wong‑Ekkabut, J."Molecular mechanism of Forkhead box M1 inhibition by thiostrepton in breast cancer cells". Oncology Reports 42, no. 3 (2019): 953-962. https://doi.org/10.3892/or.2019.7225
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team