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Synergistic combination of chemo‑phototherapy based on temozolomide/ICG‑loaded iron oxide nanoparticles for brain cancer treatment

  • Authors:
    • Young Min Kwon
    • Jae‑Young Je
    • Seung Heon Cha
    • Yunok Oh
    • Won Ho Cho
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Dong‑A University College of Medicine and Dong‑A Medical Center, Busan 49201, Republic of Korea, Department of Marine‑Bio Convergence Science, Pukyong National University, Busan 48547, Republic of Korea, Department of Neurosurgery and Medical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Busan 49241, Republic of Korea
    Copyright: © Kwon et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1709-1724
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    Published online on: August 21, 2019
       https://doi.org/10.3892/or.2019.7289
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Abstract

Chemo‑photothermal therapy for cancer treatment has received increasing attention due to its selective therapeutic effects. In the present study, the anticancer effects of drug‑loaded Fe3O4 magnetic nanoparticles (MNPs) by chemo‑photothermal therapy on U‑87 MG human glioblastoma cells was investigated. Anticancer drug‑loaded Fe3O4 MNPs were prepared by loading temozolomide (TMZ) and indocyanine green (ICG), and were characterized by X‑ray diffraction, UV‑vis spectroscopy, thermal gravimetric analysis, transmission electron microscope, as well as drug‑loading capacity. Following treatment with near‑infrared (NIR) light irradiation, the administration of Fe3O4‑TMZ‑ICG MNPs resulted in the apoptosis of U‑87 MG glioblastoma cells through the generation of reactive oxygen species. Western blot analysis and reverse transcription‑quantitative polymerase chain reaction revealed that Fe3O4‑TMZ‑ICG MNPs with NIR laser irradiation lead to significantly enhanced anticancer effects on U‑87 MG glioblastoma cells through the modulation of intrinsic and extrinsic apoptosis genes, including Bcl‑2‑associated X protein, Bcl‑2, cytochrome c, caspase‑3, Fas associated via death domain and caspase‑8. These results suggest that Fe3O4‑TMZ‑ICG MNPs may be potential candidates when administered as chemo‑phototherapy for the treatment of brain cancer.
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Kwon YM, Je JY, Cha SH, Oh Y and Cho WH: Synergistic combination of chemo‑phototherapy based on temozolomide/ICG‑loaded iron oxide nanoparticles for brain cancer treatment. Oncol Rep 42: 1709-1724, 2019.
APA
Kwon, Y.M., Je, J., Cha, S.H., Oh, Y., & Cho, W.H. (2019). Synergistic combination of chemo‑phototherapy based on temozolomide/ICG‑loaded iron oxide nanoparticles for brain cancer treatment. Oncology Reports, 42, 1709-1724. https://doi.org/10.3892/or.2019.7289
MLA
Kwon, Y. M., Je, J., Cha, S. H., Oh, Y., Cho, W. H."Synergistic combination of chemo‑phototherapy based on temozolomide/ICG‑loaded iron oxide nanoparticles for brain cancer treatment". Oncology Reports 42.5 (2019): 1709-1724.
Chicago
Kwon, Y. M., Je, J., Cha, S. H., Oh, Y., Cho, W. H."Synergistic combination of chemo‑phototherapy based on temozolomide/ICG‑loaded iron oxide nanoparticles for brain cancer treatment". Oncology Reports 42, no. 5 (2019): 1709-1724. https://doi.org/10.3892/or.2019.7289
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Spandidos Publications style
Kwon YM, Je JY, Cha SH, Oh Y and Cho WH: Synergistic combination of chemo‑phototherapy based on temozolomide/ICG‑loaded iron oxide nanoparticles for brain cancer treatment. Oncol Rep 42: 1709-1724, 2019.
APA
Kwon, Y.M., Je, J., Cha, S.H., Oh, Y., & Cho, W.H. (2019). Synergistic combination of chemo‑phototherapy based on temozolomide/ICG‑loaded iron oxide nanoparticles for brain cancer treatment. Oncology Reports, 42, 1709-1724. https://doi.org/10.3892/or.2019.7289
MLA
Kwon, Y. M., Je, J., Cha, S. H., Oh, Y., Cho, W. H."Synergistic combination of chemo‑phototherapy based on temozolomide/ICG‑loaded iron oxide nanoparticles for brain cancer treatment". Oncology Reports 42.5 (2019): 1709-1724.
Chicago
Kwon, Y. M., Je, J., Cha, S. H., Oh, Y., Cho, W. H."Synergistic combination of chemo‑phototherapy based on temozolomide/ICG‑loaded iron oxide nanoparticles for brain cancer treatment". Oncology Reports 42, no. 5 (2019): 1709-1724. https://doi.org/10.3892/or.2019.7289
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