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Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer

  • Authors:
    • Jiao Wang
    • Zhi‑Guo Hu
    • Dan Li
    • Ji‑Xion Xu
    • Zhen‑Guo Zeng
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Critical Care Medicine, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia 010017, P.R. China, Department of Respiratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Critical Care Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Pages: 1981-1995
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    Published online on: September 16, 2019
       https://doi.org/10.3892/or.2019.7314
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Abstract

Lung cancer is the leading cause of cancer mortality worldwide. Approximately 85% of all lung cancer cases are classified as non‑small cell lung cancer (NSCLC). Currently, there is no standard method to predict the survival of patients with NSCLC. Insulin‑like growth factor‑binding proteins (IGFBPs) function as modulators of IGF signaling and are attracting increasing attention for their role in NSCLC. However, the prognostic values of individual IGFBPs in NSCLC, particularly at the mRNA level, remain unknown. In the present study, the distinct expression patterns and prognostic values of IGFBP family members in patients with NSCLC through bioinformatics analysis were reported using a series of databases, including Gene Expression Profiling Interactive Analysis, Kaplan‑Meier Plotter, cBioPortal, GeneMANIA, and the Database for Annotation, Visualization and Integrated Discovery. In patients with NSCLC, IGFBP2 and IGFBP3 were significantly upregulated, while IGFBP6 was downregulated. High IGFBP1/2/4 expression was correlated with poor overall survival (OS) in all NSCLC types, especially adenocarcinoma; however, high IGFBP2/5 expression was significantly correlated with favorable OS only in patients with squamous cell carcinoma. In addition, aberrant IGFBP1/2/3/4/5 mRNA levels were associated with the prognosis of subsets of NSCLC with different clinicopathological features. These results indicated that various IGFBPs can serve as useful prognostic biomarkers and as potential targets for NSCLC therapies.
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View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

3 

van Meerbeeck JP, Fennell DA and De Ruysscher DK: Small-cell lung cancer. Lancet. 378:1741–1755. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Liu W, Ha M and Yin N: Combination of platelet count and lymphocyte to monocyte ratio is a prognostic factor in patients undergoing surgery for non-small cell lung cancer. Oncotarget. 8:73198–73207. 2017.PubMed/NCBI

5 

Jones JI and Clemmons DR: Insulin-like growth factors and their binding proteins: Biological actions. Endocr Rev. 16:3–34. 1995. View Article : Google Scholar : PubMed/NCBI

6 

Le Roith D: Seminars in medicine of the Beth Israel deaconess medical center. Insulin-like growth factors. N Engl J Med. 336:633–640. 1997. View Article : Google Scholar : PubMed/NCBI

7 

LeRoith D: Insulin-like growth factor receptors and binding proteins. Baillieres Clin Endocrinol Metab. 10:49–73. 1996. View Article : Google Scholar : PubMed/NCBI

8 

Clemmons DR: Insulin-like growth factor binding proteins and their role in controlling IGF actions. Cytokine Growth Factor Rev. 8:45–62. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Hu Q, Zhou Y, Ying K and Ruan W: IGFBP, a novel target of lung cancer? Clin Chim Acta. 466:172–177. 2017. View Article : Google Scholar : PubMed/NCBI

10 

He Y, Zhou Z, Hofstetter WL, Zhou Y, Hu W, Guo C, Wang L, Guo W, Pataer A, Correa AM, et al: Aberrant expression of proteins involved in signal transduction and DNA repair pathways in lung cancer and their association with clinical parameters. PLoS One. 7:e310872012. View Article : Google Scholar : PubMed/NCBI

11 

Guo C, Lu H, Gao W, Wang L, Lu K, Wu S, Pataer A, Huang M, El-Zein R, Lin T, et al: Insulin-like growth factor binding protein-2 level is increased in blood of lung cancer patients and associated with poor survival. PLoS One. 8:e749732013. View Article : Google Scholar : PubMed/NCBI

12 

Lee DY, Kim SJ and Lee YC: Serum insulin-like growth factor (IGF)-I and IGF-binding proteins in lung cancer patients. J Korean Med Sci. 14:401–404. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Wang Z, Wang Z, Liang Z, Liu J, Shi W, Bai P, Lin X, Magaye R and Zhao J: Expression and clinical significance of IGF-1, IGFBP-3, and IGFBP-7 in serum and lung cancer tissues from patients with non-small cell lung cancer. Onco Targets Ther. 6:1437–1444. 2013.PubMed/NCBI

14 

Zhang Y, Ying X, Han S, Wang J, Zhou X, Bai E, Zhang J and Zhu Q: Autoantibodies against insulin-like growth factor-binding protein-2 as a serological biomarker in the diagnosis of lung cancer. Int J Oncol. 42:93–100. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Chang YS, Kong G, Sun S, Liu D, El-Naggar AK, Khuri FR, Hong WK and Lee HY: Clinical significance of insulin-like growth factor-binding protein-3 expression in stage I non-small cell lung cancer. Clin Cancer Res. 8:3796–3802. 2002.PubMed/NCBI

16 

Kubasiak JC, Seder CW, Pithadia R, Basu S, Fhied C, Phillips WW, Daly S, Shersher DD, Yoder MA, Chmielewski G, et al: Value of circulating insulin-like growth factor-associated proteins for the detection of stage I non-small cell lung cancer. J Thorac Cardiovasc Surg. 149:727–734.e1-3. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Cao H, Wang G, Meng L, Shen H, Feng Z, Liu Q and Du J: Association between circulating levels of IGF-1 and IGFBP-3 and lung cancer risk: A meta-analysis. PLoS One. 7:e498842012. View Article : Google Scholar : PubMed/NCBI

18 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profling and interactive analyses. Nucleic Acids Res. 45((W1)): W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, et al: Proteomics. Tissue-based map of the human proteome. Science. 347:12604192015. View Article : Google Scholar : PubMed/NCBI

20 

Gyorffy B, Lánczky A and Szállási Z: Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovariancancer using microarray data from 1287 patients. Endocr Relat Cancer. 19:197–208. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Montojo J, Zuberi K, Rodriguez H, Bader GD and Morris Q: GeneMANIA: Fast gene network construction and function prediction for Cytoscape. F1000Res. 3:1532014. View Article : Google Scholar : PubMed/NCBI

23 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Huang da W, Sherman BT and Lempicki RA: Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37:1–13. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Baxter RC: IGF binding proteins in cancer: Mechanistic and clinical insights. Nat Rev Cancer. 14:329–341. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Ammoun S, Schmid MC, Zhou L, Ristic N, Ercolano E, Hilton DA, Perks CM and Hanemann CO: Insulin-like growth factor-binding protein-1 (IGFBP-1) regulates human schwannoma proliferation, adhesion and survival. Oncogene. 31:1710–1722. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Figueroa JA, Sharma J, Jackson JG, McDermott MJ, Hilsenbeck SG and Yee D: Recombinant insulin-like growth factor binding protein-1 inhibits IGF-I, serum, and estrogen-dependent growth of MCF-7 human breast cancer cells. J Cell Physiol. 157:229–236. 1993. View Article : Google Scholar : PubMed/NCBI

28 

Yamada H, Iijima K, Tomita O, Taguchi T, Miharu M, Kobayashi K, Okita H, Saito M, Shimizu T and Kiyokawa N: Effects of insulin-like growth factor-1 on B-cell precursor acute lymphoblastic leukemia. Int J Hematol. 97:73–82. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Leu JI, Crissey MA and Taub R: Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice. J Clin Invest. 111:129–139. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Sharma J, Gray KP, Evan C, Nakabayashi M, Fichorova R, Rider J, Mucci L, Kantoff PW and Sweeney CJ: Elevated insulin-like growth factor binding protein-1 (IGFBP-1) in men with metastatic prostate cancer starting androgen deprivation therapy (ADT) is associated with shorter time to castration resistance and overall survival. Prostate. 74:225–234. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Cao Y, Nimptsch K, Shui IM, Platz EA, Wu K, Pollak MN, Kenfield SA, Stampfer MJ and Giovannucci EL: Prediagnostic plasma IGFBP-1, IGF-1 and risk of prostate cancer. Int J Cancer. 136:2418–2426. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Yao X, Sun S, Zhou X, Guo W and Zhang L: IGF-binding protein 2 is a candidate target of therapeutic potential in cancer. Tumour Biol. 37:1451–1459. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Maciejczyk A, Szelachowska J, Czapiga B, Matkowski R, Hałoń A, Györffy B and Surowiak P: Elevated BUBR1 expression is associated with poor survival in early breast cancer patients: 15-year follow-up analysis. J Histochem Cytochem. 61:330–339. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Reeve JG, Morgan J, Schwander J and Bleehen NM: Role for membrane and secreted insulin-like growth factor-binding protein-2 in the regulation of insulin-like growth factor action in lung tumors. Cancer Res. 53:4680–4685. 1993.PubMed/NCBI

35 

Yazawa T, Sato H, Shimoyamada H, Okudela K, Woo T, Tajiri M, Ogura T, Ogawa N, Suzuki T, Mitsui H, et al: Neuroendocrine cancer-specific up-regulating mechanism of insulin-like growth factor binding protein-2 in small cell lung cancer. Am J Pathol. 175:976–987. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Fürstenberger G and Senn HJ: Insulin-like growth factors and cancer. Lancet Oncol. 3:298–302. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Lee HY, Chun KH, Liu B, Wiehle SA, Cristiano RJ, Hong WK, Cohen P and Kurie JM: Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer. Cancer Res. 62:3530–3537. 2002.PubMed/NCBI

38 

Alami N, Page V, Yu Q, Jerome L, Paterson J, Shiry L and Leyland-Jones B: Recombinant human insulin-like growth factor-binding protein 3 inhibits tumor growth and targets the Akt pathway in lung and colon cancer models. Growth Horm IGF Res. 18:487–496. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Hochscheid R, Jaques G and Wegmann B: Transfection of human insulin-like growth factor-binding protein 3 gene inhibits cell growth and tumorigenicity: A cell culture model for lung cancer. J Endocrinol. 166:553–563. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Kim JH, Choi DS, Lee OH, Oh SH, Lippman SM and Lee HY: Antiangiogenic antitumor activities of IGFBP-3 are mediated by IGF-independent suppression of Erk1/2 activation and Egr-1-mediated transcriptional events. Blood. 118:2622–2631. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Wang HH, Wang YC, Wu DW, Hung CS, Chen CY and Lee H: Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer. Tumour Biol. 39:10104283176943162017.PubMed/NCBI

42 

Han JY, Choi BG, Choi JY, Lee SY and Ju SY: The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small cell lung cancer. Lung Cancer. 54:227–234. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Walker G, MacLeod K, Williams AR, Cameron DA, Smyth JF and Langdon SP: Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer. Clin Cancer Res. 13:1438–1444. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Butt AJ, Dickson KA, McDougall F and Baxter RC: Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo. J Biol Chem. 278:29676–29685. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Tanno B, Cesi V, Vitali R, Sesti F, Giuffrida ML, Mancini C, Calabretta B and Raschellà G: Silencing of endogenous IGFBP-5 by micro RNA interference affects proliferation, apoptosis and differentiation of neuroblastoma cells. Cell Death Differ. 12:213–223. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Johnson SK and Haun RS: Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth. World J Gastroenterol. 15:3355–3366. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Yao R, Wang Y, Lubet RA and You M: Differentially expressed genes associated with mouse lung tumor progression. Oncogene. 21:5814–5821. 2002. View Article : Google Scholar : PubMed/NCBI

48 

Sueoka N, Lee HY, Wiehle S, Cristiano RJ, Fang B, Ji L, Roth JA, Hong WK, Cohen P and Kurie JM: Insulin-like growth factor binding protein-6 activates programmed cell death in non-small cell lung cancer cells. Oncogene. 19:4432–4436. 2000. View Article : Google Scholar : PubMed/NCBI

49 

Koyama N, Zhang J, Huqun, Miyazawa H, Tanaka T, Su X and Hagiwara K: Identification of IGFBP-6 as an effector of the tumor suppressor activity of SEMA3B. Oncogene. 27:6581–6589. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Kannan K, Amariglio N, Rechavi G, Jakob-Hirsch J, Kela I, Kaminski N, Getz G, Domany E and Givol D: DNA microarrays identification of primary and secondary target genes regulated by p53. Oncogene. 20:2225–2234. 2001. View Article : Google Scholar : PubMed/NCBI

51 

Bartram I, Erben U, Ortiz-Tanchez J, Blunert K, Schlee C, Neumann M, Heesch S and Baldus CD: Inhibition of IGF1-R overcomes IGFBP7-induced chemotherapy resistance in T-ALL. BMC Cancer. 15:6632015. View Article : Google Scholar : PubMed/NCBI

52 

Gutschner T, Hämmerle M, Pazaitis N, Bley N, Fiskin E, Uckelmann H, Heim A, Groβ M, Hofmann N, Geffers R, et al: Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma. Hepatology. 59:1900–1911. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Kirkner GJ, Fuchs CS and Ogino S: IGFBP3 promoter methylation in colorectal cancer: Relationship with microsatellite instability, CpG island methylator phenotype, and p53. Neoplasia. 9:1091–1098. 2007. View Article : Google Scholar : PubMed/NCBI

54 

Bialous SA and Sarna L: Lung cancer and tobacco: What is new? Nurs Clin North Am. 52:53–63. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Hu ZG, Li D, Xu JX and Zeng ZG: Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer. Oncol Rep 42: 1981-1995, 2019.
APA
Wang, J., Hu, Z., Li, D., Xu, J., & Zeng, Z. (2019). Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer. Oncology Reports, 42, 1981-1995. https://doi.org/10.3892/or.2019.7314
MLA
Wang, J., Hu, Z., Li, D., Xu, J., Zeng, Z."Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer". Oncology Reports 42.5 (2019): 1981-1995.
Chicago
Wang, J., Hu, Z., Li, D., Xu, J., Zeng, Z."Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer". Oncology Reports 42, no. 5 (2019): 1981-1995. https://doi.org/10.3892/or.2019.7314
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Hu ZG, Li D, Xu JX and Zeng ZG: Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer. Oncol Rep 42: 1981-1995, 2019.
APA
Wang, J., Hu, Z., Li, D., Xu, J., & Zeng, Z. (2019). Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer. Oncology Reports, 42, 1981-1995. https://doi.org/10.3892/or.2019.7314
MLA
Wang, J., Hu, Z., Li, D., Xu, J., Zeng, Z."Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer". Oncology Reports 42.5 (2019): 1981-1995.
Chicago
Wang, J., Hu, Z., Li, D., Xu, J., Zeng, Z."Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer". Oncology Reports 42, no. 5 (2019): 1981-1995. https://doi.org/10.3892/or.2019.7314
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