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Article

A novel therapeutic anti‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells

  • Authors:
    • So Hee Dho
    • Eun Ha Cho
    • Ji Yeon Lee
    • So‑Young Lee
    • Sung Hee Jung
    • Lark Kyun Kim
    • Jae Cheong Lim
  • View Affiliations / Copyright

    Affiliations: Radioisotope Research Division, Department of Research Reactor Utilization, Korea Atomic Energy Research Institute, Daejeon 34057, Republic of Korea, Severance Biomedical Science Institute and BK21 PLUS Project for Medical Sciences, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06230, Republic of Korea
  • Pages: 2686-2693
    |
    Published online on: September 26, 2019
       https://doi.org/10.3892/or.2019.7337
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Abstract

In recent years, efforts to treat cancer by improving the immune function of patients have received a great deal of attention. As part of the immune system, complement is also under such evaluation. Among the many components of the complement system, complement decay accelerating factor (CD55 or DAF) is known to inhibit complement‑mediated cell lysis. However, little is known about the role of CD55 in terms of cancer therapy. The present study aimed to demonstrate that increased levels of CD55 are strongly correlated with the progression of colorectal cancer. A novel CD55 chimeric monoclonal antibody was developed that may boost the immune response, thereby suppressing cancer. The CD55 antibody treatment activated complement and therefore suppressed the proliferation, invasion and migration of colorectal cancer cells. This tumoricidal activity is partly explained by the inflammatory response via the activation of proinflammatory cytokines. In addition, the CD55 antibody treatment synergistically enhanced the tumoricidal activity of 5‑FU in colorectal cancer cells, suggesting that combined treatment may be a better strategy in colorectal cancer therapy.
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1 

Ansell SM, Lesokhin AM, Borrello I, Halwani A, Scott EC, Gutierrez M, Schuster SJ, Millenson MM, Cattry D, Freeman GJ, et al: PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N Engl J Med. 372:311–319. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Garon EB, Rizvi NA, Hui R, Leighl N, Balmanoukian AS, Eder JP, Patnaik A, Aggarwal C, Gubens M, Horn L, et al: Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med. 372:2018–2028. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Macor P and Tedesco F: Complement as effector system in cancer immunotherapy. Immunol Lett. 111:6–13. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Pawluczkowycz AW, Beurskens FJ, Beum PV, Lindorfer MA, van de Winkel JG, Parren PW and Taylor RP: Binding of submaximal C1q promotes complement-dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): Considerably higher levels of CDC are induced by OFA than by RTX. J Immunol. 183:749–758. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Meyer S, Leusen JH and Boross P: Regulation of complement and modulation of its activity in monoclonal antibody therapy of cancer. MAbs. 6:1133–1144. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Szebeni J, Alving CR, Savay S, Barenholz Y, Priev A, Danino D and Talmon Y: Formation of complement-activating particles in aqueous solutions of Taxol: Possible role in hypersensitivity reactions. Int Immunopharmacol. 1:721–735. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Gilbert RD, Stanley LK, Fowler DJ, Angus EM, Hardy SA and Goodship TH: Cisplatin-induced haemolytic uraemic syndrome associated with a novel intronic mutation of CD46 treated with eculizumab. Clin Kidney J. 6:421–425. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Spendlove I, Ramage JM, Bradley R, Harris C and Durrant LG: Complement decay accelerating factor (DAF)/CD55 in cancer. Cancer Immunol Immunother. 55:987–995. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Li L, Spendlove I, Morgan J and Durrant LG: CD55 is over-expressed in the tumour environment. Br J Cancer. 84:80–86. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Durrant LG, Doran M, Austin EB and Robins RA: Induction of cellular immune responses by a murine monoclonal anti-idiotypic antibody recognizing the 791Tgp72 antigen expressed on colorectal, gastric and ovarian human tumours. Int J Cancer. 61:62–66. 1995. View Article : Google Scholar : PubMed/NCBI

11 

Dho SH, Kim SY, Chung C, Cho EH, Lee SY, Kim JY, Kim LK, Min SW, Lee J, Jung SH and Lim JC: Development of a radionuclide-labeled monoclonal anti-CD55 antibody with theranostic potential in pleural metastatic lung cancer. Sci Rep. 8:89602018. View Article : Google Scholar : PubMed/NCBI

12 

Thorsteinsson L, O'Dowd GM, Harrington PM and Johnson PM: The complement regulatory proteins CD46 and CD59, but not CD55, are highly expressed by glandular epithelium of human breast and colorectal tumour tissues. APMIS. 106:869–878. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Marisa L, de Reyniès A, Duval A, Selves J, Gaub MP, Vescovo L, Etienne-Grimaldi MC, Schiappa R, Guenot D, Ayadi M, et al: Gene expression classification of colon cancer into molecular subtypes: Characterization, validation, and prognostic value. PLoS Med. 10:e10014532013. View Article : Google Scholar : PubMed/NCBI

14 

Timmermann B, Kerick M, Roehr C, Fischer A, Isau M, Boerno ST, Wunderlich A, Barmeyer C, Seemann P, Koenig J, et al: Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis. PLoS One. 5:e156612010. View Article : Google Scholar : PubMed/NCBI

15 

Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, Skora AD, Luber BS, Azad NS, Laheru D, et al: PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 372:2509–2520. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, et al: Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 366:2443–2454. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Gustavsson B, Carlsson G, Machover D, Petrelli N, Roth A, Schmoll HJ, Tveit KM and Gibson F: A review of the evolution of systemic chemotherapy in the management of colorectal cancer. Clin Colorectal Cancer. 14:1–10. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Russo A, Maiolino S, Pagliara V, Ungaro F, Tatangelo F, Leone A, Scalia G, Budillon A, Quaglia F and Russo G: Enhancement of 5-FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles. Oncotarget. 7:79670–79687. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Modest DP, Neumann UP and Pratschke J: FOLFOXIRI plus bevacizumab as conversion-therapy for liver metastases in colorectal cancer: A necessity? Eur J Cancer. 73:71–73. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Launay M, Dahan L, Duval M, Rodallec A, Milano G, Duluc M, Lacarelle B, Ciccolini J and Seitz JF: Beating the odds: Efficacy and toxicity of dihydropyrimidine dehydrogenase-driven adaptive dosing of 5-FU in patients with digestive cancer. Br J Clin Pharmacol. 81:124–130. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Bamford S, Dawson E, Forbes S, Clements J, Pettett R, Dogan A, Flanagan A, Teague J, Futreal PA, Stratton MR and Wooster R: The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br J Cancer. 91:355–358. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Shin G, Kang TW, Yang S, Baek SJ, Jeong YS and Kim SY: GENT: Gene expression database of normal and tumor tissues. Cancer Inform. 10:149–157. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Kim HY: Analysis of variance (ANOVA) comparing means of more than two groups. Restor Dent Endod. 39:74–77. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Nakagawa M, Mizuno M, Kawada M, Uesu T, Nasu J, Takeuchi K, Okada H, Endo Y, Fujita T and Tsuji T: Polymorphic expression of decay-accelerating factor in human colorectal cancer. J Gastroenterol Hepatol. 16:184–189. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Koretz K, Brüderlein S, Henne C and Möller P: Decay-accelerating factor (DAF, CD55) in normal colorectal mucosa, adenomas and carcinomas. Br J Cancer. 66:810–814. 1992. View Article : Google Scholar : PubMed/NCBI

26 

Niehans GA, Cherwitz DL, Staley NA, Knapp DJ and Dalmasso AP: Human carcinomas variably express the complement inhibitory proteins CD46 (membrane cofactor protein), CD55 (decay-accelerating factor), and CD59 (protectin). Am J Pathol. 149:129–142. 1996.PubMed/NCBI

27 

Liu J, Miwa T, Hilliard B, Chen Y, Lambris JD, Wells AD and Song WC: The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo. J Exp Med. 201:567–577. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Mikesch JH, Schier K, Roetger A, Simon R, Buerger H and Brandt B: The expression and action of decay-accelerating factor (CD55) in human malignancies and cancer therapy. Cell Oncol. 28:223–232. 2006.PubMed/NCBI

29 

Zhao WP, Zhu B, Duan YZ and Chen ZT: Neutralization of complement regulatory proteins CD55 and CD59 augments therapeutic effect of herceptin against lung carcinoma cells. Oncol Rep. 21:1405–1411. 2009.PubMed/NCBI

30 

Boire A, Zou Y, Shieh J, Macalinao DG, Pentsova E and Massagué J: Complement component 3 adapts the cerebrospinal fluid for leptomeningeal metastasis. Cell. 168:1101.e13–1113.e13. 2017. View Article : Google Scholar

31 

Kir S, White JP, Kleiner S, Kazak L, Cohen P, Baracos VE and Spiegelman BM: Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature. 513:100–104. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Morgan J, Spendlove I and Durrant LG: The role of CD55 in protecting the tumour environment from complement attack. Tissue Antigens. 60:213–223. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Egan ES, Jiang RH, Moechtar MA, Barteneva NS, Weekes MP, Nobre LV, Gygi SP, Paulo JA, Frantzreb C, Tani Y, et al: Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion. Science. 348:711–714. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Ozen A, Comrie WA, Ardy RC, Domínguez Conde C, Dalgic B, Beser ÖF, Morawski AR, Karakoc-Aydiner E, Tutar E, Baris S, et al: CD55 deficiency, early-onset protein-losing enteropathy, and thrombosis. N Engl J Med. 377:52–61. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Visser L, de Vos AF, Hamann J, Melief MJ, van Meurs M, van Lier RA, Laman JD and Hintzen RQ: Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis. J Neuroimmunol. 132:156–163. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Hillmen P, Young NS, Schubert J, Brodsky RA, Socié G, Muus P, Röth A, Szer J, Elebute MO, Nakamura R, et al: The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med. 355:1233–1243. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dho SH, Cho EH, Lee JY, Lee SY, Jung SH, Kim LK and Lim JC: A novel therapeutic anti‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells. Oncol Rep 42: 2686-2693, 2019.
APA
Dho, S.H., Cho, E.H., Lee, J.Y., Lee, S., Jung, S.H., Kim, L.K., & Lim, J.C. (2019). A novel therapeutic anti‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells. Oncology Reports, 42, 2686-2693. https://doi.org/10.3892/or.2019.7337
MLA
Dho, S. H., Cho, E. H., Lee, J. Y., Lee, S., Jung, S. H., Kim, L. K., Lim, J. C."A novel therapeutic anti‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells". Oncology Reports 42.6 (2019): 2686-2693.
Chicago
Dho, S. H., Cho, E. H., Lee, J. Y., Lee, S., Jung, S. H., Kim, L. K., Lim, J. C."A novel therapeutic anti‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells". Oncology Reports 42, no. 6 (2019): 2686-2693. https://doi.org/10.3892/or.2019.7337
Copy and paste a formatted citation
x
Spandidos Publications style
Dho SH, Cho EH, Lee JY, Lee SY, Jung SH, Kim LK and Lim JC: A novel therapeutic anti‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells. Oncol Rep 42: 2686-2693, 2019.
APA
Dho, S.H., Cho, E.H., Lee, J.Y., Lee, S., Jung, S.H., Kim, L.K., & Lim, J.C. (2019). A novel therapeutic anti‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells. Oncology Reports, 42, 2686-2693. https://doi.org/10.3892/or.2019.7337
MLA
Dho, S. H., Cho, E. H., Lee, J. Y., Lee, S., Jung, S. H., Kim, L. K., Lim, J. C."A novel therapeutic anti‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells". Oncology Reports 42.6 (2019): 2686-2693.
Chicago
Dho, S. H., Cho, E. H., Lee, J. Y., Lee, S., Jung, S. H., Kim, L. K., Lim, J. C."A novel therapeutic anti‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells". Oncology Reports 42, no. 6 (2019): 2686-2693. https://doi.org/10.3892/or.2019.7337
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