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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2019 Volume 42 Issue 6

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

CAR T cell therapy: A new era for cancer treatment (Review)

Rimjhim Mohanty, Chitran Roy Chowdhury, Solomon Arega, Prakriti Sen, Pooja Ganguly, Niladri Ganguly
Pages: 2183-2195
Published online on: 24 September 2019

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Review

Cytotoxicity of Cichorium intybus L. metabolites (Review)

Khandaker Md Sharif Uddin Imam, Yingying Xie, Yusi Liu, Fengzhong Wang, Fengjiao Xin
Pages: 2196-2212
Published online on: 24 September 2019

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Review

Ibrutinib in CLL/SLL: From bench to bedside (Review)

Fuming Zi, Li Yu, Qingzhi Shi, Aiping Tang, Jing Cheng
Pages: 2213-2227
Published online on: 10 October 2019

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Review Open Access

Role of anabolic agents in colorectal carcinogenesis: Myths and realities (Review)

Theodore Krasanakis, Taxiarchis Konstantinos Nikolouzakis, Markos Sgantzos, Theodore Mariolis‑Sapsakos, John Souglakos, Demetrios A. Spandidos, Christina Tsitsimpikou, Aristidis Tsatsakis, John Tsiaoussis
Pages: 2228-2244
Published online on: 03 October 2019

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Article Open Access

Apurinic endonuclease 1 promotes the cisplatin resistance of lung cancer cells by inducing Parkin‑mediated mitophagy

Zheng Li, Yongqiang Wang, Linbo Wu, Yalu Dong, Jing Zhang, Fan Chen, Wei Xie, Jianguo Huang, Ning Lu
Pages: 2245-2254
Published online on: 01 October 2019

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Article Open Access

Genetic interactions between ANLN and KDR are prognostic for breast cancer survival

Xiaofeng Dai, Xiao Chen, Olivier Hakizimana, Yi Mei
Pages: 2255-2266
Published online on: 24 September 2019

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Article Open Access

Activation of the Toll‑like receptor 2 signaling pathway inhibits the proliferation of HCC cells in vitro

Yi Chen, Zuxiong Huang, Xuzheng Chen, Hanhui Ye
Pages: 2267-2278
Published online on: 27 September 2019

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Article Open Access

Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma

Shu Li, Zhou Jiang, Yirun Li, Yang Xu
Pages: 2279-2292
Published online on: 23 September 2019

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Article Open Access

p53 deficiency augments nucleolar instability after ionizing irradiation

Sangeeta Kakoti, Motohiro Yamauchi, Wenchao Gu, Reona Kato, Takaaki Yasuhara, Yoshihiko Hagiwara, Siddhartha Laskar, Takahiro Oike, Hiro Sato, Kathryn D. Held, Takashi Nakano, Atsushi Shibata
Pages: 2293-2302
Published online on: 27 September 2019

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Article Open Access

Mutations of RAS genes in endometrial polyps

Takashi Takeda, Kouji Banno, Yusuke Kobayashi, Masataka Adachi, Megumi Yanokura, Eiichiro Tominaga, Kenjiro Kosaki, Daisuke Aoki
Pages: 2303-2308
Published online on: 04 October 2019

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Article Open Access

HHLA2 is a novel prognostic predictor and potential therapeutic target in malignant glioma Corrigendum in /10.3892/or.2022.8473

Yangzhi Qi, Gang Deng, Pengfei Xu, Huikai Zhang, Fanen Yuan, Rongxin Geng, Hongxiang Jiang, Baohui Liu, Qianxue Chen
Pages: 2309-2322
Published online on: 01 October 2019

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Article Open Access

Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma

Akiko Shimbo, Hiroaki Kajiyama, Satoshi Tamauchi, Nobuhisa Yoshikawa, Yoshiki Ikeda, Kimihiro Nishino, Shiro Suzuki, Kaoru Niimi, Jun Sakata, Fumitaka Kikkawa
Pages: 2323-2332
Published online on: 03 October 2019

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Article Open Access

Gene mutation profile and risk stratification in AML1‑ETO‑positive acute myeloid leukemia based on next‑generation sequencing

Guopan Yu, Changxin Yin, Fuqun Wu, Ling Jiang, Zhongxin Zheng, Dan Xu, Jiaheng Zhou, Xuejie Jiang, Qifa Liu, Fanyi Meng
Pages: 2333-2344
Published online on: 15 October 2019

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Article Open Access

Antitumor activity of tetrandrine citrate in human glioma U87 cells in vitro and in vivo

Jingyu Sun, Yang Zhang, Yongzhan Zhen, Ju Cui, Gang Hu, Yajun Lin
Pages: 2345-2354
Published online on: 15 October 2019

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Article Open Access

Acquisition of temozolomide resistance by the rat C6 glioma cell line increases cell migration and side population phenotype

Ya Xu, Xiangcai Yang, Shuting Mei, Yi Sun, Jiejing Li
Pages: 2355-2362
Published online on: 01 October 2019

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Article Open Access

Expression of DR5 and c‑FLIP proteins as novel prognostic biomarkers for non‑small cell lung cancer patients treated with surgical resection and chemotherapy

Hongmei Zheng, Yuting Zhang, Yuting Zhan, Sile Liu, Junmi Lu, Qiuyuan Wen, Songqing Fan
Pages: 2363-2370
Published online on: 04 October 2019

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Article Open Access

miRNA‑183‑5p.1 promotes the migration and invasion of gastric cancer AGS cells by targeting TPM1 Corrigendum in /10.3892/or.2020.7902

Jun Lin, Juan Shen, Hao Yue, Zhongwei Cao
Pages: 2371-2381
Published online on: 04 October 2019

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Article Open Access

Highly sensitive detection of sentinel lymph node metastasis of breast cancer by digital PCR for RASSF1A methylation

Mizuho Abe, Naofumi Kagara, Tomohiro Miyake, Tomonori Tanei, Yasuto Naoi, Masafumi Shimoda, Kenzo Shimazu, Seung Jin Kim , Shinzaburo Noguchi
Pages: 2382-2389
Published online on: 10 October 2019

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Article Open Access

miR‑489 promotes apoptosis and inhibits invasiveness of glioma cells by targeting PAK5/RAF1 signaling pathways Retraction in /10.3892/or.2023.8564

Wei Wang, Luyang Zhang, Wei Gao, Dongyong Zhang, Zilong Zhao, Yijun Bao
Pages: 2390-2401
Published online on: 22 October 2019

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Article Open Access

Construction of a competing endogenous RNA network using differentially expressed lncRNAs, miRNAs and mRNAs in non‑small cell lung cancer

Xi‑Wen Wang, Qi‑Qiang Guo, Yang Wei, Kai‑Ming Ren, Fu‑Shuang Zheng, Jun Tang, Hong‑Yan Zhang, Jun‑Gang Zhao
Pages: 2402-2415
Published online on: 17 October 2019

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Article Open Access

BH3 profiling discriminates the anti‑apoptotic status of 5‑fluorouracil‑resistant colon cancer cells

Kazuma Ishikawa, Yutaka Kawano, Yohei Arihara, Tomohiro Kubo, Kohichi Takada, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Junji Kato
Pages: 2416-2425
Published online on: 15 October 2019

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Article Open Access

Targeting RAD51 enhances chemosensitivity of adult T‑cell leukemia‑lymphoma cells by reducing DNA double‑strand break repair

Meng Yang, Xiaoxue Tian, Zhuoyi Fan, Wenlei Yu, Zheng Li, Jie Zhou, Wenjun Zhang, Aibin Liang
Pages: 2426-2434
Published online on: 22 October 2019

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Article Open Access

Receptor‑interacting serine/threonine‑protein kinase 1 promotes the progress and lymph metastasis of gallbladder cancer

Guangwei Zhu, Qiang Du, Xiao Chen, Xiaoqian Wang, Nanhong Tang, Feifei She, Yanling Chen
Pages: 2435-2449
Published online on: 23 September 2019

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Article Open Access

Systematic profiling of a novel prognostic alternative splicing signature in hepatocellular carcinoma

Dong Zhang, Yi Duan, Zhe Wang, Jie Lin
Pages: 2450-2472
Published online on: 27 September 2019

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Article Open Access

Weighted gene coexpression analysis indicates that PLAGL2 and POFUT1 are related to the differential features of proximal and distal colorectal cancer

Yiming Lv, Binbin Xie, Bingjun Bai, Lina Shan, Wenqian Zheng, Xuefeng Huang, Hongbo Zhu
Pages: 2473-2485
Published online on: 14 October 2019

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Article Open Access

Ku80 gene knockdown by the CRISPR/Cas9 technique affects the biological functions of human thyroid carcinoma cells

Yali Fan, Jianying Li, Wei Wei, Hangrong Fang, Ying Duan, Namiao Li, Yingying Zhang, Jun Yu, Juanhong Wang
Pages: 2486-2498
Published online on: 01 October 2019

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Article Open Access

Effects of CCL5 on the biological behavior of breast cancer and the mechanisms of its interaction with tumor‑associated macrophages

Gaili An, Fang Wu, Shangke Huang, Lu Feng, Jun Bai, Shanzhi Gu, Xinhan Zhao
Pages: 2499-2511
Published online on: 01 October 2019

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Article Open Access

Core‑shell type thermo‑nanoparticles loaded with temozolomide combined with photothermal therapy in melanoma cells

Xiaoyang Hou, Yanyu Pang, Xinxin Li, Chunsheng Yang, Wenlou Liu, Guan Jiang, Yanqun Liu
Pages: 2512-2520
Published online on: 20 September 2019

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Article Open Access

Bradykinin promotes proliferation, migration, and invasion of cervical cancer cells through STAT3 signaling pathways

Wei Wang, Ying Zhou, Rui Wei, Guiying Jiang, Fei Li, Xi Chen, Xueqian Wang, Ding Ma, Ling Xi
Pages: 2521-2527
Published online on: 18 October 2019

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Article Open Access

Exosomes isolated from CAPS1‑overexpressing colorectal cancer cells promote cell migration

Bingrui Wu, Dalong Sun, Lijie Ma, Yiran Deng, Si Zhang, Ling Dong, She Chen
Pages: 2528-2536
Published online on: 09 October 2019

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Article Open Access

Cancer‑associated adipocytes exhibit distinct phenotypes and facilitate tumor progression in pancreatic cancer

Zhiwei Cai, Yun Liang, Chun Xing, Hongwei Wang, Pengfei Hu, Jialin Li, Haiyan Huang, Wei Wang, Chongyi Jiang
Pages: 2537-2549
Published online on: 10 October 2019

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Article Open Access

miR‑425‑5p is associated with poor prognosis in patients with breast cancer and promotes cancer cell progression by targeting PTEN

Sheng Xiao, Hongjia Zhu, Jian Luo, Zhenru Wu, Mingjun Xie
Pages: 2550-2560
Published online on: 14 October 2019

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Article Open Access

β‑elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A‑VEGFA pathway based on network pharmacology

Junqiu Zhu, Bo Li, Yongsuo Ji, Linglin Zhu, Yanfei Zhu, Hong Zhao
Pages: 2561-2571
Published online on: 09 October 2019

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Article Open Access

Comprehensive analysis of the lncRNA‑associated competing endogenous RNA network in breast cancer

Jing‑Jing Wang, Yue‑Qing Huang, Wei Song, Yi‑Fan Li, Han Wang, Wen‑Jie Wang, Min Huang
Pages: 2572-2582
Published online on: 15 October 2019

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Article Open Access

Integrated analysis highlights multiple long non‑coding RNAs and their potential roles in the progression of human esophageal squamous cell carcinoma

Cheng‑Yun Li, Wen‑Wen Zhang, Ji‑Lian Xiang, Xing‑Hua Wang, Jun‑Ling Wang, Jin Li
Pages: 2583-2599
Published online on: 17 October 2019

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Article Open Access

Tex10 promotes stemness and EMT phenotypes in esophageal squamous cell carcinoma via the Wnt/β‑catenin pathway

Xiaocong Xiang, Rong Xiong, Chunlei Yu, Li Deng, Jun Bie, Dongqin Xiao, Zhu Chen, Yuchuan Zhou, Xiaolei Li, Kang Liu, Gang Feng
Pages: 2600-2610
Published online on: 16 October 2019

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Article Open Access

Ammonium tetrathiomolybdate enhances the antitumor effect of cisplatin via the suppression of ATPase copper transporting beta in head and neck squamous cell carcinoma

Shoji Ryumon, Tatsuo Okui, Yuki Kunisada, Koji Kishimoto, Tsuyoshi Shimo, Kazuaki Hasegawa, Soichiro Ibaragi, Kentaro Akiyama, Nguyen Thi Thu Ha, Nur Mohammad Monsur Hassan, Akira Sasaki
Pages: 2611-2621
Published online on: 10 October 2019

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Article Open Access

Identification of TPD52 and DNAJB1 as two novel bile biomarkers for cholangiocarcinoma by iTRAQ‑based quantitative proteomics analysis

Hongyue Ren, Mingxu Luo, Jinzhong Chen, Yanming Zhou, Xiumei Li, Yanyan Zhan, Dongyan Shen, Bo Chen
Pages: 2622-2634
Published online on: 23 October 2019

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Article Open Access

IFN‑β sensitizes TRAIL‑induced apoptosis by upregulation of death receptor 5 in malignant glioma cells

Sodai Yoshimura, Emiko Sano, Yuya Hanashima, Shun Yamamuro, Koichiro Sumi, Takuya Ueda, Tomohiro Nakayama, Hiroyuki Hara, Atsuo Yoshino, Yoichi Katayama
Pages: 2635-2643
Published online on: 22 October 2019

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Article Open Access

Involvement of CHOP in activin A‑induced myeloma NS‑1 cell apoptosis

Jingyan Ge, Hongyan Sun, Jing Li, Yidi Shan, Yang Zhao, Fangwei Liao, Yu Yang, Xueling Cui, Zhonghui Liu
Pages: 2644-2654
Published online on: 22 October 2019

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Article Open Access

Crosstalk between histone modification and DNA methylation orchestrates the epigenetic regulation of the costimulatory factors, Tim‑3 and galectin‑9, in cervical cancer

Li Zhang, Sijuan Tian, Meili Pei, Minyi Zhao, Li Wang, Yifan Jiang, Ting Yang, Juan Zhao, Lihua Song, Xiaofeng Yang
Pages: 2655-2669
Published online on: 24 October 2019

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Article

Knockdown of Nedd8‑conjugating enzyme UBE2M suppresses the proliferation and induces the apoptosis of intrahepatic cholangiocarcinoma cells

Bin Zhao, Caiyan Gao, Daixiu Shi, Jie Mao, Jun Zhao, Lingyun Guo, Jiwu Guo, Zuoyi Jiao
Pages: 2670-2679
Published online on: 20 September 2019

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Article

Development of recurrence risk score using 95‑gene classifier and its application to formalin‑fixed paraffin‑embedded tissues in ER‑positive, HER2‑negative and node‑negative breast cancer

Yasuto Naoi, Yuria Saito, Kazuki Kishi, Masafumi Shimoda, Naofumi Kagara, Tomohiro Miyake, Tomonori Tanei, Kenzo Shimazu, Seung Jin Kim, Shinzaburo Noguchi
Pages: 2680-2685
Published online on: 07 October 2019

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Article

A novel therapeutic anti‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells

So Hee Dho, Eun Ha Cho, Ji Yeon Lee, So‑Young Lee, Sung Hee Jung, Lark Kyun Kim, Jae Cheong Lim
Pages: 2686-2693
Published online on: 26 September 2019

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Article

The prednisolone phosphate‑induced suppression of the angiogenic function of tumor‑associated macrophages enhances the antitumor effects of doxorubicin on B16.F10 murine melanoma cells in vitro

Emilia Licarete, Valentin Florian Rauca, Lavinia Luput, Laura Patras, Alina Sesarman, Manuela Banciu
Pages: 2694-2705
Published online on: 01 October 2019

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Article

SRPX and HMCN1 regulate cancer‑associated fibroblasts to promote the invasiveness of ovarian carcinoma

Chao Lien Liu, Hung Wei Pan, Pao Ling Torng, Ming Huei Fan, Tsui Lien Mao
Pages: 2706-2715
Published online on: 17 October 2019

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Article

Downregulation of MUTYH contributes to cisplatin‑resistance of esophageal squamous cell carcinoma cells by promoting Twist‑mediated EMT

Yanxia Guo, Yuxiu Jia, Shikang Wang, Ning Liu, Dongfang Gao, Lu Zhang, Zhaomin Lin, Shuling Wang, Feng Kong, Chuanliang Peng, Yongqing Liu
Pages: 2716-2727
Published online on: 01 October 2019

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Article

Upregulation of circular RNA circ‑FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR‑646/VAMP2 and miR‑647/MDM2 signaling pathways

Dan Sun, Jianing Liu, Lili Zhou
Pages: 2728-2737
Published online on: 10 October 2019

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Article

Microarray profile of circular RNAs identifies hsa_circRNA_102459 and hsa_circRNA_043621 as important regulators in oral squamous cell carcinoma

Wei Deng, Wei Peng, Tao Wang, Jingxin Chen, Xunding Qiu, Liangbin Fu, Shuangxi Zhu
Pages: 2738-2749
Published online on: 14 October 2019

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Article

High levels of Notch intracellular cleaved domain are associated with stemness and reduced bevacizumab efficacy in patients with advanced colon cancer

Francesca Negri, Cecilia Bozzetti, Giuseppe Pedrazzi, Cinzia Azzoni, Lorena Bottarelli, Anna Squadrilli, Costanza Lagrasta, Ione Tamagnini, Alessandra Bisagni, Moira Ragazzi, Rosa Porzio, Gianluca Tomasello, Daniele Mori, Francesco Leonardi, Letizia Gnetti, Pellegrino Crafa, Roberto Sala, Stefano Cascinu
Pages: 2750-2758
Published online on: 01 October 2019

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Article

Downregulation of miR‑143 modulates KRAS expression in colorectal carcinoma cells

Hong Liu, Jiansheng Liu, Junkai Huo, Kaihua Li, Kai Li, Haosu Guo, Yirong Yang
Pages: 2759-2767
Published online on: 07 October 2019

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Article

Targeting YAP suppresses ovarian cancer progression through regulation of the PI3K/Akt/mTOR pathway

Xiao Wei, Yijuan Jia, Hua Lou, Jingjing Ma, Quanfu Huang, Yunchong Meng, Chaoyang Sun, Zongyuan Yang, Xiaoting Li, Sen Xu, Xin Yang, Teng Ji, Qinglei Gao
Pages: 2768-2776
Published online on: 14 October 2019

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Article

RSK4 inhibits breast cancer cell proliferation and invasion in vitro, and is correlated with estrogen receptor upregulation in breast cancer

Hong Huo, Xinqing Ye, Honghe Yang, Qiuyun Li, Yi Jiang
Pages: 2777-2787
Published online on: 20 September 2019

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Article

Palmitoylome profiling indicates that androgens regulate the palmitoylation of α‑tubulin in prostate cancer‑derived LNCaP cells and supernatants

Wenqing Li, Junhua Zhang, Lihui Zou, Jian Cui, Fei Su, Junhua Jin, Fei Xiao, Ming Liu, Gang Zhao
Pages: 2788-2796
Published online on: 24 September 2019

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Article

Suppressive effects of the sodium‑glucose cotransporter 2 inhibitor tofogliflozin on colorectal tumorigenesis in diabetic and obese mice

Junichi Kato, Yohei Shirakami, Masaya Ohnishi, Taku Mizutani, Masaya Kubota, Hiroyasu Sakai, Takashi Ibuka, Takuji Tanaka, Masahito Shimizu
Pages: 2797-2805
Published online on: 07 October 2019

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Article

Follistatin‑like protein 1 knockdown elicits human gastric cancer cell apoptosis via a STAT6‑dependent pathway

Xingang Peng, Peige Wang, Shikuan Li, Yingjun Jiang, Changliang Wu
Pages: 2806-2813
Published online on: 24 September 2019

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Article

Οlive tree blossom polyphenolic extracts exert antioxidant and antimutagenic activities in vitro and in various cell lines

Paraskevi Kouka, Fotios Tekos, Kalliopi Valta, Panagiotis Mavros, Aristidis S. Veskoukis, Apostolis Angelis, Alexios-Leandros Skaltsounis, Demetrios Kouretas
Pages: 2814-2825
Published online on: 23 October 2019

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Article

Establishment and characterization of a mouse tumor cell line with irreversible downregulation of MHC class I molecules

Karolina Lhotakova, Adrianna Grzelak, Ingrid Polakova, Julie Vackova, Michal Smahel
Pages: 2826-2835
Published online on: 04 October 2019

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Article

Potential role for second‑generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia harboring additional clonal chromosome abnormalities: A retrospective CML Cooperative Study Group analysis

Maho Ishikawa, Noriyoshi Iriyama, Michihide Tokuhira, Tomoiku Takaku, Eriko Sato, Kei‑Ji Sugimoto, Tomonori Nakazato, Hiroyuki Fujita, Yuta Kimura, Isao Fujioka, Norio Komatsu, Norio Asou, Masahiro Kizaki, Yoshihiro Hatta, Tatsuya Kawaguchi
Pages: 2836-2843
Published online on: 27 September 2019

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Article

DDR1 promotes breast tumor growth by suppressing antitumor immunity

Xing Zhong, Weiwei Zhang, Tianhao Sun
Pages: 2844-2854
Published online on: 27 September 2019

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Correction Open Access

[Corrigendum] A 19‑miRNA Support Vector Machine classifier and a 6‑miRNA risk score system designed for ovarian cancer patients

Jingwei Dong, Mingjun Xu
Pages: 2855-2855
Published online on: 23 October 2019

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Correction Open Access

[Corrigendum] Lycorine inhibits cell proliferation and migration by inhibiting ROCK1/cofilin‑induced actin dynamics in HepG2 hepatoblastoma cells

Wuyi Liu, Qian Zhang, Qin Tang, Changpeng  Hu, Jingbin  Huang, Yali Liu, Yanyi Lu, Qing  Wang, Guobing  Li, Rong Zhang
Pages: 2856-2856
Published online on: 10 October 2019

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Article Open Access

Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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