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Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma

  • Authors:
    • Akiko Shimbo
    • Hiroaki Kajiyama
    • Satoshi Tamauchi
    • Nobuhisa Yoshikawa
    • Yoshiki Ikeda
    • Kimihiro Nishino
    • Shiro Suzuki
    • Kaoru Niimi
    • Jun Sakata
    • Fumitaka Kikkawa
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi 466‑8550, Japan, Department of Gynecology, Graduate School of Medicine, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑8681, Japan
    Copyright: © Shimbo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2323-2332
    |
    Published online on: October 3, 2019
       https://doi.org/10.3892/or.2019.7352
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Abstract

Recently, connective tissue growth factor (CTGF) was demonstrated to be associated with aggressive characteristics, including proliferation, invasion and metastasis, in a number of malignancies. Here, we investigated the expression and function of CTGF in epithelial ovarian carcinoma (EOC) to clarify its molecular mechanism and clinical significance. Paraffin sections from clinical samples of EOC (N=104) were immunostained with the CTGF antibody, and then the staining positivity was semiquantitatively examined. Moreover, we explored the role of CTGF expression in the migration‑promoting effect on and chemoresistance of EOC cells. The results revealed that of the 104 EOC patients, the low and high CTGF staining expression rates were 65 (62.5%) and 39 (37.5%), respectively. Patients belonging to the higher‑level CTGF group showed poorer progression‑free (PFS) and overall survival (OS) rates than those in the lower‑level group [PFS (log‑rank: P=0.0076) and OS (log‑rank: P=0.0078), respectively]. Multivariable analysis showed that CTGF expression was a significant predictor of poorer PFS and OS [PFS: HR (high vs. low): 1.837, 95% CI: 1.023‑3.289 (P=0.0418); OS: HR: 2.141, 95% CI: 1.077‑4.296 (P=0.0300)]. In in vitro studies, in acquired paclitaxel (PTX)‑resistant EOC cells, the silencing of CTGF expression led to the restoration of PTX sensitivity. Furthermore, we confirmed that the TGF‑β‑dependent migration‑promoting effect on these CTGF‑depleted cells was completely inhibited. In conclusion, the results of the present study suggest the possible involvement of CTGF in the migration‑promoting effect and chemoresistance of EOC, suggesting that it may be a target for overcoming the malignant properties of EOC.
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View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Brun JL, Feyler A, Chene G, Saurel J, Brun G and Hocke C: Long-term results and prognostic factors in patients with epithelial ovarian cancer. Gynecol Oncol. 78:21–27. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2:442–454. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Boyer B, Valles AM and Edme N: Induction and regulation of epithelial-mesenchymal transitions. Biochem Pharmacol. 60:1091–1099. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Vernon AE and LaBonne C: Tumor metastasis: A new twist on epithelial-mesenchymal transitions. Curr Biol. 14:R719–R721. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Eisenkop SM, Friedman RL and Wang HJ: Complete cytoreductive surgery is feasible and maximizes survival in patients with advanced epithelial ovarian cancer: A prospective study. Gynecol Oncol. 69:103–108. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Kajiyama H, Mizuno M, Shibata K, Kawai M, Nagasaka T and Kikkawa F: Extremely poor postrecurrence oncological outcome for patients with recurrent mucinous ovarian cancer. Int J Clin Oncol. 19:121–126. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Kajiyama H, Shibata K, Mizuno M, Umezu T, Suzuki S, Yamamoto E, Fujiwara S, Kawai M, Nagasaka T and Kikkawa F: Long-term clinical outcome of patients with recurrent epithelial ovarian carcinoma: Is it the same for each histological type? Int J Gynecol Cancer. 22:394–399. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Brigstock DR, Goldschmeding R, Katsube KI, Lam SC, Lau LF, Lyons K, Naus C, Perbal B, Riser B, Takigawa M and Yeger H: Proposal for a unified CCN nomenclature. Mol Pathol. 56:127–128. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Brigstock DR: The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocr Rev. 20:189–206. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Leask A and Abraham DJ: All in the CCN family: Essential matricellular signaling modulators emerge from the bunker. J Cell Sci. 119:4803–4810. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Tsai HC, Su HL, Huang CY, Fong YC, Hsu CJ and Tang CH: CTGF increases matrix metalloproteinases expression and subsequently promotes tumor metastasis in human osteosarcoma through down-regulating miR-519d. Oncotarget. 5:3800–3812. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Han Q, Zhang HY, Zhong BL, Wang XJ, Zhang B and Chen H: MicroRNA-145 inhibits cell migration and invasion and regulates epithelial-mesenchymal transition (EMT) by targeting connective tissue growth factor (CTGF) in esophageal squamous cell carcinoma. Med Sci Monit. 22:3925–3934. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Lai D, Ho KC, Hao Y and Yang X: Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res. 71:2728–2738. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Yang K, Gao K, Hu G, Wen Y, Lin C and Li X: CTGF enhances resistance to 5-FU-mediating cell apoptosis through FAK/MEK/ERK signal pathway in colorectal cancer. Onco Targets Ther. 9:7285–7295. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Tsai HC, Huang CY, Su HL and Tang CH: CCN2 enhances resistance to cisplatin-mediating cell apoptosis in human osteosarcoma. PLoS One. 9:e901592014. View Article : Google Scholar : PubMed/NCBI

17 

Wang L, He J, Xu H, Xu L and Li N: MiR-143 targets CTGF and exerts tumor-suppressing functions in epithelial ovarian cancer. Am J Transl Res. 8:2716–2726. 2016.PubMed/NCBI

18 

Kajiyama H, Kikkawa F, Suzuki T, Shibata K, Ino K and Mizutani S: Prolonged survival and decreased invasive activity attributable to dipeptidyl peptidase IV overexpression in ovarian carcinoma. Cancer Res. 62:2753–2757. 2002.PubMed/NCBI

19 

Kajiyama H, Shibata K, Ino K, Mizutani S, Nawa A and Kikkawa F: The expression of dipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cells. Cancer Sci. 101:347–354. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Kajiyama H, Shibata K, Terauchi M, Yamashita M, Ino K, Nawa A and Kikkawa F: Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells. Int J Oncol. 31:277–283. 2007.PubMed/NCBI

21 

Maeda O, Shibata K, Hosono S, Fujiwara S, Kajiyama H, Ino K, Nawa A, Tamakoshi K and Kikkawa F: Spectrin αII and βII tetramers contribute to platinum anticancer drug resistance in ovarian serous adenocarcinoma. Int J Cancer. 130:113–121. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Utsumi F, Kajiyama H, Nakamura K, Tanaka H, Mizuno M, Ishikawa K, Kondo H, Kano H, Hori M and Kikkawa F: Effect of indirect nonequilibrium atmospheric pressure plasma on anti-proliferative activity against chronic chemo-resistant ovarian cancer cells in vitro and in vivo. PLoS One. 8:e815762013. View Article : Google Scholar : PubMed/NCBI

23 

Sakata J, Utsumi F, Suzuki S, Niimi K, Yamamoto E, Shibata K, Senga T, Kikkawa F and Kajiyama H: Inhibition of ZEB1 leads to inversion of metastatic characteristics and restoration of paclitaxel sensitivity of chronic chemoresistant ovarian carcinoma cells. Oncotarget. 8:99482–99494. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Hosono S, Kajiyama H, Terauchi M, Shibata K, Ino K, Nawa A and Kikkawa F: Expression of Twist increases the risk for recurrence and for poor survival in epithelial ovarian carcinoma patients. Br J Cancer. 96:314–320. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Sugiyama K, Kajiyama H, Shibata K, Yuan H, Kikkawa F and Senga T: Expression of the miR200 family of microRNAs in mesothelial cells suppresses the dissemination of ovarian cancer cells. Mol Cancer Ther. 13:2081–2091. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Kurman RJ, Carcangiu ML, Herrington CS and Young RH: WHO Classification of Tumours of Female Reproductive OrgansFourth. IARC Press; 2014

28 

Zeppernick F and Meinhold-Heerlein I: The new FIGO staging system for ovarian, fallopian tube, and primary peritoneal cancer. Arch Gynecol Obstet. 290:839–842. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Chen VW, Ruiz B, Killeen JL, Coté TR, Wu XC and Correa CN: Pathology and classification of ovarian tumors. Cancer 97 (10 Suppl). S2631–S2642. 2003. View Article : Google Scholar

30 

Sakata J, Kajiyama H, Suzuki S, Utsumi F, Niimi K, Sekiya R, Shibata K, Senga T and Kikkawa F: Impact of positive ZEB1 expression in patients with epithelial ovarian carcinoma as an oncologic outcome-predicting indicator. Oncol Lett. 14:4287–4293. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Lau TS, Chan LK, Wong EC, Hui CW, Sneddon K, Cheung TH, Yim SF, Lee JH, Yeung CS, Chung TK and Kwong J: A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFα-TGFα-EGFR. Oncogene. 36:3576–3587. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Nakamura M, Ono YJ, Kanemura M, Tanaka T, Hayashi M, Terai Y and Ohmichi M: Hepatocyte growth factor secreted by ovarian cancer cells stimulates peritoneal implantation via the mesothelial-mesenchymal transition of the peritoneum. Gynecol Oncol. 139:345–354. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Wei W, Kong B, Yang Q and Qu X: Hepatocyte growth factor enhances ovarian cancer cell invasion through downregulation of thrombospondin-1. Cancer Biol Ther. 9:79–87. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Alvarez H, Corvalan A, Roa JC, Argani P, Murillo F, Edwards J, Beaty R, Feldmann G, Hong SM, Mullendore M, et al: Serial analysis of gene expression identifies connective tissue growth factor expression as a prognostic biomarker in gallbladder cancer. Clin Cancer Res. 14:2631–2638. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Bennewith KL, Huang X, Ham CM, Graves EE, Erler JT, Kambham N, Feazell J, Yang GP, Koong A and Giaccia AJ: The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth. Cancer Res. 69:775–784. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Boag JM, Beesley AH, Firth MJ, Freitas JR, Ford J, Brigstock DR, de Klerk NH and Kees UR: High expression of connective tissue growth factor in pre-B acute lymphoblastic leukaemia. Br J Haematol. 138:740–748. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Li LY, Li EM, Wu ZY, Huang X, Shen JH, Xu XE, Wu JY, Huang Q and Xu LY: Connective tissue growth factor expression in precancerous lesions of human esophageal epithelium and prognostic significance in esophageal squamous cell carcinoma. Dis Esophagus. 24:337–345. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Wang MY, Chen PS, Prakash E, Hsu HC, Huang HY, Lin MT, Chang KJ and Kuo ML: Connective tissue growth factor confers drug resistance in breast cancer through concomitant up-regulation of Bcl-xL and cIAP1. Cancer Res. 69:3482–3491. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Mao Z, Ma X, Rong Y, Cui L, Wang X, Wu W, Zhang J and Jin D: Connective tissue growth factor enhances the migration of gastric cancer through downregulation of E-cadherin via the NF-kB pathway. Cancer Sci. 102:104–110. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Sugiyama T, Kamura T, Kigawa J, Terakawa N, Kikuchi Y, Kita T, Suzuki M, Sato I and Taguchi K: Clinical characteristics of clear cell carcinoma of the ovary: A distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy. Cancer. 88:2584–2589. 2000. View Article : Google Scholar : PubMed/NCBI

41 

Shimada M, Kigawa J, Ohishi Y, Yasuda M, Suzuki M, Hiura M, Nishimura R, Tabata T, Sugiyama T and Kaku T: Clinicopathological characteristics of mucinous adenocarcinoma of the ovary. Gynecol Oncol. 113:331–334. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Tsai HC, Huang CY, Su HL and Tang CH: CTGF increases drug resistance to paclitaxel by upregulating survivin expression in human osteosarcoma cells. Biochim Biophys Acta. 1843:846–854. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Edwards LA, Woolard K, Son MJ, Li A, Lee J, Ene C, Mantey SA, Maric D, Song H, Belova G, et al: Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion. J Natl Cancer Inst. 103:1162–1178. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Eguchi D, Ikenaga N, Ohuchida K, Kozono S, Cui L, Fujiwara K, Fujino M, Ohtsuka T, Mizumoto K and Tanaka M: Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor. J Surg Res. 181:225–233. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Yang F, Tuxhorn JA, Ressler SJ, McAlhany SJ, Dang TD and Rowley DR: Stromal expression of connective tissue growth factor promotes angiogenesis and prostate cancer tumorigenesis. Cancer Res. 65:8887–8895. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Kim HC, Ji W, Kim MY, Colby TV, Jang SJ, Lee CK, Han SB and Kim DS: Interstitial pneumonia related to undifferentiated connective tissue disease: Pathologic pattern and prognosis. Chest. 147:165–172. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Tothill RW, Tinker AV, George J, Brown R, Fox SB, Lade S, Johnson DS, Trivett MK, Etemadmoghadam D, Locandro B, et al: Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clin Cancer Res. 14:5198–5208. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Crosas-Molist E, Bertran E and Fabregat I: Cross-Talk Between TGF-β and NADPH oxidases during liver fibrosis and hepatocarcinogenesis. Curr Pharm Des. 21:5964–5976. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Dhanasekaran R, Nakamura I, Hu C, Chen G, Oseini AM, Seven ES, Miamen AG, Moser CD, Zhou W, van Kuppevelt TH, et al: Activation of the transforming growth factor-β/SMAD transcriptional pathway underlies a novel tumor-promoting role of sulfatase 1 in hepatocellular carcinoma. Hepatology. 61:1269–1283. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Liu J, Chen S, Wang W, Ning BF, Chen F, Shen W, Ding J, Chen W, Xie WF and Zhang X: Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways. Cancer Lett. 379:49–59. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Kroening S, Solomovitch S, Sachs M, Wullich B and Goppelt-Struebe M: Regulation of connective tissue growth factor (CTGF) by hepatocyte growth factor in human tubular epithelial cells. Nephrol Dial Transplant. 24:755–762. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Tsai CC, Wu SB, Kau HC and Wei YH: Essential role of connective tissue growth factor (CTGF) in transforming growth factor-β1 (TGF-β1)-induced myofibroblast transdifferentiation from Graves' orbital fibroblasts. Sci Rep. 8:72762018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shimbo A, Kajiyama H, Tamauchi S, Yoshikawa N, Ikeda Y, Nishino K, Suzuki S, Niimi K, Sakata J, Kikkawa F, Kikkawa F, et al: Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma. Oncol Rep 42: 2323-2332, 2019.
APA
Shimbo, A., Kajiyama, H., Tamauchi, S., Yoshikawa, N., Ikeda, Y., Nishino, K. ... Kikkawa, F. (2019). Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma. Oncology Reports, 42, 2323-2332. https://doi.org/10.3892/or.2019.7352
MLA
Shimbo, A., Kajiyama, H., Tamauchi, S., Yoshikawa, N., Ikeda, Y., Nishino, K., Suzuki, S., Niimi, K., Sakata, J., Kikkawa, F."Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma". Oncology Reports 42.6 (2019): 2323-2332.
Chicago
Shimbo, A., Kajiyama, H., Tamauchi, S., Yoshikawa, N., Ikeda, Y., Nishino, K., Suzuki, S., Niimi, K., Sakata, J., Kikkawa, F."Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma". Oncology Reports 42, no. 6 (2019): 2323-2332. https://doi.org/10.3892/or.2019.7352
Copy and paste a formatted citation
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Spandidos Publications style
Shimbo A, Kajiyama H, Tamauchi S, Yoshikawa N, Ikeda Y, Nishino K, Suzuki S, Niimi K, Sakata J, Kikkawa F, Kikkawa F, et al: Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma. Oncol Rep 42: 2323-2332, 2019.
APA
Shimbo, A., Kajiyama, H., Tamauchi, S., Yoshikawa, N., Ikeda, Y., Nishino, K. ... Kikkawa, F. (2019). Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma. Oncology Reports, 42, 2323-2332. https://doi.org/10.3892/or.2019.7352
MLA
Shimbo, A., Kajiyama, H., Tamauchi, S., Yoshikawa, N., Ikeda, Y., Nishino, K., Suzuki, S., Niimi, K., Sakata, J., Kikkawa, F."Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma". Oncology Reports 42.6 (2019): 2323-2332.
Chicago
Shimbo, A., Kajiyama, H., Tamauchi, S., Yoshikawa, N., Ikeda, Y., Nishino, K., Suzuki, S., Niimi, K., Sakata, J., Kikkawa, F."Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma". Oncology Reports 42, no. 6 (2019): 2323-2332. https://doi.org/10.3892/or.2019.7352
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