Open Access

Expression of DR5 and c‑FLIP proteins as novel prognostic biomarkers for non‑small cell lung cancer patients treated with surgical resection and chemotherapy

  • Authors:
    • Hongmei Zheng
    • Yuting Zhang
    • Yuting Zhan
    • Sile Liu
    • Junmi Lu
    • Qiuyuan Wen
    • Songqing Fan
  • View Affiliations

  • Published online on: October 4, 2019     https://doi.org/10.3892/or.2019.7355
  • Pages: 2363-2370
  • Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

TRAIL‑R2 (DR5), one of the death receptors, can activate the extrinsic apoptosis pathway, while cellular FLICE‑inhibitory protein (c‑FLIP) can inhibit this pathway. Both of them play important roles in the occurrence and development of most tumors. To date, there is no relevant report concerning the relationship between expression of DR5 and c‑FLIP protein and clinicopathological/prognostic implications in patients with non‑small cell lung cancer (NSCLC) treated with surgical resection and chemotherapy. Thus, the aim of the present study was to investigate the potential prognostic significance of DR5 and c‑FLIP in NSCLC patients and their predictive roles in the chemotherapeutic response. In the present study, DR5 and c‑FLIP were detected by immunohistochemistry (IHC) in tissue microarrays of NSCLC. The results showed that the expression levels of DR5 and c‑FLIP were significantly higher in lung squamous cell carcinoma (SCC) and lung adenocarcinoma (ADC) tissues compared with levels noted in the non‑cancerous control lung tissues (all P<0.05). In addition, DR5 expression was significantly increased in lung ADC (P<0.001), whereas, c‑FLIP was higher in lung SCC (P<0.001) and smoker patients with clinical stage III (P=0.019, P=0.016, respectively). In addition, NSCLC patients with overexpression of DR5 and loss of c‑FLIP expression exhibited a higher overall survival (OS) rate as determined by Kaplan‑Meier analysis (P=0.029, P=0.038, respectively). Multivariate analysis confirmed that high expression of DR5 and loss of c‑FLIP expression were independent favorable prognostic factors for NSCLC patients (P=0.016, P=0.035, respectively). In conclusion, overexpression of DR5 and loss of c‑FLIP expression may serve as novel favorable prognostic biomarkers for NSCLC patients treated with chemotherapy after radical resection and used as predictors for tumor response to chemotherapy drugs.
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December-2019
Volume 42 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zheng H, Zhang Y, Zhan Y, Liu S, Lu J, Wen Q and Fan S: Expression of DR5 and c‑FLIP proteins as novel prognostic biomarkers for non‑small cell lung cancer patients treated with surgical resection and chemotherapy. Oncol Rep 42: 2363-2370, 2019
APA
Zheng, H., Zhang, Y., Zhan, Y., Liu, S., Lu, J., Wen, Q., & Fan, S. (2019). Expression of DR5 and c‑FLIP proteins as novel prognostic biomarkers for non‑small cell lung cancer patients treated with surgical resection and chemotherapy. Oncology Reports, 42, 2363-2370. https://doi.org/10.3892/or.2019.7355
MLA
Zheng, H., Zhang, Y., Zhan, Y., Liu, S., Lu, J., Wen, Q., Fan, S."Expression of DR5 and c‑FLIP proteins as novel prognostic biomarkers for non‑small cell lung cancer patients treated with surgical resection and chemotherapy". Oncology Reports 42.6 (2019): 2363-2370.
Chicago
Zheng, H., Zhang, Y., Zhan, Y., Liu, S., Lu, J., Wen, Q., Fan, S."Expression of DR5 and c‑FLIP proteins as novel prognostic biomarkers for non‑small cell lung cancer patients treated with surgical resection and chemotherapy". Oncology Reports 42, no. 6 (2019): 2363-2370. https://doi.org/10.3892/or.2019.7355