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Article

Upregulation of circular RNA circ‑FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR‑646/VAMP2 and miR‑647/MDM2 signaling pathways

  • Authors:
    • Dan Sun
    • Jianing Liu
    • Lili Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Heilongjiang Provincial Hospital, Harbin, Heilongjiang 150000, P.R. China, Department of Gynecology and Obstetrics, Heilongjiang Provincial Hospital, Harbin, Heilongjiang 150000, P.R. China
  • Pages: 2728-2737
    |
    Published online on: October 10, 2019
       https://doi.org/10.3892/or.2019.7366
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Abstract

Ovarian cancer (OC) is a common cancer of the human genital system. Circular RNAs (circRNAs) play an important role in carcinogenesis and progression of various cancers. The present study aimed to clarify the expression profile and functions of circ‑FAM53B in the progression of OC and reveal its underlying mechanisms. Relative levels of circ‑FAM53B in OC specimens and cell lines were determined by quantitative real‑time polymerase chain reaction (qRT‑PCR). The clinical significance of circ‑FAM53B in OC patients was analyzed through Fisher's exact test, Kaplan‑Meier curves, and Cox regression analysis. Subsequently, the regulatory effects of circ‑FAM53B on the proliferative, apoptotic, migratory, and invasive potential of OC cells were determined by loss/gain‑of‑function experiments. Mechanistically, bioinformatics analysis and luciferase reporter gene assay were used to reveal the potential molecular mechanisms of circ‑FAM53B in OC. circ‑FAM53B was overexpressed in OC specimens and cells and correlated with clinical severity and poor prognosis of OC patients. The overexpression of circ‑FAM53B accelerated the proliferation, migration, and invasion of HO8910 cells; however, it decreased the number of apoptotic cells. Silencing of circ‑FAM53B induced the opposite effect. Through dual‑luciferase reporter gene assay and functional experiments, the potential functions of circ‑FAM53B/miRNA‑646/vesicle‑associated membrane protein 2 (VAMP2) and circ‑FAM53B/miRNA‑647/mouse double minute 2 (MDM2) in mediating the progression of OC were identified. Collectively, the present results indicated that circ‑FAM53B could be a competing endogenous RNA (ceRNA) to competitively sponge miR‑646 and miR‑647 to upregulate VAMP2 and MDM2 expression at the post‑transcriptional level, thus mediating the cellular behaviors of OC cells.
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1 

Bast RC Jr, Hennessy B and Mills GB: The biology of ovarian cancer: New opportunities for translation. Nat Rev Cancer. 9:415–428. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Timmermans M, Sonke GS, Slangen BFM, Baalbergen A, Bekkers RLM, Fons G, Gerestein CG, Kruse AJ, Roes EM, Zusterzeel PLM, et al: Outcome of surgery in advanced ovarian cancer varies between geographical regions; opportunities for improvement in the netherlands. Eur J Surg Oncol. 45:1425–1431. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Morice P, Gouy S and Leary A: Mucinous ovarian carcinoma. N Engl J Med. 380:1256–1266. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Stewart C, Ralyea C and Lockwood S: Ovarian cancer: An integrated review. Semin Oncol Nurs. 35:151–156. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, et al: Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 495:333–338. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF and Sharpless NE: Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 19:141–157. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Zang J, Lu D and Xu A: The interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and function. J Neurosci Res. Dec 21–2018.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

9 

Hao L, Rong W, Bai L, Cui H, Zhang S, Li Y, Chen D and Meng X: Upregulated circular RNA circ_0007534 indicates an unfavorable prognosis in pancreatic ductal adenocarcinoma and regulates cell proliferation, apoptosis, and invasion by sponging miR-625 and miR-892b. J Cell Biochem. 120:3780–3789. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Xu Y, Yao Y, Zhong X, Leng K, Qin W, Qu L, Cui Y and Jiang X: Downregulated circular RNA hsa_circ_0001649 regulates proliferation, migration and invasion in cholangiocarcinoma cells. Biochem Biophys Res Commun. 496:455–461. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Aufiero S, Reckman YJ, Pinto YM and Creemers EE: Circular RNAs open a new chapter in cardiovascular biology. Nat Rev Cardiol. 16:503–514. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Li KS, Pan F, Mao XD, Liu C and Chen YJ: Biological functions of circular RNAs and their roles in occurrence of reproduction and gynecological diseases. Am J Transl Res. 11:1–15. 2019.PubMed/NCBI

13 

Bach DH, Lee SK and Sood AK: Circular RNAs in cancer. Mol Ther Nucleic Acids. 16:118–129. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Yang W, Liu Y, Gao R, Xiu Z and Sun T: Knockdown of cZNF292 suppressed hypoxic human hepatoma SMMC7721 cell proliferation, vasculogenic mimicry, and radioresistance. Cell Signal. 60:122–135. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Matboli M, Shafei AE, Ali MA, Ashry AM, Kamal KM, Agag MA, Reda I, Tash EF and Ali M: circRNAs (hsa_circ_00156, hsa_circ_000224, and hsa_circ_000520) are novel potential biomarkers in hepatocellular carcinoma. J Cell Biochem. Nov 13–2018.(Epub ahead of print).

16 

Guo J, Duan H, Li Y, Yang L and Yuan L: A novel circular RNA circ-ZNF652 promotes hepatocellular carcinoma metastasis through inducing snail-mediated epithelial-mesenchymal transition by sponging miR-203/miR-502-5p. Biochem Biophys Res Commun. 513:812–819. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Wang T and Wang X, Du Q, Wu N, Liu X, Chen Y and Wang X: The circRNA circP4HB promotes NSCLC aggressiveness and metastasis by sponging miR-133a-5p. Biochem Biophys Res Commun. 513:904–911. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Gao Y, Zhang C, Liu Y and Wang M: Circular RNA profiling reveals circRNA1656 as a novel biomarker in high grade serous ovarian cancer. Biosci Trends. 13:204–211. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Pan H, Tang L, Jiang H, Li X, Wang R, Gao J and Li Q: Enhanced expression of circ_0000267 in hepatocellular carcinoma indicates poor prognosis and facilitates cell progression by sponging miR-646. J Cell Biochem. Feb 5–2019.(Epub ahead of print). View Article : Google Scholar :

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Yang C, Wei Y, Yu L and Xiao Y: Identification of altered circular RNA expression in serum exosomes from patients with papillary thyroid carcinoma by high-throughput sequencing. Med Sci Monit. 25:2785–2791. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Teng F, Xu J, Zhang M, Liu S, Gu Y, Zhang M, Wang X, Ni J, Qian B, Shen R and Jia X: Comprehensive circular RNA expression profiles and the tumor-suppressive function of circHIPK3 in ovarian cancer. Int J Biochem Cell Biol. 112:8–17. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Mao W, Huang X, Wang L, Zhang Z, Liu M, Li Y, Luo M, Yao X, Fan J and Geng J: Circular RNA hsa_circ_0068871 regulates FGFR3 expression and activates STAT3 by targeting miR-181a-5p to promote bladder cancer progression. J Exp Clin Cancer Res. 38:1692019. View Article : Google Scholar : PubMed/NCBI

24 

Li X, He M, Guo J and Cao T: Upregulation of circular RNA circ-ERBB2 predicts unfavorable prognosis and facilitates the progression of gastric cancer via miR-503/CACUL1 and miR-637/MMP-19 signaling. Biochem Biophys Res Commun. 511:926–930. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Chan JA, Krichevsky AM and Kosik KS: MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res. 65:6029–6033. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Lei B, Huang Y, Zhou Z, Zhao Y, Thapa AJ, Li W, Cai W and Deng Y: Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR-181a to modulate SIRT1 expression. J Cell Biochem. 120:6698–6708. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Zhou YX, Wang C, Mao LW, Wang YL, Xia LQ, Zhao W, Shen J and Chen J: Long noncoding RNA HOTAIR mediates the estrogen-induced metastasis of endometrial cancer cells via the miR-646/NPM1 axis. Am J Physiol Cell Physiol. 314:C690–C701. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Zhang P, Tang WM, Zhang H, Li YQ, Peng Y, Wang J, Liu GN, Huang XT, Zhao JJ, Li G, et al: MiR-646 inhibited cell proliferation and EMT-induced metastasis by targeting FOXK1 in gastric cancer. Br J Cancer. 117:525–534. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Zhang YS, Chen T, Cai YJ, Dong J, Bai F, Gao X, Tian L, Duan N and Liu D: MicroRNA-647 promotes the therapeutic effectiveness of argon-helium cryoablation and inhibits cell proliferation through targeting TRAF2 via the NF-κB signaling pathway in non-small cell lung cancer. Onco Targets Ther. 11:6777–6784. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Ye G, Huang K, Yu J, Zhao L, Zhu X, Yang Q, Li W, Jiang Y, Zhuang B, Liu H, et al: MicroRNA-647 targets SRF-MYH9 axis to suppress invasion and metastasis of gastric cancer. Theranostics. 7:3338–3353. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Ralston E, Beushausen S and Ploug T: Expression of the synaptic vesicle proteins VAMPs/synaptobrevins 1 and 2 in non-neural tissues. J Biol Chem. 269:15403–15406. 1994.PubMed/NCBI

33 

Raja SA, Abbas S, Shah STA, Tariq A, Bibi N, Yousuf A, Khawaja A, Nawaz M, Mehmood A, Khan MJ and Hussain A: Increased expression levels of Syntaxin 1A and Synaptobrevin 2/vesicle-associated membrane protein-2 are associated with the progression of bladder cancer. Genet Mol Biol. 42:40–47. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Li L, Wang X and Liu D: MicroRNA-185 inhibits proliferation, migration and invasion in human osteosarcoma MG63 cells by targeting vesicle-associated membrane protein 2. Gene. 696:80–87. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Wade M, Li YC and Wahl GM: MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer. 13:83–96. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, et al: In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 303:844–848. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Sawada R, Maehara R, Oshikiri T, Nakamura T, Itoh T, Kodama Y, Kakeji Y and Zen Y: MDM2 copy number increase: A poor prognostic, molecular event in esophageal squamous cell carcinoma. Hum Pathol. 89:1–9. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Wang W, Wu J, Fei X, Chen W, Li Y, Shen K and Zhu L: CHD1L promotes cell cycle progression and cell motility by up-regulating MDM2 in breast cancer. Am J Transl Res. 11:1581–1592. 2019.PubMed/NCBI

39 

Tang Y, Xuan Y, Qiao G, Ou Z, He Z, Zhu Q, Liao M and Yin G: MDM2 promotes epithelial-mesenchymal transition through activation of Smad2/3 signaling pathway in lung adenocarcinoma. Onco Targets Ther. 12:2247–2258. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun D, Liu J and Zhou L: Upregulation of circular RNA circ‑FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR‑646/VAMP2 and miR‑647/MDM2 signaling pathways. Oncol Rep 42: 2728-2737, 2019.
APA
Sun, D., Liu, J., & Zhou, L. (2019). Upregulation of circular RNA circ‑FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR‑646/VAMP2 and miR‑647/MDM2 signaling pathways. Oncology Reports, 42, 2728-2737. https://doi.org/10.3892/or.2019.7366
MLA
Sun, D., Liu, J., Zhou, L."Upregulation of circular RNA circ‑FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR‑646/VAMP2 and miR‑647/MDM2 signaling pathways". Oncology Reports 42.6 (2019): 2728-2737.
Chicago
Sun, D., Liu, J., Zhou, L."Upregulation of circular RNA circ‑FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR‑646/VAMP2 and miR‑647/MDM2 signaling pathways". Oncology Reports 42, no. 6 (2019): 2728-2737. https://doi.org/10.3892/or.2019.7366
Copy and paste a formatted citation
x
Spandidos Publications style
Sun D, Liu J and Zhou L: Upregulation of circular RNA circ‑FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR‑646/VAMP2 and miR‑647/MDM2 signaling pathways. Oncol Rep 42: 2728-2737, 2019.
APA
Sun, D., Liu, J., & Zhou, L. (2019). Upregulation of circular RNA circ‑FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR‑646/VAMP2 and miR‑647/MDM2 signaling pathways. Oncology Reports, 42, 2728-2737. https://doi.org/10.3892/or.2019.7366
MLA
Sun, D., Liu, J., Zhou, L."Upregulation of circular RNA circ‑FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR‑646/VAMP2 and miR‑647/MDM2 signaling pathways". Oncology Reports 42.6 (2019): 2728-2737.
Chicago
Sun, D., Liu, J., Zhou, L."Upregulation of circular RNA circ‑FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR‑646/VAMP2 and miR‑647/MDM2 signaling pathways". Oncology Reports 42, no. 6 (2019): 2728-2737. https://doi.org/10.3892/or.2019.7366
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