Targeting YAP suppresses ovarian cancer progression through regulation of the PI3K/Akt/mTOR pathway

  • Authors:
    • Xiao Wei
    • Yijuan Jia
    • Hua Lou
    • Jingjing Ma
    • Quanfu Huang
    • Yunchong Meng
    • Chaoyang Sun
    • Zongyuan Yang
    • Xiaoting Li
    • Sen Xu
    • Xin Yang
    • Teng Ji
    • Qinglei Gao
  • View Affiliations

  • Published online on: October 14, 2019     https://doi.org/10.3892/or.2019.7370
  • Pages: 2768-2776
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Abstract

Ovarian cancer (OC) is highly metastatic due to frequent peritoneal dissemination, and its treatment poses a major challenge in clinical practice. Yes‑associated protein (YAP) is known to be associated with the development of multiple tumors. However, whether targeting YAP can restrain OC progression and the underlying mechanisms have yet to be fully elucidated. In the present study, YAP was found to be highly expressed in OC, and its expression was correlated with the prognosis of OC patients. Moreover, silencing of YAP markedly inhibited the malignant behavior of OC cells, possibly through regulation of the PI3K/Akt/mTOR pathway. Notably, peptide 17, a YAP inhibitor, exerted a significant attenuating effect on OC progression by diminishing the activation of the PI3K/Akt/mTOR pathway in vitro as well as in vivo. Taken together, these findings demonstrated that targeting YAP attenuated OC progression and suggested the potential application of peptide 17 in OC therapy, thus providing new insights into improving the treatment of OC.
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December-2019
Volume 42 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wei X, Jia Y, Lou H, Ma J, Huang Q, Meng Y, Sun C, Yang Z, Li X, Xu S, Xu S, et al: Targeting YAP suppresses ovarian cancer progression through regulation of the PI3K/Akt/mTOR pathway. Oncol Rep 42: 2768-2776, 2019
APA
Wei, X., Jia, Y., Lou, H., Ma, J., Huang, Q., Meng, Y. ... Gao, Q. (2019). Targeting YAP suppresses ovarian cancer progression through regulation of the PI3K/Akt/mTOR pathway. Oncology Reports, 42, 2768-2776. https://doi.org/10.3892/or.2019.7370
MLA
Wei, X., Jia, Y., Lou, H., Ma, J., Huang, Q., Meng, Y., Sun, C., Yang, Z., Li, X., Xu, S., Yang, X., Ji, T., Gao, Q."Targeting YAP suppresses ovarian cancer progression through regulation of the PI3K/Akt/mTOR pathway". Oncology Reports 42.6 (2019): 2768-2776.
Chicago
Wei, X., Jia, Y., Lou, H., Ma, J., Huang, Q., Meng, Y., Sun, C., Yang, Z., Li, X., Xu, S., Yang, X., Ji, T., Gao, Q."Targeting YAP suppresses ovarian cancer progression through regulation of the PI3K/Akt/mTOR pathway". Oncology Reports 42, no. 6 (2019): 2768-2776. https://doi.org/10.3892/or.2019.7370