Novel evidence indicates the presence and replication of hepatitis B virus in breast cancer tissue

  • Authors:
    • Bo Qin
    • Kaitao Zhao
    • Jianguo Wei
    • Xin Wang
    • Minjun Xu
    • Juan Lang
    • Honggang Sun
    • Ketao Jin
  • View Affiliations

  • Published online on: October 30, 2019     https://doi.org/10.3892/or.2019.7393
  • Pages: 296-305
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Abstract

As a member of the liver tropic virus family, hepatitis B virus (HBV) was thought to only infect and replicate within the liver. Sodium taurocholate co‑transporting polypeptide (NTCP) has been identified as a functional cellular receptor and a major determinant of liver tropism and HBV entry level species specificity. In the present study, the Oncomine database was used to explore differences in NTCP expression among cancerous and normal tissues. The results revealed that NTCP was highly expressed in breast cancer (BC), which was subsequently verified in clinical samples. Furthermore, in the BC tissue of patients with chronic HBV, HBV antigens, viral DNA/RNA and specific viral particles were detected via immunohistochemistry, ELISA, western blotting, reverse transcription‑quantitative PCR and electron microscopy. Different HBV biomarkers and Dane particles were detected in BC. Furthermore, high levels of HBV‑specific RNAs, the characteristic signals of HBV replication, were also detected, indicating that HBV infects BC tissue by binding to NTCP and replicating within. Based on the data of the present study, BC tissue may represent a second location of HBV infection and replication in addition to the liver.
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January-2020
Volume 43 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Qin B, Zhao K, Wei J, Wang X, Xu M, Lang J, Sun H and Jin K: Novel evidence indicates the presence and replication of hepatitis B virus in breast cancer tissue. Oncol Rep 43: 296-305, 2020
APA
Qin, B., Zhao, K., Wei, J., Wang, X., Xu, M., Lang, J. ... Jin, K. (2020). Novel evidence indicates the presence and replication of hepatitis B virus in breast cancer tissue. Oncology Reports, 43, 296-305. https://doi.org/10.3892/or.2019.7393
MLA
Qin, B., Zhao, K., Wei, J., Wang, X., Xu, M., Lang, J., Sun, H., Jin, K."Novel evidence indicates the presence and replication of hepatitis B virus in breast cancer tissue". Oncology Reports 43.1 (2020): 296-305.
Chicago
Qin, B., Zhao, K., Wei, J., Wang, X., Xu, M., Lang, J., Sun, H., Jin, K."Novel evidence indicates the presence and replication of hepatitis B virus in breast cancer tissue". Oncology Reports 43, no. 1 (2020): 296-305. https://doi.org/10.3892/or.2019.7393