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Article

Novel evidence indicates the presence and replication of hepatitis B virus in breast cancer tissue

  • Authors:
    • Bo Qin
    • Kaitao Zhao
    • Jianguo Wei
    • Xin Wang
    • Minjun Xu
    • Juan Lang
    • Honggang Sun
    • Ketao Jin
  • View Affiliations / Copyright

    Affiliations: Shaoxing People's Hospital, The First Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang 312000, P.R. China, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, P.R. China
  • Pages: 296-305
    |
    Published online on: October 30, 2019
       https://doi.org/10.3892/or.2019.7393
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Abstract

As a member of the liver tropic virus family, hepatitis B virus (HBV) was thought to only infect and replicate within the liver. Sodium taurocholate co‑transporting polypeptide (NTCP) has been identified as a functional cellular receptor and a major determinant of liver tropism and HBV entry level species specificity. In the present study, the Oncomine database was used to explore differences in NTCP expression among cancerous and normal tissues. The results revealed that NTCP was highly expressed in breast cancer (BC), which was subsequently verified in clinical samples. Furthermore, in the BC tissue of patients with chronic HBV, HBV antigens, viral DNA/RNA and specific viral particles were detected via immunohistochemistry, ELISA, western blotting, reverse transcription‑quantitative PCR and electron microscopy. Different HBV biomarkers and Dane particles were detected in BC. Furthermore, high levels of HBV‑specific RNAs, the characteristic signals of HBV replication, were also detected, indicating that HBV infects BC tissue by binding to NTCP and replicating within. Based on the data of the present study, BC tissue may represent a second location of HBV infection and replication in addition to the liver.
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1 

Ramírez-Soto MC, Ortega-Cáceres G and Cabezas C: Trends in mortality burden of hepatocellular carcinoma, cirrhosis, and fulminant hepatitis before and after roll-out of the first pilot vaccination program against hepatitis B in Peru: An analysis of death certificate data. Vaccine. 35:3808–3812. 2017. View Article : Google Scholar : PubMed/NCBI

2 

World Health Organization: Hepatitis B vaccines: WHO position paper, July 2017-Recommendations. Vaccine. 37:223–225. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Fairman J, Liu KH and Menne S: Prevention of liver tumor formation in woodchucks with established hepatocellular carcinoma by treatment with cationic liposome-DNA complexes. BMC Cancer. 17:1722017. View Article : Google Scholar : PubMed/NCBI

4 

Qin B, Zhou Y, Zhou G, Xu X, Wang Y and Chen J: Substitutions of rtL228 and/or L229 are involved in the regulation of replication and HBsAg secretion in hepatitis B virus, and do not affect susceptibility to nucleos(t)ide analogs. Mol Med Rep. 16:9678–9684. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Li W: The hepatitis B virus receptor. Annu Rev Cell Dev Biol. 31:125–147. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Yan H and Li W: Sodium taurocholate cotransporting polypeptide acts as a receptor for hepatitis B and D virus. Dig Dis. 33:388–396. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Ni Y, Lempp FA, Mehrle S, Nkongolo S, Kaufman C, Fälth M, Stindt J, Königer C, Nassal M, Kubitz R, et al: Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes. Gastroenterology. 146:1070–1083. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Zhou M, Zhao K, Yao Y, Yuan Y, Pei R, Wang Y, Chen J, Hu X, Zhou Y, Chen X and Wu C: Productive HBV infection of well-differentiated, hNTCP-expressing human hepatoma-derived (Huh7) cells. Virol Sin. 32:465–475. 2017. View Article : Google Scholar : PubMed/NCBI

9 

He W, Ren B, Mao F, Jing Z, Li Y, Liu Y, Peng B, Yan H, Qi Y, Sun Y, et al: Hepatitis D virus infection of mice expressing human sodium taurocholate co-transporting polypeptide. PLoS Pathog. 11:e10048402015. View Article : Google Scholar : PubMed/NCBI

10 

Blank A, Markert C, Hohmann N, Carls A, Mikus G, Lehr T, Alexandrov A, Haag M, Schwab M, Urban S and Haefeli WE: First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B. J Hepatol. 65:483–489. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, et al: A Novel tricyclic polyketide, Vanitaracin A, specifically inhibits the entry of hepatitis B and D viruses by targeting sodium taurocholate cotransporting polypeptide. J Virol. 89:11945–11953. 2015. View Article : Google Scholar : PubMed/NCBI

12 

De Meyer S, Gong ZJ, Suwandhi W, van Pelt J, Soumillion A and Yap SH: Organ and species specificity of hepatitis B virus (HBV) infection: A review of literature with a special reference to preferential attachment of HBV to human hepatocytes. J Viral Hepat. 4:145–153. 1997. View Article : Google Scholar : PubMed/NCBI

13 

Xu X, Yan Q, Wang Y and Dong X: NTN4 is associated with breast cancer metastasis via regulation of EMT-related biomarkers. Oncol Rep. 37:449–457. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Qin B, Budeus B, Cao L, Wu C, Wang Y, Zhang X, Rayner S, Hoffmann D, Lu M and Chen X: The amino acid substitutions rtP177G and rtF249A in the reverse transcriptase domain of hepatitis B virus polymerase reduce the susceptibility to tenofovir. Antiviral Res. 97:93–100. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Esparza-López J, Ramos-Elías PA, Castro-Sánchez A, Rocha-Zavaleta L, Escobar-Arriaga E, Zentella-Dehesa A, León-Rodríguez E, Medina-Franco H and Ibarra-Sánchez MJ: Primary breast cancer cell culture yields intra-tumor heterogeneous subpopulations expressing exclusive patterns of receptor tyrosine kinases. BMC Cancer. 16:7402016. View Article : Google Scholar : PubMed/NCBI

16 

Naipal KA, Verkaik NS, Sánchez H, van Deurzen CH, den Bakker MA, Hoeijmakers JH, Kanaar R, Vreeswijk MP, Jager A and van Gent DC: Tumor slice culture system to assess drug response of primary breast cancer. BMC Cancer. 16:782016. View Article : Google Scholar : PubMed/NCBI

17 

Huang Y, Burns DJ, Rich BE, MacNeil IA, Dandapat A, Soltani SM, Myhre S, Sullivan BF, Lange CA, Furcht LT and Laing LG: Development of a test that measures real-time HER2 signaling function in live breast cancer cell lines and primary cells. BMC Cancer. 17:1992017. View Article : Google Scholar : PubMed/NCBI

18 

Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, Sun YL, Zhang L, Zhang QF, Popov VL, Li C, et al: Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med. 364:1523–1532. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Santos AP, Levi JE, Lemos MF, Calux SJ, Oba IT and Moreira RC: An in-house real-time polymerase chain reaction: Standardisation and comparison with the Cobas Amplicor HBV monitor and Cobas AmpliPrep/Cobas TaqMan HBV tests for the quantification of hepatitis B virus DNA. Mem Inst Oswaldo Cruz. 111:134–140. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Salpini R, Piermatteo L, Gill U, Battisti A, Stazi F, Guenci T, Giannella S, Serafini V, Kennedy PTF, Perno CF, et al: Quantification of intrahepatic total HBV DNA in liver biopsies of HBV-infected patients by a modified version of COBAS® Ampliprep/COBAS®TaqMan HBV test v2.0. Med Microbiol Immunol. 206:295–299. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Kohls K, Schmidt D, Holdenrieder S, Müller SC and Ellinger J: Detection of cell-free lncRNA in serum of cancer patients. Urologe A. 54:819–825. 2015.(In German). View Article : Google Scholar : PubMed/NCBI

22 

Hayes CN, Zhang Y, Makokha GN, Hasan MZ, Omokoko MD and Chayama K: Early events in hepatitis B virus infection: From the cell surface to the nucleus. J Gastroenterol Hepatol. 31:302–309. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Pei R, Qin B, Zhang X, Zhu W, Kemper T, Ma Z, Trippler M, Schlaak J, Chen X and Lu M: Interferon-induced proteins with tetratricopeptide repeats 1 and 2 are cellular factors that limit hepatitis B virus replication. J Innate Immun. 6:182–191. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Helgstrand JT, Røder MA, Klemann N, Toft BG, Lichtensztajn DY, Brooks JD, Brasso K, Vainer B and Iversen P: Trends in incidence and 5-year mortality in men with newly diagnosed, metastatic prostate cancer-A population-based analysis of 2 national cohorts. Cancer. 124:2931–2938. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Lin BL, Chen JF, Qiu WH, Wang KW, Xie DY, Chen XY, Liu QL, Peng L, Li JG, Mei YY, et al: Allogeneic bone marrow-derived mesenchymal stromal cells for hepatitis B virus-related acute-on-chronic liver failure: A randomized controlled trial. Hepatology. 66:209–219. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Wei XL, Qiu MZ, Chen WW, Jin Y, Ren C, Wang F, Luo HY, Wang ZQ, Zhang DS, Wang FH, et al: The status of HBV infection influences metastatic pattern and survival in Chinese patients with pancreatic cancer. J Transl Med. 11:2492013. View Article : Google Scholar : PubMed/NCBI

29 

Morales-Romero J, Vargas G and García-Román R: Occult HBV infection: A faceless enemy in liver cancer development. Viruses. 6:1590–1611. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Tajima K, Takahashi N, Ishizawa K, Murai K, Akagi T, Noji H, Sasaki O, Wano M, Itoh J, Kato Y, et al: Tohoku Hematology Forum: High prevalence of diffuse large B-cell lymphoma in occult hepatitis B virus-infected patients in the Tohoku district in Eastern Japan. J Med Virol. 88:2206–2210. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Yan H, Liu Y, Sui J and Li W: NTCP opens the door for hepatitis B virus infection. Antiviral Res. 121:24–30. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Bility MT, Li F, Cheng L and Su L: Liver immune-pathogenesis and therapy of human liver tropic virus infection in humanized mouse models. J Gastroenterol Hepatol. 28 (Suppl 1):S120–S124. 2013. View Article : Google Scholar

33 

Watashi K and Wakita T: Hepatitis B virus and hepatitis D virus entry, species specificity, and tissue tropism. Cold Spring Harb Perspect Med. 5:a0213782015. View Article : Google Scholar : PubMed/NCBI

34 

Summers J and Mason WS: Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell. 29:403–415. 1982. View Article : Google Scholar : PubMed/NCBI

35 

Bai L, Zhang X, Kozlowski M, Li W, Wu M, Liu J, Chen L, Zhang J, Huang Y and Yuan Z: Extracellular hepatitis B virus RNAs are heterogeneous in length and circulate as capsid-antibody complexes in addition to virions in chronic hepatitis B patients. J Virol. 92:e00798–18. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Dandri M and Locarnini S: New insight in the pathobiology of hepatitis B virus infection. Gut. 61 (Suppl 1):i6–i17. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Nakamoto Y and Kaneko S: Mechanisms of viral hepatitis induced liver injury. Curr Mol Med. 3:537–544. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Liu WC and Liu QY: Molecular mechanisms of gender disparity in hepatitis B virus-associated hepatocellular carcinoma. World J Gastroenterol. 20:6252–6261. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Suba Z: Circulatory estrogen level protects against breast cancer in obese women. Recent Patents Anticancer Drug Discov. 8:154–167. 2013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Qin B, Zhao K, Wei J, Wang X, Xu M, Lang J, Sun H and Jin K: Novel evidence indicates the presence and replication of hepatitis B virus in breast cancer tissue. Oncol Rep 43: 296-305, 2020.
APA
Qin, B., Zhao, K., Wei, J., Wang, X., Xu, M., Lang, J. ... Jin, K. (2020). Novel evidence indicates the presence and replication of hepatitis B virus in breast cancer tissue. Oncology Reports, 43, 296-305. https://doi.org/10.3892/or.2019.7393
MLA
Qin, B., Zhao, K., Wei, J., Wang, X., Xu, M., Lang, J., Sun, H., Jin, K."Novel evidence indicates the presence and replication of hepatitis B virus in breast cancer tissue". Oncology Reports 43.1 (2020): 296-305.
Chicago
Qin, B., Zhao, K., Wei, J., Wang, X., Xu, M., Lang, J., Sun, H., Jin, K."Novel evidence indicates the presence and replication of hepatitis B virus in breast cancer tissue". Oncology Reports 43, no. 1 (2020): 296-305. https://doi.org/10.3892/or.2019.7393
Copy and paste a formatted citation
x
Spandidos Publications style
Qin B, Zhao K, Wei J, Wang X, Xu M, Lang J, Sun H and Jin K: Novel evidence indicates the presence and replication of hepatitis B virus in breast cancer tissue. Oncol Rep 43: 296-305, 2020.
APA
Qin, B., Zhao, K., Wei, J., Wang, X., Xu, M., Lang, J. ... Jin, K. (2020). Novel evidence indicates the presence and replication of hepatitis B virus in breast cancer tissue. Oncology Reports, 43, 296-305. https://doi.org/10.3892/or.2019.7393
MLA
Qin, B., Zhao, K., Wei, J., Wang, X., Xu, M., Lang, J., Sun, H., Jin, K."Novel evidence indicates the presence and replication of hepatitis B virus in breast cancer tissue". Oncology Reports 43.1 (2020): 296-305.
Chicago
Qin, B., Zhao, K., Wei, J., Wang, X., Xu, M., Lang, J., Sun, H., Jin, K."Novel evidence indicates the presence and replication of hepatitis B virus in breast cancer tissue". Oncology Reports 43, no. 1 (2020): 296-305. https://doi.org/10.3892/or.2019.7393
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