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Article

Upregulation of thioredoxin and its reductase attenuates arsenic trioxide‑induced growth suppression in human pulmonary artery smooth muscle cells by reducing oxidative stress

  • Authors:
    • Woo Hyun Park
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Research Institute for Endocrine Sciences, Medical School, Chonbuk National University, Jeonju, Jeollabuk 54907, Republic of Korea
  • Pages: 358-367
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    Published online on: November 21, 2019
       https://doi.org/10.3892/or.2019.7414
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Abstract

The thioredoxin (Trx) system is an important enzymatic complex involved in cellular redox homeostasis. Arsenic trioxide (ATO; As2O3) is known to trigger cell death in vascular smooth muscle cells (VSMCs) via oxidative stress. In the present study, the effects of changes in thioredoxin 1 (Trx1) and Trx reductase1 (TrxR1) on cell growth, death, reactive oxygen species (ROS), and glutathione (GSH) levels were evaluated in ATO‑treated human pulmonary artery smooth muscle cells (HPASMCs). ATO inhibited growth and induced cell death in the HPASMCs at 24 h. Overexpression of Trx1 and TrxR1 using adenoviruses attenuated cell growth inhibition caused by ATO and partially prevented cell death. ATO increased ROS levels including the mitochondrial superoxide anion (O2•-) at 5 min. Administration of adTrx1 or adTrxR1 reduced the increased mitochondrial O2•- level in these cells. HPASMCs treated with Trx1 or TrxR1 siRNA showed increases in ROS levels with or without treatment of ATO at 5 min. Although ATO transiently increased GSH levels at 5 min, Trx1 and TrxR1 siRNAs reduced the increased GSH levels in these cells. In addition, PX‑12 (a Trx1 inhibitor) and auranofin (a TrxR1 inhibitor) diminished the cellular metabolism in HPASMCs at 4 h, accompanied by an increase in ROS level and a decrease in GSH level. In conclusion, upregulation of Trx1 and TrxR1 somewhat decreased cell growth inhibition and death in ATO‑treated HPASMCs, which was accompanied by reduced oxidative stress.
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1 

Irani K: Oxidant signaling in vascular cell growth, death, and survival: A review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling. Circ Res. 87:179–183. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Perez-Vizcaino F, Cogolludo A and Moreno L: Reactive oxygen species signaling in pulmonary vascular smooth muscle. Respir Physiol Neurobiol. 174:212–220. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Trachootham D, Alexandre J and Huang P: Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach? Nat Rev Drug Discov. 8:579–591. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Zelko IN, Mariani TJ and Folz RJ: Superoxide dismutase multigene family: A comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic Biol Med. 33:337–349. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Wilcox CS: Reactive oxygen species: Roles in blood pressure and kidney function. Curr Hypertens Rep. 4:160–166. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Collet JF and Messens J: Structure, function, and mechanism of thioredoxin proteins. Antioxid Redox Signal. 13:1205–1216. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Lim JY, Yoon SO, Hong SW, Kim JW, Choi SH and Cho JY: Thioredoxin and thioredoxin-interacting protein as prognostic markers for gastric cancer recurrence. World J Gastroenterol. 18:5581–5588. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Pramanik KC and Srivastava SK: Apoptosis signal-regulating kinase 1-thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis. Antioxid Redox Signal. 17:1417–1432. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Dunn LL, Buckle AM, Cooke JP and Ng MK: The emerging role of the thioredoxin system in angiogenesis. Arterioscler Thromb Vasc Biol. 30:2089–2098. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Tipple TE: The thioredoxin system in neonatal lung disease. Antioxid Redox Signal. 21:1916–1925. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Xu J, Li T, Wu H and Xu T: Role of thioredoxin in lung disease. Pulm Pharmacol Ther. 25:154–162. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Nakamura T, Nakamura H, Hoshino T, Ueda S, Wada H and Yodoi J: Redox regulation of lung inflammation by thioredoxin. Antioxid Redox Signal. 7:60–71. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Galmarini CM: Drug evaluation: The thioredoxin inhibitor PX-12 in the treatment of cancer. Curr Opin Investig Drugs. 7:1108–1115. 2006.PubMed/NCBI

14 

May HC, Yu JJ, Guentzel MN, Chambers JP, Cap AP and Arulanandam BP: Repurposing Auranofin, Ebselen, and PX-12 as antimicrobial agents targeting the thioredoxin system. Front Microbiol. 9:3362018. View Article : Google Scholar : PubMed/NCBI

15 

Wondrak GT: Redox-directed cancer therapeutics: Molecular mechanisms and opportunities. Antioxid Redox Signal. 11:3013–3069. 2009. View Article : Google Scholar : PubMed/NCBI

16 

You BR, Shin HR, Han BR and Park WH: PX-12 induces apoptosis in Calu-6 cells in an oxidative stress-dependent manner. Tumour Biol. 36:2087–2095. 2015. View Article : Google Scholar : PubMed/NCBI

17 

You BR, Shin HR and Park WH: PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis. Int J Oncol. 44:301–308. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Shin HR, You BR and Park WH: PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion. Oncol Lett. 6:1804–1810. 2013. View Article : Google Scholar : PubMed/NCBI

19 

You BR and Park WH: Auranofin induces mesothelioma cell death through oxidative stress and GSH depletion. Oncol Rep. 35:546–551. 2016. View Article : Google Scholar : PubMed/NCBI

20 

You BR, Shin HR, Han BR, Kim SH and Park WH: Auranofin induces apoptosis and necrosis in HeLa cells via oxidative stress and glutathione depletion. Mol Med Rep. 11:1428–1434. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Khairul I, Wang QQ, Jiang YH, Wang C and Naranmandura H: Metabolism, toxicity and anticancer activities of arsenic compounds. Oncotarget. 8:23905–23926. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Waxman S and Anderson KC: History of the development of arsenic derivatives in cancer therapy. Oncologist. (6 Suppl 2):S3–S10. 2001. View Article : Google Scholar

23 

Chou WC, Jie C, Kenedy AA, Jones RJ, Trush MA and Dang CV: Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci USA. 101:4578–4583. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Miller WH Jr, Schipper HM, Lee JS, Singer J and Waxman S: Mechanisms of action of arsenic trioxide. Cancer Res. 62:3893–3903. 2002.PubMed/NCBI

25 

Park WH, Seol JG, Kim ES, Hyun JM, Jung CW, Lee CC, Kim BK and Lee YY: Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis. Cancer Res. 60:3065–3071. 2000.PubMed/NCBI

26 

Zhang W, Liu Y, An Z, Huang D, Qi Y and Zhang Y: Mediating effect of ROS on mtDNA damage and low ATP content induced by arsenic trioxide in mouse oocytes. Toxicol In Vitro. 25:979–984. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Li JX, Shen YQ, Cai BZ, Zhao J, Bai X, Lu YJ and Li XQ: Arsenic trioxide induces the apoptosis in vascular smooth muscle cells via increasing intracellular calcium and ROS formation. Mol Biol Rep. 37:1569–1576. 2010. View Article : Google Scholar : PubMed/NCBI

28 

You BR and Park WH: Arsenic trioxide induces human pulmonary fibroblast cell death via increasing ROS levels and GSH depletion. Oncol Rep. 28:749–757. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Cha Y, Park DW, Lee CH, Baek SH, Kim SY, Kim JR and Kim JH: Arsenic trioxide induces apoptosis in human colorectal adenocarcinoma HT-29 cells through ROS. Cancer Res Treat. 38:54–60. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Lu J, Chew EH and Holmgren A: Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc Natl Acad Sci USA. 104:12288–12293. 2007. View Article : Google Scholar : PubMed/NCBI

31 

States JC, Srivastava S, Chen Y and Barchowsky A: Arsenic and cardiovascular disease. Toxicol Sci. 107:312–323. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Rahman MM, Ng JC and Naidu R: Chronic exposure of arsenic via drinking water and its adverse health impacts on humans. Environ Geochem Health. 31 (Suppl 1):S189–S200. 2009. View Article : Google Scholar

33 

Rahman M, Tondel M, Ahmad SA, Chowdhury IA, Faruquee MH and Axelson O: Hypertension and arsenic exposure in Bangladesh. Hypertension. 33:74–78. 1999. View Article : Google Scholar : PubMed/NCBI

34 

Tseng CH: Cardiovascular disease in arsenic-exposed subjects living in the arseniasis-hyperendemic areas in Taiwan. Atherosclerosis. 199:12–18. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Islam LN, Nabi AH, Rahman MM and Zahid MS: Association of respiratory complications and elevated serum immunoglobulins with drinking water arsenic toxicity in human. J Environ Sci Health A Tox Hazard Subst Environ Eng. 42:1807–1814. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Park WH, Han BR, Park HK and Kim SZ: Arsenic trioxide induces growth inhibition and death in human pulmonary artery smooth muscle cells accompanied by mitochondrial O2•- increase and GSH depletion. Environ Toxicol. 2018. View Article : Google Scholar :

37 

You BR and Park WH: Suberoylanilide hydroxamic acid induces thioredoxin1-mediated apoptosis in lung cancer cells via up-regulation of miR-129-5p. Mol Carcinog. 56:2566–2577. 2017. View Article : Google Scholar : PubMed/NCBI

38 

You BR and Park WH: Down-regulation of thioredoxin1 is involved in death of Calu-6 lung cancer cells treated with suberoyl bishydroxamic acid. J Cell Biochem. 117:1250–1261. 2016. View Article : Google Scholar : PubMed/NCBI

39 

You BR, Kim SH and Park WH: Reactive oxygen species, glutathione, and thioredoxin influence suberoyl bishydroxamic acid-induced apoptosis in A549 lung cancer cells. Tumour Biol. 36:3429–3439. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Park WH: Pyrogallol induces the death of human pulmonary fibroblast cells through ROS increase and GSH depletion. Int J Oncol. 49:785–792. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Berridge MV, Herst PM and Tan AS: Tetrazolium dyes as tools in cell biology: New insights into their cellular reduction. Biotechnol Annu Rev. 11:127–152. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Han YH, Kim SH, Kim SZ and Park WH: Caspase inhibitor decreases apoptosis in pyrogallol-treated lung cancer Calu-6 cells via the prevention of GSH depletion. Int J Oncol. 33:1099–1105. 2008.PubMed/NCBI

43 

Arnér ES and Holmgren A: The thioredoxin system in cancer. Semin Cancer Biol. 16:420–426. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Fernandes AP, Capitanio A, Selenius M, Brodin O, Rundlöf AK and Björnstedt M: Expression profiles of thioredoxin family proteins in human lung cancer tissue: Correlation with proliferation and differentiation. Histopathology. 55:313–320. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Sugiura H and Ichinose M: Oxidative and nitrative stress in bronchial asthma. Antioxid Redox Signal. 10:785–797. 2008. View Article : Google Scholar : PubMed/NCBI

46 

You BR and Park WH: Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels. Int J Oncol. 44:1745–1755. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Schenk H, Klein M, Erdbrügger W, Dröge W and Schulze-Osthoff K: Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1. Proc Natl Acad Sci USA. 91:1672–1676. 1994. View Article : Google Scholar : PubMed/NCBI

48 

Hirota K, Murata M, Sachi Y, Nakamura H, Takeuchi J, Mori K and Yodoi J: Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB. J Biol Chem. 274:27891–27897. 1999. View Article : Google Scholar : PubMed/NCBI

49 

Bloomfield KL, Osborne SA, Kennedy DD, Clarke FM and Tonissen KF: Thioredoxin-mediated redox control of the transcription factor Sp1 and regulation of the thioredoxin gene promoter. Gene. 319:107–116. 2003. View Article : Google Scholar : PubMed/NCBI

50 

Daloso DM, Müller K, Obata T, Florian A, Tohge T, Bottcher A, Riondet C, Bariat L, Carrari F, Nunes-Nesi A, et al: Thioredoxin, a master regulator of the tricarboxylic acid cycle in plant mitochondria. Proc Natl Acad Sci USA. 112:E1392–E1400. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Jin Y, Zhang X, Shu L, Chen L, Sun L, Qian H, Liu W and Fu Z: Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish (Danio rerio). Chemosphere. 78:846–852. 2010. View Article : Google Scholar : PubMed/NCBI

52 

Sarkar S, Mukherjee S, Chattopadhyay A and Bhattacharya S: Differential modulation of cellular antioxidant status in zebrafish liver and kidney exposed to low dose arsenic trioxide. Ecotoxicol Environ Saf. 135:173–182. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Kim HR, Kim EJ, Yang SH, Jeong ET, Park C, Kim SJ, Youn MJ, So HS and Park R: Combination treatment with arsenic trioxide and sulindac augments their apoptotic potential in lung cancer cells through activation of caspase cascade and mitochondrial dysfunction. Int J Oncol. 28:1401–1408. 2006.PubMed/NCBI

54 

Sarkar S, Mukherjee S, Chattopadhyay A and Bhattacharya S: Low dose of arsenic trioxide triggers oxidative stress in zebrafish brain: Expression of antioxidant genes. Ecotoxicol Environ Saf. 107:1–8. 2014. View Article : Google Scholar : PubMed/NCBI

55 

Dai J, Weinberg RS, Waxman S and Jing Y: Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system. Blood. 93:268–277. 1999. View Article : Google Scholar : PubMed/NCBI

56 

Han YH, Kim SZ, Kim SH and Park WH: Induction of apoptosis in arsenic trioxide-treated lung cancer A549 cells by buthionine sulfoximine. Mol Cells. 26:158–164. 2008.PubMed/NCBI

57 

Han YH, Kim SH, Kim SZ and Park WH: Apoptosis in arsenic trioxide-treated Calu-6 lung cells is correlated with the depletion of GSH levels rather than the changes of ROS levels. J Cell Biochem. 104:862–878. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Park WH: Upregulation of thioredoxin and its reductase attenuates arsenic trioxide‑induced growth suppression in human pulmonary artery smooth muscle cells by reducing oxidative stress. Oncol Rep 43: 358-367, 2020.
APA
Park, W.H. (2020). Upregulation of thioredoxin and its reductase attenuates arsenic trioxide‑induced growth suppression in human pulmonary artery smooth muscle cells by reducing oxidative stress. Oncology Reports, 43, 358-367. https://doi.org/10.3892/or.2019.7414
MLA
Park, W. H."Upregulation of thioredoxin and its reductase attenuates arsenic trioxide‑induced growth suppression in human pulmonary artery smooth muscle cells by reducing oxidative stress". Oncology Reports 43.1 (2020): 358-367.
Chicago
Park, W. H."Upregulation of thioredoxin and its reductase attenuates arsenic trioxide‑induced growth suppression in human pulmonary artery smooth muscle cells by reducing oxidative stress". Oncology Reports 43, no. 1 (2020): 358-367. https://doi.org/10.3892/or.2019.7414
Copy and paste a formatted citation
x
Spandidos Publications style
Park WH: Upregulation of thioredoxin and its reductase attenuates arsenic trioxide‑induced growth suppression in human pulmonary artery smooth muscle cells by reducing oxidative stress. Oncol Rep 43: 358-367, 2020.
APA
Park, W.H. (2020). Upregulation of thioredoxin and its reductase attenuates arsenic trioxide‑induced growth suppression in human pulmonary artery smooth muscle cells by reducing oxidative stress. Oncology Reports, 43, 358-367. https://doi.org/10.3892/or.2019.7414
MLA
Park, W. H."Upregulation of thioredoxin and its reductase attenuates arsenic trioxide‑induced growth suppression in human pulmonary artery smooth muscle cells by reducing oxidative stress". Oncology Reports 43.1 (2020): 358-367.
Chicago
Park, W. H."Upregulation of thioredoxin and its reductase attenuates arsenic trioxide‑induced growth suppression in human pulmonary artery smooth muscle cells by reducing oxidative stress". Oncology Reports 43, no. 1 (2020): 358-367. https://doi.org/10.3892/or.2019.7414
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