|
1
|
Hirsch FR, Scagliotti GV, Mulshine JL,
Kwon R, Curran WJ Jr, Wu YL and Paz-Ares L: Lung cancer: Current
therapies and new targeted treatments. Lancet. 389:299–311. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Herbst RS, Heymach JV and Lippman SM: Lung
cancer. N Engl J Med. 359:1367–1380. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Siegel R, Naishadham D and Jemal A: Cancer
statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Goruppi S, Patten RD, Force T and Kyriakis
JM: Helix-loop-helix protein p8, a transcriptional regulator
required for cardiomyocyte hypertrophy and cardiac fibroblast
matrix metalloprotease induction. Mol Cell Biol. 27:993–1006. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Mallo GV, Fiedler F, Calvo EL, Ortiz EM,
Vasseur S, Keim V, Morisset J and Iovanna JL: Cloning and
expression of the rat p8 cDNA, a new gene activated in pancreas
during the acute phase of pancreatitis, pancreatic development, and
regeneration, and which promotes cellular growth. J Biol Chem.
272:32360–32369. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Jiang YF, Vaccaro MI, Fiedler F, Calvo EL
and Iovanna JL: Lipopolysaccharides induce p8 mRNA expression in
vivo and in vitro. Biochem Biophys Res Commun. 260:686–690. 1999.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Taïeb D, Malicet C, Garcia S, Rocchi P,
Arnaud C, Dagorn JC, Iovanna JL and Vasseur S: Inactivation of
stress protein p8 increases murine carbon tetrachloride
hepatotoxicity via preserved CYP2E1 activity. Hepatology.
42:176–182. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Zinke I, Schütz CS, Katzenberger JD, Bauer
M and Pankratz MJ: Nutrient control of gene expression in
Drosophila: Microarray analysis of starvation and sugar-dependent
response. EMBO J. 21:6162–6173. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Mu Y, Yan X, Li D, Zhao D, Wang L, Wang X,
Gao D, Yang J, Zhang H, Li Y, et al: NUPR1 maintains autolysosomal
efflux by activating SNAP25 transcription in cancer cells.
Autophagy. 14:654–670. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Jung SH, Lee A, Yim SH, Hu HJ, Choe C and
Chung YJ: Simultaneous copy number gains of NUPR1 and ERBB2
predicting poor prognosis in early-stage breast cancer. BMC Cancer.
12:3822012. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Iovanna JL: Expression of the
stress-associated protein p8 is a requisite for tumor development.
Int J Gastrointest Cancer. 31:89–98. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Vasseur S, Hoffmeister A, Garcia S, Bagnis
C, Dagorn JC and Iovanna JL: p8 is critical for tumour development
induced by rasV12 mutated protein and E1A oncogene. EMBO Rep.
3:165–170. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Ito Y, Yoshida H, Motoo Y, Iovanna JL,
Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, et
al: Expression of p8 protein in medullary thyroid carcinoma.
Anticancer Res. 25:3419–3423. 2005.PubMed/NCBI
|
|
14
|
Su SB, Motoo Y, Iovanna JL, Xie MJ and
Sawabu N: Effect of camostat mesilate on the expression of
pancreatitis-associated protein (PAP), p8, and cytokines in rat
spontaneous chronic pancreatitis. Pancreas. 23:134–140. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Guo X, Wang W, Hu J, Feng K, Pan Y, Zhang
L and Feng Y: Lentivirus-mediated RNAi knockdown of NUPR1 inhibits
human nonsmall cell lung cancer growth in vitro and in vivo. Anat
Rec (Hoboken). 295:2114–2121. 2012. View
Article : Google Scholar : PubMed/NCBI
|
|
16
|
Vasseur S, Vidal Mallo G, Fiedler F,
Bödeker H, Cánepa E, Moreno S and Iovanna JL: Cloning and
expression of the human p8, a nuclear protein with mitogenic
activity. Eur J Biochem. 259:670–675. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Hamidi T, Algül H, Cano CE, Sandi MJ,
Molejon MI, Riemann M, Calvo EL, Lomberk G, Dagorn JC, Weih F, et
al: Nuclear protein 1 promotes pancreatic cancer development and
protects cells from stress by inhibiting apoptosis. J Clin Invest.
122:2092–2103. 2012. View
Article : Google Scholar : PubMed/NCBI
|
|
18
|
Santofimia-Castaño P, Rizzuti B, Abián O,
Velázquez-Campoy A, Iovanna JL and Neira JL: Amphipathic helical
peptides hamper protein-protein interactions of the intrinsically
disordered chromatin nuclear protein 1 (NUPR1). Biochim Biophys
Acta Gen Subj. 1862:1283–1295. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Neira JL, Bintz J, Arruebo M, Rizzuti B,
Bonacci T, Vega S, Lanas A, Velázquez-Campoy A, Iovanna JL and
Abián O: Identification of a drug targeting an intrinsically
disordered protein involved in pancreatic adenocarcinoma. Sci Rep.
7:397322017. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W,
Zhu H, Yu AD, Xie X, Ma D and Yuan J: Small molecule regulators of
autophagy identified by an image-based high-throughput screen. Proc
Natl Acad Sci USA. 104:19023–19028. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Chen QY, Wu LJ, Wu YQ, Lu GH, Jiang ZY,
Zhan JW, Jie Y and Zhou JY: Molecular mechanism of trifluoperazine
induces apoptosis in human A549 lung adenocarcinoma cell lines. Mol
Med Rep. 2:811–817. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Annabi B, Pilorget A, Bousquet-Gagnon N,
Gingras D and Béliveau R: Calmodulin inhibitors trigger the
proteolytic processing of membrane type-1 matrix metalloproteinase,
but not its shedding in glioblastoma cells. Biochem J. 359:325–333.
2001. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Chen MH, Lin KJ, Yang WLR, Kao YW, Chen
TW, Chao SC, Chang PM, Liu CY, Tzeng CH, Chao Y, et al: Gene
expression-based chemical genomics identifies heat-shock protein 90
inhibitors as potential therapeutic drugs in cholangiocarcinoma.
Cancer. 119:293–303. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Shin SY, Kim CG, Hong DD, Kim JH and Lee
YH: Implication of Egr-1 in trifluoperazine-induced growth
inhibition in human U87MG glioma cells. Exp Mol Med. 36:380–386.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Yeh CT, Wu ATH, Chang PMH, Chen KY, Yang
CN, Yang SC, Ho CC, Chen CC, Kuo YL, Lee PY, et al:
Trifluoperazine, an antipsychotic agent, inhibits cancer stem cell
growth and overcomes drug resistance of lung cancer. Am J Respir
Crit Care Med. 186:1180–1188. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Miller N: Glybera and the future of gene
therapy in the European Union. Nat Rev Drug Discov. 11:4192012.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Shi J, Zheng D, Liu Y, Sham MH, Tam P,
Farzaneh F and Xu R: Overexpression of soluble TRAIL induces
apoptosis in human lung adenocarcinoma and inhibits growth of tumor
xenografts in nude mice. Cancer Res. 65:1687–1692. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Xiao W, Chirmule N, Schnell MA, Tazelaar
J, Hughes JV and Wilson JM: Route of administration determines
induction of T-cell-independent humoral responses to
adeno-associated virus vectors. Mol Ther. 1:323–329. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Santofimia-Castaño P, Xia Y, Lan W, Zhou
Z, Huang C, Peng L, Soubeyran P, Velázquez-Campoy A, Abián O,
Rizzuti B, et al: Ligand-based design identifies a potent NUPR1
inhibitor exerting anticancer activity via necroptosis. J Clin
Invest. 129:2500–2513. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Goruppi S and Iovanna JL: Stress-inducible
protein p8 is involved in several physiological and pathological
processes. J Biol Chem. 285:1577–1581. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Li J, Ren S, Liu Y, Lian Z, Dong B, Yao Y
and Xu Y: Knockdown of NUPR1 inhibits the proliferation of
glioblastoma cells via ERK1/2, p38 MAPK and caspase-3. J
Neurooncol. 132:15–26. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Gironella M, Malicet C, Cano C, Sandi MJ,
Hamidi T, Tauil RMN, Baston M, Valaco P, Moreno S, Lopez F, et al:
p8/nupr1 regulates DNA-repair activity after double-strand gamma
irradiation-induced DNA damage. J Cell Physiol. 221:594–602. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Malicet C, Dagorn JC, Neira JL and Iovanna
JL: p8 and prothymosin alpha: Unity is strength. Cell Cycle.
5:829–830. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Sandi MJ, Hamidi T, Malicet C, Cano C,
Loncle C, Pierres A, Dagorn JC and Iovanna JL: p8 expression
controls pancreatic cancer cell migration, invasion, adhesion, and
tumorigenesis. J Cell Physiol. 226:3442–3451. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Chandler RJ, Sands MS and Venditti CP:
Recombinant adeno- associated viral integration and genotoxicity:
Insights from animal models. Hum Gene Ther. 28:314–322. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Wu L, Liu YY, Li ZX, Zhao Q, Wang X, Yu Y,
Wang YY, Wang YQ and Luo F: Anti-tumor effects of penfluridol
through dysregulation of cholesterol homeostasis. Asian Pac J
Cancer Prev. 15:489–494. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Hait WN, Byrne TN, Piepmeier J, Durivage
HJ, Choudhury S, Davis CA and Gates JA: The effect of calmodulin
inhibitors with bleomycin on the treatment of patients with high
grade gliomas. Cancer Res. 50:6636–6640. 1990.PubMed/NCBI
|
|
38
|
Hait WN, Morris S, Lazo JS, Figlin RJ,
Durivage HJ, White K and Schwartz PE: Phase I trial of combined
therapy with bleomycin and the calmodulin antagonist,
trifluoperazine. Cancer Chemother Pharmacol. 23:358–362. 1989.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Feng Z, Xia Y, Gao T, Xu F, Lei Q, Peng C,
Yang Y, Xue Q, Hu X, Wang Q, et al: The antipsychotic agent
trifluoperazine hydrochloride suppresses triple-negative breast
cancer tumor growth and brain metastasis by inducing G0/G1 arrest
and apoptosis. Cell Death Dis. 9:10062018. View Article : Google Scholar : PubMed/NCBI
|
