Open Access

Ginsenoside CK induces apoptosis and suppresses proliferation and invasion of human osteosarcoma cells through the PI3K/mTOR/p70S6K1 pathway

  • Authors:
    • Kang Chen
    • Jianbao Jiao
    • Jinwei Xue
    • Taoping Chen
    • Yu Hou
    • Yuantao Jiang
    • Ligang Qian
    • Yunfei Wang
    • Zheng Ma
    • Zhixing Liang
    • Bo Sun
    • Qiao Ren
  • View Affiliations

  • Published online on: January 13, 2020     https://doi.org/10.3892/or.2020.7460
  • Pages: 886-896
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteosarcoma is one of the most malignant bone tumors, and its major threats are aggressive invasion and early tumor metastasis, which result in a poor prognosis and high mortality. Accumulating evidence indicates that ginsenoside compound K (CK) has a significant antitumor effect, particularly on the inhibition of proliferation and invasion of numerous human tumors. In the present study, it was revealed that CK inhibited the viability and proliferation of osteosarcoma cells. Moreover, it was demonstrated that CK induced apoptosis and inhibited the migration and invasion of osteosarcoma cells via apoptotic staining, Annexin V/PI staining, and Transwell invasion assays. Furthermore, at the molecular level, the present results confirmed that apoptosis and invasion‑related proteins were regulated by CK, which was possibly related to the blockade of the PI3K/mTOR/p70S6K1 signaling pathway. In summary, the present findings indicated that CK inhibited viability and proliferation, induced apoptosis, and inhibited the migration and invasion of osteosarcoma cells through the PI3K/mTOR/p70S6K1 signaling pathway.

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March 2020
Volume 43 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Chen, K., Jiao, J., Xue, J., Chen, T., Hou, Y., Jiang, Y. ... Ren, Q. (2020). Ginsenoside CK induces apoptosis and suppresses proliferation and invasion of human osteosarcoma cells through the PI3K/mTOR/p70S6K1 pathway. Oncology Reports, 43, 886-896. https://doi.org/10.3892/or.2020.7460
MLA
Chen, K., Jiao, J., Xue, J., Chen, T., Hou, Y., Jiang, Y., Qian, L., Wang, Y., Ma, Z., Liang, Z., Sun, B., Ren, Q."Ginsenoside CK induces apoptosis and suppresses proliferation and invasion of human osteosarcoma cells through the PI3K/mTOR/p70S6K1 pathway". Oncology Reports 43.3 (2020): 886-896.
Chicago
Chen, K., Jiao, J., Xue, J., Chen, T., Hou, Y., Jiang, Y., Qian, L., Wang, Y., Ma, Z., Liang, Z., Sun, B., Ren, Q."Ginsenoside CK induces apoptosis and suppresses proliferation and invasion of human osteosarcoma cells through the PI3K/mTOR/p70S6K1 pathway". Oncology Reports 43, no. 3 (2020): 886-896. https://doi.org/10.3892/or.2020.7460