Open Access

Downregulation of GPSM2 is associated with primary resistance to paclitaxel in breast cancer

  • Authors:
    • Zhe Zhang
    • Zhi Li
    • Mingming Deng
    • Bofang Liu
    • Xing Xin
    • Zhenkun Zhao
    • Ye Zhang
    • Qingjie Lv
  • View Affiliations

  • Published online on: January 17, 2020     https://doi.org/10.3892/or.2020.7471
  • Pages: 965-974
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Paclitaxel is one of the most effective chemotherapy drugs for breast cancer worldwide but 20‑30% patients show primary resistance to the drug. Screening and identification of markers that facilitate effective and rapid prediction of sensitivity to paclitaxel is therefore an urgent medical requirement. In the present study, G protein signaling modulator 2 (GPSM2) mRNA levels were significantly associated with taxane sensitivity in experiments based on the Gene Expression Omnibus (GEO) online database. Immunohistochemical analysis consistently revealed a significant association of GPSM2 protein levels with paclitaxel sensitivity in breast cancer patients. Knockdown of GPSM2 reduced the sensitivity of breast cancer cells to paclitaxel via regulation of the cell cycle. Animal experiments further corroborated our in vitro findings. These results suggest that GPSM2 plays an important role in breast cancer resistance, supporting its utility as a potential target for improving drug susceptibility in patients as well as a marker of paclitaxel sensitivity.

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March 2020
Volume 43 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Zhang, Z., Li, Z., Deng, M., Liu, B., Xin, X., Zhao, Z. ... Lv, Q. (2020). Downregulation of GPSM2 is associated with primary resistance to paclitaxel in breast cancer. Oncology Reports, 43, 965-974. https://doi.org/10.3892/or.2020.7471
MLA
Zhang, Z., Li, Z., Deng, M., Liu, B., Xin, X., Zhao, Z., Zhang, Y., Lv, Q."Downregulation of GPSM2 is associated with primary resistance to paclitaxel in breast cancer". Oncology Reports 43.3 (2020): 965-974.
Chicago
Zhang, Z., Li, Z., Deng, M., Liu, B., Xin, X., Zhao, Z., Zhang, Y., Lv, Q."Downregulation of GPSM2 is associated with primary resistance to paclitaxel in breast cancer". Oncology Reports 43, no. 3 (2020): 965-974. https://doi.org/10.3892/or.2020.7471