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Article

Pioglitazone as a modulator of the chemoresistance of renal cell adenocarcinoma to methotrexate

  • Authors:
    • Iwona Piątkowska‑Chmiel
    • Monika Gawrońska‑Grzywacz
    • Dorota Natorska‑Chomicka
    • Mariola Herbet
    • Marcin Sysa
    • Magdalena Iwan
    • Agnieszka Korga
    • Jarosław Dudka
  • View Affiliations / Copyright

    Affiliations: Department of Toxicology, Faculty of Pharmacy and Medical Analytics Division, Medical University of Lublin, PL 20‑090 Lublin, Poland
  • Pages: 1019-1030
    |
    Published online on: January 29, 2020
       https://doi.org/10.3892/or.2020.7482
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Abstract

Kidney cancer is one of the most lethal urological malignancies associated with a high risk of mortality. Recent studies have shown that several antidiabetic drugs may limit the risk of the growth of different types of cancer. Pioglitazone (PIO) belongs to a novel class of antidiabetic drugs called thiazolidinediones (TZDs), which are commonly used in the treatment of type 2 diabetes. This drug has been demonstrated to exert an inhibitory effect on cell growth in colon, prostatic, breast and pancreatic cancer lines. The aim of the present study was to assess the inhibitory effect of PIO on the proliferation of the renal adenocarcinoma cell line 769‑P. In addition, the proapoptotic potential of combined treatment with PIO and methotrexate (MTX) was evaluated, as well as the impact of the above drugs on the cell cycle of the 769‑P cells. The present study showed that PIO efficaciously inhibited the proliferation and viability of renal cancer cells, and it induced sub‑G1 cell cycle arrest and a decrease in the number of cells in the G2 phase, which indicated cytotoxic activity. PIO also exhibited proapoptotic properties at the lowest dose applied (10 µM). Furthermore, combined therapy with PIO and MTX increased the sensitivity of tumor cells to MTX while at the same time this combined therapy did not exhibit a cytotoxic effect to normal kidney cells. In renal adenocarcinoma cells, the combination of the above cytostatic agent at the lowest dose administered (MTX, 5 µM) with the peroxisome proliferator‑activated receptor γ agonist PIO exhibited better efficacy in triggering the process of apoptosis than that displayed by MTX alone.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Torre LA, Siegel RL, Ward EM and Jemal A: Global cancer incidence and mortality rates and trends-an update. Cancer Epidemiol Biomarkers Prev. 25:16–27. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Al-Dimassi S, Abou-Antoun T and El-Sibai M: Cancer cell resistance mechanisms: A mini review. Clin Transl Oncol. 16:511–516. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Ljungberg B, Campbell SC, Choi HY, Jacqmin D, Lee JE, Weikert S and Kiemeney LA: The epidemiology of renal cell carcinoma. Eur Urol. 60:615–621. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Cancer Research UK: Kidney cancer statistics. https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/kidney-cancer/incidence-heading-ZeroApril 13–2019

7 

Lipworth L, Tarone RE, Lund L and McLaughlin JK: Epidemiologic characteristics and risk factors for renal cell cancer. Clin Epidemiol. 1:33–43. 2009.PubMed/NCBI

8 

Capitanio U, Bensalah K, Bex A, Boorjian SA, Bray F, Coleman J, Gore JL, Sun M, Wood C and Russo P: Epidemiology of renal cell carcinoma. Eur Urol. 75:74–84. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Mathew A, Devesa SS, Fraumeni JF Jr and Chow WH: Global increases in kidney cancer incidence, 1973–1992. Eur J Cancer Prev. 11:171–178. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Habib SL, Prihoda TJ, Luna M and Werner SA: Diabetes and risk of renal cell carcinoma. J Cancer. 3:42–48. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Shi Y and Hu FB: The global implications of diabetes and cancer. Lancet. 383:1947–1948. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Song XS, Fan B, Ma C, Yu ZL, Bai SS, Zhang Z, Zhao H, Zhu XQ, He SL, Chen F, et al: Clinical research on the correlations between type 2 diabetes mellitus and renal clear cell carcinoma. Zhonghua Wai Ke Za Zhi. 51:627–630. 2013.(In Chinese). PubMed/NCBI

13 

Hou Y, Zhou M, Xie J, Chao P, Feng Q and Wu J: High glucose levels promote the proliferation of breast cancer cells through GTPases. Breast Cancer (Dove Med Press). 9:429–436. 2017.PubMed/NCBI

14 

Giovannucci E, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, Habel LA, Pollak M, Regensteiner JG and Yee D: Diabetes and cancer: A consensus report. Diabetes Care. 33:1674–1685. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Psutka SP, Stewart SB, Boorjian SA, Lohse CM, Tollefson MK, Cheville JC, Leibovich BC and Thompson RH: Diabetes mellitus is independently associated with an increased risk of mortality in patients with clear cell renal cell carcinoma. J Urol. 192:1620–1627. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Sen S, He Y, Koya D and Kanasaki K: Cancer biology in diabetes. J Diabetes Investig. 5:251–264. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Pearson-Stuttard J, Zhou B, Kontis V, Bentham J, Gunter MJ and Ezzati M: Worldwide burden of cancer attributable to diabetes and high body-mass index: A comparative risk assessment. Lancet Diabetes Endocrinol. 6:95–104. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Kasznicki J, Sliwinska A and Drzewoski J: Metformin in cancer prevention and therapy. Ann Transl Med. 2:572014.PubMed/NCBI

19 

Zhu C, Wei J, Tian X, Li Y and Li X: Prognostic role of PPAR-γ and PTEN in the renal cell carcinoma. Int J Clin Exp Pathol. 8:12668–12677. 2015.PubMed/NCBI

20 

Liu J, Li M, Song B, Jia C, Zhang L, Bai X and Hu W: Metformin inhibits renal cell carcinoma in vitro and in vivo xenograft. Urol Oncol. 31:264–270. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Yuan J, Takahashi A, Masumori N, Uchida K, Hisasue S, Kitamura H, Itoh N and Tsukamoto T: Ligands for peroxisome proliferator-activated receptor gamma have potent antitumor effect against human renal cell carcinoma. Urology. 65:594–599. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Grygiel-Górniak B: Peroxisome proliferator-activated receptors and their ligands: Nutritional and clinical implications-a review. Nutr J. 13:17–25. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Fröhlich E and Wahl R: Chemotherapy and chemoprevention by thiazolidinediones. BioMed Res Int. 2015:8453402015. View Article : Google Scholar : PubMed/NCBI

24 

Zhang GY, Ahmed N, Riley C, Oliva K, Barker G, Quinn MA and Rice GE: Enhanced expression of peroxisome proliferator-activated receptor gamma in epithelial ovarian carcinoma. Br J Cancer. 92:113–119. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Inoue K, Kawahito Y, Tsubouchi Y, Kohno M, Yoshimura R, Yoshikawa T and Sano H: Expression of peroxisome proliferator-activated receptor gamma in renal cell carcinoma and growth inhibition by its agonists. Biochem Biophys Res Commun. 287:727–732. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Bull AW: The role of peroxisome proliferator-activated receptor gamma in colon cancer and inflammatory bowel disease. Arch Pathol Lab Med. 127:1121–1123. 2003.PubMed/NCBI

27 

Smith MR and Kantoff PW: Peroxisome proliferator-activated receptor gamma (PPAR gamma) as a novel target for prostate cancer. Invest New Drugs. 20:195–200. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Mansure JJ, Nassim R, Chevalier S, Szymanski K, Rocha J, Aldousari S and Kassouf W: A novel mechanism of PPAR gamma induction via EGFR signalling constitutes rational for combination therapy in bladder cancer. PLoS One. 8:e559972013. View Article : Google Scholar : PubMed/NCBI

29 

Lakshmi SP, Reddy AT, Banno A and Reddy RC: PPAR agonists for the prevention and treatment of lung cancer. PPAR Res. 2017:82527962017. View Article : Google Scholar : PubMed/NCBI

30 

Sarafidis PA and Bakris GL: Protection of the kidney by thiazolidinediones: An assessment from bench to bedside. Kidney Int. 70:1223–1233. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Sarafidis PA, Georgianos PI and Lasaridis AN: PPAR-γ agonism for cardiovascular and renal protection. Cardiovasc Ther. 29:377–384. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Hagner N and Joerger M: Cancer chemotherapy: Targeting folic acid synthesis. Cancer Manag Res. 2:293–301. 2010.PubMed/NCBI

33 

Gonen N and Assaraf YG: Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance. Drug Resist Updat. 15:183–210. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Morales C, Ribas M, Aiza G and Peinado MA: Genetic determinants of methotrexate responsiveness and resistance in colon cancer cells. Oncogene. 24:6842–6847. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Wang J and Li G: Mechanisms of methotrexate resistance in osteosarcoma cell lines and strategies for overcoming this resistance. Oncol Lett. 9:940–944. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Bertino JR, Göker E, Gorlick R, Li WW and Banerjee D: Resistance mechanisms to methotrexate in tumors. Oncologist. 1:223–226. 1996. View Article : Google Scholar : PubMed/NCBI

37 

Assaraf YG: Molecular basis of antifolate resistance. Cancer Metastasis Rev. 26:153–181. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Chen ZS, Lee K, Walther S, Raftogianis RB, Kuwano M, Zeng H and Kruh GD: Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 62:3144–3150. 2002.PubMed/NCBI

39 

Sirotnak FM, Wendel HG, Bornmann WG, Tong WP, Miller VA, Scher HI and Kris MG: Co-administration of probenecid, an inhibitor of a cMOAT/MRP-like plasma membrane ATPase, greatly enhanced the efficacy of a new 10-deazaaminopterin against human solid tumors in vivo. Clin Cancer Res. 6:3705–3712. 2000.PubMed/NCBI

40 

Ichioka D, Miyazaki J, Inoue T, Kageyama S, Sugimoto M, Mitsuzuka K, Matsui Y, Shiraishi Y, Kinoshita H, Wakeda H, et al: Impact of renal function of patients with advanced urothelial cancer on eligibility for first-line chemotherapy and treatment outcomes. Jpn J Clin Oncol. 45:867–873. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Koga H, Selvendiran K, Sivakumar R, Yoshida T, Torimura T, Ueno T and Sata M: PPARγ potentiates anticancer effects of gemcitabine on human pancreatic cancer cells. Int J Oncol. 40:679–685. 2012.PubMed/NCBI

42 

Ling S, Feng T, Ke Q, Fan N, Li L, Li Z, Dong C, Wang C, Xu F, Li Y and Wang L: Metformin inhibits proliferation and enhances chemosensitivity of intrahepatic cholangiocarcinoma cell lines. Oncol Rep. 31:2611–2618. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Mahmoud MF and El Shazly SM: Pioglitazone protects against cisplatin induced nephrotoxicity in rats and potentiates its anticancer activity against human renal adenocarcinoma cell lines. Food Chem Toxicol. 51:114–122. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Wlodkowic D, Telford W, Skommer J and Darzynkiewicz Z: Apoptosis and beyond: Cytometry in studies of programmed cell death. Methods Cell Biol. 103:55–98. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Guan YF, Zhang YH, Breyer RM, Davis L and Breyer MD: Expression of peroxisome proliferator-activated receptor gamma (PPAR gamma) in human transitional bladder cancer and its role in inducing cell death. Neoplasia. 1:330–339. 1999. View Article : Google Scholar : PubMed/NCBI

46 

Hashimoto Y, Shimada Y, Itami A, Ito T, Kawamura J, Kawabe A, Kaganoi J, Maeda M, Watanabe G and Imamura M: Growth inhibition through activation of peroxisome proliferator-activated receptor gamma in human oesophageal squamous cell carcinoma. Eur J Cancer. 39:2239–2246. 2003. View Article : Google Scholar : PubMed/NCBI

47 

Mössner R, Schulz U, Krüger U, Middel P, Schinner S, Füzesi L, Neumann C and Reich K: Agonists of peroxisome proliferator-activated receptor gamma inhibit cell growth in malignant melanoma. J Invest Dermatol. 119:576–582. 2002. View Article : Google Scholar : PubMed/NCBI

48 

Youssef J and Badr M: Peroxisome proliferator-activated receptors and cancer: Challenges and opportunities. Br J Pharmacol. 164:68–82. 2011. View Article : Google Scholar : PubMed/NCBI

49 

Yang FG, Zhang ZW, Xin DQ, Shi CJ, Wu JP, Guo YL and Guan YF: Peroxisome proliferator-activated receptor γ ligands induce cell cycle arrest and apoptosis in human renal carcinoma cell lines. Acta Pharmacol Sin. 26:753–761. 2005. View Article : Google Scholar : PubMed/NCBI

50 

Elrod HA and Sun SY: PPAR gamma and apoptosis in cancer. PPAR Res. 2008:7041652008. View Article : Google Scholar : PubMed/NCBI

51 

Bonofiglio D, Cione E, Qi H, Pingitore A, Perri M, Catalano S, Vizza D, Panno ML, Genchi G, Fuqua SA and Andò S: Combined low doses of PPAR gamma and RXR ligands trigger an intrinsic apoptotic pathway in human breast cancer cells. Am J Pathol. 175:1270–1280. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Rumi MA, Sato H, Ishihara S, Ortega C, Kadowaki Y and Kinoshita Y: Growth inhibition of esophageal squamous carcinoma cells by peroxisome proliferator-activated receptor-γ ligands. J Lab Clin Med. 140:17–26. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Piątkowska‑Chmiel I, Gawrońska‑Grzywacz M, Natorska‑Chomicka D, Herbet M, Sysa M, Iwan M, Korga A and Dudka J: Pioglitazone as a modulator of the chemoresistance of renal cell adenocarcinoma to methotrexate. Oncol Rep 43: 1019-1030, 2020.
APA
Piątkowska‑Chmiel, I., Gawrońska‑Grzywacz, M., Natorska‑Chomicka, D., Herbet, M., Sysa, M., Iwan, M. ... Dudka, J. (2020). Pioglitazone as a modulator of the chemoresistance of renal cell adenocarcinoma to methotrexate. Oncology Reports, 43, 1019-1030. https://doi.org/10.3892/or.2020.7482
MLA
Piątkowska‑Chmiel, I., Gawrońska‑Grzywacz, M., Natorska‑Chomicka, D., Herbet, M., Sysa, M., Iwan, M., Korga, A., Dudka, J."Pioglitazone as a modulator of the chemoresistance of renal cell adenocarcinoma to methotrexate". Oncology Reports 43.3 (2020): 1019-1030.
Chicago
Piątkowska‑Chmiel, I., Gawrońska‑Grzywacz, M., Natorska‑Chomicka, D., Herbet, M., Sysa, M., Iwan, M., Korga, A., Dudka, J."Pioglitazone as a modulator of the chemoresistance of renal cell adenocarcinoma to methotrexate". Oncology Reports 43, no. 3 (2020): 1019-1030. https://doi.org/10.3892/or.2020.7482
Copy and paste a formatted citation
x
Spandidos Publications style
Piątkowska‑Chmiel I, Gawrońska‑Grzywacz M, Natorska‑Chomicka D, Herbet M, Sysa M, Iwan M, Korga A and Dudka J: Pioglitazone as a modulator of the chemoresistance of renal cell adenocarcinoma to methotrexate. Oncol Rep 43: 1019-1030, 2020.
APA
Piątkowska‑Chmiel, I., Gawrońska‑Grzywacz, M., Natorska‑Chomicka, D., Herbet, M., Sysa, M., Iwan, M. ... Dudka, J. (2020). Pioglitazone as a modulator of the chemoresistance of renal cell adenocarcinoma to methotrexate. Oncology Reports, 43, 1019-1030. https://doi.org/10.3892/or.2020.7482
MLA
Piątkowska‑Chmiel, I., Gawrońska‑Grzywacz, M., Natorska‑Chomicka, D., Herbet, M., Sysa, M., Iwan, M., Korga, A., Dudka, J."Pioglitazone as a modulator of the chemoresistance of renal cell adenocarcinoma to methotrexate". Oncology Reports 43.3 (2020): 1019-1030.
Chicago
Piątkowska‑Chmiel, I., Gawrońska‑Grzywacz, M., Natorska‑Chomicka, D., Herbet, M., Sysa, M., Iwan, M., Korga, A., Dudka, J."Pioglitazone as a modulator of the chemoresistance of renal cell adenocarcinoma to methotrexate". Oncology Reports 43, no. 3 (2020): 1019-1030. https://doi.org/10.3892/or.2020.7482
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