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Article

DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas

  • Authors:
    • Mai‑Qing Yang
    • Lin‑Lin Bai
    • Lei Lei
    • Yi‑Wen Zheng
    • Zhao Wang
    • Zhi‑Han Li
    • Chen‑Chen Liu
    • Wen‑Jing Huang
    • Hong‑Tao Xu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Pathology, Shenyang 242 Hospital, Shenyang, Liaoning 110001, P.R. China
  • Pages: 1338-1348
    |
    Published online on: February 3, 2020
       https://doi.org/10.3892/or.2020.7488
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Abstract

DEK has been revealed to be overexpressed in many cancers and associated with cancer progression. The aim of the present study was to elucidate the role of DEK with a specific focus on its underlying mechanism in lung cancers. DEK expression in lung cancers and normal lung tissues and the correlations between DEK expression and clinicopathological parameters of lung cancers were investigated using the data from The Cancer Genome Atlas (TCGA). DEK expression was upregulated by DEK transfection or downregulated by DEK shRNA interference in A549 and H1299 cells. The effects of DEK on the Wnt signaling pathway and epithelial‑mesenchymal transition (EMT) were examined using western blotting. Proliferative and invasive abilities were observed in A549 and H1299 cells treated with DEK using an MTT assay, colony formation assay, and Transwell migration and invasion assays. The expression of DEK was higher in lung cancer tissues than that in normal lung tissues. DEK expression was positively correlated with the expression of epidermal growth factor receptor (EGFR) and KRAS in lung adenocarcinomas. High expression of DEK indicated poor prognosis in lung adenocarcinomas (P=0.018). Enhanced expression of DEK upregulated the levels of active‑β‑catenin and Wnt target genes, such as cyclin D1, c‑Myc and MMP7 and increased the proliferative and invasive abilities of lung cancer cells. Enhanced expression of DEK in A549 and H1299 cells also increased the levels of EGFR, KRAS, vimentin, Snail, and N‑cadherin, and decreased the level of E‑cadherin. The opposite results were obtained with knockdown of DEK expression. DEK was highly expressed in lung cancers and indicated poor prognosis in lung adenocarcinomas. DEK expression activated the Wnt signaling pathway and EMT process and promoted the proliferation and invasion of lung cancers.
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1 

DeSantis CE, Miller KD, Goding Sauer A, Jemal A and Siegel RL: Cancer statistics for African Americans, 2019. CA Cancer J Clin. 69:211–233. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Li J, Guo W, Ran J, Tang R, Lin H, Chen X, Ning B, Li J, Zhou Y, Chen LC, et al: Five-year lung cancer mortality risk analysis and topography in Xuan Wei: A spatiotemporal correlation analysis. BMC Public Health. 19:1732019. View Article : Google Scholar : PubMed/NCBI

3 

Barta JA, Powell CA and Wisnivesky JP: Global epidemiology of lung cancer. Ann Glob Health. 85:82019. View Article : Google Scholar : PubMed/NCBI

4 

Nedović-Vuković M, Laušević D, Ljaljević A, Golubović M and Trajković G: Lung cancer mortality in Montenegro, 1990 to 2015. Croat Med J. 60:26–32. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Haas K, Brillante C, Sharp L, Elzokaky AK, Pasquinelli M, Feldman L, Kovitz KL and Joo M: Lung cancer screening: assessment of health literacy and readability of online educational resources. BMC Public Health. 18:13562018. View Article : Google Scholar : PubMed/NCBI

6 

Oze I, Ito H, Nishino Y, Hattori M, Nakayama T, Miyashiro I, Matsuo K and Ito Y: Trends in small-cell lung cancer survival in 1993–2006 based on population-based cancer registry data in Japan. J Epidemiol. 29:347–353. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Riveiro-Falkenbach E, Ruano Y, Garcia-Martin RM, Lora D, Cifdaloz M, Acquadro F, Ballestín C, Ortiz-Romero PL, Soengas MS and Rodríguez-Peralto JL: DEK oncogene is overexpressed during melanoma progression. Pigment Cell Melanoma Res. 30:194–202. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Yang Y, Gao M, Lin Z, Chen L, Jin Y, Zhu G, Wang Y and Jin T: DEK promoted EMT and angiogenesis through regulating PI3K/AKT/mTOR pathway in triple-negative breast cancer. Oncotarget. 8:98708–98722. 2017.PubMed/NCBI

9 

Lin D, Dong X, Wang K, Wyatt AW, Crea F, Xue H, Wang Y, Wu R, Bell RH, Haegert A, et al: Identification of DEK as a potential therapeutic target for neuroendocrine prostate cancer. Oncotarget. 6:1806–1820. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Waldmann T, Scholten I, Kappes F, Hu HG and Knippers R: The DEK protein-an abundant and ubiquitous constituent of mammalian chromatin. Gene. 343:1–9. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Fu GK, Grosveld G and Markovitz DM: DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer. Proc Natl Acad Sci USA. 94:1811–1815. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Kappes F, Scholten I, Richter N, Gruss C and Waldmann T: Functional domains of the ubiquitous chromatin protein DEK. Mol Cell Biol. 24:6000–6010. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Matrka MC, Watanabe M, Muraleedharan R, Lambert PF, Lane AN, Romick-Rosendale LE and Wells SI: Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis. PLoS One. 12:e01779522017. View Article : Google Scholar : PubMed/NCBI

14 

Böhm F, Kappes F, Scholten I, Richter N, Matsuo H, Knippers R and Waldmann T: The SAF-box domain of chromatin protein DEK. Nucleic Acids Res. 33:1101–1110. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Kappes F, Burger K, Baack M, Fackelmayer FO and Gruss C: Subcellular localization of the human proto-oncogene protein DEK. J Biol Chem. 276:26317–26323. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Waldmann T, Eckerich C, Baack M and Gruss C: The ubiquitous chromatin protein DEK alters the structure of DNA by introducing positive supercoils. J Biol Chem. 277:24988–24994. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Sandén C and Gullberg U: The DEK oncoprotein and its emerging roles in gene regulation. Leukemia. 29:1632–1636. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Xu Y, Liang Z, Li C, Yang Z and Chen L: LCMR1 interacts with DEK to suppress apoptosis in lung cancer cells. Mol Med Rep. 16:4159–4164. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Boer J, Mahmoud H, Raimondi S, Grosveld G and Krance R: Loss of the DEK-CAN fusion transcript in a child with t(6;9) acute myeloid leukemia following chemotherapy and allogeneic bone marrow transplantation. Leukemia. 11:299–300. 1997. View Article : Google Scholar : PubMed/NCBI

20 

Zhou QC, Deng XF, Yang J, Jiang H, Qiao MX, Liu HH, Qian Z, Hou LL and Hu HG: Oncogene DEK is highly expressed in lung cancerous tissues and positively regulates cell proliferation as well as invasion. Oncol Lett. 15:8573–8581. 2018.PubMed/NCBI

21 

Ou Y, Xia R, Kong F, Zhang X, Yu S, Jiang L, Zheng L and Lin L: Overexpression of DEK is an indicator of poor prognosis in patients with gastric adenocarcinoma. Oncol Lett. 11:1823–1828. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Xu X, Zou L, Yao Q, Zhang Y, Gan L and Tang L: Silencing DEK downregulates cervical cancer tumorigenesis and metastasis via the DEK/p-Ser9-GSK-3β/p-Tyr216-GSK-3β/β-catenin axis. Oncol Rep. 38:1035–1042. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Liu K, Feng T, Liu J, Zhong M and Zhang S: Silencing of the DEK gene induces apoptosis and senescence in CaSki cervical carcinoma cells via the up-regulation of NF-κB p65. Biosci Rep. 32:323–332. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK and Varambally S: UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 19:649–658. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Wang J, Sun L, Yang M, Luo W, Gao Y, Liu Z, Qiu X and Wang E: DEK depletion negatively regulates Rho/ROCK/MLC pathway in non-small cell lung cancer. J Histochem Cytochem. 61:510–521. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Wang Y, Lei L, Zheng YW, Zhang L, Li ZH, Shen HY, Jiang GY, Zhang XP, Wang EH and Xu HT: Odd-skipped related 1 inhibits lung cancer proliferation and invasion by reducing Wnt signaling through the suppression of SOX9 and β-catenin. Cancer Sci. 109:1799–1810. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Lei L, Wang Y, Zheng YW, Fei LR, Shen HY, Li ZH, Huang WJ, Yu JH and Xu HT: Overexpression of Nemo-like kinase promotes the proliferation and invasion of lung cancer cells and indicates poor prognosis. Curr Cancer Drug Targets. 19:674–680. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Soekarman D, von Lindern M, van der Plas DC, Selleri L, Bartram CR, Martiat P, Culligan D, Padua RA, Hasper-Voogt KP, Hagemeijer A, et al: Dek-can rearrangement in translocation (6;9)(p23;q34). Leukemia. 6:489–494. 1992.PubMed/NCBI

29 

Capitano ML and Broxmeyer HE: A role for intracellular and extracellular DEK in regulating hematopoiesis. Curr Opin Hematol. 24:300–306. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Sandén C, Nilsson HJ and Gullberg U: The DEK oncoprotein is upregulated by multiple leukemia-associated fusion genes. Blood Cells Mol Dis. 54:284–285. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Diaz-Serrano A, Gella P, Jimenez E, Zugazagoitia J and Paz-Ares Rodriguez L: Targeting EGFR in lung cancer: Current standards and developments. Drugs. 78:893–911. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Jurišić V, Obradovic J, Pavlović S and Djordjevic N: Epidermal growth factor receptor gene in non-small-cell lung cancer: The importance of promoter polymorphism investigation. Anal Cell Pathol (Amst). 2018:61921872018.PubMed/NCBI

33 

Bernicker EH, Allen TC and Cagle PT: Update on emerging biomarkers in lung cancer. J Thorac Dis. 11 (Suppl 1):S81–S88. 2019. View Article : Google Scholar : PubMed/NCBI

34 

van Neerven SM and Vermeulen L: The interplay between intrinsic and extrinsic Wnt signaling in controlling intestinal transformation. Differentiation. 108:17–23. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Schaefer KN and Peifer M: Wnt/Beta-catenin signaling regulation and a role for biomolecular condensates. Dev Cell. 48:429–444. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang MQ, Bai LL, Lei L, Zheng YW, Wang Z, Li ZH, Liu CC, Huang WJ and Xu HT: DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas. Oncol Rep 43: 1338-1348, 2020.
APA
Yang, M., Bai, L., Lei, L., Zheng, Y., Wang, Z., Li, Z. ... Xu, H. (2020). DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas. Oncology Reports, 43, 1338-1348. https://doi.org/10.3892/or.2020.7488
MLA
Yang, M., Bai, L., Lei, L., Zheng, Y., Wang, Z., Li, Z., Liu, C., Huang, W., Xu, H."DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas". Oncology Reports 43.4 (2020): 1338-1348.
Chicago
Yang, M., Bai, L., Lei, L., Zheng, Y., Wang, Z., Li, Z., Liu, C., Huang, W., Xu, H."DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas". Oncology Reports 43, no. 4 (2020): 1338-1348. https://doi.org/10.3892/or.2020.7488
Copy and paste a formatted citation
x
Spandidos Publications style
Yang MQ, Bai LL, Lei L, Zheng YW, Wang Z, Li ZH, Liu CC, Huang WJ and Xu HT: DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas. Oncol Rep 43: 1338-1348, 2020.
APA
Yang, M., Bai, L., Lei, L., Zheng, Y., Wang, Z., Li, Z. ... Xu, H. (2020). DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas. Oncology Reports, 43, 1338-1348. https://doi.org/10.3892/or.2020.7488
MLA
Yang, M., Bai, L., Lei, L., Zheng, Y., Wang, Z., Li, Z., Liu, C., Huang, W., Xu, H."DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas". Oncology Reports 43.4 (2020): 1338-1348.
Chicago
Yang, M., Bai, L., Lei, L., Zheng, Y., Wang, Z., Li, Z., Liu, C., Huang, W., Xu, H."DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas". Oncology Reports 43, no. 4 (2020): 1338-1348. https://doi.org/10.3892/or.2020.7488
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