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Identification of KIF15 as a potential therapeutic target and prognostic factor for glioma

  • Authors:
    • Qilong Wang
    • Bin Han
    • Wu Huang
    • Chunjian Qi
    • Fang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Nanjing Medical University Affiliated Changzhou No. 2 People's Hospital, Changzhou, Jiangsu 213003, P.R. China, Department of Central Lab, Nanjing Medical University Affiliated Changzhou No. 2 People's Hospital, Changzhou, Jiangsu 213003, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1035-1044
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    Published online on: February 21, 2020
       https://doi.org/10.3892/or.2020.7510
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Abstract

Glioma is the most commonly diagnosed primary intracranial malignant tumor with rapid growth, easy recurrence and thus poor prognosis. In the present study, the role of kinesin‑12 (KIF15) in glioma was revealed. Immunohistochemical staining and western blot analysis were used to detect the protein expression. An MTT assay was performed to evaluate cell proliferation. Flow cytometric analysis was utilized to assess cell apoptosis and the cell cycle. A mouse xenograft model was constructed for in vivo study. The results indicated that KIF15 was significantly upregulated in glioma tumor tissues and positively correlated with pathological staging, recurrence risk and poor prognosis. Silencing of KIF15 could inhibit cell proliferation and stemness of glioma cells, arrest cells in the G2 phase and induce cell apoptosis. The in vivo study verified the inhibitory effect of KIF15 knockdown on tumor growth. The mechanism study demonstrated the regulation of apoptosis‑ and cycle‑related proteins in the KIF15 KD‑induced inhibition of glioma. KIF15 was revealed to function as a tumor promoter in the development and progression of glioma. KIF15 also served as a prognostic indicator for glioma and may be a therapeutic target for glioma therapy.
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1 

Weller M, Pfister SM, Wick W, Hegi ME, Reifenberger G and Stupp R: Molecular neuro-oncology in clinical practice: A new horizon. Lancet Oncol. 14:e370–e379. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK and DePinho RA: Malignant glioma: Genetics and biology of a grave matter. Genes Dev. 15:1311–1333. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Wen PY and Kesari S: Malignant gliomas in adults. New Engl J Med. 359:492–507. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Nutt CL, Mani DR, Betensky RA, Tamayo P, Cairncross JG, Ladd C, Pohl U, Hartmann C, Mclaughlin ME, Batchelor TT, et al: Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. Cancer Res. 63:1602–1607. 2003.PubMed/NCBI

5 

Nayak L and Reardon DA: High-Grade gliomas. Continuum (Minneap Minn). 23:1548–1563. 2017.PubMed/NCBI

6 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, et al: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. New Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Khasraw M and Lassman AB: Advances in the treatment of malignant gliomas. Curr Oncol Rep. 12:26–33. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Cohen AL and Colman H: Glioma biology and molecular markers. Cancer Treat Res. 163:15–30. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Kros JM, Mustafa DM, Dekker LJ, Sillevis Smitt PA, Luider TM and Zheng PP: Circulating glioma biomarkers. Neuro Oncol. 17:343–360. 2015.PubMed/NCBI

10 

Hirokawa N and Tanaka Y: Kinesin superfamily proteins (KIFs): Various functions and their relevance for important phenomena in life and diseases. Exp Cell Res. 334:16–25. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Hirokawa N, Bloom GS and Vallee RB: Cytoskeletal architecture and immunocytochemical localization of microtubule-associated proteins in regions of axons associated with rapid axonal transport: The beta, beta′-iminodipropionitrile-intoxicated axon as a model system. J Cell Biol. 101:227–239. 1985. View Article : Google Scholar : PubMed/NCBI

12 

Hirokawa N, Niwa S and Tanaka Y: Molecular motors in neurons: Transport mechanisms and roles in brain function, development, and disease. Neuron. 68:610–638. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Okada Y, Yamazaki H, Sekine-Aizawa Y and Hirokawa N: The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors. Cell. 81:769–780. 1995. View Article : Google Scholar : PubMed/NCBI

14 

Ari C, Borysov SI, Wu J, Padmanabhan J and Potter H: Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function. Neurobiol Aging. 35:1839–1849. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Mcguire JR, Rong J, Li SH and Li XJ: Interaction of huntingtin- associated protein-1 with kinesin light chain: Implications in intracellular trafficking in neurons. J Biol Chem. 281:3552–3559. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Yang W, Tanaka Y, Bundo M and Hirokawa N: Antioxidant signaling involving the microtubule motor KIF12 is an intracellular target of nutrition excess in beta cells. Dev Cell. 31:202–214. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Mrug M, Li R, Cui X, Schoeb TR, Churchill GA and Guay-Woodford LM: Kinesin family member 12 is a candidate polycystic kidney disease modifier in the cpk mouse. J Am Soc Nephrol. 16:905–916. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Mazumdar M, Lee JH, Sengupta K, Ried T, Rane S and Misteli T: Tumor formation via loss of a molecular motor protein. Curr Biol. 16:1559–1564. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Chandrasekaran G, Tátrai P and Gergely F: Hitting the brakes: Targeting microtubule motors in cancer. Br J Cancer. 113:693–698. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Wang W, Shi Y, Li J, Cui W and Yang B: Up-Regulation of KIF14 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in cervical cancer. Bioscience Rep. 36:e3152016. View Article : Google Scholar

21 

Sturgill EG, Norris SR, Guo Y and Ohi R: Kinesin-5 inhibitor resistance is driven by kinesin-12. J Cell Biol. 213:213–227. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Wang J, Guo X, Xie C and Jiang J: KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway. Brit J Cancer. 117:245–255. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Milic B, Chakraborty A, Han K, Bassik MC and Block SM: KIF15 nanomechanics and kinesin inhibitors, with implications for cancer chemotherapeutics. Proc Natl Acad Sci USA. 115:E4613–E4622. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Pollack IF, Finkelstein SD, Woods J, Burnham J, Holmes EJ, Hamilton RL, Yates AJ, Boyett JM, Finlay JL, Sposto R, et al: Expression of p53 and prognosis in children with malignant gliomas. New Engl J Med. 346:420–427. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Omuro A and Deangelis LM: Glioblastoma and other malignant gliomas: A clinical review. JAMA. 310:1842–1850. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Tafani M, De Vito M, Frati A, Pellegrini L, De Santis E, Sette G, Eramo A, Sale P, Mari E, Santoro A, et al: Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma. J Neuroinflamm. 8:322011. View Article : Google Scholar

27 

Sampson JH, Choi BD, Sanchez-Perez L, Suryadevara CM, Snyder DJ, Flores CT, Schmittling RJ, Nair SK, Reap EA, Norberg PK, et al: EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss. Clin Cancer Res. 20:972–984. 2016. View Article : Google Scholar

28 

Yan Z, Wang J, Wang C, Jiao Y, Qi W and Che S: MiR-96/HBP1/Wnt/β-catenin regulatory circuitry promotes glioma growth. FEBS Lett. 588:3038–3046. 2016. View Article : Google Scholar

29 

Wykosky J, Gibo DM, Stanton C and Debinski W: Interleukin-13 receptor alpha 2, EphA2, and Fos-related antigen 1 as molecular denominators of high-grade astrocytomas and specific targets for combinatorial therapy. Clin Cancer Res. 14:199–208. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Han Y, Wu Z, Wu T, Huang Y, Cheng Z, Li X, Sun T, Xie X, Zhou Y and Du Z: Tumor-suppressive function of long noncoding RNA MALAT1 in glioma cells by downregulation of MMP2 and inactivation of ERK/MAPK signaling. Cell Death Dis. 7:e21232016. View Article : Google Scholar : PubMed/NCBI

31 

Cao S, Wang Y, Li J, Lv M, Niu H and Tian Y: Tumor-suppressive function of long noncoding RNA MALAT1 in glioma cells by suppressing miR-155 expression and activating FBXW7 function. Am J Cancer Res. 6:2561–2574. 2016.PubMed/NCBI

32 

Wang J, Ma S, Ma R, Qu X, Liu W, Lv C, Zhao S and Gong Y: KIF2A silencing inhibits the proliferation and migration of breast cancer cells and correlates with unfavorable prognosis in breast cancer. BMC Cancer. 14:4612014. View Article : Google Scholar : PubMed/NCBI

33 

Iltzsche F, Simon K, Stopp S, Pattschull G, Francke S, Wolter P, Hauser S, Murphy DJ, Garcia P, Rosenwald A and Gaubatz S: An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. Oncogene. 36:110–121. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Venere M, Horbinski C, Crish JF, Jin X, Vasanji A, Major J, Burrows AC, Chang C, Prokop J, Wu Q, et al: The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma. Sci Transl Med. 7:143r–304r. 2015. View Article : Google Scholar

35 

Matsuda M, Yamamoto T, Matsumura A and Kaneda Y: Highly efficient eradication of intracranial glioblastoma using Eg5 siRNA combined with HVJ envelope. Gene Ther. 16:1465–1476. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Exertier P, Javerzat S, Wang B, Franco M, Herbert J, Platonova N, Winandy M, Pujol N, Nivelles O and Ormenese S: Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5. Oncotarget. 4:2302–2316. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Chen S, Han M, Chen W, He Y, Huang B, Zhao P, Huang Q, Gao L, Qu X and Li X: KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP. Oncol Rep. 35:971–977. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Liu M, Nadar VC, Kozielski F, Kozlowska M, Yu W and Baas PW: Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation and branching. J Neurosci. 30:14896–14906. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Xu M, Liu D, Dong Z, Wang X, Wang X, Liu Y, Baas PW and Liu M: Kinesin-12 influences axonal growth during zebrafish neural development. Cytoskeleton (Hoboken). 71:555–563. 2015. View Article : Google Scholar

40 

Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O'Hare MJ and Old LJ: Humoral immunity to human breast cancer: Antigen definition and quantitative analysis of mRNA expression. Cancer Immun. 1:42001.PubMed/NCBI

41 

Zou JX, Duan Z, Wang J, Sokolov A, Xu J, Chen CZ, Li JJ and Chen HW: Kinesin family deregulation coordinated by bromodomain protein ANCCA and histone methyltransferase MLL for breast cancer cell growth, survival, and tamoxifen resistance. Mol Cancer Res. 12:539–549. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Bidkhori G, Narimani Z, Hosseini Ashtiani S, Moeini A, Nowzari-Dalini A and Masoudi-Nejad A: Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinoma. PLoS One. 8:e675522013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Q, Han B, Huang W, Qi C and Liu F: Identification of KIF15 as a potential therapeutic target and prognostic factor for glioma. Oncol Rep 43: 1035-1044, 2020.
APA
Wang, Q., Han, B., Huang, W., Qi, C., & Liu, F. (2020). Identification of KIF15 as a potential therapeutic target and prognostic factor for glioma. Oncology Reports, 43, 1035-1044. https://doi.org/10.3892/or.2020.7510
MLA
Wang, Q., Han, B., Huang, W., Qi, C., Liu, F."Identification of KIF15 as a potential therapeutic target and prognostic factor for glioma". Oncology Reports 43.4 (2020): 1035-1044.
Chicago
Wang, Q., Han, B., Huang, W., Qi, C., Liu, F."Identification of KIF15 as a potential therapeutic target and prognostic factor for glioma". Oncology Reports 43, no. 4 (2020): 1035-1044. https://doi.org/10.3892/or.2020.7510
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Q, Han B, Huang W, Qi C and Liu F: Identification of KIF15 as a potential therapeutic target and prognostic factor for glioma. Oncol Rep 43: 1035-1044, 2020.
APA
Wang, Q., Han, B., Huang, W., Qi, C., & Liu, F. (2020). Identification of KIF15 as a potential therapeutic target and prognostic factor for glioma. Oncology Reports, 43, 1035-1044. https://doi.org/10.3892/or.2020.7510
MLA
Wang, Q., Han, B., Huang, W., Qi, C., Liu, F."Identification of KIF15 as a potential therapeutic target and prognostic factor for glioma". Oncology Reports 43.4 (2020): 1035-1044.
Chicago
Wang, Q., Han, B., Huang, W., Qi, C., Liu, F."Identification of KIF15 as a potential therapeutic target and prognostic factor for glioma". Oncology Reports 43, no. 4 (2020): 1035-1044. https://doi.org/10.3892/or.2020.7510
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