Pathology of circulating tumor cells and the available capture tools (Review)

  • Authors:
    • Yibing Guan
    • Fangshi Xu
    • Juanhua Tian
    • Hongwei Chen
    • Chuance Yang
    • Shanlong Huang
    • Ke Gao
    • Ziyan Wan
    • Mingrui Li
    • Minxin He
    • Tie Chong
  • View Affiliations

  • Published online on: March 6, 2020     https://doi.org/10.3892/or.2020.7533
  • Pages: 1355-1364
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Abstract

Circulating tumor cells (CTCs), are tumor cells that diffuse into the circulating blood and serve an important role in the progress of cancer. During the early stages of cancer, CTCs undergo an epithelial‑mesenchymal transition and obtain a more invasive phenotype. Subsequently, the tumor cells enter the circulating blood with the aid of immune cells, and enter a dormant state upon reaching distal organs. As the tumor progresses, metastasis may occur under certain conditions. The capture technologies available for CTCs are based on antibody‑based capture, or capture based on the physical properties of CTCs, as well as modern technologies that integrate both these methods. Emerging modern technologies have increased the accuracy and efficiency of tumor cell capture, and have thus improved our understanding of tumor cells, and the molecular mechanisms underlying their properties. CTCs serve an important role in disease progression, prediction of patient prognosis and individualized treatment.

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May 2020
Volume 43 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Guan, Y., Xu, F., Tian, J., Chen, H., Yang, C., Huang, S. ... Chong, T. (2020). Pathology of circulating tumor cells and the available capture tools (Review). Oncology Reports, 43, 1355-1364. https://doi.org/10.3892/or.2020.7533
MLA
Guan, Y., Xu, F., Tian, J., Chen, H., Yang, C., Huang, S., Gao, K., Wan, Z., Li, M., He, M., Chong, T."Pathology of circulating tumor cells and the available capture tools (Review)". Oncology Reports 43.5 (2020): 1355-1364.
Chicago
Guan, Y., Xu, F., Tian, J., Chen, H., Yang, C., Huang, S., Gao, K., Wan, Z., Li, M., He, M., Chong, T."Pathology of circulating tumor cells and the available capture tools (Review)". Oncology Reports 43, no. 5 (2020): 1355-1364. https://doi.org/10.3892/or.2020.7533