Open Access

Ciprofloxacin promotes polarization of CD86+CD206‑ macrophages to suppress liver cancer

  • Authors:
    • Mengtian Fan
    • Sicheng Chen
    • Yaguang Weng
    • Xian Li
    • Yingjiu Jiang
    • Xiaowen Wang
    • Mengjun Bie
    • Liqin An
    • Menghao Zhang
    • Bin Chen
    • Gaigai Huang
    • Jinghong Wu
    • Mengying Zhu
    • Qiong Shi
  • View Affiliations

  • Published online on: April 29, 2020     https://doi.org/10.3892/or.2020.7602
  • Pages: 91-102
  • Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gut microbiota can promote tumor development by producing toxic metabolites and inhibiting the function of immune cells. Previous studies have demonstrated that gut microbiota can reach the liver through the circulation and promote the occurrence of liver cancer. Ciprofloxacin, an effective broad‑spectrum antimicrobial agent, can promote cell apoptosis and regulate the function of immune cells. As an important part of the tumor microenvironment, macrophages play an important role in tumor regulation. The present study demonstrated that the treatment of macrophages with ciprofloxacin was able to promote the production of interleukin‑1β, tumor necrosis factor‑α and the polarization of CD86+CD206‑ macrophages, while inhibiting the polarization of CD86‑CD206+ macrophages. This transformation may help macrophages promote tumor cell apoptosis, inhibit tumor cell proliferation, reduce metastasis and downregulate the phosphoinositide 3‑kinase/AKT signaling pathway in liver cancer cell lines. In vivo experiments demonstrated that macrophages treated with ciprofloxacin inhibited the growth of subcutaneous implanted tumors in nude mice. In conclusion, the findings of the present study indicated that ciprofloxacin may inhibit liver cancer by upregulating the expression of CD86+CD206‑ macrophages. This study further revealed the biological mechanism underlying the potential value of ciprofloxacin in antitumor therapy and provided new targets for the treatment of liver cancer.
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July 2020
Volume 44 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Fan, M., Chen, S., Weng, Y., Li, X., Jiang, Y., Wang, X. ... Shi, Q. (2020). Ciprofloxacin promotes polarization of CD86+CD206‑ macrophages to suppress liver cancer. Oncology Reports, 44, 91-102. https://doi.org/10.3892/or.2020.7602
MLA
Fan, M., Chen, S., Weng, Y., Li, X., Jiang, Y., Wang, X., Bie, M., An, L., Zhang, M., Chen, B., Huang, G., Wu, J., Zhu, M., Shi, Q."Ciprofloxacin promotes polarization of CD86+CD206‑ macrophages to suppress liver cancer". Oncology Reports 44.1 (2020): 91-102.
Chicago
Fan, M., Chen, S., Weng, Y., Li, X., Jiang, Y., Wang, X., Bie, M., An, L., Zhang, M., Chen, B., Huang, G., Wu, J., Zhu, M., Shi, Q."Ciprofloxacin promotes polarization of CD86+CD206‑ macrophages to suppress liver cancer". Oncology Reports 44, no. 1 (2020): 91-102. https://doi.org/10.3892/or.2020.7602